Severe intrahepatic cholestasis of pregnancy due to a Sertoli-Leydig cell tumour in a woman with polycystic ovary syndrome: a case report
Intrahepatic cholestasis of pregnancy (ICP) is a common gestational complication characterized by pruritus and elevated bile acids, usually occurring in the third trimester when the serum estrogen and progeste... (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - November 2, 2022 Category: OBGYN Authors: Feng Yun, Leyi Fu, Dong Xu, Fan Qu and Fangfang Wang Tags: Case report Source Type: research
Embryonal Rhabdomyosarcoma of the Uterine Cervix: A Clinicopathologic Study of 94 Cases Emphasizing Issues in Differential Diagnosis Staging, and Prognostic Factors
This study highlights the intriguing clinical aspects of cERMS including its long-known tendency to occur in the young but also more recently appreciated association with DICER1 syndrome. Establishing the diagnosis may still be difficult because of the hazard of sampling a neoplasm which in areas may appear remarkably bland and also because of its potential confusion with other neoplasms. This study indicates that this tumor has a good prognosis at this site and in selected cases a conservative surgical approach is a realistic consideration. (Source: The American Journal of Surgical Pathology)
Source: The American Journal of Surgical Pathology - October 20, 2022 Category: Pathology Tags: Original Articles Source Type: research
11-Oxygenated androgens are not secreted by the human ovary: In-vivo data from four different cases of hyperandrogenism
Conclusion This study confirms that 11-OHA4 and 11-KT are not synthesized by the ovary. We propose that the T/11-KT ratio as well as 11-OHA4 could help identify predominant adrenal androgen excess and distinguish neoplastic and non-neoplastic ovarian androgen source.PMID:36239921 | DOI:10.1530/EJE-22-0518 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 14, 2022 Category: Endocrinology Authors: Matthias K Auer James M Hawley Christian Lottspeich Martin Bidlingmaier Andrea Sappl Hanna F Nowotny Lea Tschaidse Marcus Treitl Martin Reincke Brian G Keevil Nicole Reisch Source Type: research
11-Oxygenated androgens are not secreted by the human ovary: In-vivo data from four different cases of hyperandrogenism
Conclusion This study confirms that 11-OHA4 and 11-KT are not synthesized by the ovary. We propose that the T/11-KT ratio as well as 11-OHA4 could help identify predominant adrenal androgen excess and distinguish neoplastic and non-neoplastic ovarian androgen source.PMID:36239921 | DOI:10.1530/EJE-22-0518 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 14, 2022 Category: Endocrinology Authors: Matthias K Auer James M Hawley Christian Lottspeich Martin Bidlingmaier Andrea Sappl Hanna F Nowotny Lea Tschaidse Marcus Treitl Martin Reincke Brian G Keevil Nicole Reisch Source Type: research
11-Oxygenated androgens are not secreted by the human ovary: In-vivo data from four different cases of hyperandrogenism
Conclusion This study confirms that 11-OHA4 and 11-KT are not synthesized by the ovary. We propose that the T/11-KT ratio as well as 11-OHA4 could help identify predominant adrenal androgen excess and distinguish neoplastic and non-neoplastic ovarian androgen source.PMID:36239921 | DOI:10.1530/EJE-22-0518 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 14, 2022 Category: Endocrinology Authors: Matthias K Auer James M Hawley Christian Lottspeich Martin Bidlingmaier Andrea Sappl Hanna F Nowotny Lea Tschaidse Marcus Treitl Martin Reincke Brian G Keevil Nicole Reisch Source Type: research
11-Oxygenated androgens are not secreted by the human ovary: In-vivo data from four different cases of hyperandrogenism
Conclusion This study confirms that 11-OHA4 and 11-KT are not synthesized by the ovary. We propose that the T/11-KT ratio as well as 11-OHA4 could help identify predominant adrenal androgen excess and distinguish neoplastic and non-neoplastic ovarian androgen source.PMID:36239921 | DOI:10.1530/EJE-22-0518 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 14, 2022 Category: Endocrinology Authors: Matthias K Auer James M Hawley Christian Lottspeich Martin Bidlingmaier Andrea Sappl Hanna F Nowotny Lea Tschaidse Marcus Treitl Martin Reincke Brian G Keevil Nicole Reisch Source Type: research
cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor
Cyclic adenosine monophosphate/Protein kinase A (cAMP/PKA) signaling pathway is the master regulator of endocrine tissue function. The level, compartmentalization and amplitude of cAMP response are finely regulated by phosphodiesterases (PDEs). PDE8 is responsible of cAMP hydrolysis and its expression has been characterized in all steroidogenic cell types in rodents including adrenal and Leydig cells in rodents however scarce data are currently available in humans. Here we demonstrate that human Leydig cells express both PDE8A and PDE8B isoforms. Interestingly, we found that the expression of PDE8B but not of PDE8A is incr...
Source: Frontiers in Endocrinology - October 7, 2022 Category: Endocrinology Source Type: research
Bilateral Ovarian Sertoli-Leydig Cell Tumors Harboring < em > DICER1 < /em > Germline and Distinct Somatic Mutations: Case Report and Literature Review
We describe a 15-year-old female with bilateral, asynchronous Sertoli-Leydig cell tumors (SLCT). Both tumors harbored an identical germline frameshift mutation as well as unique somatic DICER1 hot-spot point mutations. Discussion: A review of bilateral SLCTs demonstrates that all patients with available DICER1 mutation status carried a germline DICER1 mutation (100%, 9 of 9). In cases with known somatic DICER1 status on bilateral tumors, all harbored distinct somatic mutations (100%, 5 of 5). Our findings support the notion that bilateral ovarian SLCTs are indeed separate events and do not represent recurrent or metastatic...
Source: Fetal and Pediatric Pathology - September 19, 2022 Category: Pathology Authors: Caitlin E Hughes Jiancong Liang Vera Paulson Huiying Wang Source Type: research
Is testis sparing surgery safe in patients with incidental small testicular lesions referring to a fertility center? A retrospective analysis reporting factors correlated to malignancy and long-term oncological outcomes
CONCLUSION: Ultrasonographic characteristics and intraoperative appearance of the lesion can predict the malignant nature of small testicular lesions, guiding their surgical management in patients referring to a fertility center. Based on our experience, clinicians may safely perform TSS in carefully selected patients.PMID:36075820 | DOI:10.1016/j.urolonc.2022.08.002 (Source: Urologic Oncology)
Source: Urologic Oncology - September 8, 2022 Category: Urology & Nephrology Authors: Andrea Gobbo Luciano Negri Paolo Casale Vittorio Fasulo Giovanni Lughezzani Cesare Saitta Renzo Benaglia Nicol ò Maria Buffi Paolo Levi Setti Source Type: research
Is testis sparing surgery safe in patients with incidental small testicular lesions referring to a fertility center? A retrospective analysis reporting factors correlated to malignancy and long-term oncological outcomes
CONCLUSION: Ultrasonographic characteristics and intraoperative appearance of the lesion can predict the malignant nature of small testicular lesions, guiding their surgical management in patients referring to a fertility center. Based on our experience, clinicians may safely perform TSS in carefully selected patients.PMID:36075820 | DOI:10.1016/j.urolonc.2022.08.002 (Source: Urologic Oncology)
Source: Urologic Oncology - September 8, 2022 Category: Urology & Nephrology Authors: Andrea Gobbo Luciano Negri Paolo Casale Vittorio Fasulo Giovanni Lughezzani Cesare Saitta Renzo Benaglia Nicol ò Maria Buffi Paolo Levi Setti Source Type: research
Familial Male-Limited Precocious Puberty (FMPP) and Testicular Germ Cell Tumors
CONCLUSION: There is a strong suggestion that FMPP might increase the risk of development of testicular GCTs in early adulthood compared to the risk in the general population. Therefore, prolonged patient monitoring from mid-pubertal age onwards including instruction for self-examination and periodic testicular ultrasound investigation in patients with a germline LHCGR pathogenic variants might contribute to early detection and thus early treatment of testicular GCT.PMID:36071555 | DOI:10.1210/clinem/dgac516 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - September 7, 2022 Category: Endocrinology Authors: Cezanne D Kooij Annelies M C Mavinkurve-Groothuis Idske C L Kremer Hovinga Leendert H J Looijenga Tuula Rinne Jacques C Giltay Laetitia M O de Kort Aart J Klijn Ronald R de Krijger Annemarie A Verrijn Stuart Source Type: research
Ovarian Sertoli-Leydig cell tumor: A case report
Asian J Surg. 2022 Sep 3:S1015-9584(22)01044-2. doi: 10.1016/j.asjsur.2022.07.113. Online ahead of print.NO ABSTRACTPMID:36064481 | DOI:10.1016/j.asjsur.2022.07.113 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - September 5, 2022 Category: Surgery Authors: Guoyan Liu Weifang Liu Jinbo Ma Yueling Tang Jianyu Ye Source Type: research
Transcriptional comparison of Testicular Adrenal Rest Tumors with fetal and adult tissues
CONCLUSION: Our data suggest that TART is induced -most likely via activation of a cAMP/PKA dependent receptor- from a progenitor cell into a unique mature adrenal-like cell type, sometimes exhibiting both adrenal and testicular features.PMID:36047744 | DOI:10.1530/EJE-22-0143 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 1, 2022 Category: Endocrinology Authors: Mariska A M Schr öder Fred C G J Sweep Antonius E van Herwaarden Rod T Mitchell Jitske Eliveld Ans M M van Pelt Alan E Rowan Darren Korbie Nike M M L Stikkelbroeck Hedi L Claahsen-van der Grinten Paul N Span Source Type: research
Transcriptional comparison of Testicular Adrenal Rest Tumors with fetal and adult tissues
CONCLUSION: Our data suggest that TART is induced -most likely via activation of a cAMP/PKA dependent receptor- from a progenitor cell into a unique mature adrenal-like cell type, sometimes exhibiting both adrenal and testicular features.PMID:36047744 | DOI:10.1530/EJE-22-0143 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 1, 2022 Category: Endocrinology Authors: Mariska A M Schr öder Fred C G J Sweep Antonius E van Herwaarden Rod T Mitchell Jitske Eliveld Ans M M van Pelt Alan E Rowan Darren Korbie Nike M M L Stikkelbroeck Hedi L Claahsen-van der Grinten Paul N Span Source Type: research
Transcriptional comparison of Testicular Adrenal Rest Tumors with fetal and adult tissues
CONCLUSION: Our data suggest that TART is induced -most likely via activation of a cAMP/PKA dependent receptor- from a progenitor cell into a unique mature adrenal-like cell type, sometimes exhibiting both adrenal and testicular features.PMID:36047744 | DOI:10.1530/EJE-22-0143 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - September 1, 2022 Category: Endocrinology Authors: Mariska A M Schr öder Fred C G J Sweep Antonius E van Herwaarden Rod T Mitchell Jitske Eliveld Ans M M van Pelt Alan E Rowan Darren Korbie Nike M M L Stikkelbroeck Hedi L Claahsen-van der Grinten Paul N Span Source Type: research
