Outcomes in ovarian Sertoli-Leydig cell tumor: A report from the International Pleuropulmonary Blastoma/DICER1 and Ovarian and Testicular Stromal Tumor Registries
CONCLUSION: Most individuals with SLCT fare well, though specific risk factors such as mesenchymal heterologous elements are associated with poor prognosis. We also highlight the role of DICER1 surveillance in early detection of SLCT, facilitating stage IA resection.PMID:38657450 | DOI:10.1016/j.ygyno.2024.04.005 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 24, 2024 Category: Cancer & Oncology Authors: Alexander T Nelson Anne K Harris Dave Watson Junne Kamihara Kenneth S Chen Jennifer N Stall Kyle M Devins Robert H Young Damon R Olson Paige H R Mallinger Sarah G Mitchell Lindsey M Hoffman Gail Halliday Amina M Suleymanova Julia L Glade Bender Yoav H Mes Source Type: research
Familial syndromes associated with testicular and paratesticular neoplasms: a comprehensive review
AbstractA syndromic association between a subset of testicular/paratesticular neoplasms is well established. Such examples include Carney complex and large cell calcifying Sertoli cell tumor, Peutz-Jeghers syndrome and intratubular large cell hyalinizing Sertoli cell neoplasia, and VHL syndrome and clear cell papillary cystadenoma of the epididymis.However, recent studies proposed potential novel links between some testicular and paratesticular neoplasms with certain tumor syndromes. While more studies are still needed to solidify these associations, recent research suggests that a subset of Leydig cell tumors may arise in...
Source: Virchows Archiv - April 15, 2024 Category: Pathology Source Type: research
Steroidogenic Acute Regulatory Protein Is a Useful Marker for Sex-Cord-Stroma Tumors and Normal and Neoplastic Adrenocortical Tissue
CONCLUSIONS.—: Our data provide a comprehensive overview on the patterns of StAR immunostaining in human tumors and suggest a diagnostic utility of StAR immunohistochemistry for supporting a diagnosis of Leydig cell tumors or of normal or neoplastic adrenocortical tissue.PMID:38484775 | DOI:10.5858/arpa.2023-0281-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 14, 2024 Category: Laboratory Medicine Authors: Maximilian Lennartz Daniela Amezada Doris H öflmayer Sebastian Dwertmann Rico Clara von Bargen Simon Kind Viktor Reiswich Florian Viehweger Florian Lutz Veit Bertram Christoph Fraune Natalia Gorbokon S ören Weidemann Claudia Hube-Magg Anne Menz Ria Uhli Source Type: research
Steroidogenic Acute Regulatory Protein Is a Useful Marker for Sex-Cord-Stroma Tumors and Normal and Neoplastic Adrenocortical Tissue
CONCLUSIONS.—: Our data provide a comprehensive overview on the patterns of StAR immunostaining in human tumors and suggest a diagnostic utility of StAR immunohistochemistry for supporting a diagnosis of Leydig cell tumors or of normal or neoplastic adrenocortical tissue.PMID:38484775 | DOI:10.5858/arpa.2023-0281-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 14, 2024 Category: Laboratory Medicine Authors: Maximilian Lennartz Daniela Amezada Doris H öflmayer Sebastian Dwertmann Rico Clara von Bargen Simon Kind Viktor Reiswich Florian Viehweger Florian Lutz Veit Bertram Christoph Fraune Natalia Gorbokon S ören Weidemann Claudia Hube-Magg Anne Menz Ria Uhli Source Type: research
Steroidogenic Acute Regulatory Protein Is a Useful Marker for Sex-Cord-Stroma Tumors and Normal and Neoplastic Adrenocortical Tissue
CONCLUSIONS.—: Our data provide a comprehensive overview on the patterns of StAR immunostaining in human tumors and suggest a diagnostic utility of StAR immunohistochemistry for supporting a diagnosis of Leydig cell tumors or of normal or neoplastic adrenocortical tissue.PMID:38484775 | DOI:10.5858/arpa.2023-0281-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 14, 2024 Category: Laboratory Medicine Authors: Maximilian Lennartz Daniela Amezada Doris H öflmayer Sebastian Dwertmann Rico Clara von Bargen Simon Kind Viktor Reiswich Florian Viehweger Florian Lutz Veit Bertram Christoph Fraune Natalia Gorbokon S ören Weidemann Claudia Hube-Magg Anne Menz Ria Uhli Source Type: research
Steroidogenic Acute Regulatory Protein Is a Useful Marker for Sex-Cord-Stroma Tumors and Normal and Neoplastic Adrenocortical Tissue
CONCLUSIONS.—: Our data provide a comprehensive overview on the patterns of StAR immunostaining in human tumors and suggest a diagnostic utility of StAR immunohistochemistry for supporting a diagnosis of Leydig cell tumors or of normal or neoplastic adrenocortical tissue.PMID:38484775 | DOI:10.5858/arpa.2023-0281-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 14, 2024 Category: Laboratory Medicine Authors: Maximilian Lennartz Daniela Amezada Doris H öflmayer Sebastian Dwertmann Rico Clara von Bargen Simon Kind Viktor Reiswich Florian Viehweger Florian Lutz Veit Bertram Christoph Fraune Natalia Gorbokon S ören Weidemann Claudia Hube-Magg Anne Menz Ria Uhli Source Type: research
Steroidogenic Acute Regulatory Protein Is a Useful Marker for Sex-Cord-Stroma Tumors and Normal and Neoplastic Adrenocortical Tissue
CONCLUSIONS.—: Our data provide a comprehensive overview on the patterns of StAR immunostaining in human tumors and suggest a diagnostic utility of StAR immunohistochemistry for supporting a diagnosis of Leydig cell tumors or of normal or neoplastic adrenocortical tissue.PMID:38484775 | DOI:10.5858/arpa.2023-0281-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 14, 2024 Category: Laboratory Medicine Authors: Maximilian Lennartz Daniela Amezada Doris H öflmayer Sebastian Dwertmann Rico Clara von Bargen Simon Kind Viktor Reiswich Florian Viehweger Florian Lutz Veit Bertram Christoph Fraune Natalia Gorbokon S ören Weidemann Claudia Hube-Magg Anne Menz Ria Uhli Source Type: research
Cryptorchidism and puberty
Cryptorchidism is the condition in which one or both testes have not descended adequately into the scrotum. The congenital form of cryptorchidism is one of the most prevalent urogenital anomalies in male newborns. In the acquired form of cryptorchidism, the testis that was previously descended normally is no longer located in the scrotum. Cryptorchidism is associated with an increased risk of infertility and testicular germ cell tumors. However, data on pubertal progression are less well-established because of the limited number of studies. Here, we aim to review the currently available data on pubertal development in boys...
Source: Frontiers in Endocrinology - March 12, 2024 Category: Endocrinology Source Type: research
Review on Sertoli-Leydig Cell Tumours of the Ovary
Discov Med. 2024 Feb;36(181):234-247. doi: 10.24976/Discov.Med.202436181.22.ABSTRACTSertoli-Leydig cell tumours (SLCTs) represent a subset of mixed sex cord-stromal tumours (SCSTs), a rare form of non-epithelial ovarian tumours comprising less than 7% of malignant cases. Among other types of SCSTs, SLCTs are one of the more prevalent types observed in young adults. SLCTs are classified into 5 histologic categories based on differentiation levels and histological variants. Diverse chromosomal and genetic mutations have been identified in SLCTs, with the most well-studied being the genetic mutations observed in the Dicer 1, ...
Source: Discovery Medicine - February 27, 2024 Category: Research Authors: Corinne Muscat Jean Calleja-Agius Source Type: research
