11-Oxygenated androgens are not secreted by the human ovary: In-vivo data from four different cases of hyperandrogenism

Conclusion This study confirms that 11-OHA4 and 11-KT are not synthesized by the ovary. We propose that the T/11-KT ratio as well as 11-OHA4 could help identify predominant adrenal androgen excess and distinguish neoplastic and non-neoplastic ovarian androgen source.PMID:36239921 | DOI:10.1530/EJE-22-0518

Source: European Journal of Endocrinology - October 14, 2022 Category: Endocrinology Authors: Matthias K Auer James M Hawley Christian Lottspeich Martin Bidlingmaier Andrea Sappl Hanna F Nowotny Lea Tschaidse Marcus Treitl Martin Reincke Brian G Keevil Nicole Reisch Source Type: research