Protein kinase B (Akt) blockade inhibits LH/hCG-mediated 17,20-lyase, but not 17 α-hydroxylase activity of Cyp17a1 in mouse Leydig cell steroidogenesis

In conclusion, in the mouse Leydig cell line mLTC1, we found substantial Akt dependence of the 17,20-lyase activity and testosterone synthesis. Our results indicate that different intracellular pathways modulate selectively the dual activity of Cyp17a1.PMID:37640196 | DOI:10.1016/j.cellsig.2023.110872

Source: Cellular Signalling - August 28, 2023 Category: Cytology Authors: Elia Paradiso Clara Lazzaretti Samantha Sperduti Beatrice Melli Tommaso Trenti Simonetta Tagliavini Laura Roli Fabio D'Achille Ester Beltr án-Frutos Manuela Simoni Livio Casarini Source Type: research