Sertoli cell tumor in a 35-year-old woman – case report
Sertoli ‐Leydig cell tumors are very rare and account (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 1, 2024 Category: OBGYN Authors: Tatiana Bujnowska, Irmina Buda, Ma łgorzata Reinholz-Jaskólska Source Type: research
Quantitative Characterization of Ectopic Adrenal Gene Expression in Fetal Testes in 21-Hydroxylase Deficient Mice
Horm Metab Res. 2024 Jan;56(1):38-44. doi: 10.1055/a-2216-0269. Epub 2024 Jan 3.ABSTRACTTesticular adrenal rest tumors (TART) are a frequent and fertility impairing long-term complication in males with classic congenital adrenal hyperplasia. Due to lack of clear experimental data on their origin, they are hypothesized to be derived from ectopic adrenocortical cells within testicular tissue mainly growing upon stimulation by chronically elevated levels of adrenocorticotropin (ACTH). Alternatively, a more totipotent embryological origin has been discussed as the potential source of these tumors. The aim of this study was to ...
Source: Cell Research - January 3, 2024 Category: Cytology Authors: Maximilian Weniger Maria Mattes Thomas G P Gr ünewald Katrin K öhler Angela H übner Felix Beuschlein Nicole Reisch Source Type: research
Quantitative Characterization of Ectopic Adrenal Gene Expression in
Fetal Testes in 21-Hydroxylase Deficient Mice
Horm Metab Res 2024; 56: 38-44 DOI: 10.1055/a-2216-0269Testicular adrenal rest tumors (TART) are a frequent and fertility impairing
long-term complication in males with classic congenital adrenal hyperplasia. Due
to lack of clear experimental data on their origin, they are hypothesized to be
derived from ectopic adrenocortical cells within testicular tissue mainly
growing upon stimulation by chronically elevated levels of adrenocorticotropin
(ACTH). Alternatively, a more totipotent embryological origin has been discussed
as the potential source of these tumors. Th...
Source: Hormone and Metabolic Research - January 3, 2024 Category: Endocrinology Authors: Weniger, Maximilian Mattes, Maria Gr ünewald, Thomas G.P. K öhler, Katrin H übner, Angela Beuschlein, Felix Reisch, Nicole Tags: Original Article: Endocrine Research Source Type: research
Ovarian Leydig Cell Tumor Associated with Recurrent Torsion and Virilization in an Adolescent Patient
Ovarian tumors are rare in children; however, their incidence increases with age. Of these ovarian tumors, Leydig cell tumors are some of the rarest, accounting for (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - December 16, 2023 Category: OBGYN Authors: Lauren Roth, Anne K. Smith, Natalia Buza, Barbara Coons, David Stitelman, Alla Vash-Margita Source Type: research
Cancers, Vol. 15, Pages 5864: Relevance of Molecular Pathology for the Diagnosis of Sex Cord & ndash;Stromal Tumors of the Ovary: A Narrative Review
Cancers, Vol. 15, Pages 5864: Relevance of Molecular Pathology for the Diagnosis of Sex Cord–Stromal Tumors of the Ovary: A Narrative Review
Cancers doi: 10.3390/cancers15245864
Authors:
Alexis Trecourt
Marie Donzel
Nadjla Alsadoun
Fabienne Allias
Mojgan Devouassoux-Shisheboran
Ovarian sex cord–stromal tumors (SCSTs) account for 8% of all primary ovarian neo-plasms. Accurate diagnosis is crucial since each subtype has a specific prognostic and treatment. Apart from fibrosarcomas, stromal tumors are benign while sex cord tumors may recur, sometimes with a significant time to relapse. ...
Source: Cancers - December 15, 2023 Category: Cancer & Oncology Authors: Alexis Trecourt Marie Donzel Nadjla Alsadoun Fabienne Allias Mojgan Devouassoux-Shisheboran Tags: Review Source Type: research
Hirsutism as the initial presentation of malignant ovarian Leydig cell tumor: A case report
We report a case of 24-year-old virgin female who was referred to our hospital after being diagnosed with steroid cell tumor-not otherwise specified. Prior to her admission, the patient had been treated unsuccessfully with oral contraceptive pills due to male-pattern facial hair growth, abdominal cramps, and irregular menstrual cycle. Lack of improvement warranted further investigations. Hormonal studies showed an elevated total testosterone, dehydroepiandrosterone sulfate, and morning fasting cortisol. Ultrasonography and computed tomography confirmed the presence of a large pelvic mass with mixed solid and cystic compone...
Source: Clinical Case Reports - October 19, 2023 Category: General Medicine Authors: Hasan Arafat,
Marah Khaldy,
Ahmad Abu Munshar,
Amer Zughayyer Tags: CASE REPORT Source Type: research
X-linked RBBP7 mutation causes maturation arrest and testicular tumors
Maturation arrest (MA) is a subtype of non-obstructive azoospermia, and male infertility is a known risk factor for testicular tumors. However, the genetic basis for many affected individuals remains unknown. Here, we identified a deleterious hemizygous variant of X-linked retinoblastoma-binding protein 7 (RBBP7) as a potential key cause of MA, which was also found to be associated with the development of Leydig cell tumors. This mutation resulted in premature protein translation termination, affecting the sixth WD40 domain of the RBBP7 and the interaction of the mutated RBBP7 with histone H4. Decreased BRCA1 and increased...
Source: Journal of Clinical Investigation - October 16, 2023 Category: Biomedical Science Authors: Jingping Li, Huimei Zheng, Jiaru Hou, Jianhua Chen, Fengbin Zhang, Xiaohang Yang, Fan Jin, Yongmei Xi Source Type: research
Coexisting ovarian serous cystadenoma with fibroma: A very unusual combination
J Cancer Res Ther. 2023 Jul-Sep;19(5):1474-1476. doi: 10.4103/jcrt.jcrt_2319_21.ABSTRACTSurface epithelial neoplasms are the most common ovarian tumors, constituting around 60% of all ovarian malignancies. They are classified as benign, borderline, and malignant. Ovarian cystadenomas are common benign epithelial neoplasms which carry an excellent prognosis. Ovarian thecoma-fibroma groups are uncommon sex cord-stromal neoplasms, constituting 1.0%-4.0% of all ovarian tumors. Most of them are benign and often found in postmenopausal patients. Combination tumors in the ovary are known. The most common combination is mucinous c...
Source: Cell Research - October 3, 2023 Category: Cytology Authors: Kirti Balhara Varuna Mallya Nita Khurana Anjali Tempe Source Type: research
Imaging in gynecological disease: clinical and ultrasound characteristics of recurrent ovarian stromal cell tumors
CONCLUSIONS: Some granulosa cell and Sertoli-Leydig cell recurrences manifest typical ultrasound patterns. However, some were described as unilocular cysts. Unilocular cysts are usually classified as benign, but in patients in follow-up for a granulosa cell tumor or Sertoli-Leydig cell tumor, they should be considered suspicious of recurrence. This article is protected by copyright. All rights reserved.PMID:37774092 | DOI:10.1002/uog.27504 (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - September 29, 2023 Category: Radiology Authors: F Moro M T Giudice G Bolomini M C Moruzzi F Mascilini L Quagliozzi F Ciccarone G Scambia A Fagotti L Valentin A C Testa Source Type: research
Imaging in gynecological disease: clinical and ultrasound characteristics of recurrent ovarian stromal cell tumors
CONCLUSIONS: Some granulosa cell and Sertoli-Leydig cell recurrences manifest typical ultrasound patterns. However, some were described as unilocular cysts. Unilocular cysts are usually classified as benign, but in patients in follow-up for a granulosa cell tumor or Sertoli-Leydig cell tumor, they should be considered suspicious of recurrence. This article is protected by copyright. All rights reserved.PMID:37774092 | DOI:10.1002/uog.27504 (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - September 29, 2023 Category: Radiology Authors: F Moro M T Giudice G Bolomini M C Moruzzi F Mascilini L Quagliozzi F Ciccarone G Scambia A Fagotti L Valentin A C Testa Source Type: research
Imaging in gynecological disease: clinical and ultrasound characteristics of recurrent ovarian stromal cell tumors
CONCLUSIONS: Some granulosa cell and Sertoli-Leydig cell recurrences manifest typical ultrasound patterns. However, some were described as unilocular cysts. Unilocular cysts are usually classified as benign, but in patients in follow-up for a granulosa cell tumor or Sertoli-Leydig cell tumor, they should be considered suspicious of recurrence. This article is protected by copyright. All rights reserved.PMID:37774092 | DOI:10.1002/uog.27504 (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - September 29, 2023 Category: Radiology Authors: F Moro M T Giudice G Bolomini M C Moruzzi F Mascilini L Quagliozzi F Ciccarone G Scambia A Fagotti L Valentin A C Testa Source Type: research
The long non-coding RNA transcript, LOC100130460 (CAND1.11) gene, encodes a novel protein highly expressed in cancer cells and tumor human testis tissues
CONCLUSIONS: This report is one of the few providing evidence that a lncRNA produces a protein expressed in normal human tissues and overexpressed in several testicular cancers, suggesting its involvement in regulating cell proliferation and differentiation. Although further studies are needed to validate the results, our data indicate that CAND1.11 could be a potential new prognostic biomarker to use in proliferation and cancer.PMID:37661873 | DOI:10.3233/CBM-230160 (Source: Cancer Biomarkers : Section A of Disease Markers)
Source: Cancer Biomarkers : Section A of Disease Markers - September 4, 2023 Category: Cancer & Oncology Authors: Aldo Donizetti Massimo Venditti Davide Arcainolo Vincenza Aliperti Anna Maria Carrese Marco De Sio Sergio Minucci Michele Caraglia Francesco Aniello Source Type: research
The long non-coding RNA transcript, LOC100130460 (CAND1.11) gene, encodes a novel protein highly expressed in cancer cells and tumor human testis tissues
CONCLUSIONS: This report is one of the few providing evidence that a lncRNA produces a protein expressed in normal human tissues and overexpressed in several testicular cancers, suggesting its involvement in regulating cell proliferation and differentiation. Although further studies are needed to validate the results, our data indicate that CAND1.11 could be a potential new prognostic biomarker to use in proliferation and cancer.PMID:37661873 | DOI:10.3233/CBM-230160 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 4, 2023 Category: Cancer & Oncology Authors: Aldo Donizetti Massimo Venditti Davide Arcainolo Vincenza Aliperti Anna Maria Carrese Marco De Sio Sergio Minucci Michele Caraglia Francesco Aniello Source Type: research
The long non-coding RNA transcript, LOC100130460 (CAND1.11) gene, encodes a novel protein highly expressed in cancer cells and tumor human testis tissues
CONCLUSIONS: This report is one of the few providing evidence that a lncRNA produces a protein expressed in normal human tissues and overexpressed in several testicular cancers, suggesting its involvement in regulating cell proliferation and differentiation. Although further studies are needed to validate the results, our data indicate that CAND1.11 could be a potential new prognostic biomarker to use in proliferation and cancer.PMID:37661873 | DOI:10.3233/CBM-230160 (Source: Cancer Biomarkers : Section A of Disease Markers)
Source: Cancer Biomarkers : Section A of Disease Markers - September 4, 2023 Category: Cancer & Oncology Authors: Aldo Donizetti Massimo Venditti Davide Arcainolo Vincenza Aliperti Anna Maria Carrese Marco De Sio Sergio Minucci Michele Caraglia Francesco Aniello Source Type: research
