Clinical, Diagnostic, and Treatment Characteristics of Orbital Liposarcoma
To clarify the clinical, diagnostic and treatment characteristics of orbital liposarcoma. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - January 16, 2024 Category: Opthalmology Authors: Wei Wu, Xin Kang, Wei Fang, Yueyue Li, Rui Ma, Mingshen Ma, Yan Hei, Qi Wang, Xiaoyi Wang, Xuetao Mu, Shuixi Zhao, Xinji Yang Tags: Original Articles Source Type: research
Genetically engineered mouse model of pleomorphic liposarcoma: Immunophenotyping and histologic characterization
CONCLUSION: Genetically engineered RPP mice reliably produced soft-tissue tumors consistent with pleomorphic liposarcoma, which immunological findings similar to other soft-tissue sarcomas. This model may demonstrate utility in testing treatments for this rare disease, including immunomodulatory therapies.PMID:38199172 | PMC:PMC10788790 | DOI:10.1016/j.neo.2023.100956 (Source: Neoplasia)
Source: Neoplasia - January 10, 2024 Category: Cancer & Oncology Authors: Jeffrey Mark Brown Rahi Patel Kyllie Smith-Fry Michael Ward Trudy Oliver Kevin B Jones Source Type: research
Cancers, Vol. 16, Pages 271: Genetic, Epigenetic and Transcriptome Alterations in Liposarcoma for Target Therapy Selection
G. Yakubovskaya
Liposarcoma (LPS) is one of the most common adult soft-tissue sarcomas (STS), characterized by a high diversity of histopathological features as well as to a lesser extent by a spectrum of molecular abnormalities. Current targeted therapies for STS do not include a wide range of drugs and surgical resection is the mainstay of treatment for localized disease in all subtypes, while many LPS patients initially present with or ultimately progress to advanced disease that is either unresectable, metastatic or both. The understanding of the molecular characteristics of liposarcoma subtypes is becoming an impo...
Source: Cancers - January 8, 2024 Category: Cancer & Oncology Authors: Ekaterina A. Lesovaya Timur I. Fetisov Beniamin Yu. Bokhyan Varvara P. Maksimova Evgeny P. Kulikov Gennady A. Belitsky Kirill I. Kirsanov Marianna G. Yakubovskaya Tags: Review Source Type: research
A case of mediastinal liposarcoma with extensive invasion of pericardium and major vessels achieved complete resection after abemaciclib targeted therapy
Asian J Surg. 2024 Jan 5:S1015-9584(23)02134-6. doi: 10.1016/j.asjsur.2023.12.166. Online ahead of print.NO ABSTRACTPMID:38182520 | DOI:10.1016/j.asjsur.2023.12.166 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - January 5, 2024 Category: Surgery Authors: Zhenkun Liu Rulan Wang Rui Jiang Qinghua Zhou Source Type: research
A case of mediastinal liposarcoma with extensive invasion of pericardium and major vessels achieved complete resection after abemaciclib targeted therapy
Asian J Surg. 2024 Jan 5:S1015-9584(23)02134-6. doi: 10.1016/j.asjsur.2023.12.166. Online ahead of print.NO ABSTRACTPMID:38182520 | DOI:10.1016/j.asjsur.2023.12.166 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - January 5, 2024 Category: Surgery Authors: Zhenkun Liu Rulan Wang Rui Jiang Qinghua Zhou Source Type: research
GSE202361 Neoadjuvant immune checkpoint blockade in retroperitoneal dedifferentiated liposarcoma and extremity/trunk undifferentiated pleomorphic sarcoma (NCT03307616)
Contributors : Christina L Roland ; Chia C Wu ; Elise F Nassif ; Emily Z KeungSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRecent evidence suggests that immune checkpoint blockade (ICB) has some activity in metastatic dedifferentiated liposarcoma (DDLPS) and undifferentiated pleomorphic sarcoma (UPS). We conducted a randomized, non-comparative phase 2 trial (NCT03307616) of nivolumab or nivolumab/ipilimumab in patients with resectable retroperitoneal DDLPS (n=17) and extremity/truncal UPS (n=10), with UPS patients receiving concurrent radiation therapy. The primary endpoint of path...
Source: GEO: Gene Expression Omnibus - January 1, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE230773 Gene expression profiles associated with myxoid liposarcoma scaffold culture compared to monolayer growth and effect of fusion oncogene FUS-DDIT3
Contributors : Parmida Ranji ; Emma Jonasson ; Lisa Andersson ; Stefan Filges ; Manuel Luna Santamar ía ; Soheila Dolatabadi ; Pierre Åman ; Anders StåhlbergSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMyxoid liposarcoma (MLS) is the second most common type of liposarcoma and is characterized by the fusion oncogene FUS ‐DDIT3 or the less common EWSR1‐DDIT3. FUS-DDIT3 is causative in tumor development, but the molecular function of FUS-DDIT3 remains largely unknown. In addition, the tumor microenvironment is important in MLS development. However, due to a lack of rele...
Source: GEO: Gene Expression Omnibus - December 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE191132 Gene expression profiles associated with myxoid liposarcoma scaffold culture compared to xenograft and effect of fusion oncogene FUS-DDIT3
Contributors : Anders St åhlberg ; Stefan FilgesSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMyxoid liposarcoma (MLS) is the second most common type of liposarcoma and is characterized by the fusion oncogene FUS ‐DDIT3 or the less common EWSR1‐DDIT3. While the presence of FUS-DDIT3 as a driver oncoprotein in most MLS cases has been confirmed, the exact molecular action behind the capacity of FUS-DDIT3 for transformation is still unclear and therefore creates a challenge in finding new treatments against this type of cancer. The importance of the microenvironment for tumor p...
Source: GEO: Gene Expression Omnibus - December 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
FRS2 regulated by miR-429 and miR-206 promotes angiogenesis in osteosarcoma
This study aims to explore the clinical implications and biological function of FRS2 in osteosarcoma, and the potential regulatory microRNAs (miRNAs) governing its expression. Our study indicated significant upregulation of FRS2 in osteosarcoma cells and tissues by Western blotting and immunohistochemical staining. Elevated FRS2 expression correlated positively with increased angiogenesis and poor prognosis, possibly serving as an independent prognostic indicator for osteosarcoma patients. Functional assays revealed that attenuating FRS2 in osteosarcoma cells could mitigate proliferation, migration, and angiogenesis of vas...
Source: Gene - December 30, 2023 Category: Genetics & Stem Cells Authors: Yan Zhu Ziying Liu Lili Cao Gentao Fan Ronghao Ji Liming Zhang Suolang Daji Hao Zhu Yicun Wang Guangxin Zhou Source Type: research
Multi-omics joint analysis revealed the metabolic profile of retroperitoneal liposarcoma
AbstractRetroperitoneal liposarcoma (RLPS) is the main subtype of retroperitoneal soft sarcoma (RSTS) and has a poor prognosis and few treatment options, except for surgery. The proteomic and metabolic profiles of RLPS have remained unclear. The aim of our study was to reveal the metabolic profile of RLPS. Here, we performed proteomic analysis (n = 10), metabolomic analysis (n = 51), and lipidomic analysis (n = 50) of retroperitoneal dedifferentiated liposarcoma (RDDLPS) and retroperitoneal well-differentiated liposarcoma (RWDLPS) tissue and paired adjacent adipose tissue obtained during surgery. Data analysis mainly revea...
Source: Frontiers of Medicine - December 29, 2023 Category: General Medicine Source Type: research
Comments on and illustrations of the WFUMB CEUS liver guidelines: Rare malignant mesenchymal liver lesions
Med Ultrason. 2023 Nov 22. doi: 10.11152/mu-4302. Online ahead of print.ABSTRACTThe diagnosis or rare mesenchymal malignant lesions of the liver may be a challenge owing to the rarity of the disease and is usually made by histological confirmation. An ultrasound examination with, if required, color Doppler sonography and contrast-enhanced ultrasound, taking into account the clinical background of the patient, may help to focus the differential diagnosis. In this review, we describe the pathological and ultrasound features of several rare mesenchymal malignant liver lesions which include undifferentiated sarcoma of the live...
Source: Medical Ultrasonography - December 27, 2023 Category: Radiology Authors: Ehsan Safai Zadeh Nicole Schreiber Christian G örg Katharina Paulina Huber Kathleen M öller Analisa Berzigotti Thomas Thomsen Christian Jenssen Ernst-Michael Jung Adrian Lim Masayuki Kitano Ryo Shimizu Yi Dong Xin Wu Cui David Srivastava Christoph F Die Source Type: research
