Ovarian Leydig cell tumour diagnosis in a postmenopausal woman with uterine bleeding: a case report and literature review
J Obstet Gynaecol. 2022 Feb 15:1-3. doi: 10.1080/01443615.2022.2027897. Online ahead of print.NO ABSTRACTPMID:35164632 | DOI:10.1080/01443615.2022.2027897 (Source: Journal of Obstetrics and Gynaecology)
Source: Journal of Obstetrics and Gynaecology - February 15, 2022 Category: OBGYN Authors: Asuka Higuchi Shunichiro Tsuji Tsukuru Amano Kyoko Kasahara Fuminori Kimura Takashi Murakami Source Type: research
Distinct somatic DICER1 hotspot mutations in three metachronous ovarian Sertoli-Leydig cell tumors in a patient with DICER1 syndrome
Sertoli-Leydig cell tumor (SLCT) is a rare mixed sex cord-stromal tumor comprising less than 0.5% of all ovarian cancers [1]. Somatic DICER1 hotspot variants in the RNase IIIb domain are identified in nearly all moderately and poorly differentiated SLCT [2 –4]. The development of bilateral SLCT is extremely rare [1,3], typically seen as metachronous tumors arising 2 to 6 years apart in patients with DICER1 syndrome caused by germline pathogenic loss-of-function DICER1 variants [5]. In prior reports, bilateral SLCT tumors in four patients have been r eported to be independent primary tumors [5,6]. (Source: Cancer Genetics and Cytogenetics)
Source: Cancer Genetics and Cytogenetics - January 5, 2022 Category: Genetics & Stem Cells Authors: Annie Garcia, Lauren Desrosiers, Sarah Scollon, Stephanie Gruner, Jacquelyn Reuther, Ilavarasi Gandhi, Ninad Patil, Maren Y. Fuller, Hongzheng Dai, Donna Muzny, Richard A. Gibbs, Jennifer L. Bercaw-Pratt, Seema L. Rao, Nino Rainusso, Kevin E. Fisher, Fran Source Type: research
Testicular Lesions in Infertile Men
CONCLUSIONS: The high incidence of Leydig cell tumors and the accuracy of FSE for these lesions demonstrate the interest in FSE. In contrast, FSE is not reliable for fibrous lesions, and surgeons should be aware that a fibrosis result often corresponds with regressed tumors.PMID:34935941 | DOI:10.1093/ajcp/aqab214 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 22, 2021 Category: Pathology Authors: Margot Dupeux Florian Maxwell Laurence Rocher Vincent Izard Catherine Guettier Sophie Ferlicot Source Type: research
Testicular Lesions in Infertile Men
CONCLUSIONS: The high incidence of Leydig cell tumors and the accuracy of FSE for these lesions demonstrate the interest in FSE. In contrast, FSE is not reliable for fibrous lesions, and surgeons should be aware that a fibrosis result often corresponds with regressed tumors.PMID:34935941 | DOI:10.1093/ajcp/aqab214 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 22, 2021 Category: Pathology Authors: Margot Dupeux Florian Maxwell Laurence Rocher Vincent Izard Catherine Guettier Sophie Ferlicot Source Type: research
Testicular Lesions in Infertile Men
CONCLUSIONS: The high incidence of Leydig cell tumors and the accuracy of FSE for these lesions demonstrate the interest in FSE. In contrast, FSE is not reliable for fibrous lesions, and surgeons should be aware that a fibrosis result often corresponds with regressed tumors.PMID:34935941 | DOI:10.1093/ajcp/aqab214 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 22, 2021 Category: Pathology Authors: Margot Dupeux Florian Maxwell Laurence Rocher Vincent Izard Catherine Guettier Sophie Ferlicot Source Type: research
Testicular Lesions in Infertile Men
CONCLUSIONS: The high incidence of Leydig cell tumors and the accuracy of FSE for these lesions demonstrate the interest in FSE. In contrast, FSE is not reliable for fibrous lesions, and surgeons should be aware that a fibrosis result often corresponds with regressed tumors.PMID:34935941 | DOI:10.1093/ajcp/aqab214 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 22, 2021 Category: Pathology Authors: Margot Dupeux Florian Maxwell Laurence Rocher Vincent Izard Catherine Guettier Sophie Ferlicot Source Type: research
Testicular Lesions in Infertile Men
CONCLUSIONS: The high incidence of Leydig cell tumors and the accuracy of FSE for these lesions demonstrate the interest in FSE. In contrast, FSE is not reliable for fibrous lesions, and surgeons should be aware that a fibrosis result often corresponds with regressed tumors.PMID:34935941 | DOI:10.1093/ajcp/aqab214 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 22, 2021 Category: Pathology Authors: Margot Dupeux Florian Maxwell Laurence Rocher Vincent Izard Catherine Guettier Sophie Ferlicot Source Type: research
Testicular Lesions in Infertile Men
CONCLUSIONS: The high incidence of Leydig cell tumors and the accuracy of FSE for these lesions demonstrate the interest in FSE. In contrast, FSE is not reliable for fibrous lesions, and surgeons should be aware that a fibrosis result often corresponds with regressed tumors.PMID:34935941 | DOI:10.1093/ajcp/aqab214 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 22, 2021 Category: Pathology Authors: Margot Dupeux Florian Maxwell Laurence Rocher Vincent Izard Catherine Guettier Sophie Ferlicot Source Type: research
Testicular Lesions in Infertile Men
CONCLUSIONS: The high incidence of Leydig cell tumors and the accuracy of FSE for these lesions demonstrate the interest in FSE. In contrast, FSE is not reliable for fibrous lesions, and surgeons should be aware that a fibrosis result often corresponds with regressed tumors.PMID:34935941 | DOI:10.1093/ajcp/aqab214 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 22, 2021 Category: Pathology Authors: Margot Dupeux Florian Maxwell Laurence Rocher Vincent Izard Catherine Guettier Sophie Ferlicot Source Type: research
Testicular Lesions in Infertile Men
CONCLUSIONS: The high incidence of Leydig cell tumors and the accuracy of FSE for these lesions demonstrate the interest in FSE. In contrast, FSE is not reliable for fibrous lesions, and surgeons should be aware that a fibrosis result often corresponds with regressed tumors.PMID:34935941 | DOI:10.1093/ajcp/aqab214 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 22, 2021 Category: Pathology Authors: Margot Dupeux Florian Maxwell Laurence Rocher Vincent Izard Catherine Guettier Sophie Ferlicot Source Type: research
Testicular Lesions in Infertile Men
CONCLUSIONS: The high incidence of Leydig cell tumors and the accuracy of FSE for these lesions demonstrate the interest in FSE. In contrast, FSE is not reliable for fibrous lesions, and surgeons should be aware that a fibrosis result often corresponds with regressed tumors.PMID:34935941 | DOI:10.1093/ajcp/aqab214 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - December 22, 2021 Category: Pathology Authors: Margot Dupeux Florian Maxwell Laurence Rocher Vincent Izard Catherine Guettier Sophie Ferlicot Source Type: research
Transcriptomic analysis of MA-10 tumor Leydig cells treated with adipose derived hormones adiponectin and resistin
In this study, we wanted to identify which genes are directly regulated by these hormones using the MA-10 tumor Leydig cell model. To do this, we treated these cells with adiponectin or resistin, followed by RNA extraction and RNA-Seq transcriptome analysis. Interestingly, genes upregulated by the globular form of adiponectin (gACRP30) were associated to steroid hormones biosynthesis, whereas resistin had no effect on the transcriptome of MA-10 Leydig cells. Moreover, the expression of the Star gene, encoding the steroidogenic acute regulatory protein, was increased in response to treatments with 0.5 mM 8Br-cAMP. Such stim...
Source: Reproductive Biology - December 20, 2021 Category: Reproduction Medicine Authors: Ha Tuyen Nguyen Luc J Martin Source Type: research
Effect of androgens on Sertoli cell maturation in human testis from birth to puberty
ConclusionsAndrogen action on Sertoli cells is required for onset of spermatogenesis and premature androgen secretion by LCT can induce spermatogenesis in the vicinity of the tumor. AR ir appeared earlier than onset of spermatogenesis, with large interindividual variability. The timing and mechanisms of Sertoli cell responsiveness to androgens are important issues for understanding the induction of spermatogenesis at puberty. (Source: Basic and Clinical Andrology)
Source: Basic and Clinical Andrology - December 14, 2021 Category: Urology & Nephrology Source Type: research
Clinical heterogeneity and reduced penetrance in DICER1 syndrome: a report of three families
CONCLUSIONS: Among our patients, three developed tumors most frequently associated with DICER1 syndrome (i.e. pleuropulmonary blastoma, nephroblastoma, and Sertoli-Leydig cell tumor). One developed a peculiar sarcoma of the spinal cord not previously described in DICER1 syndrome. Genetic testing in relatives highlighted the paternal origin and reduced penetrance in all families, with thyroid benign lesions as the most common features in otherwise unaffected individuals.PMID:34761719 | DOI:10.1177/03008916211058788 (Source: Tumori)
Source: Tumori - November 11, 2021 Category: Cancer & Oncology Authors: Jacopo Azzollini Andrea Ferrari Alessandra Stracuzzi Stefano Chiaravalli Monica Terenziani Filippo Spreafico Maurizia Grasso Paola Collini Valeria Pensotti Maura Massimino Eloisa Arbustini Siranoush Manoukian Source Type: research
