A recurrent NTRK1 tyrosine kinase domain mutation pair is characteristic in a subset of dedifferentiated liposarcomas
Dedifferentiated liposarcoma (DDLPS) is a common form of liposarcoma with challenging treatment modalities. Pan-TRK immunopositivity can be often observed without NTRK gene fusion in soft tissue sarcomas with myogenic differentiation. Expression and the role of NTRK in DDLPS are under-studied. We sought to identify activating mutations of the NTRK genes. (Source: European Journal of Cancer)
Source: European Journal of Cancer - March 13, 2024 Category: Cancer & Oncology Authors: Zolt án Lippai, Bálint Péterfia, Gergő Papp, Katalin Dezső, Gábor Bedics, Zsuzsanna Pápai, Meindert H Lamers, Rosan CM Kuin, Károly Szuhai, Zoltán Sápi Tags: Original Research Source Type: research
Update on Dosing and Fractionation for Neoadjuvant Radiotherapy for Localized Soft Tissue Sarcoma
Opinion statementNeoadjuvant radiotherapy (RT) over 5 –6 weeks with daily doses of 1.8–2.0 Gy to a total dose of 50–50.4 Gy is standard of care for localized high-grade soft tissue sarcomas (STS) of the extremities and trunk wall. One exception is myxoid liposarcomas where the phase II DOREMY trial applying a preoperative dose of 36 Gy in 2 Gy fr actions (3–4 weeks treatment) has achieved excellent local control rates of 100% after a median follow-up of 25 months.Hypofractionated preoperative RT has been investigated in a number of phase II single-arm studies suggesting that daily doses of 2.75 –8 Gy over 1–3 w...
Source: Current Treatment Options in Oncology - March 13, 2024 Category: Cancer & Oncology Source Type: research
Well-differentiated liposarcomas and dedifferentiated liposarcomas: Systemic treatment options for two sibling neoplasms
Soft tissue sarcomas are a heterogeneous group of neoplasms with both simple and complex karyotypes, representing 0.7 % of all cancers [1]. Adipocytic neoplasms are among the most common mesenchymal tumors, with liposarcomas accounting for approximately 20 % of all soft tissue sarcomas [2]. Liposarcoma presents primarily as tumors in adults, with a peak incidence between the ages of 50 to 65; however, a small proportion of liposarcoma cases are seen in younger populations [3]. Liposarcoma can be divided into three main categories: (1) atypical lipomatous tumors or well-differentiated liposarcoma (ALT or WDLPS) and ded...
Source: Cancer Treatment Reviews - March 9, 2024 Category: Cancer & Oncology Authors: A. Kyriazoglou, A. Pagkali, I. Kotsantis, P. Economopoulou, M. Kyrkasiadou, M. Moutafi, N. Gavrielatou, M. Anastasiou, A. Boulouta, A. Pantazopoulos, M. Giannakakou, A. Digklia, A. Psyrri Tags: Systematic or Meta-analysis Studies Source Type: research
