The Locked-in Syndrome: Perspectives from Ethics, History, and Phenomenology

AbstractThe existential situation of persons who suffer from the locked-in syndrome (LIS) raises manifold issues significant to medical anthropology, phenomenology, biomedical ethics, and neuroethics that have not yet been systematically explored. The present special issue ofNeuroethics illustrates the joint effort of a consolidating network of scholars from various disciplines in Europe, North America and Japan to go in that direction, and to explore LIS beyond clinical studies and quality of life assessments.
Source: Neuroethics - Category: Medical Ethics Source Type: research

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This study demonstrates that body part-specific somatosensory imagery differentially activates somatosensory cortex in a topographically specific manner; evidence which was surprisingly still lacking in the literature. It also offers proof of concept for a novel somatosensory imagery-based fMRI-BCI control strategy, with particularly high potential for visually and motor-impaired patients. The strategy could also be transferred to lower MRI field strengths and to mobile functional near-infrared spectroscopy. Finally, given that communication BCIs provide the BCI user with a form of feedback based on their brain signals and...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
The unidentified patient, from Maryland, suffered a rare but devastating brain-stem stroke which paralysed her from head-to-toe. She was diagnosed with locked-in syndrome.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
ConclusionOur patient developed locked-in syndrome after use of cocaine. Given the prevalence of its use in the United States, cocaine use should be included among the potential causes of locked-in syndrome.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Publication date: Available online 16 November 2019Source: Brain StimulationAuthor(s): Takeshi Satow, Taro Komuro, Takuya Yamaguchi, Nobuhiko Tanabe, Tatsuya Mima
Source: Brain Stimulation - Category: Neurology Source Type: research
New Zealand pharmacist Anstey Campbell decided to start the morning of January 17 with a light jog before heading off to work, noticing that the prickling sensation hadn't subsided by lunchtime.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: Available online 2 November 2019Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Yifan Yan, Athena Demertzi, Yinyan Xia, Jing Wang, Nantu Hu, Zhiliang Zhang, Haibo Di, Steven LaureysAbstractBackgroundLocked-in syndrome (LIS) characterizes individuals who have experienced pontine lesions, who have limited motor output but with preserved cognitive abilities. Despite their severe physical impairment, individuals with LIS self-profess a higher quality of life than generally expected. Such third-person expectations about LIS are shaped by personal and cultural factors in western countries.Objec...
Source: Annals of Physical and Rehabilitation Medicine - Category: Rehabilitation Source Type: research
Conclusion: Bilateral cerebral peduncle infarction may be related to cerebral perfusion insufficiency caused by the stenosis or occlusion of vertebrobasilar artery and its branches. The main clinical manifestations are locked-in syndrome and persistent vegetative state. The specific imaging feature of “Mickey Mouse ear”-like infarction is associated with a poor prognosis.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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Source: Nutritional Neuroscience - Category: Nutrition Authors: Source Type: research
Peter Coghlan, of Manchester, was diagnosed with locked-in syndrome in 2011. At his lowest point, he didn't want to live, but he turned his recovery around.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Conclusions Our results indicate that anti–pan-NF-associated neuropathy differs from anti–NF-155-associated neuropathy, and epitope and subclass play a major role in the pathogenesis and severity of anti–NF-associated neuropathy and should be determined to correctly classify patients, also in respect to possible differences in therapeutic response.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Autoimmune diseases, All Clinical Neurology, Guillain-Barre syndrome, Chronic inflammatory demyelinating polyneuropathy Article Source Type: research
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