Complex Decisions
Hastings Cent Rep. 2022 Nov;52(6):2. doi: 10.1002/hast.1438.ABSTRACTEssays and articles in the November-December 2022 issue of the Hastings Center Report explore the complexities of medical decision-making. A case-study essay, for example, argues that the dismaying decision to perform resuscitation efforts on a patient who had obviously been dead for some time can be understood in the context of the harmful practice of defensive medicine. A narrative essay concerns whether an adolescent with locked-in syndrome should be asked her wishes about life-sustaining interventions, and the articles illuminate the ethical value of t...
Source: The Hastings Center Report - December 20, 2022 Category: Medical Ethics Authors: Laura Haupt Source Type: research

Complex Decisions
Hastings Cent Rep. 2022 Nov;52(6):2. doi: 10.1002/hast.1438.ABSTRACTEssays and articles in the November-December 2022 issue of the Hastings Center Report explore the complexities of medical decision-making. A case-study essay, for example, argues that the dismaying decision to perform resuscitation efforts on a patient who had obviously been dead for some time can be understood in the context of the harmful practice of defensive medicine. A narrative essay concerns whether an adolescent with locked-in syndrome should be asked her wishes about life-sustaining interventions, and the articles illuminate the ethical value of t...
Source: The Hastings Center Report - December 20, 2022 Category: Medical Ethics Authors: Laura Haupt Source Type: research

Complex Decisions
Hastings Cent Rep. 2022 Nov;52(6):2. doi: 10.1002/hast.1438.ABSTRACTEssays and articles in the November-December 2022 issue of the Hastings Center Report explore the complexities of medical decision-making. A case-study essay, for example, argues that the dismaying decision to perform resuscitation efforts on a patient who had obviously been dead for some time can be understood in the context of the harmful practice of defensive medicine. A narrative essay concerns whether an adolescent with locked-in syndrome should be asked her wishes about life-sustaining interventions, and the articles illuminate the ethical value of t...
Source: The Hastings Center Report - December 20, 2022 Category: Medical Ethics Authors: Laura Haupt Source Type: research

Complex Decisions
Hastings Cent Rep. 2022 Nov;52(6):2. doi: 10.1002/hast.1438.ABSTRACTEssays and articles in the November-December 2022 issue of the Hastings Center Report explore the complexities of medical decision-making. A case-study essay, for example, argues that the dismaying decision to perform resuscitation efforts on a patient who had obviously been dead for some time can be understood in the context of the harmful practice of defensive medicine. A narrative essay concerns whether an adolescent with locked-in syndrome should be asked her wishes about life-sustaining interventions, and the articles illuminate the ethical value of t...
Source: The Hastings Center Report - December 20, 2022 Category: Medical Ethics Authors: Laura Haupt Source Type: research

Complex Decisions
Hastings Cent Rep. 2022 Nov;52(6):2. doi: 10.1002/hast.1438.ABSTRACTEssays and articles in the November-December 2022 issue of the Hastings Center Report explore the complexities of medical decision-making. A case-study essay, for example, argues that the dismaying decision to perform resuscitation efforts on a patient who had obviously been dead for some time can be understood in the context of the harmful practice of defensive medicine. A narrative essay concerns whether an adolescent with locked-in syndrome should be asked her wishes about life-sustaining interventions, and the articles illuminate the ethical value of t...
Source: The Hastings Center Report - December 20, 2022 Category: Medical Ethics Authors: Laura Haupt Source Type: research

Complex Decisions
Hastings Cent Rep. 2022 Nov;52(6):2. doi: 10.1002/hast.1438.ABSTRACTEssays and articles in the November-December 2022 issue of the Hastings Center Report explore the complexities of medical decision-making. A case-study essay, for example, argues that the dismaying decision to perform resuscitation efforts on a patient who had obviously been dead for some time can be understood in the context of the harmful practice of defensive medicine. A narrative essay concerns whether an adolescent with locked-in syndrome should be asked her wishes about life-sustaining interventions, and the articles illuminate the ethical value of t...
Source: The Hastings Center Report - December 20, 2022 Category: Medical Ethics Authors: Laura Haupt Source Type: research

Complex Decisions
Hastings Cent Rep. 2022 Nov;52(6):2. doi: 10.1002/hast.1438.ABSTRACTEssays and articles in the November-December 2022 issue of the Hastings Center Report explore the complexities of medical decision-making. A case-study essay, for example, argues that the dismaying decision to perform resuscitation efforts on a patient who had obviously been dead for some time can be understood in the context of the harmful practice of defensive medicine. A narrative essay concerns whether an adolescent with locked-in syndrome should be asked her wishes about life-sustaining interventions, and the articles illuminate the ethical value of t...
Source: The Hastings Center Report - December 20, 2022 Category: Medical Ethics Authors: Laura Haupt Source Type: research

Subacute brainstem ischemic syndrome in juvenile neurofibromatosis type 2: An underrecognized condition
We report the case of a teenager with a neurofibromatosis Type 2 (NF2) presenting a locked-in syndrome due to a brainstem ischemic syndrome. The presence of sudden or rapidly worsening onset of neurological deficits in NF2 patients, should evoke this underknown entity and not only tumors as predisposed by NF2. (Source: Clinical Case Reports)
Source: Clinical Case Reports - December 6, 2022 Category: General Medicine Authors: Agla ë Blauen, Christine Lenfant, Thierry Duprez, Marie‐Cécile Nassogne Tags: CASE REPORT Source Type: research

Investigating Structure-Function Connectivity in a Patient With Locked-In Syndrome by 7 T Magnetic Resonance Imaging: A Case Report
Conclusions: These results provide tentative evidences to reveal the important role of PCC and corpus callosum in the LIS patient. These findings may be informative to the study of patients with LIS. (Source: The Neurologist)
Source: The Neurologist - November 1, 2022 Category: Neurology Tags: Case Report/Case Series Source Type: research

Acute vertical pendular nystagmus: eye-movement analysis and review of the literature
AbstractVertical pendular nystagmus (PN) rarely occurs with acute pontine lesions. To hypothesize a pathophysiology for acute vertical PN, we analyzed the clinical characteristics and quantitative eye-movement recordings of one new case with acute vertical PN and an additional 11 patients from the literature. Most patients had extensive pontine lesions causing either the locked-in syndrome or unresponsiveness, but two conscious patients had focal lesions restricted to the paramedian caudal pontine tegmentum. All patients presented a complete or partial horizontal gaze palsy, and about half showed ocular bobbing before or d...
Source: Journal of Neurology - October 31, 2022 Category: Neurology Source Type: research

Slow Firing Single Units Are Essential for Optimal Decoding of Silent Speech
The motivation of someone who is locked-in, that is, paralyzed and mute, is to find relief for their loss of function. The data presented in this report is part of an attempt to restore one of those lost functions, namely, speech. An essential feature of the development of a speech prosthesis is optimal decoding of patterns of recorded neural signals during silent or covert speech, that is, speaking “inside the head” with output that is inaudible due to the paralysis of the articulators. The aim of this paper is to illustrate the importance of both fast and slow single unit firings recorded from an individual with lock...
Source: Frontiers in Human Neuroscience - August 3, 2022 Category: Neuroscience Source Type: research

The locked-in syndrome: The early French descriptions
Rev Neurol (Paris). 2022 Jul 25:S0035-3787(22)00643-9. doi: 10.1016/j.neurol.2022.03.017. Online ahead of print.ABSTRACTThe classic 1966 description of locked-in syndrome was performed by Plum and Posner. Here, we revisit the world's first case report of this condition, which was presented in 1875 by Camille Darolles, an intern supervised by François Damaschino, at a monthly meeting of the Société Anatomique de Paris chaired by Jean-Martin Charcot. We also review the fascination of classic writers with this syndrome, including Alexandre Dumas, a genius of literature and known admirer of the medical sciences who, in the ...
Source: Revue Neurologique - July 28, 2022 Category: Neurology Authors: H A G Teive M G Ferreira L Coutinho C H F Camargo R P Munhoz O Walusinski Source Type: research

Posttraumatic Locked-in Syndrome from Combined Brainstem and Upper Cervical Injury in Childhood: A Case Report
Neurochirurgie. 2022 May 26:S0028-3770(22)00096-0. doi: 10.1016/j.neuchi.2022.05.003. Online ahead of print.ABSTRACTLocked in syndrome (LIS) is a condition characterized by quadriplegia, lower cranial nerve palsies and mutism in which only vertical eye movements and upper eyelid movements are preserved while the patient's state of consciousness is intact and the most common cause is Pontine infarction after vertebrobasilar system occlusion. We hereby present a case report of LIS secondary to cervicomedullary contusion after head trauma. Due to the possibility of neurological recovery, early and accurate diagnosis is import...
Source: Neurochirurgie - June 1, 2022 Category: Neurosurgery Authors: Tufan Agah Kartum Gul çin Baş Rah şan Kemerdere Mehmet Murat Hanc ı Source Type: research

Posttraumatic Locked-in Syndrome from Combined Brainstem and Upper Cervical Injury in Childhood: A Case Report
Neurochirurgie. 2022 May 26:S0028-3770(22)00096-0. doi: 10.1016/j.neuchi.2022.05.003. Online ahead of print.ABSTRACTLocked in syndrome (LIS) is a condition characterized by quadriplegia, lower cranial nerve palsies and mutism in which only vertical eye movements and upper eyelid movements are preserved while the patient's state of consciousness is intact and the most common cause is Pontine infarction after vertebrobasilar system occlusion. We hereby present a case report of LIS secondary to cervicomedullary contusion after head trauma. Due to the possibility of neurological recovery, early and accurate diagnosis is import...
Source: Neuro-Chirurgie - June 1, 2022 Category: Neurosurgery Authors: Tufan Agah Kartum Gul çin Baş Rah şan Kemerdere Mehmet Murat Hanc ı Source Type: research