Cocaine as a rare cause of locked-in syndrome: a case report
ConclusionOur patient developed locked-in syndrome after use of cocaine. Given the prevalence of its use in the United States, cocaine use should be included among the potential causes of locked-in syndrome. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - November 18, 2019 Category: General Medicine Source Type: research
Transcranial Direct Current Stimulation for a Patient with Locked-in Syndrome
Publication date: Available online 16 November 2019Source: Brain StimulationAuthor(s): Takeshi Satow, Taro Komuro, Takuya Yamaguchi, Nobuhiko Tanabe, Tatsuya Mima (Source: Brain Stimulation)
Source: Brain Stimulation - November 17, 2019 Category: Neurology Source Type: research
Transcranial Direct Current Stimulation for a Patient with Locked-in Syndrome
Locked-in syndrome (LIS) was first introduced by Plum and Posner. It refers to the combination of quadriplegia and anarthria brought about by disruption of the corticospinal and corticobulbar pathways of the brain stem, respectively [1]. Patients with LIS are alert and aware of their environment but cannot speak or move their limbs. They retain the capacity to use vertical eye movements and blinking to communicate. LIS occurs following disruption of the motor tracts in the ventral brain stem and at least 60% of the cases are caused by stroke [2].Early and intensive rehabilitation reportedly improves the functional outcome ...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - November 15, 2019 Category: Neurology Authors: Takeshi Satow, Taro Komuro, Takuya Yamaguchi, Nobuhiko Tanabe, Tatsuya Mima Source Type: research
Ethics of life-sustaining treatment in locked-in syndrome: a Chinese survey
ConclusionsDifferences in opinions about end of life in LIS are affected by personal characteristics. The current survey did not identify a dissociation between personal preferences and general opinions, potentially because of a social uniformity in China where individualism is less pronounced. Future open-ended surveys could identify specific needs of caregivers so that strategic interventions to reduce ethical debasement are designed. (Source: Annals of Physical and Rehabilitation Medicine)
Source: Annals of Physical and Rehabilitation Medicine - November 2, 2019 Category: Rehabilitation Source Type: research
An Analysis of Clinical Characteristics of Rare Bilateral Cerebral Peduncular Infarction
Conclusion: Bilateral cerebral peduncle infarction may be related to cerebral perfusion insufficiency caused by the stenosis or occlusion of vertebrobasilar artery and its branches. The main clinical manifestations are locked-in syndrome and persistent vegetative state. The specific imaging feature of “Mickey Mouse ear”-like infarction is associated with a poor prognosis. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - October 24, 2019 Category: Neurology Source Type: research
Hyperhomocysteinemia induced locked-in syndrome in a young adult due to folic acid deficiency
. (Source: Nutritional Neuroscience)
Source: Nutritional Neuroscience - October 22, 2019 Category: Nutrition Authors: Satyendra Kumar Sonkar Satish Kumar Neeraj Kumar Singh Ruchika Tandon Source Type: research
Anti-pan-neurofascin IgG3 as a marker of fulminant autoimmune neuropathy
Conclusions
Our results indicate that anti–pan-NF-associated neuropathy differs from anti–NF-155-associated neuropathy, and epitope and subclass play a major role in the pathogenesis and severity of anti–NF-associated neuropathy and should be determined to correctly classify patients, also in respect to possible differences in therapeutic response. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - August 15, 2019 Category: Neurology Authors: Stengel, H., Vural, A., Brunder, A.-M., Heinius, A., Appeltshauser, L., Fiebig, B., Giese, F., Dresel, C., Papagianni, A., Birklein, F., Weis, J., Huchtemann, T., Schmidt, C., Körtvelyessy, P., Villmann, C., Meinl, E., Sommer, C., Leypoldt, F., Do Tags: Autoimmune diseases, All Clinical Neurology, Guillain-Barre syndrome, Chronic inflammatory demyelinating polyneuropathy Article Source Type: research
God locked you in the room, but left a window open: A case report of spinal cord stimulation in locked-in syndrome
Publication date: Available online 12 August 2019Source: Brain StimulationAuthor(s): Zhenchao Huang, Xiaofeng Xu, Qing Dong, Lei Wei, Yanjun Lin, Ju Jiao, Zhengqi Lu, Feng Qin (Source: Brain Stimulation)
Source: Brain Stimulation - August 14, 2019 Category: Neurology Source Type: research
God locked you in the room, but left a window open: A case report of spinal cord stimulation in locked-in syndrome
We reported the first application of cervical SCS in a classic LIS patient with encouraging outcomes. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - August 11, 2019 Category: Neurology Authors: Zhenchao Huang, Xiaofeng Xu, Qing Dong, Lei Wei, Yanjun Lin, Ju Jiao, Zhengqi Lu, Feng Qin Source Type: research
The Locked-in Syndrome: Perspectives from Ethics, History, and Phenomenology
AbstractThe existential situation of persons who suffer from the locked-in syndrome (LIS) raises manifold issues significant to medical anthropology, phenomenology, biomedical ethics, and neuroethics that have not yet been systematically explored. The present special issue ofNeuroethics illustrates the joint effort of a consolidating network of scholars from various disciplines in Europe, North America and Japan to go in that direction, and to explore LIS beyond clinical studies and quality of life assessments. (Source: Neuroethics)
Source: Neuroethics - August 7, 2019 Category: Medical Ethics Source Type: research
Impact of the Japanese Disability Homecare System on ALS Patients ’ Decision to Receive Tracheostomy with Invasive Ventilation
This study aims to fill this gap by collecting and analyzing patients’ and family members’ narratives. In Japan, about 30% of ALS patients utilize TIV. This rate is much higher than in most other developed countries. Patients’ narratives illuminate the psychological and especially the c ontextual factors of their decision-making. Many Japanese patients who currently use a ventilator say that their family members encouraged them to prolong their lives through ventilation. These family members have done so because patients are able to use long-term ventilation for only ¥1000 (around $11) per month, and can also access...
Source: Neuroethics - July 3, 2019 Category: Medical Ethics Source Type: research
Late recovery of responsiveness after intra-thecal baclofen pump implantation and the role of diffuse pain and severe spasticity: a case report
AbstractPatients with a prolonged disorder of consciousness (DoC) may present with severe spasticity and diffuse pain, which might impair motor output, thus preventing any possible behavioral responsiveness. A 26-year-old man affected by frontoparietal hemorrhage was operated by hematoma evacuation and decompressive craniectomy; coma persisted for 1 month; cranioplasty and ventriculo-peritoneal shunting was performed after 4 months. At admission in rehabilitation, he was diagnosed as vegetative state/unresponsive wakefulness syndrome (VS/UWS). The implantation of intrathecal baclofen (ITB) pump (Medtronic SynchroMed™ ...
Source: Acta Neurochirurgica - July 2, 2019 Category: Neurosurgery Source Type: research
The history of BCI: From a vision for the future to real support for personhood in people with locked-in syndrome
AbstractThe history of brain-computer interfaces (BCI) developed from a mere idea in the days of early digital technology to today ’s highly sophisticated approaches for signal detection, recording, and analysis. In the 1960s, electroencephalography (EEG) was tied to the laboratory due to equipment and recording requirements. Today, amplifiers exist that are built in the electrode cap and are so resistant to movement artefact s that data collection in the field is no longer a critical issue. Within 60 years, the field has moved from simple and artefact-sensitive EEG recording to making real the vision of brain-computer ...
Source: Neuroethics - May 28, 2019 Category: Medical Ethics Source Type: research
Semantic and BCI-performance in completely paralyzed patients: Possibility of language attrition in completely locked in syndrome.
In this study we have investigated effects of semantic content of sentences presented to a CLIS patient on the performance of the BCI system during a YES/NO paradigm. Comparison of communication success rate in BCI classification between different semantic categories indicate that semantic content of sentences presented to a CLIS patient can affect the BCI performance. Affected concepts are mostly associated with executive words. These findings can be beneficial towards development of more reliable communication device for patients in CLIS. In addition, these results may assist in elucidating the cognitive changes in compl...
Source: Brain and Language - May 27, 2019 Category: Neurology Authors: Khalili Ardali M, Rana A, Purmohammad M, Birbaumer N, Chaudhary U Tags: Brain Lang Source Type: research
