The long non-coding RNA transcript, LOC100130460 (CAND1.11) gene, encodes a novel protein highly expressed in cancer cells and tumor human testis tissues
CONCLUSIONS: This report is one of the few providing evidence that a lncRNA produces a protein expressed in normal human tissues and overexpressed in several testicular cancers, suggesting its involvement in regulating cell proliferation and differentiation. Although further studies are needed to validate the results, our data indicate that CAND1.11 could be a potential new prognostic biomarker to use in proliferation and cancer.PMID:37661873 | DOI:10.3233/CBM-230160 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 4, 2023 Category: Cancer & Oncology Authors: Aldo Donizetti Massimo Venditti Davide Arcainolo Vincenza Aliperti Anna Maria Carrese Marco De Sio Sergio Minucci Michele Caraglia Francesco Aniello Source Type: research
The long non-coding RNA transcript, LOC100130460 (CAND1.11) gene, encodes a novel protein highly expressed in cancer cells and tumor human testis tissues
CONCLUSIONS: This report is one of the few providing evidence that a lncRNA produces a protein expressed in normal human tissues and overexpressed in several testicular cancers, suggesting its involvement in regulating cell proliferation and differentiation. Although further studies are needed to validate the results, our data indicate that CAND1.11 could be a potential new prognostic biomarker to use in proliferation and cancer.PMID:37661873 | DOI:10.3233/CBM-230160 (Source: Cancer Biomarkers : Section A of Disease Markers)
Source: Cancer Biomarkers : Section A of Disease Markers - September 4, 2023 Category: Cancer & Oncology Authors: Aldo Donizetti Massimo Venditti Davide Arcainolo Vincenza Aliperti Anna Maria Carrese Marco De Sio Sergio Minucci Michele Caraglia Francesco Aniello Source Type: research
The long non-coding RNA transcript, LOC100130460 (CAND1.11) gene, encodes a novel protein highly expressed in cancer cells and tumor human testis tissues
CONCLUSIONS: This report is one of the few providing evidence that a lncRNA produces a protein expressed in normal human tissues and overexpressed in several testicular cancers, suggesting its involvement in regulating cell proliferation and differentiation. Although further studies are needed to validate the results, our data indicate that CAND1.11 could be a potential new prognostic biomarker to use in proliferation and cancer.PMID:37661873 | DOI:10.3233/CBM-230160 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 4, 2023 Category: Cancer & Oncology Authors: Aldo Donizetti Massimo Venditti Davide Arcainolo Vincenza Aliperti Anna Maria Carrese Marco De Sio Sergio Minucci Michele Caraglia Francesco Aniello Source Type: research
The long non-coding RNA transcript, LOC100130460 (CAND1.11) gene, encodes a novel protein highly expressed in cancer cells and tumor human testis tissues
CONCLUSIONS: This report is one of the few providing evidence that a lncRNA produces a protein expressed in normal human tissues and overexpressed in several testicular cancers, suggesting its involvement in regulating cell proliferation and differentiation. Although further studies are needed to validate the results, our data indicate that CAND1.11 could be a potential new prognostic biomarker to use in proliferation and cancer.PMID:37661873 | DOI:10.3233/CBM-230160 (Source: Cancer Biomarkers : Section A of Disease Markers)
Source: Cancer Biomarkers : Section A of Disease Markers - September 4, 2023 Category: Cancer & Oncology Authors: Aldo Donizetti Massimo Venditti Davide Arcainolo Vincenza Aliperti Anna Maria Carrese Marco De Sio Sergio Minucci Michele Caraglia Francesco Aniello Source Type: research
The long non-coding RNA transcript, LOC100130460 (CAND1.11) gene, encodes a novel protein highly expressed in cancer cells and tumor human testis tissues
CONCLUSIONS: This report is one of the few providing evidence that a lncRNA produces a protein expressed in normal human tissues and overexpressed in several testicular cancers, suggesting its involvement in regulating cell proliferation and differentiation. Although further studies are needed to validate the results, our data indicate that CAND1.11 could be a potential new prognostic biomarker to use in proliferation and cancer.PMID:37661873 | DOI:10.3233/CBM-230160 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - September 4, 2023 Category: Cancer & Oncology Authors: Aldo Donizetti Massimo Venditti Davide Arcainolo Vincenza Aliperti Anna Maria Carrese Marco De Sio Sergio Minucci Michele Caraglia Francesco Aniello Source Type: research
The long non-coding RNA transcript, LOC100130460 (CAND1.11) gene, encodes a novel protein highly expressed in cancer cells and tumor human testis tissues
CONCLUSIONS: This report is one of the few providing evidence that a lncRNA produces a protein expressed in normal human tissues and overexpressed in several testicular cancers, suggesting its involvement in regulating cell proliferation and differentiation. Although further studies are needed to validate the results, our data indicate that CAND1.11 could be a potential new prognostic biomarker to use in proliferation and cancer.PMID:37661873 | DOI:10.3233/CBM-230160 (Source: Cancer Biomarkers : Section A of Disease Markers)
Source: Cancer Biomarkers : Section A of Disease Markers - September 4, 2023 Category: Cancer & Oncology Authors: Aldo Donizetti Massimo Venditti Davide Arcainolo Vincenza Aliperti Anna Maria Carrese Marco De Sio Sergio Minucci Michele Caraglia Francesco Aniello Source Type: research
The long non-coding RNA transcript, LOC100130460 (CAND1.11) gene, encodes a novel protein highly expressed in cancer cells and tumor human testis tissues
CONCLUSIONS: This report is one of the few providing evidence that a lncRNA produces a protein expressed in normal human tissues and overexpressed in several testicular cancers, suggesting its involvement in regulating cell proliferation and differentiation. Although further studies are needed to validate the results, our data indicate that CAND1.11 could be a potential new prognostic biomarker to use in proliferation and cancer.PMID:37661873 | DOI:10.3233/CBM-230160 (Source: Cancer Biomarkers : Section A of Disease Markers)
Source: Cancer Biomarkers : Section A of Disease Markers - September 4, 2023 Category: Cancer & Oncology Authors: Aldo Donizetti Massimo Venditti Davide Arcainolo Vincenza Aliperti Anna Maria Carrese Marco De Sio Sergio Minucci Michele Caraglia Francesco Aniello Source Type: research
An enzyme-free method for isolating testicular macrophages from rodent models
J Immunol Methods. 2023 Sep 1:113551. doi: 10.1016/j.jim.2023.113551. Online ahead of print.ABSTRACTMacrophages are the major type of immune cell in the testis of both humans and rodents. Testicular macrophages (TMs) play critical roles in maintaining the testicular microenvironment, such as Leydig cell-dependent hormone production, spermatogenesis, and immune balance. A substantial number of studies have used rodent models to investigate the functions of TMs with various methods and harvest macrophages from the testis. Studies have demonstrated that enzyme digestion, an essential part of these methods, can improve the num...
Source: Journal of Immunological Methods - September 3, 2023 Category: Allergy & Immunology Authors: Wei Cai Yalong Yang Source Type: research
An enzyme-free method for isolating testicular macrophages from rodent models
J Immunol Methods. 2023 Sep 1:113551. doi: 10.1016/j.jim.2023.113551. Online ahead of print.ABSTRACTMacrophages are the major type of immune cell in the testis of both humans and rodents. Testicular macrophages (TMs) play critical roles in maintaining the testicular microenvironment, such as Leydig cell-dependent hormone production, spermatogenesis, and immune balance. A substantial number of studies have used rodent models to investigate the functions of TMs with various methods and harvest macrophages from the testis. Studies have demonstrated that enzyme digestion, an essential part of these methods, can improve the num...
Source: Journal of Immunological Methods - September 3, 2023 Category: Allergy & Immunology Authors: Wei Cai Yalong Yang Source Type: research
Protein kinase B (Akt) blockade inhibits LH/hCG-mediated 17,20-lyase, but not 17 α-hydroxylase activity of Cyp17a1 in mouse Leydig cell steroidogenesis
In conclusion, in the mouse Leydig cell line mLTC1, we found substantial Akt dependence of the 17,20-lyase activity and testosterone synthesis. Our results indicate that different intracellular pathways modulate selectively the dual activity of Cyp17a1.PMID:37640196 | DOI:10.1016/j.cellsig.2023.110872 (Source: Cellular Signalling)
Source: Cellular Signalling - August 28, 2023 Category: Cytology Authors: Elia Paradiso Clara Lazzaretti Samantha Sperduti Beatrice Melli Tommaso Trenti Simonetta Tagliavini Laura Roli Fabio D'Achille Ester Beltr án-Frutos Manuela Simoni Livio Casarini Source Type: research
Protein kinase B (Akt) blockade inhibits LH/hCG-mediated 17,20-lyase, but not 17 α-hydroxylase activity of Cyp17a1 in mouse Leydig cell steroidogenesis
In conclusion, in the mouse Leydig cell line mLTC1, we found substantial Akt dependence of the 17,20-lyase activity and testosterone synthesis. Our results indicate that different intracellular pathways modulate selectively the dual activity of Cyp17a1.PMID:37640196 | DOI:10.1016/j.cellsig.2023.110872 (Source: Cellular Signalling)
Source: Cellular Signalling - August 28, 2023 Category: Cytology Authors: Elia Paradiso Clara Lazzaretti Samantha Sperduti Beatrice Melli Tommaso Trenti Simonetta Tagliavini Laura Roli Fabio D'Achille Ester Beltr án-Frutos Manuela Simoni Livio Casarini Source Type: research
Protein kinase B (Akt) blockade inhibits LH/hCG-mediated 17,20-lyase, but not 17 α-hydroxylase activity of Cyp17a1 in mouse Leydig cell steroidogenesis
In conclusion, in the mouse Leydig cell line mLTC1, we found substantial Akt dependence of the 17,20-lyase activity and testosterone synthesis. Our results indicate that different intracellular pathways modulate selectively the dual activity of Cyp17a1.PMID:37640196 | DOI:10.1016/j.cellsig.2023.110872 (Source: Cellular Signalling)
Source: Cellular Signalling - August 28, 2023 Category: Cytology Authors: Elia Paradiso Clara Lazzaretti Samantha Sperduti Beatrice Melli Tommaso Trenti Simonetta Tagliavini Laura Roli Fabio D'Achille Ester Beltr án-Frutos Manuela Simoni Livio Casarini Source Type: research
Curcumin effects on Leydig cell functions and potential therapeutic uses
Endocr Oncol. 2023 Feb 1;3(1):e220075. doi: 10.1530/EO-22-0075. eCollection 2023 Jan 1.ABSTRACTCurcumin has been ascribed with countless therapeutic effects, but its impact on testicular function has been scarcely researched. Leydig cells comprise the androgen-secreting population of the testis and may give rise to Leydig cell tumours (LCTs). Due to their steroid-secreting nature, LCTs entail endocrine, reproductive, and psychological disorders. Approximately 10% are malignant and do not respond to chemotherapy and radiotherapy. The aim of this study was to assess curcumin's impact on Leydig cells' functions and its potent...
Source: Ann Oncol - July 12, 2023 Category: Cancer & Oncology Authors: Trinidad Raices Mar ía Luisa Varela Adriana Mar ía Belén Abiuso Elba N Pereyra Carolina Mondillo Omar P Pignataro Mar ía Fernanda Riera Source Type: research
Curcumin effects on Leydig cell functions and potential therapeutic uses
Endocr Oncol. 2023 Feb 1;3(1):e220075. doi: 10.1530/EO-22-0075. eCollection 2023 Jan 1.ABSTRACTCurcumin has been ascribed with countless therapeutic effects, but its impact on testicular function has been scarcely researched. Leydig cells comprise the androgen-secreting population of the testis and may give rise to Leydig cell tumours (LCTs). Due to their steroid-secreting nature, LCTs entail endocrine, reproductive, and psychological disorders. Approximately 10% are malignant and do not respond to chemotherapy and radiotherapy. The aim of this study was to assess curcumin's impact on Leydig cells' functions and its potent...
Source: Ann Oncol - July 12, 2023 Category: Cancer & Oncology Authors: Trinidad Raices Mar ía Luisa Varela Adriana Mar ía Belén Abiuso Elba N Pereyra Carolina Mondillo Omar P Pignataro Mar ía Fernanda Riera Source Type: research
