A Rare Manifestation of Airway Invasion from Pulmonary Artery Liposarcoma
Am J Respir Crit Care Med. 2024 Apr 17. doi: 10.1164/rccm.202308-1377IM. Online ahead of print.NO ABSTRACTPMID:38631026 | DOI:10.1164/rccm.202308-1377IM (Source: Respiratory Care)
Source: Respiratory Care - April 17, 2024 Category: Respiratory Medicine Authors: Jinrui Miao Run Tong Yongming Zhang Mingming Deng Yiding Bian Ruixia Li Gang Hou Source Type: research
Imaging features of perinephric myxoid pseudotumors of fat
ConclusionsPMPTF is a rare, benign, and underrecognized lesion that may mimic malignancy, particularly retroperitoneal well-differentiated liposarcoma. The imaging features of this unusual pseudosarcoma differ in native and transplanted kidneys. Improved awareness of this entity will facilitate appropriate patient management and avoid unnecessary intervention.Graphical Abstract (Source: Abdominal Imaging)
Source: Abdominal Imaging - April 13, 2024 Category: Radiology Source Type: research
Primary renal epithelioid dedifferentiated liposarcoma mimicking a GLI1-amplified neoplasm
Pathol Res Pract. 2024 Apr 2;257:155279. doi: 10.1016/j.prp.2024.155279. Online ahead of print.NO ABSTRACTPMID:38608370 | DOI:10.1016/j.prp.2024.155279 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - April 12, 2024 Category: Pathology Authors: Isidro Machado Arantxa Juaristi Abaunz Reyes Claramunt Tulio M Silva Cleofe Romagosa Marta Ses é Javier Hernandez-Losa Jos é A López-Guerrero Antonio Llombart-Bosch Source Type: research
Nuclear morphological atypia in biopsy accurately reflects the prognosis of myxoid liposarcoma
In this study, we determined whether nuclear morphology may be used to predict the prognosis of MLS in primary biopsy specimens. Two pathologists evaluated nuclear morphology using the modified WHO/ISUP and Fuhrman grades. Survival analyses were performed by grouping nuclear high- and low-grades. We examined 53 MLS cases, which included 29 (54.7%) male and 24 (45.3%) female patients with a median age of 46 years (interquartile range, 37 − 60). In total, 7 (13.2%) and 16 (30.2%) cases were assigned to the high nuclear grade group based on the modified WHO/ISUP and Fuhrman gradings, respectively. Survival analyses re...
Source: Virchows Archiv - March 28, 2024 Category: Pathology Source Type: research
Best Overall Response-associated Signature to Doxorubicin in Soft Tissue Sarcomas: A Transcriptomic Analysis from ANNOUNCE
CONCLUSIONS: The refined REDSARC signature provides a potential tool to direct the application of doxorubicin in sarcomas and other malignancies. Validation and further refinement of the signature in other potentially subtype specific prospective cohorts is recommended.PMID:38536068 | DOI:10.1158/1078-0432.CCR-23-3936 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - March 27, 2024 Category: Cancer & Oncology Authors: Jiangang Liu David S Moura Robin L Jones Amit Aggarwal Ebert J Philip Andrew J Wagner Jennifer Wright Javier Mart ín-Broto William D Tap Source Type: research
Best Overall Response-associated Signature to Doxorubicin in Soft Tissue Sarcomas: A Transcriptomic Analysis from ANNOUNCE
CONCLUSIONS: The refined REDSARC signature provides a potential tool to direct the application of doxorubicin in sarcomas and other malignancies. Validation and further refinement of the signature in other potentially subtype specific prospective cohorts is recommended.PMID:38536068 | DOI:10.1158/1078-0432.CCR-23-3936 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - March 27, 2024 Category: Cancer & Oncology Authors: Jiangang Liu David S Moura Robin L Jones Amit Aggarwal Ebert J Philip Andrew J Wagner Jennifer Wright Javier Mart ín-Broto William D Tap Source Type: research
Evaluation of AJCC staging system and proposal of a novel stage grouping system in retroperitoneal liposarcoma: the Fudan Zhongshan experience
ConclusionCompared with 8th AJCC TNM, 7th AJCC TNM staging system showed a more homogeneous staging distribution and a slight improvement in the prognostic accuracy of RPLS. The revised T-stage and nTNM systems showed better risk stratification performance. The FNCLCC stage was found to have high prognostic value, further emphasising histological grade is the least negligible prognostic factor in predicting patient survival. The constructed nomogram model enables individualized prognostic analysis and helps to develop risk-adapted therapy for RPLS patients. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 27, 2024 Category: Cancer & Oncology Source Type: research
ASO Visual Abstract: Comparing Multivisceral Resection with Tumor-Only Resection of Liposarcoma Using the Win Ratio
Ann Surg Oncol. 2024 Mar 24. doi: 10.1245/s10434-024-15108-z. Online ahead of print.NO ABSTRACTPMID:38523226 | DOI:10.1245/s10434-024-15108-z (Source: Ann Oncol)
Source: Ann Oncol - March 25, 2024 Category: Cancer & Oncology Authors: Leva Gorji Melica Nikahd Amblessed Onuma Diamantis Tsilimigras J Madison Hyer Samantha Ruff Farhan Z Ilyas Carlo Contreras Valerie P Grignol Alex Kim Raphael Pollock Timothy M Pawlik Joal D Beane Source Type: research
Neutrophil-to-lymphocyte ratio for the prediction of soft tissue sarcomas response to pre-operative radiation therapy
CONCLUSION: This study is the first to evaluate NLR as a prognostic biomarker in STS patients treated with pre-operative radiotherapy. A higher NLR after pre-operative radiotherapy was associated with increased disease progression.PMID:38521165 | DOI:10.1016/j.radonc.2024.110239 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 23, 2024 Category: Radiology Authors: Constanza Martinez Rie Asso Neelabh Rastogi Carolyn Freeman Fabio Cury Source Type: research
Surgical management of urethral obstruction secondary to perineal liposarcoma in a dog: a case report
Swelling of the perineal region in male dogs is most commonly caused by a perineal hernia. Clinical signs associated with perineal hernia are constipation, tenesmus or stranguria. This case report documents a ... (Source: BMC Veterinary Research)
Source: BMC Veterinary Research - March 23, 2024 Category: Veterinary Research Authors: Nat ália Korytárová, Beate Bosch, Luise Grace Klass and Pavel Slunsky Tags: Case Report Source Type: research
Can DNA Methylation Profiling Classify Histologic Subtypes and Grades in Soft Tissue Sarcoma?
CONCLUSION: We observed a different DNA methylation pattern between soft tissue sarcomas and normal tissues. Liposarcoma was distinguished from leiomyosarcoma using methylation profiling. High-grade soft tissue sarcoma samples showed a hypermethylation pattern compared with low-grade ones. Our findings indicate the need for research using methylation profiling to better understand the diverse biological characteristics of soft tissue sarcoma. Such research should include studies with sufficient samples and a variety of subtypes, as well as analyses of the expression and function of related genes. Additionally, efforts to l...
Source: Clinical Orthopaedics and Related Research - March 22, 2024 Category: Orthopaedics Authors: Hyunho Kim Min Wook Joo Joohee Yoon Hong Sik Park June Hyuk Kim Joo Hwan Lee Sung Hwan Kim Seul Ki Lee Yang-Guk Chung Yoon Joo Cho Source Type: research
Can DNA Methylation Profiling Classify Histologic Subtypes and Grades in Soft Tissue Sarcoma?
CONCLUSION: We observed a different DNA methylation pattern between soft tissue sarcomas and normal tissues. Liposarcoma was distinguished from leiomyosarcoma using methylation profiling. High-grade soft tissue sarcoma samples showed a hypermethylation pattern compared with low-grade ones. Our findings indicate the need for research using methylation profiling to better understand the diverse biological characteristics of soft tissue sarcoma. Such research should include studies with sufficient samples and a variety of subtypes, as well as analyses of the expression and function of related genes. Additionally, efforts to l...
Source: Clinical Orthopaedics and Related Research - March 22, 2024 Category: Orthopaedics Authors: Hyunho Kim Min Wook Joo Joohee Yoon Hong Sik Park June Hyuk Kim Joo Hwan Lee Sung Hwan Kim Seul Ki Lee Yang-Guk Chung Yoon Joo Cho Source Type: research
Can DNA Methylation Profiling Classify Histologic Subtypes and Grades in Soft Tissue Sarcoma?
CONCLUSION: We observed a different DNA methylation pattern between soft tissue sarcomas and normal tissues. Liposarcoma was distinguished from leiomyosarcoma using methylation profiling. High-grade soft tissue sarcoma samples showed a hypermethylation pattern compared with low-grade ones. Our findings indicate the need for research using methylation profiling to better understand the diverse biological characteristics of soft tissue sarcoma. Such research should include studies with sufficient samples and a variety of subtypes, as well as analyses of the expression and function of related genes. Additionally, efforts to l...
Source: Clinical Orthopaedics and Related Research - March 22, 2024 Category: Orthopaedics Authors: Hyunho Kim Min Wook Joo Joohee Yoon Hong Sik Park June Hyuk Kim Joo Hwan Lee Sung Hwan Kim Seul Ki Lee Yang-Guk Chung Yoon Joo Cho Source Type: research
Can DNA Methylation Profiling Classify Histologic Subtypes and Grades in Soft Tissue Sarcoma?
CONCLUSION: We observed a different DNA methylation pattern between soft tissue sarcomas and normal tissues. Liposarcoma was distinguished from leiomyosarcoma using methylation profiling. High-grade soft tissue sarcoma samples showed a hypermethylation pattern compared with low-grade ones. Our findings indicate the need for research using methylation profiling to better understand the diverse biological characteristics of soft tissue sarcoma. Such research should include studies with sufficient samples and a variety of subtypes, as well as analyses of the expression and function of related genes. Additionally, efforts to l...
Source: Clinical Orthopaedics and Related Research - March 22, 2024 Category: Orthopaedics Authors: Hyunho Kim Min Wook Joo Joohee Yoon Hong Sik Park June Hyuk Kim Joo Hwan Lee Sung Hwan Kim Seul Ki Lee Yang-Guk Chung Yoon Joo Cho Source Type: research
Gene of the month: DDIT3
DNA damage-inducible transcript 3 (DDIT3) gene, mapped to the human chromosome 12q13.3, encodes a protein that belongs to the CCAAT/enhancer-binding protein family of transcription factors. DDIT3 is involved in the proliferative control that responds to endoplasmic reticulum stress in normal conditions, dimerising other transcription factors with basic leucine zipper (bZIP) structural motifs. DDIT3 plays a significant role during cell differentiation, especially adipogenesis, arresting the maturation of adipoblasts. In disease, FUS/EWSR1::DDIT3 fusion is the pathogenic event that drives the development of myxoid liposarcom...
Source: Journal of Clinical Pathology - March 20, 2024 Category: Pathology Authors: Diaz-Perez, J. A., Kerr, D. A. Tags: Gene of the month Source Type: research
