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Leydig cell tumor of the testis with characteristic contrast patterns of tumor and non-tumorous testicular parenchyma on MRI: a case report
ConclusionSince the contrast findings in the non-tumorous testicular parenchymal region on CE-T1WI likely match the histopathological features of LCT, our case suggests that the presence of non-tumorous testicular parenchymal enhancement on imaging might indicate a diagnosis of LCT. (Source: Abdominal Imaging)
Source: Abdominal Imaging - July 10, 2023 Category: Radiology Source Type: research

Reclassification of two germline DICER1 splicing variants leads to DICER1 syndrome diagnosis
We present two unrelated patients suspected to have DICER1 syndrome. Both females (aged 13 and 15 years) presented with multinodular goiter (thyroid follicular nodular disease) and ovarian tumours. One was diagnosed with an ovarian Sertoli-Leydig cell tumour (SLCT) and the other, with an ovarian juvenile granulosa cell tumour, later reclassified as a retiform variant of SLCT. Genetic screening showed no germline pathogenic variants inDICER1. However, two potentially splicing variants were found,DICER1 c.5365-4A>G and c.5527+3A>G. Also, typical somaticDICER1 RNase IIIb hotspot mutations were detected in the thyroid ...
Source: Familial Cancer - May 30, 2023 Category: Cancer & Oncology Source Type: research

Combination treatment of cordycepin and radiation induces MA-10 mouse Leydig tumor cell death via ROS accumulation and DNA damage
Am J Cancer Res. 2023 Apr 15;13(4):1329-1346. eCollection 2023.ABSTRACTLeydig cell tumor is the most frequent non-germ cell tumors of testis. The biggest challenge of using radiotherapy to treat testicular cancer is in effectively killing cancer cells and maintaining reproductive function after treatment. Our recently published article showed that cordycepin could enhance radiosensitivity to induce mouse Leydig tumor cell apoptosis by inducing cell cycle arrest, caspase pathway and endoplasmic reticulum (ER) stress. In the present study, the potency and mechanism of a previous combination treatment protocol on reactive oxy...
Source: Cell Research - May 11, 2023 Category: Cytology Authors: Yi-Ping Lee Chin-Ru Lin Sih-Shang Chen Rong-Jane Chen Yuan-Hua Wu Ying-Hui Chen Bu-Miin Huang Source Type: research

Sonographic characteristics of ovarian Leydig cell tumor
Ultrasound Obstet Gynecol. 2023 Apr 6. doi: 10.1002/uog.26212. Online ahead of print.NO ABSTRACTPMID:37021749 | DOI:10.1002/uog.26212 (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - April 6, 2023 Category: Radiology Authors: M Bruno G Capanna C Di Florio L Sollima M Guido M Ludovisi Source Type: research

A Boy with 46,XX Karyotype (SRY double-positive) having a Leydig Cell Tumor
J Clin Res Pediatr Endocrinol. 2023 Mar 29. doi: 10.4274/jcrpe.galenos.2023.2022-9-14. Online ahead of print.ABSTRACTLeydig cell tumors are the most common type of testicular sex cord stromal tumors. Presence of Y chromosome is associated with tumor risk in sex development disorder (DSD), however tumor development without Y chromosome are extremely rare. A 16-year-old boy diagnosed with Leydig cell tumor due to a mass in the right testis was referred after the right orchiectomy. In physical examination, left testis was 10 ml, and a labium residue in penoscrotal region with bilateral gynecomastia was present. Karyotype was ...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - March 29, 2023 Category: Endocrinology Authors: Merve Gullu Sultan Ayd ın Tarkan Kalkan Tang ül Pınarcı Do ğa Turkkahraman Source Type: research