Commentary: Correction procedures in brain-age prediction
Publication date: Available online 24 February 2020Source: NeuroImage: ClinicalAuthor(s): Ann-Marie G. de Lange, James H. Cole (Source: NeuroImage: Clinical)
Source: NeuroImage: Clinical - February 27, 2020 Category: Radiology Source Type: research

Tracking the neurodegenerative gradient after spinal cord injury
Publication date: Available online 25 February 2020Source: NeuroImage: ClinicalAuthor(s): Michela Azzarito, Maryam Seif, Sreenath Kyathanahally, Armin Curt, Patrick Freund (Source: NeuroImage: Clinical)
Source: NeuroImage: Clinical - February 27, 2020 Category: Radiology Source Type: research

Perinatal thalamic injury: MRI predictors of electrical status epilepticus in sleep and long-term neurodevelopment
Publication date: Available online 25 February 2020Source: NeuroImage: ClinicalAuthor(s): Bart van den Munckhof, Anne F. Zwart, Lauren C. Weeke, Nathalie H.P. Claessens, Joost D.J. Plate, Alexander Leemans, Hugo J. Kuijf, Heleen C. van Teeseling, Frans S.S. Leijten, Manon J.N. Benders, Kees P.J. Braun, Linda S. de Vries, Floor E. Jansen (Source: NeuroImage: Clinical)
Source: NeuroImage: Clinical - February 27, 2020 Category: Radiology Source Type: research

The Benefit of Foresight?An Ethical Evaluation of Predictive Testing for Psychosis in Clinical Practice
Publication date: Available online 25 February 2020Source: NeuroImage: ClinicalAuthor(s): Natalie M Lane, Stuart A Hunter, Stephen M Lawrie (Source: NeuroImage: Clinical)
Source: NeuroImage: Clinical - February 27, 2020 Category: Radiology Source Type: research

Cross-network coupling of neural oscillations in the dynamic pain connectome reflects chronic neuropathic pain in multiple sclerosis
Publication date: Available online 26 February 2020Source: NeuroImage: ClinicalAuthor(s): J.A. Kim, R.B. Bosma, K.S. Hemington, A. Rogachov, N.R. Osborne, J.C. Cheng, J. Oh, B.T. Dunkley, K.D. Davis (Source: NeuroImage: Clinical)
Source: NeuroImage: Clinical - February 27, 2020 Category: Radiology Source Type: research

Interaction of APOE4 alleles and PET tau imaging in former contact sport athletes
Publication date: 2020Source: NeuroImage: Clinical, Volume 26Author(s): Anna Vasilevskaya, Foad Taghdiri, Charles Burke, Apameh Tarazi, Seyed Ali Naeimi, Mozghan Khodadadi, Ruma Goswami, Christine Sato, Mark Grinberg, Danielle Moreno, Richard Wennberg, David Mikulis, Robin Green, Brenda Colella, Karen D. Davis, Pablo Rusjan, Sylvain Houle, Charles Tator, Ekaterina Rogaeva, Maria C. TartagliaAbstractBackgroundGenetic polymorphisms like apolipoprotein E (APOE) and microtubule-associated protein tau (MAPT) genes increase the risk of neurodegeneration.Methods38 former players (age 52.63±14.02) of contact sports underwen...
Source: NeuroImage: Clinical - February 24, 2020 Category: Radiology Source Type: research

Prospective memory in prodromal Alzheimer's Disease: real world relevance and correlations with cortical thickness and hippocampal subfield volumes
Publication date: Available online 22 February 2020Source: NeuroImage: ClinicalAuthor(s): Volkan Nurdal, Alfie Wearn, Michael Knight, Risto Kauppinen, Elizabeth CoulthardAbstractINTRODUCTIONProspective memory (PM) is a marker of independent living in Alzheimer's disease. PM requires cue identification (prospective component) and remembering what should happen in response to the cue (retrospective component). We assessed neuroanatomical basis and functional relevance of PM.METHODS84 older participants (53-94 years old, 58% male) with or without Mild Cognitive Impairment (MCI) performed PM tests, Activities of Daily Living (...
Source: NeuroImage: Clinical - February 24, 2020 Category: Radiology Source Type: research

Motor effects of deep brain stimulation correlate with increased functional connectivity in Parkinson's disease: An MEG study
Publication date: Available online 21 February 2020Source: NeuroImage: ClinicalAuthor(s): Lennard I. Boon, Arjan Hillebrand, Wouter V. Potters, Rob M.A. de Bie, Naomi Prent, Maarten Bot, P. Richard Schuurman, Cornelis J. Stam, Anne-Fleur van Rootselaar, Henk W. BerendseAbstractDeep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established symptomatic treatment in Parkinson's disease, yet its mechanism of action is not fully understood. Locally in the STN, stimulation lowers beta band power, in parallel with symptom relief. Therefore, beta band oscillations are sometimes referred to as “anti-kinetic&r...
Source: NeuroImage: Clinical - February 23, 2020 Category: Radiology Source Type: research

Focal alterations of the callosal area III in primary lateral sclerosis: an MRI planimetry and texture analysis
Conclusions: This T1w-MRI study demonstrated focused regional CC atrophy and texture alterations limited to the callosal area III (which comprises fibers projecting into the primary motor cortices) in PLS, in comparison to a higher variability in CC size in ALS. (Source: NeuroImage: Clinical)
Source: NeuroImage: Clinical - February 23, 2020 Category: Radiology Source Type: research

The role of limbic structures in financial abilities of Mild Cognitive Impairment Patients
This study aims at examining the correlation between the pattern of brain atrophy of MCI patients and performance on financial abilities. Forty-four MCI patients and thirty-seven healthy controls underwent structural magnetic resonance imaging, and assessment of financial abilities by means of the Numerical Activities of Daily Living Financial battery (NADL-F). As compared to healthy controls, MCI patients showed impaired performance in three out of the seven domains assessed by NADL-F: Item purchase, percentage, and financial concepts. The patients’ performance in the NADL-F correlated with memory, language, visuo-s...
Source: NeuroImage: Clinical - February 21, 2020 Category: Radiology Source Type: research

Abnormal amygdala subregional-sensorimotor connectivity correlates with positive symptom in schizophrenia
In conclusion, this study found that patients with FES had abnormal functional connectivity in the amygdala subregions, and the altered rsFC was associated with positive symptoms. The present findings demonstrate the disruptive rsFC patterns of amygdala subregional-sensorimotor networks in FES and may provide new insights into the neuronal pathophysiology of FES. (Source: NeuroImage: Clinical)
Source: NeuroImage: Clinical - February 21, 2020 Category: Radiology Source Type: research

Altered gray matter volumes in post-stroke depressive patients after subcortical stroke
This study aims to extract changes in the gray matter of these patients and test how these changes account for the PSD symptoms. High-resolution T1 weighted images were collected from 23 PSD patients diagnosed with subcortical stroke. Voxel-based morphometry and support vector machine analyses were used to analyze the data. The results were compared with those collected from 33 non-PSD patients. PSD group showed decreased gray matter volume (GMV) in the left middle frontal gyrus (MFG) when compared to the non-PSD patients. Together with the clinical and demographic variables, the MFG's GMV predictive model was able to dist...
Source: NeuroImage: Clinical - February 21, 2020 Category: Radiology Source Type: research

Greater functional connectivity within the cingulo-opercular and ventral attention networks is related to better fluent reading: A resting-state functional connectivity study
We examined both within- and between-network functional connectivity of these four networks in 26 8–12-year-old children with dyslexia and 30 age-matched typical readers using resting-state functional MRI. Fluency and nonfluency behavioral reading measures were collected, and the scores were analyzed together with the functional data. Children with reading difficulties did not differ in functional connectivity for the four networks compared to typical readers. Grouping the entire cohort into low vs. high fluency-level reading groups, however, revealed significantly higher functional connectivity values within the cin...
Source: NeuroImage: Clinical - February 20, 2020 Category: Radiology Source Type: research

Altered intra- and inter-network functional connectivity in patients with persistent postural-perceptual dizziness
CONCLUSIONIn PPPD patients, dysfunction in the precuneus may cause abnormalities in external environment monitoring and in posture and movement regulation. Compensatory strategies may then be adopted to maintain balance. At the local level, information exchange between the two cerebral hemispheres is enhanced via the corpus callosum. At the whole brain level, through enhancement of functional activities of the visual network, the integration of multiple sensations and the regulation of posture and movement are primarily driven by visual information. (Source: NeuroImage: Clinical)
Source: NeuroImage: Clinical - February 20, 2020 Category: Radiology Source Type: research

Morphometry and gyrification in bipolar disorder and schizophrenia: a comparative MRI study
Publication date: Available online 19 February 2020Source: NeuroImage: ClinicalAuthor(s): Nuno Madeira, João Valente Duarte, Ricardo Martins, Gabriel Nascimento Costa, António Macedo, Miguel Castelo-BrancoAbstractSchizophrenia is believed to be a neurodevelopmental disease with high heritability. Differential diagnosis is often challenging, especially in early phases, namely with other psychotic disorders or even mood disorders. such as bipolar disorder with psychotic symptoms. Key pathophysiological changes separating these two classical psychoses remain poorly understood, and current evidence favors a more ...
Source: NeuroImage: Clinical - February 20, 2020 Category: Radiology Source Type: research

Amygdala response to emotional faces in adolescents with persistent post-concussion symptoms
Publication date: Available online 19 February 2020Source: NeuroImage: ClinicalAuthor(s): Luisa Bohorquez-Montoya, Lezlie Y. España, Amy M. Nader, Robyn E. Furger, Andrew R. Mayer, Timothy B. MeierAbstractApproximately 30% of adolescents with concussion develop persistent post-concussion symptoms (PPCS) that include emotional symptoms. Elevated amygdalae reactivity to emotional faces has been reported in a variety of psychopathologies characterized by emotional symptoms overlapping with those in PPCS. We tested the hypothesis that amygdalae reactivity to emotional faces in adolescents with PPCS+ is elevated compared...
Source: NeuroImage: Clinical - February 20, 2020 Category: Radiology Source Type: research

Cortical Oxygenation during Exposure Therapy – In Situ fNIRS Measurements in Arachnophobia
Publication date: Available online 19 February 2020Source: NeuroImage: ClinicalAuthor(s): David Rosenbaum, Elisabeth J. Leehr, Julian Rubel, Moritz J. Maier, Valeria Pagliaro, Kira Deutsch, Justin Hudak, Florian G. Metzger, Andreas J. Fallgatter, Ann-Christine EhlisAbstractExposure therapy is a well-studied and highly efficacious treatment for phobic disorders. Although the neurobiological model of fear is well underpinned by various studies, the mechanisms of exposure therapy are still under discussion. Partly, this is due to the fact that most neurophysiological methods like fMRI are not able to be used in the natural th...
Source: NeuroImage: Clinical - February 20, 2020 Category: Radiology Source Type: research

Altered Resting-State Functional Connectivity in Adolescents is Associated with PTSD Symptoms and Trauma Exposure
Publication date: Available online 19 February 2020Source: NeuroImage: ClinicalAuthor(s): Jony Sheynin, Elizabeth R. Duval, Yana Lokshina, J. Cobb Scott, Mike Angstadt, Daniel Kessler, Li Zhang, Raquel E. Gur, Ruben C. Gur, Israel LiberzonAbstractAlterations in resting-state functional connectivity (rsFC) have been demonstrated in Posttraumatic Stress Disorder (PTSD). However, such reports have primarily focused on adult participants, whereas findings in adolescents with PTSD are mixed and not entirely consistent with the adult literature. Here, we examined rsFC in a non-treatment seeking adolescent sample with posttraumat...
Source: NeuroImage: Clinical - February 20, 2020 Category: Radiology Source Type: research

Predicting individual clinical trajectories of depression with generative embedding
Publication date: Available online 17 February 2020Source: NeuroImage: ClinicalAuthor(s): Stefan Frässle, Andre F. Marquand, Lianne Schmaal, Richard Dinga, Dick J. Veltman, Nic J.A. van der Wee, Marie-José van Tol, Dario Schöbi, Brenda W.J.H. Penninx, Klaas E. StephanABSTRACTPatients with major depressive disorder (MDD) show heterogeneous treatment response and highly variable clinical trajectories: while some patients experience swift recovery, others show relapsing-remitting or chronic courses. Predicting individual clinical trajectories at an early stage is a key challenge for psychiatry and might facil...
Source: NeuroImage: Clinical - February 18, 2020 Category: Radiology Source Type: research

Examining the functional activity of different obsessive–compulsive symptom dimensions in Tourette syndrome
ConclusionOur findings implicate areas previously reported to be involved in OCD, as well as areas not typically implicated in OCD, suggesting that the neurobiological profile of TS+OCD is intermediate to pure TS and pure OCD. (Source: NeuroImage: Clinical)
Source: NeuroImage: Clinical - February 14, 2020 Category: Radiology Source Type: research

nInteraction of APOE4 alleles and PET Tau Imaging In Former Contact Sport Athletes
Publication date: Available online 13 February 2020Source: NeuroImage: ClinicalAuthor(s): Anna Vasilevskaya, Foad Taghdiri, Charles Burke, Apameh Tarazi, Seyed Ali Naeimi, Mozghan Khodadadi, Ruma Goswami, Christine Sato, Mark Grinberg, Danielle Moreno, Richard Wennberg, David Mikulis, Robin Green, Brenda Colella, Karen D. Davis, Pablo Rusjan, Sylvain Houle, Charles Tator, Ekaterina Rogaeva, Maria C. TartagliaAbstractBackground: Genetic polymorphisms like apolipoprotein E (APOE) and microtubule-associated protein tau (MAPT) genes increase the risk of neurodegeneration.Methods: 38 former players (age 52.63±14.02) of c...
Source: NeuroImage: Clinical - February 14, 2020 Category: Radiology Source Type: research

Neocortical morphometry in Huntington's disease:Indication of the coexistence of abnormal neurodevelopmental and neurodegenerative processes
Publication date: Available online 13 February 2020Source: NeuroImage: ClinicalAuthor(s): Jean-Francois Mangin, Denis Rivière, Edouard Duchesnay, Yann Cointepas, Véronique Gaura, Christophe Verny, Philippe Damier, Pierre Krystkowiak, Anne-Catherine Bachoud-Lévi, Philippe Hantraye, Philippe Remy, Gwenaëlle DouaudAbstractHuntington's disease (HD) is an inherited, autosomal dominant disorder that is characteristically thought of as a degenerative disorder. Despite cellular and molecular grounds suggesting HD could also impact normal development, there has been scarce systems-level data obtained from ...
Source: NeuroImage: Clinical - February 14, 2020 Category: Radiology Source Type: research

Basal forebrain atrophy in frontotemporal dementia
Publication date: Available online 13 February 2020Source: NeuroImage: ClinicalAuthor(s): Rhian S. Convery, Mollie R. Neason, David M. Cash, M. Jorge Cardoso, Marc Modat, Sebastien Ourselin, Jason D. Warren, Jonathan D. Rohrer, Martina BocchettaAbstractBackground: The basal forebrain is a subcortical structure that plays an important role in learning, attention, and memory. Despite the known subcortical involvement in frontotemporal dementia (FTD), there is little research into the role of the basal forebrain in this disease. We aimed to investigate differences in basal forebrain volumes between clinical, genetic, and path...
Source: NeuroImage: Clinical - February 14, 2020 Category: Radiology Source Type: research

Genome-wide association study of white matter hyperintensity volume in elderly persons without dementia
Conclusions: A novel locus near HS3ST3A1 and MIR548H3 genes was associated with WMHV levels and it may be involved in neurodegenerative diseases. (Source: NeuroImage: Clinical)
Source: NeuroImage: Clinical - February 8, 2020 Category: Radiology Source Type: research

Alleviation of ADHD symptoms by non-invasive right prefrontal stimulation is correlated with EEG activity
Publication date: Available online 6 February 2020Source: NeuroImage: ClinicalAuthor(s): Uri Alyagon, Hamutal Shahar, Aviad Hadar, Noam Barnea-Ygael, Avi Lazarovits, Hadar Shalev, Abraham ZangenAbstractAttention deficit hyperactivity disorder (ADHD) is a prevalent disorder with effective pharmacological treatment that benefits most patients. However, about one-third fail to benefit while others search non-pharmacological alternatives, and for those options are scarce. One alternative treatment option is to alter abnormal right prefrontal cortex (rPFC) activity, given that rPFC abnormality has been repeatedly implicated in ...
Source: NeuroImage: Clinical - February 6, 2020 Category: Radiology Source Type: research

Sub-graph Entropy based Network Approaches for Classifying Adolescent Obsessive-Compulsive Disorder from Resting-State Functional MRI
Publication date: Available online 6 February 2020Source: NeuroImage: ClinicalAuthor(s): Bhaskar Sen, Gail A. Bernstein, Bryon A. Mueller, Kathryn R. Cullen, Keshab K. ParhiAbstractThis paper presents a novel approach for classifying obsessive-compulsive disorder (OCD) in adolescents from resting-state fMRI data. Currently, the state-of-the-art for diagnosing OCD in youth involves interviews with adolescent patients and their parents by an experienced clinician, symptom rating scales based on Diagnostic and Statistical Manual of Mental Disorders (DSM), and behavioral observation. Discovering signal processing and network-b...
Source: NeuroImage: Clinical - February 6, 2020 Category: Radiology Source Type: research

Somatosensory evoked fields predict response to vagus nerve stimulation
Publication date: Available online 4 February 2020Source: NeuroImage: ClinicalAuthor(s): Karim Mithani, Simeon Wong, Mirriam Mikhail, Haatef Pourmotabbed, Elizabeth Pang, Roy Sharma, Ivanna Yau, Ayako Ochi, Hiroshi Otsubo, O. Carter Snead, Elizabeth Donner, Cristina Go, Elysa Widjaja, Abbas Babajami-Feremi, George M. IbrahimAbstractThere is an unmet need to develop robust predictive algorithms to preoperatively identify pediatric epilepsy patients who will respond to vagus nerve stimulation (VNS). Given the similarity in the neural circuitry between vagus and median nerve afferent projections to the primary somatosensory c...
Source: NeuroImage: Clinical - February 5, 2020 Category: Radiology Source Type: research

Systems Modeling of White Matter Microstructural Abnormalities in Alzheimer's Disease
Discussion: Incorporation of image analysis with gene network analysis enhances our understanding of disease progression and facilitates identification of novel therapeutic strategies for AD. (Source: NeuroImage: Clinical)
Source: NeuroImage: Clinical - February 5, 2020 Category: Radiology Source Type: research

Is monetary reward processing altered in drug-naïve youth with a behavioral addiction? Findings from internet gaming disorder
Publication date: Available online 4 February 2020Source: NeuroImage: ClinicalAuthor(s): Yuan-Wei Yao, Lu Liu, Patrick D. Worhunsky, Sarah Lichenstein, Shan-Shan Ma, Lei Zhu, Xin-Hui Shi, Songshan Yang, Dr. Jin-Tao Zhang, Sarah W. YipAbstractCurrent models of addiction biology highlight altered neural responses to non-drug rewards as a central feature of addiction. However, given that drugs of abuse can directly impact reward-related dopamine circuitry, it is difficult to determine the extent to which reward processing alterations are a trait feature of individuals with addictions, or primarily a consequence of exogenous d...
Source: NeuroImage: Clinical - February 5, 2020 Category: Radiology Source Type: research

Multi-modal normalization of resting-state using local physiology reduces changes in functional connectivity patterns observed in mTBI patients
In this study, multi-modal neuroimaging data including BOLD rs-fMRI, baseline cerebral blood flow (CBF0) and cerebrovascular reactivity (CVR; acquired using a hypercapnic gas breathing challenge) were collected in 23 subjects with reported mTBI (14.6 ± 14.9 months post-injury) and 27 age-matched healthy controls. Despite no group differences in CVR within the networks of interest (P> 0.05, corrected), significantly higher CBF0 was documented in the mTBI subjects (P
Source: NeuroImage: Clinical - February 5, 2020 Category: Radiology Source Type: research

Increased Hippocampal Shape Asymmetry and Volumetric Ventricular Asymmetry in Autism
Publication date: Available online 5 February 2020Source: NeuroImage: ClinicalAuthor(s): Rose Richards, Ellen Greimel, Dorit Kliemann, Inga K. Koerte, Gerd Schulte-Körne, Martin Reuter, Christian WachingerAbstractAutism spectrum disorder (ASD) is a prevalent and fast-growing pervasive neurodevelopmental disorder worldwide. Despite the prevalence of ASD and the breadth of research conducted on the disorder, a conclusive etiology has yet to be established and controversy still exists about anatomical abnormalities in ASD. In particular, structural asymmetries have seldom been investigated in ASD, especially in subcortic...
Source: NeuroImage: Clinical - February 5, 2020 Category: Radiology Source Type: research

Topography of Cortical Thinning in the Lewy Body Diseases
Conclusions: The pattern of cortical thinning is similar in DLB and PD-associated cognitive impairment, overlapping with and extending beyond AD signature regions to involve fusiform, precentral, and paracentral regions. Cortical thinning in AD signature and fusiform regions in these diseases reflects cognitive impairment and is markedly accentuated by amyloid co-pathology. Further work will be required to determine whether the distinct topography of cortical thinning in DLB and PD-associated cognitive impairment might have value as a diagnostic and/ or outcome biomarker in clinical trials. (Source: NeuroImage: Clinical)
Source: NeuroImage: Clinical - February 2, 2020 Category: Radiology Source Type: research

Analyzing the Co-localization of Substantia Nigra Hyper-Echogenicities and Iron Accumulation in Parkinson's Disease: A multi-modal atlas study with transcranial ultrasound and MRI
Publication date: Available online 1 February 2020Source: NeuroImage: ClinicalAuthor(s): Seyed-Ahmad Ahmadi, Kai Bötzel, Johannes Levin, Juliana Maiostre, Tassilo Klein, Wolfgang Wein, Verena Rozanski, Olaf Dietrich, Birgit Ertl-Wagner, Nassir Navab, Annika PlateAbstractBackgroundTranscranial B-mode sonography (TCS) can detect hyperechogenic speckles in the area of the substantia nigra (SN) in Parkinson's disease (PD). These speckles correlate with iron accumulation in the SN tissue, but an exact volumetric localization in and around the SN is still unknown. Areas of increased iron content in brain tissue can be detec...
Source: NeuroImage: Clinical - February 2, 2020 Category: Radiology Source Type: research

Voxel-based analysis of gray matter relaxation rates shows different correlation patterns for cognitive impairment and physical disability in relapsing-remitting multiple sclerosis.
ConclusionIn relapsing-remitting MS patients, GM microstructural changes correlate diffusely with physical disability, independent of atrophy, with a preferential role of the sensorimotor cortices. Neuronal damage in the limbic system and dorsolateral prefrontal cortices correlates with cognitive dysfunction. (Source: NeuroImage: Clinical)
Source: NeuroImage: Clinical - January 30, 2020 Category: Radiology Source Type: research

Correlation of microglial activation with white matter changes in dementia with Lewy bodies
Publication date: Available online 28 January 2020Source: NeuroImage: ClinicalAuthor(s): Nicolas Nicastro, Elijah Mak, Guy B. Williams, Ajenthan Surendranathan, William Richard Bevan-Jones, Luca Passamonti, Patricia Vazquez Rodriguez, Li Su, Robert Arnold, Tim D. Fryer, Young T. Hong, Franklin I. Aigbirhio, James B. Rowe, John T. O'brienAbstractDementia with Lewy bodies (DLB) is characterized by alpha-synuclein protein deposition with variable degree of concurrent Alzheimer's pathology. Neuroinflammation is also increasingly recognized as a significant contributor to degeneration. We aimed to examine the relationship betwe...
Source: NeuroImage: Clinical - January 30, 2020 Category: Radiology Source Type: research

Modelling prognostic trajectories of cognitive decline due to Alzheimer's disease
Publication date: Available online 26 January 2020Source: NeuroImage: ClinicalAuthor(s): Joseph Giorgio, Susan Landau, William Jagust, Peter Tino, Zoe Kourtzi, for the Alzheimer's Disease Neuroimaging InitiativeAbstractAlzheimer's disease (AD) is characterised by a dynamic process of neurocognitive changes from normal cognition to mild cognitive impairment (MCI) and progression to dementia. However, not all individuals with MCI develop dementia. Predicting whether individuals with MCI will decline (i.e. progressive MCI) or remain stable (i.e. stable MCI) is impeded by patient heterogeneity due to comorbidities that may lea...
Source: NeuroImage: Clinical - January 28, 2020 Category: Radiology Source Type: research

Ventral stream hierarchy underlying perceptual organization in adolescents with autism
Publication date: Available online 25 January 2020Source: NeuroImage: ClinicalAuthor(s): Laurie-Anne Sapey-Triomphe, Bart Boets, Lien Van Eylen, Ilse Noens, Stefan Sunaert, Jean Steyaert, Johan WagemansAbstractObject recognition relies on a hierarchically organized ventral visual stream, with both bottom-up and top-down processes. Here, we aimed at investigating the neural underpinnings of perceptual organization along the ventral visual stream in Autism Spectrum Disorders (ASD), and at determining whether this would be associated with decreased top-down processing in ASD. Nineteen typically developing (TD) adolescents and...
Source: NeuroImage: Clinical - January 27, 2020 Category: Radiology Source Type: research

Reproducibility, reliability and variability of FA and MD in the older healthy population: a test-retest multiparametric analysis
Publication date: Available online 25 January 2020Source: NeuroImage: ClinicalAuthor(s): Pedro A. Luque Laguna, Anna J.E. Combes, Johannes Streffer, Steven Einstein, Maarten Timmers, Steve C.R. Williams, Flavio Dell'Acqua (Source: NeuroImage: Clinical)
Source: NeuroImage: Clinical - January 25, 2020 Category: Radiology Source Type: research

Examining the Functional Activity of Different Obsessive-Compulsive Symptom Dimensions in Tourette Syndrome
Conclusion: Our findings implicate areas previously reported to be involved in OCD, as well as areas not typically implicated in OCD, suggesting that the neurobiological profile of TS+OCD is intermediate to pure TS and pure OCD. (Source: NeuroImage: Clinical)
Source: NeuroImage: Clinical - January 25, 2020 Category: Radiology Source Type: research

Neonatal morphometric similarity mapping for predicting brain age and characterizing neuroanatomic variation associated with preterm birth
Publication date: Available online 23 January 2020Source: NeuroImage: ClinicalAuthor(s): Paola Galdi, Manuel Blesa, David Q. Stoye, Gemma Sullivan, Gillian J. Lamb, Alan J. Quigley, Michael J. Thrippleton, Mark E. Bastin, James P. BoardmanAbstractMulti-contrast MRI captures information about brain macro- and micro-structure which can be combined in an integrated model to obtain a detailed “fingerprint” of the anatomical properties of an individual’s brain. Inter-regional similarities between features derived from structural and diffusion MRI, including regional volumes, diffusion tensor metrics, neurite o...
Source: NeuroImage: Clinical - January 24, 2020 Category: Radiology Source Type: research

Striatal reactivity to reward under threat-of-shock and working memory load in adults at increased familial risk for major depression: A preliminary study
ConclusionFindings suggest that HVul might be at increased risk of developing anhedonic symptoms due to weaker encoding of reward value, higherdifficultytoengageingoal-orientedbehaviorsandincreasedsensitivitytonegativefeedback, particularly in stressful contexts. These findings open new avenues for a better understanding of the mechanisms underlying how the complex interaction between the systems of stress and reward responsiveness contribute to the vulnerability to MDD, and how cognitive resources might modulate this interaction. (Source: NeuroImage: Clinical)
Source: NeuroImage: Clinical - January 24, 2020 Category: Radiology Source Type: research

Rewiring the Extremely Preterm Brain: Altered Structural Connectivity Relates to Language Function
Publication date: Available online 22 January 2020Source: NeuroImage: ClinicalAuthor(s): Maria E. Barnes-Davis, Brady J. Williamson, Stephanie L. Merhar, Scott K. Holland, Darren S. KadisAbstractChildren born preterm are at increased risk for cognitive impairment, with higher-order functions such as language being especially vulnerable. Previously, we and others have reported increased interhemispheric functional connectivity in children born extremely preterm; the finding appears at odds with literature showing decreased integrity of the corpus callosum, the primary commissural bundle, in preterm children. We address the ...
Source: NeuroImage: Clinical - January 24, 2020 Category: Radiology Source Type: research

Mild Traumatic Brain Injury Impacts Associations Between Limbic System Microstructure and Post-Traumatic Stress Disorder Symptomatology
ConclusionsThese findings suggest that the microstructure of limbic and paralimbic brain regions may influence PTSD symptomatology. Further, given the additional associations observed between microstructure and symptom severity in veterans with head trauma, we speculate that mTBI may exacerbate the impact of brain microstructure on PTSD symptoms, especially within regions of the brain known to be vulnerable to chronic stress. A heightened sensitivity to the microstructural environment of the brain could partially explain why individuals with PTSD and mTBI comorbidity experience more severe symptoms and poorer illness progn...
Source: NeuroImage: Clinical - January 24, 2020 Category: Radiology Source Type: research

Distinguishing between paediatric brain tumour types using multi-parametric magnetic resonance imaging and machine learning: a multi-site study
Publication date: Available online 23 January 2020Source: NeuroImage: ClinicalAuthor(s): James T. Grist, Stephanie Withey, Lesley MacPherson, Adam Oates, Stephen Powell, Jan Novak, Laurence Abernethy, Barry Pizer, Richard Grundy, Simon Bailey, Dipayan Mitra, Theodoros N. Arvanitis, Dorothee P. Auer, Shivaram Avula, Andrew C PeetAbstractThe imaging and subsequent accurate diagnosis of paediatric brain tumours presents a radiological challenge, with magnetic resonance imaging playing a key role in providing tumour specific imaging information. Diffusion weighted and perfusion imaging are commonly used to aid the non-invasive...
Source: NeuroImage: Clinical - January 24, 2020 Category: Radiology Source Type: research

Cerebral functional activity and connectivity changes in anti-N-methyl-D-aspartate receptor encephalitis: a resting-state fMRI study
Publication date: Available online 23 January 2020Source: NeuroImage: ClinicalAuthor(s): Luhui Cai, Yanli Liang, Huanjian Huang, Xia Zhou, Jinou ZhengAbstractBackgroundAnti–N-methyl-D-aspartate receptor (NMDAR) encephalitis showing severe neuropsychiatric symptoms is the most common type of autoimmune encephalitis. However, the corresponding standard clinical magnetic resonance imaging (MRI) presents normal or atypical in the majority of patients with anti-NMDAR encephalitis. Here, this study aimed to investigate the alterations in brain functional activity in patients with anti-NMDAR encephalitis and whether these a...
Source: NeuroImage: Clinical - January 24, 2020 Category: Radiology Source Type: research

Using connectivity-based real-time fMRI neurofeedback to modulate attentional and resting state networks in people with high trait anxiety
Publication date: Available online 23 January 2020Source: NeuroImage: ClinicalAuthor(s): Elenor Morgenroth, Francesca Saviola, James Gilleen, Beth Allen, Michael Lührs, Michael W. Eysenck, Paul AllenAbstractHigh levels of trait anxiety are associated with impaired attentional control, changes in brain activity during attentional control tasks and altered network resting state functional connectivity (RSFC). Specifically, dorsolateral prefrontal cortex to anterior cingulate cortex (DLPFC – ACC) functional connectivity, thought to be crucial for effective and efficient attentional control, is reduced in high trait...
Source: NeuroImage: Clinical - January 24, 2020 Category: Radiology Source Type: research

Does the superior fronto-occipital fascicle exist in the human brain? Fiber dissection and brain functional mapping in 90 patients with gliomas
In conclusion, in the present study we attempted to investigate the existence of the SFOF using an anatomical and functional approach. According to our results, the SFOF may not exist in the human brain. (Source: NeuroImage: Clinical)
Source: NeuroImage: Clinical - January 22, 2020 Category: Radiology Source Type: research

Reorganization of Rich-Clubs in Functional Brain Networks during Propofol-Induced Unconsciousness and Natural Sleep
Conclusions: Our study demonstrated that the rich-club reorganization in functional brain networks is characterized by switching of rich-club nodes between the high-order cognitive and sensory and motor networks during propofol-induced alteration of consciousness and natural sleep. These findings will help understand the common neurological mechanism of pharmacological and physiological unconsciousness. (Source: NeuroImage: Clinical)
Source: NeuroImage: Clinical - January 21, 2020 Category: Radiology Source Type: research

Improving the Detection of Autism Spectrum Disorder by Combining Structural and Functional MRI Information
Publication date: Available online 17 January 2020Source: NeuroImage: ClinicalAuthor(s): Mladen Rakić, Mariano Cabezas, Kaisar Kushibar, Arnau Oliver, Xavier LladóAbstractAutism Spectrum Disorder (ASD) is a brain disorder that is typically characterized by deficits in social communication and interaction, as well as restrictive and repetitive behaviors and interests. During the last years, there has been an increase in the use of magnetic resonance imaging (MRI) to help in the detection of common patterns in autism subjects versus typical controls for classification purposes. In this work, we propose a method for t...
Source: NeuroImage: Clinical - January 18, 2020 Category: Radiology Source Type: research

Outward subcortical curvature associated with sub-clinical depression symptoms in adolescents
ConclusionThis is one of the first studies to examine subcortical morphology of basal ganglia and thalamic regions related to StD in adolescents, and the first study to report mostly positive associations between StD, volume and outward morphology in youths. These findings could reflect intact neurogenesis or resilience to depression, however longitudinal research is needed to further understand the neurobiology of StD in adolescents. (Source: NeuroImage: Clinical)
Source: NeuroImage: Clinical - January 18, 2020 Category: Radiology Source Type: research