Lycopene enhances bone neoformation in calvaria bone defects of ovariectomized rats
Braz Dent J. 2023 May-Jun;34(3):50-56. doi: 10.1590/0103-6440202304980.ABSTRACTOsteoporosis can affect a significant part of the population and fractures are the most common complications associated with this disease, leading to high public health costs. Thus, the prevention of fractures is relevant to individuals with signs and symptoms as well as to the health system. Postmenopausal osteoporosis has been associated with oxidative stress, emphasizing the importance of an efficient defense system to maintain bone health. Lycopene is a carotenoid with antioxidant properties that may stimulate osteoblastogenesis and inhibit ...
Source: Braz Dent J - July 19, 2023 Category: Dentistry Authors: Vit ória Ricardo Luiz Gustavo de Sousa Isabela Hallak Regalo Dimitrius Leonardo Pitol Karina Fittipaldi Bombonato-Prado Simone Cecilio Hallak Regalo Selma Siessere Source Type: research
Lycopene enhances bone neoformation in calvaria bone defects of ovariectomized rats
Braz Dent J. 2023 May-Jun;34(3):50-56. doi: 10.1590/0103-6440202304980.ABSTRACTOsteoporosis can affect a significant part of the population and fractures are the most common complications associated with this disease, leading to high public health costs. Thus, the prevention of fractures is relevant to individuals with signs and symptoms as well as to the health system. Postmenopausal osteoporosis has been associated with oxidative stress, emphasizing the importance of an efficient defense system to maintain bone health. Lycopene is a carotenoid with antioxidant properties that may stimulate osteoblastogenesis and inhibit ...
Source: Braz Dent J - July 19, 2023 Category: Dentistry Authors: Vit ória Ricardo Luiz Gustavo de Sousa Isabela Hallak Regalo Dimitrius Leonardo Pitol Karina Fittipaldi Bombonato-Prado Simone Cecilio Hallak Regalo Selma Siessere Source Type: research
Lycopene enhances bone neoformation in calvaria bone defects of ovariectomized rats
Braz Dent J. 2023 May-Jun;34(3):50-56. doi: 10.1590/0103-6440202304980.ABSTRACTOsteoporosis can affect a significant part of the population and fractures are the most common complications associated with this disease, leading to high public health costs. Thus, the prevention of fractures is relevant to individuals with signs and symptoms as well as to the health system. Postmenopausal osteoporosis has been associated with oxidative stress, emphasizing the importance of an efficient defense system to maintain bone health. Lycopene is a carotenoid with antioxidant properties that may stimulate osteoblastogenesis and inhibit ...
Source: Braz Dent J - July 19, 2023 Category: Dentistry Authors: Vit ória Ricardo Luiz Gustavo de Sousa Isabela Hallak Regalo Dimitrius Leonardo Pitol Karina Fittipaldi Bombonato-Prado Simone Cecilio Hallak Regalo Selma Siessere Source Type: research
Lycopene enhances bone neoformation in calvaria bone defects of ovariectomized rats
Braz Dent J. 2023 May-Jun;34(3):50-56. doi: 10.1590/0103-6440202304980.ABSTRACTOsteoporosis can affect a significant part of the population and fractures are the most common complications associated with this disease, leading to high public health costs. Thus, the prevention of fractures is relevant to individuals with signs and symptoms as well as to the health system. Postmenopausal osteoporosis has been associated with oxidative stress, emphasizing the importance of an efficient defense system to maintain bone health. Lycopene is a carotenoid with antioxidant properties that may stimulate osteoblastogenesis and inhibit ...
Source: Braz Dent J - July 19, 2023 Category: Dentistry Authors: Vit ória Ricardo Luiz Gustavo de Sousa Isabela Hallak Regalo Dimitrius Leonardo Pitol Karina Fittipaldi Bombonato-Prado Simone Cecilio Hallak Regalo Selma Siessere Source Type: research
Lycopene enhances bone neoformation in calvaria bone defects of ovariectomized rats
Braz Dent J. 2023 May-Jun;34(3):50-56. doi: 10.1590/0103-6440202304980.ABSTRACTOsteoporosis can affect a significant part of the population and fractures are the most common complications associated with this disease, leading to high public health costs. Thus, the prevention of fractures is relevant to individuals with signs and symptoms as well as to the health system. Postmenopausal osteoporosis has been associated with oxidative stress, emphasizing the importance of an efficient defense system to maintain bone health. Lycopene is a carotenoid with antioxidant properties that may stimulate osteoblastogenesis and inhibit ...
Source: Braz Dent J - July 19, 2023 Category: Dentistry Authors: Vit ória Ricardo Luiz Gustavo de Sousa Isabela Hallak Regalo Dimitrius Leonardo Pitol Karina Fittipaldi Bombonato-Prado Simone Cecilio Hallak Regalo Selma Siessere Source Type: research
Lycopene enhances bone neoformation in calvaria bone defects of ovariectomized rats
Braz Dent J. 2023 May-Jun;34(3):50-56. doi: 10.1590/0103-6440202304980.ABSTRACTOsteoporosis can affect a significant part of the population and fractures are the most common complications associated with this disease, leading to high public health costs. Thus, the prevention of fractures is relevant to individuals with signs and symptoms as well as to the health system. Postmenopausal osteoporosis has been associated with oxidative stress, emphasizing the importance of an efficient defense system to maintain bone health. Lycopene is a carotenoid with antioxidant properties that may stimulate osteoblastogenesis and inhibit ...
Source: Braz Dent J - July 19, 2023 Category: Dentistry Authors: Vit ória Ricardo Luiz Gustavo de Sousa Isabela Hallak Regalo Dimitrius Leonardo Pitol Karina Fittipaldi Bombonato-Prado Simone Cecilio Hallak Regalo Selma Siessere Source Type: research
A Modular Approach for the Synthesis of Natural and Artificial Terpenoids
Angew Chem Int Ed Engl. 2023 Jul 13:e202307626. doi: 10.1002/anie.202307626. Online ahead of print.ABSTRACTMany terpenoids with isoprene unit(s) demonstrating critical biological activities have been isolated and characterized. Although there are natural and many artificial methods for their syntheses, there is a great demand for better understanding of the corresponding structure-activity relationship, efficiency, and diversity. In this work, we have developed a robust chem-stamp strategy for the construction of the key isoprene unit, which consists of two steps: one-carbon extension of aldehydes to the alkenyl boronates ...
Source: Angewandte Chemie - July 13, 2023 Category: Chemistry Authors: Weiyi Wang Dongyu Huang Yibo Yu Hui Qian Shengming Ma Source Type: research
Antioxidant and anti-apoptotic potency of allicin and lycopene against methotrexate-induced cardiac injury in rats
This study aimed to explore whether allicin (ALC) and lycopene (LP) could offer protection against the harmful effects of methotrexate (MTX), a type of chemotherapy drug known for its severe side effects, on the heart of rats. In this experiment, seven groups of rats (n = 7) were used. The first group was given saline as a control vehicle, the second group was given ALC at a dosage of 20 mg/kg orally, the third group was given LP at a dosage of 10 mg/kg orally, and the fourth group was given MTX at a dosage of 20 mg/kg intraperitoneally on the 15th day of the experiment. The remaining three groups received treatments, incl...
Source: Environmental Science and Pollution Research International - July 13, 2023 Category: Environmental Health Authors: Mohamed Aboubakr Ahmed Farag Ahmed Elfadadny Mohamed Alkafafy Ahmed Soliman Mohamed Elbadawy Source Type: research
A Modular Approach for the Synthesis of Natural and Artificial Terpenoids
Angew Chem Int Ed Engl. 2023 Jul 13:e202307626. doi: 10.1002/anie.202307626. Online ahead of print.ABSTRACTMany terpenoids with isoprene unit(s) demonstrating critical biological activities have been isolated and characterized. Although there are natural and many artificial methods for their syntheses, there is a great demand for better understanding of the corresponding structure-activity relationship, efficiency, and diversity. In this work, we have developed a robust chem-stamp strategy for the construction of the key isoprene unit, which consists of two steps: one-carbon extension of aldehydes to the alkenyl boronates ...
Source: Angewandte Chemie - July 13, 2023 Category: Chemistry Authors: Weiyi Wang Dongyu Huang Yibo Yu Hui Qian Shengming Ma Source Type: research
Protective effects of lycopene against zearalenone-induced reproductive toxicity in early pregnancy through anti-inflammatory, antioxidant and anti-apoptotic effects
Food Chem Toxicol. 2023 Jul 8:113936. doi: 10.1016/j.fct.2023.113936. Online ahead of print.ABSTRACTZearalenone is a mycotoxin that is widely present in feed and raw materials and can cause severe reproductive toxicity. Lycopene is a natural carotenoid with antioxidant and anti-inflammatory pharmacological effects, but the protective effects of lycopene against zearalenone-induced uterine damage have not been reported. The aim of this study was to investigate the protective effect of lycopene treatment in early pregnancy on zearalenone-induced uterine damage and pregnancy impairment and its mechanism. Reproductive toxicity...
Source: Food and Chemical Toxicology - July 10, 2023 Category: Food Science Authors: Jungang Kang Yang Li Zhanfei Ma Yabo Wang Weifeng Zhu Guojun Jiang Source Type: research
Protective effects of lycopene against zearalenone-induced reproductive toxicity in early pregnancy through anti-inflammatory, antioxidant and anti-apoptotic effects
Food Chem Toxicol. 2023 Jul 8:113936. doi: 10.1016/j.fct.2023.113936. Online ahead of print.ABSTRACTZearalenone is a mycotoxin that is widely present in feed and raw materials and can cause severe reproductive toxicity. Lycopene is a natural carotenoid with antioxidant and anti-inflammatory pharmacological effects, but the protective effects of lycopene against zearalenone-induced uterine damage have not been reported. The aim of this study was to investigate the protective effect of lycopene treatment in early pregnancy on zearalenone-induced uterine damage and pregnancy impairment and its mechanism. Reproductive toxicity...
Source: Food and Chemical Toxicology - July 10, 2023 Category: Food Science Authors: Jungang Kang Yang Li Zhanfei Ma Yabo Wang Weifeng Zhu Guojun Jiang Source Type: research
Molecules, Vol. 28, Pages 4900: Combination of Lycopene and Curcumin Synergistically Alleviates Testosterone-Propionate-Induced Benign Prostatic Hyperplasia in Sprague Dawley Rats via Modulating Inflammation and Proliferation
Conclusion: The lycopene and curcumin combination is a potential and more effective agent to prevent or treat BPH. (Source: Molecules)
Source: Molecules - June 21, 2023 Category: Chemistry Authors: Shanshan Wang Wenjiang He Wenzhi Li Jin-Rong Zhou Zhiyun Du Tags: Article Source Type: research
Molecules, Vol. 28, Pages 4866: Physicochemical Aspects, Bioactive Compounds, Phenolic Profile and In Vitro Antioxidant Activity of Tropical Red Fruits and Their Blend
The objective was to evaluate and compare the physicochemical characteristics, bioactive compounds, profile of phenolic compounds and in vitro antioxidant activity of pulps of three species of tropical red fruits (acerola, guava and pitanga) and of the blend produced from the combination. The pulps showed significant values of bioactive compounds, with emphasis on acerola, which had the highest levels in all parameters, except for lycopene, with the highest content in pitanga pulp. Nineteen phenolic compounds were identified, being phenolic acids, flavanols, anthocyanin and stilbene; of these, eighteen were quantified in a...
Source: Molecules - June 20, 2023 Category: Chemistry Authors: Yarosl ávia Ferreira Paiva Rossana Maria Feitosa de Figueir êdo Alexandre Jos é de Melo Queiroz Lumara Tatiely Santos Amadeu Francislaine Suelia dos Santos Carolaine Gomes dos Reis Ana J úlia de Brito Araújo Carvalho Marcos dos Santos Lima Ant ônio Tags: Article Source Type: research
Lycopene attenuates chlorpyrifos-induced hepatotoxicity in rats via activation of Nrf2/HO-1 axis
In conclusion, LCP possesses protective effects against CPF-induced hepatotoxicity. These include antioxidation and activation of the Nrf2/HO-1 axis.PMID:37329850 | DOI:10.1016/j.ecoenv.2023.115122 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - June 17, 2023 Category: Environmental Health Authors: Ashraf B Abdel-Naim Emad H M Hassanein Lenah S Binmahfouz Amina M Bagher Rawan H Hareeri Mardi M Algandaby Yousef A J Fadladdin Lotfi Aleya Mohamed M Abdel-Daim Source Type: research
Lycopene attenuates chlorpyrifos-induced hepatotoxicity in rats via activation of Nrf2/HO-1 axis
In conclusion, LCP possesses protective effects against CPF-induced hepatotoxicity. These include antioxidation and activation of the Nrf2/HO-1 axis.PMID:37329850 | DOI:10.1016/j.ecoenv.2023.115122 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - June 17, 2023 Category: Environmental Health Authors: Ashraf B Abdel-Naim Emad H M Hassanein Lenah S Binmahfouz Amina M Bagher Rawan H Hareeri Mardi M Algandaby Yousef A J Fadladdin Lotfi Aleya Mohamed M Abdel-Daim Source Type: research
