Comprehensive, Technology- Based, Team Approach for a Patient with Locked-In Syndrome: A Case Report of Improved Function
Can the successful implication of an interdisciplinary, multi-sensory, multi-modal, technology based treatment approach to motor and communication deficits in a stroke survivor with LIS improve function and quality of life? (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - September 27, 2016 Category: Rehabilitation Authors: Kimberly Hreha, Keara Savage, Madeline Lutjen, Kara Langhamer, Jeremiah Nieves Source Type: research
Locked-in syndrome in a patient with acute obstructive hydrocephalus, caused by large unruptured aneurysm of the basilar artery (BA)
. (Source: British Journal of Neurosurgery)
Source: British Journal of Neurosurgery - September 15, 2016 Category: Neurosurgery Authors: Zlatko Koli ć Melita Kukuljan Duje Vukas David Bonifa čić Kristina Vrbanec Ivana Karla Frani ć Source Type: research
Basilar artery dissection: A rare complication of posterior fossa epidermoid cyst resection, and evaluation of the possible effects of cerebrospinal fluid drainage on disease progression
We report a rare case of a 45-year-old female with an unruptured basilar artery dissecting aneurysm presenting with locked-in syndrome due to brainstem ischemia eleven months following resection of a giant cerebellopontine angle epidermoid cyst and three months after insertion of ventriculo peritoneal shunt due to hydrocephalus. The etiology of basilar artery dissection and the effect of hydrocephalus and ventricular cerebrospinal fluid drainage on disease progression in this patient are unclear. Our report suggests a possible effect of hydrocephalus and ventricular cerebrospinal fluid drainage on intracranial arterial dis...
Source: Journal of Clinical Neuroscience - August 31, 2016 Category: Neuroscience Source Type: research
Can self-relevant stimuli help assessing patients with disorders of consciousness?
Abstract
Emotional and self-relevant stimuli are able to automatically attract attention and their use in patients suffering from disorders of consciousness (DOC) might help detecting otherwise hidden signs of cognition. We here recorded EEG in three Locked-in syndrome (LIS) and four Vegetative State/Unresponsive Wakefulness Syndrome (VS/UWS) patients while they listened to the voice of a family member or an unfamiliar voice during a passive. Data indicate that, in a passive listening condition, the familiar voice induces stronger alpha desynchronization than the unfamiliar one. In an active condition, the...
Source: Consciousness and Cognition - June 24, 2016 Category: Neurology Authors: Del Giudice R, Blume C, Wislowska M, Lechinger J, Heib DP, Pichler G, Donis J, Michitsch G, Gnjezda MT, Chinchilla M, Machado C, Schabus M Tags: Conscious Cogn Source Type: research
LIS and BCIs: a Local, Pluralist, and Pragmatist Approach to 4E Cognition
Abstract
Four previous papers in this journal have discussed the role of Brain-Computer Interfaces (BCIs) in the lives of Locked-In Syndrome (LIS) patients in terms of the four “E” frameworks for cognition – extended, embedded, embodied, and enactive (also called enacted) cognition. This paper argues that in the light of more recent literature on these 4E frameworks, none of the four papers has taken quite the right approach to deciding which, if any, of the E frameworks is the best one for the job. More specifically, I argue for an approach that is pragmatist rather than purely metaphysical, plural...
Source: Neuroethics - June 13, 2016 Category: Medical Ethics Source Type: research
Unraveling motor networks in patients with chronic disorders of consciousness: A promising minimally invasive approach.
Abstract
Behavioral responsiveness and awareness levels correlate with the degree of functional connectivity within cortical-thalamocortical networks, whose breakdown accounts for chronic disorders of consciousness (DOC). Our study was aimed at assessing the role of the primary motor area (M1) and premotor-M1 circuitry dysfunction in motor output deterioration in minimally conscious state (MCS) and unresponsive wakefulness syndrome (UWS) patients. As a control group, we included a healthy subject (HC) sample in the study. We evaluated the effects of different types of transcranial magnetic stimuli over M1 ...
Source: Brain Research - June 7, 2016 Category: Neurology Authors: Naro A, Leo A, Buda A, Manuli A, Bramanti A, Bramanti P, Calabrò RS Tags: Brain Res Source Type: research
Resting-state networks distinguish locked-in from vegetative state patients
Conclusions This study reinforces previous reports on the preservation of the default mode network in locked-in syndrome in contrast to vegetative state but extends them by suggesting that other networks might be relevant to the diagnosis of locked-in syndrome. The aforementioned analysis of fMRI brain activity at rest might be a step in the development of a diagnostic biomarker to distinguish locked-in syndrome from vegetative state. (Source: NeuroImage: Clinical)
Source: NeuroImage: Clinical - June 6, 2016 Category: Radiology Source Type: research
Évaluation clinique d’une interface cerveau–machine auditive à destination des personnes en Locked-in syndrome complet
Publication date: April 2016 Source:Neurophysiologie Clinique/Clinical Neurophysiology, Volume 46, Issue 2 Author(s): Perrine Séguin, Mélodie Fouillen, Anatole Otman, Jacques Luauté, Pascal Giraux, Dominique Morlet, Emmanuel Maby, Jérémie Mattout Les handicaps moteurs très sévères peuvent provoquer une perte complète de la communication par disparition de toute voie d’expression. La situation la plus typique est le syndrome d’enfermement, Locked-in syndrome (LIS), résultant d’une lésion haute du tronc cérébral. Dans sa forme complète, le patient ne peut pas du tout communiquer. Cet ...
Source: Neurophysiologie Clinique - June 3, 2016 Category: Neuroscience Source Type: research
Posterior Circulation Ischemia or Occlusion in Five Adults With Failing Fontan Circulation
Conclusions In adults with failing Fontan circulation there is a potential for neurologic complications as a result of venous congestion with elevated central venous pressures, and aberrant posterior circulation. The patient’s history and brain imaging may be used to identify at-risk patients and to tailor perioperative management during Fontan conversion or heart transplantation to mitigate the risk for brainstem ischemia. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - May 19, 2016 Category: Cardiovascular & Thoracic Surgery Source Type: research
Evaluation of the visual function of patients with locked-in syndrome: Report of 13 cases.
Authors: Graber M, Challe G, Alexandre MF, Bodaghi B, LeHoang P, Touitou V
Abstract
Although visual function is thought to be preserved in patients with locked-in syndrome (LIS), enabling them to communicate through vertical or lateral eye movements or blinking of the upper eyelid, nothing is known about the actual visual function of patients with LIS. The goal of this study is to evaluate the visual function of patients with LIS which may enable better evaluation of the state of consciousness of these patients. Patients with LIS seen in a single neurovascular unit of a tertiary center between 1997 and 201...
Source: Journal Francais d Ophtalmologie - May 10, 2016 Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Transcranial Alternating Current Stimulation in Patients with Chronic Disorder of Consciousness: A Possible Way to Cut the Diagnostic Gordian Knot?
Abstract
Unresponsive wakefulness syndrome (UWS) is a chronic disorder of consciousness (DOC) characterized by a lack of awareness and purposeful motor behaviors, owing to an extensive brain connectivity impairment. Nevertheless, some UWS patients may retain residual brain connectivity patterns, which may sustain a covert awareness, namely functional locked-in syndrome (fLIS). We evaluated the possibility of bringing to light such residual neural networks using a non-invasive neurostimulation protocol. To this end, we enrolled 15 healthy individuals and 26 DOC patients (minimally conscious state-MCS- and U...
Source: Brain Topography - April 8, 2016 Category: Neuroscience Authors: Naro A, Bramanti P, Leo A, Russo M, Calabrò RS Tags: Brain Topogr Source Type: research
The hyperdense basilar artery sign: a case of locked-in syndrome
Conclusion
This case highlights the need for a high index of suspicion to make a diagnosis of locked-in syndrome in the Emergency Department, especially in young patients with no apparent risk factors for an ischemic stroke. The hyperdense basilar artery sign is one of the earliest signs on non-contrast CT imaging and may be the only clue to guide further management in a patient with basilar artery occlusion. (Source: International Journal of Emergency Medicine)
Source: International Journal of Emergency Medicine - February 29, 2016 Category: Emergency Medicine Source Type: research
A Case Report of Locked-in Syndrome Due to Bilateral Vertebral Artery Dissection After Cervical Spine Manipulation Treated by Arterial Embolectomy
Abstract: Cervical spine manipulation (CSM) is a commonly spinal manipulative therapies for the relief of cervical spine-related conditions worldwide, but its use remains controversial. CSM may carry the potential for serious neurovascular complications, primarily due to vertebral artery dissection (VAD) and subsequent vertebrobasilar stroke. Here, we reported a rare case of locked-in syndrome (LIS) due to bilaterial VAD after CSM treated by arterial embolectomy.
A 36-year-old right-handed man was admitted to our hospital with numbness and weakness of limbs after treating with CSM for neck for half an hour. Gradually, alt...
Source: Medicine - February 1, 2016 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
