Effect of androgens on Sertoli cell maturation in human testis from birth to puberty

ConclusionsAndrogen action on Sertoli cells is required for onset of spermatogenesis and premature androgen secretion by LCT can induce spermatogenesis in the vicinity of the tumor. AR ir appeared earlier than onset of spermatogenesis, with large interindividual variability. The timing and mechanisms of Sertoli cell responsiveness to androgens are important issues for understanding the induction of spermatogenesis at puberty.
Source: Basic and Clinical Andrology - Category: Urology & Nephrology Source Type: research