A Brief Overview of the Molecular Landscape of Myelodysplastic Neoplasms
This article reviews the genetic abnormalities of MDS in adults with a brief review of germline predisposition syndromes.PMID:38785456 | DOI:10.3390/curroncol31050175 (Source: Current Oncology)
Source: Current Oncology - May 24, 2024 Category: Cancer & Oncology Authors: Rami Abdulbaki Sheeja T Pullarkat Source Type: research
Combining inotuzumab ozogamicin with PARP inhibitors olaparib and talazoparib exerts synergistic cytotoxicity in acute lymphoblastic leukemia by inhibiting DNA strand break repair
Oncol Rep. 2024 Jul;52(1):90. doi: 10.3892/or.2024.8749. Epub 2024 May 24.ABSTRACTInotuzumab ozogamicin (IO), a novel therapeutic drug for relapsed or refractory acute lymphoblastic leukemia (RR)‑(ALL), is a humanized anti‑cluster of differentiation (CD) 22 monoclonal antibody conjugated with calicheamicin that causes DNA single‑ and double‑strand breaks. Although the efficacy of IO is significantly improved compared with that of conventional chemotherapies, the prognosis for RR‑ALL remains poor, highlighting the need for more effective treatment strategies. The present study examined the role of DNA damage repai...
Source: Oncology Reports - May 24, 2024 Category: Cancer & Oncology Authors: Naoko Ida Miyuki Okura Saki Tanaka Naoko Hosono Takahiro Yamauchi Source Type: research
Design and synthesis of Meldrum's acid based 7-azaindole anchored 1,2,3-triazole hybrids as anticancer agents
RSC Med Chem. 2024 Mar 11;15(5):1709-1721. doi: 10.1039/d4md00015c. eCollection 2024 May 22.ABSTRACTA series of Meldrum's acid, 7-azaindole and 1,2,3-triazole hybrids were synthesized and evaluated for their in vitro anticancer activity against five different cancer cell lines viz. MCF-7 (breast cancer), HeLa (cervical cancer), DU-145 (prostate cancer), HepG2 (liver cancer) and K562 (myelogenous leukemia cell). Among the series, compound 6b containing a 4-methyl substitution showed potent activity against HeLa cell line. Cell cycle analysis revealed that compound 6b induced cell cycle arrest at the G2/M phase and induced a...
Source: Cell Research - May 24, 2024 Category: Cytology Authors: Murali Krishna Vanga Rambabu Bhukya Vishnu Thumma S S S S Sudha Ambadipudi V Lakshma Nayak Sai Balaji Andugulapati Vijjulatha Manga Source Type: research
Evaluating zanubrutinib for the treatment of adults with chronic lymphocytic leukemia or small lymphocytic lymphoma
Expert Rev Hematol. 2024 May 24:1-10. doi: 10.1080/17474086.2024.2356257. Online ahead of print.ABSTRACTINTRODUCTION: This review evaluates zanubrutinib as a treatment option for adults with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Zanubrutinib, a covalent BTK (Bruton's tyrosine kinase) inhibitor, was recently approved by the US FDA based in part on head-to-head data demonstrating improved efficacy and safety compared to ibrutinib.AREAS COVERED: The review discusses the efficacy, safety, and comparative advantages of zanubrutinib, highlighting its safety profile compared to other BTK inhibitors....
Source: Expert Review of Hematology - May 24, 2024 Category: Hematology Authors: Nathalie Javidi-Sharifi Jennifer R Brown Source Type: research
Co ‐occurrence of rhino‐orbital mucormycosis and acute lymphoblastic leukemia post‐COVID‐19 infection in a young adolescent male: A case report from a low middle‐income country
We describe the clinical presentation, diagnosis, treatment, and outcome of this patient, and discuss the possible interactions and implications of these three conditions. A young 16-year-old male patient without significant clinical history was admitted with complaints of low-grade intermittent fever, fatigue, malaise, restlessness, and unexplained weight loss for the past 2 months. A bone marrow biopsy confirmed the diagnosis of B-ALL. Following the diagnosis of B-ALL, the patient underwent initiation of chemotherapy. Following the initial two cycles of chemotherapy, the patient experienced fever and cough and tested ...
Source: Clinical Case Reports - May 24, 2024 Category: General Medicine Authors: Maneesha Lingarapu,
Bisma Shaikh,
Ajeet Singh,
Mustafa Ahmed Khan,
Malik Olatunde Oduoye,
Nancy Kamboj,
Mahmood Danishwar Tags: CASE REPORT Source Type: research
Discovery of cytotoxic truncated vitamin D derivatives against both bortezomib ‐sensitive and bortezomib‐resistant multiple myeloma phenotypes
AbstractMultiple myeloma (MM) is an incurable hematological malignancy with increasing incidence and mortality rates, with a worldwide incidence of 160,000 cases per year. Currently approved treatments, including bortezomib treatment, have adverse effects that ultimately lead to the development of resistance. Inadequate vitamin D (VD) levels are frequently observed in patients with MM, and its supplementation has anti-proliferative effects on different MM phenotypes. However, the risk of hypercalcemia restricts the application of VD in cancer therapy; therefore, we analyzed truncated VD analogs with anticancer effects but ...
Source: Medicinal Chemistry Research - May 24, 2024 Category: Chemistry Source Type: research
Acute cardiovascular complications of disseminated intravascular coagulation in acute myeloid leukemia
Disseminated intravascular coagulation (DIC) is a common complication of all leukemia subtypes, but it is an especially prominent feature of Acute Myeloid Leukemias (AML). DIC complicating AML can lead to a variety of complications, however, its association with acute cardiovascular complications has not been reported before. (Source: Thrombosis Research)
Source: Thrombosis Research - May 24, 2024 Category: Hematology Authors: Ghada Araji, Ahmad Mustafa, Muhammad Niazi, Chapman Wei, Rubal Sharma, Saif Abu-Baker, Georges Khattar, Suzanne El-Sayegh, Marcel Odaimi Tags: Full Length Article Source Type: research
Cancers, Vol. 16, Pages 1996: Chronic Lymphocytic Leukemia: Management of Adverse Events in the Era of Targeted Agents
o Marasca
The treatment landscape for CLL has undergone a profound transformation with the advent of targeted agents (TAs) like Bruton’s Tyrosine Kinase inhibitors (BTKis) and BCL-2 inhibitors (BCL-2is). These agents target crucial cellular pathways in CLL, offering superior efficacy over traditional chemo-immunotherapy, which has led to improved progression-free and overall survival rates. This advancement promises enhanced disease control and potentially normal life expectancy for many patients. However, the journey is not without challenges, as these TAs are associated with a range of adverse events (A...
Source: Cancers - May 24, 2024 Category: Cancer & Oncology Authors: Andrea Galitzia Monica Maccaferri Francesca Romana Mauro Roberta Murru Roberto Marasca Tags: Review Source Type: research
CAR T-cell therapy in rheumatology-What we know so far?
Z Rheumatol. 2024 May 23. doi: 10.1007/s00393-024-01514-x. Online ahead of print.ABSTRACTAutoreactive B‑cells play a key role in the pathogenesis of autoimmune diseases, such systemic lupus erythematosus (SLE). An efficient depletion of B‑cells therefore plays a special role in autoimmune diseases, especially in cases with a severe course of the disease. Treatment with chimeric antigen receptor (CAR) T‑cells, which was originally developed for the treatment of B‑cell lymphomas and leukemias, provides the possibility to deplete B‑cells even in deep tissues. The initial results from case series with this procedure ...
Source: Zeitschrift fur Rheumatologie - May 23, 2024 Category: Rheumatology Authors: Melanie Hagen Andreas Wirsching Daniela Bohr Jule Taubmann Fabian M üller Andreas Mackensen Ricardo Grieshaber-Bouyer Georg Schett Source Type: research
Antibiotic Resistance Profile of < em > Staphylococcus aureus < /em > in Cancer Patients at Laquintinie Hospital in Douala, Littoral Region, Cameroon
This study is aimed at isolating and establishing the distribution of antibiotic-resistant Staphylococcus aureus from fecal samples in subjects with cancer admitted to the Oncology Department at Laquintinie Hospital in Douala, in the Littoral Region of Cameroon. A cross-sectional study was conducted from October 2021 to March 2023. Cancer and noncancer patients were suffering from Staphylococcus aureus infection. The isolation of Staphylococcus aureus was based on culture on the specific medium. The Kirby-Bauer disk diffusion method was used for drug susceptibility testing. Of the 507 patients studied, 307 (60.55%) were ca...
Source: Biomed Res - May 23, 2024 Category: Research Authors: Michael Francis Kengne Armelle T Mbaveng Victor Kuete Source Type: research
Inotuzumab Ozogamicin: First Pediatric Approval
This article summarizes the milestones in the development of inotuzumab ozogamicin leading to this first approval for the treatment of relapsed or refractory CD22-positive B-cell precursor ALL in pediatric patients.PMID:38780741 | DOI:10.1007/s40272-024-00634-w (Source: Paediatric Drugs)
Source: Paediatric Drugs - May 23, 2024 Category: Pediatrics Authors: Sohita Dhillon Source Type: research
Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support
CONCLUSIONS: Findings from this review were based on seven studies and 644 participants. Definite conclusions are challenging given the relatively few included studies, low number of included participants, heterogeneity of intervention and outcome reporting, and overall certainty of evidence. To increase the certainty of the true effect of a restrictive RBC transfusion strategy on clinical outcomes, there is a need for rigorously designed and executed studies. The evidence is largely based on two populations: adults with acute leukaemia receiving intensive chemotherapy and adults with haematologic malignancy requiring HSCT...
Source: Cochrane Database of Systematic Reviews - May 23, 2024 Category: General Medicine Authors: Michael Radford Lise J Estcourt Emily Sirotich Tyler Pitre Joanne Britto Megan Watson Susan J Brunskill Dean A Fergusson Carolyn Dor ée Donald M Arnold Source Type: research
Choanephora infundibulifera Rhinosinusitis in Man with Acute Lymphoblastic Leukemia, Tennessee, USA
We describe C. infundibulifera rhinosinusitis in a young man with leukemia in Tennessee, USA.PMID:38782142 | DOI:10.3201/eid3006.230794 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - May 23, 2024 Category: Infectious Diseases Authors: Anita Max Heather L Glasgow Teresa C B Santiago Ashley Holland Hiroto Inaba Connie F Ca ñete-Gibas Nathan P Wiederhold Randall T Hayden Elisabeth E Adderson Source Type: research
Effects of exercise and doxorubicin on acute diaphragm neuromuscular transmission failure
Exp Neurol. 2024 May 21:114818. doi: 10.1016/j.expneurol.2024.114818. Online ahead of print.ABSTRACTDoxorubicin (DOX) is a highly effective anthracycline antibiotic used to treat a wide variety of cancers including breast cancer, leukemia and lymphoma. Unfortunately, clinical use of DOX is limited due to adverse off-target effects resulting in fatigue, respiratory muscle weakness and dyspnea. The diaphragm is the primary muscle of inspiration and respiratory insufficiency is likely the result of both muscle weakness and neural impairment. However, the contribution of neuropathology to DOX-induced respiratory muscle dysfunc...
Source: Experimental Neurology - May 23, 2024 Category: Neurology Authors: Branden L Nguyen Dryden R Baumfalk Stephanie S Lapierre-Nguyen Renjia Zhong Vivian Doerr Ryan N Montalvo Lan Wei-LaPierre Ashley J Smuder Source Type: research
Bovine Leukemia Virus molecular detection and associated factors among dairy herd workers in Antioquia, Colombia
Acta Trop. 2024 May 21:107253. doi: 10.1016/j.actatropica.2024.107253. Online ahead of print.ABSTRACTThe Bovine Leukemia Virus (BLV) affects mainly cattle, is transmitted by exposure to contaminated biological fluids, and generates lymphomas in 5% of infected animals. The zoonotic potential of BLV has been studied, and it is currently unknown if it circulates in human workers on dairy herds in Antioquia. Objective: To determine the frequency of BLV detection, the circulating genotypes of the virus, and the factors associated with its circulation in workers for dairy herds in Antioquia, Colombia. Through a cross-sectional s...
Source: Acta Tropica - May 23, 2024 Category: Infectious Diseases Authors: Willington Mendoza Juan Pablo Isaza Lucelly L ópez Albeiro L ópez-Herrera Lina A Guti érrez Source Type: research
