Small Nucleolar RNAs as Diagnostic and Prognostic Biomarkers in Cancer: A Systematic Review and Meta-Analysis
CONCLUSION: The results strongly suggested that snoRNAs could serve as potential novel indicators for prognosis and diagnosis in cancers. This systematic review followed the guidelines of the Transparent Reporting of Systematic Review and Meta-Analyses (PROSPERO register: CRD42020209096).PMID:38752263 | DOI:10.1177/15330338241245939 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - May 16, 2024 Category: Cancer & Oncology Authors: Liyun Gao Junfei Fan Jiayin He Xiangxin Che Xin Wang Chunhua Han Source Type: research
Small Nucleolar RNAs as Diagnostic and Prognostic Biomarkers in Cancer: A Systematic Review and Meta-Analysis
CONCLUSION: The results strongly suggested that snoRNAs could serve as potential novel indicators for prognosis and diagnosis in cancers. This systematic review followed the guidelines of the Transparent Reporting of Systematic Review and Meta-Analyses (PROSPERO register: CRD42020209096).PMID:38752263 | DOI:10.1177/15330338241245939 (Source: Cell Research)
Source: Cell Research - May 16, 2024 Category: Cytology Authors: Liyun Gao Junfei Fan Jiayin He Xiangxin Che Xin Wang Chunhua Han Source Type: research
Picornavirus VP3 protein induces autophagy through the TP53-BAD-BAX axis to promote viral replication
This study provides insight for developing broad-spectrum antivirals and genetic engineering attenuated vaccines against picornaviruses.Abbreviations: 3-MA, 3-methyladenine; ATG, autophagy related; BAD, BCL2 associated agonist of cell death; BAK1, BCL2 antagonist/killer 1; BAX, BCL2 associated X, apoptosis regulator; BBC3/PUMA, BCL2 binding component 3; BCL2, BCL2 apoptosis regulator; BID, BH3 interacting domain death agonist; BIP-V5, BAX inhibitor peptide V5; CFLAR/FLIP, CASP8 and FADD like apoptosis regulator; CPE, cytopathic effects; CQ, chloroquine; CV, coxsackievirus; DAPK, death associated protein kinase; DRAM, DNA d...
Source: Autophagy - May 16, 2024 Category: Cytology Authors: Ruoqing Mao Zixiang Zhu Fan Yang Dehui Sun Xiaoli Zhou Weijun Cao Xiaodong Qin Wen Dang Huanan Liu Hong Tian Keshan Zhang Qingfeng Wu Xiangtao Liu Haixue Zheng Source Type: research
Application of Molecular dynamics-based pharmacophore and machine learning approach to identify novel Mcl1 inhibitors through drug repurposing and mechanic research.
Phys. Chem. Chem. Phys., 2024, Accepted Manuscript DOI: 10.1039/D4CP00576G, PaperHanxun Wang, Zhuo Qi, Wenxiong Lian, Lanyan Ma, Shizun Wang, Haihan Liu, Yu Jin, Huali Yang, Jian Wang, Maosheng Cheng Myeloid cell leukemia 1 (Mcl1), a critical protein that regulates apoptosis, has been considered as a promising target for antitumor drugs. The conventional pharmacophore screening approach has limitations in conformation... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - May 16, 2024 Category: Chemistry Authors: Hanxun Wang Source Type: research
Case study with dosimetric analysis: Total body irradiation to a patient with a left ventricular assist device
A patient with a left ventricular assist device, treated with total body irradiation. Key Clinical MessageA patient presented with cardiogenic shock, requiring the implantation of a left ventricular assist device (LVAD), and acute myeloblastic leukemia. This necessitated total body irradiation (TBI) while balancing dose reduction to the LVAD components to avoid potential radiation damage. Here we outline our treatment approach and dose estimates to the LVAD.AbstractThis case report discusses the delivery of TBI to a patient with an LVAD. This treatment required radiation-dose determinations and consequential reductions for...
Source: Clinical Case Reports - May 16, 2024 Category: General Medicine Authors: Matthew Webster,
Olga M. Dona Lemus,
Dandan Zheng,
Joshua N. Wancura,
Sean Tanny,
Gukan Sakthivel,
Louis Constine Tags: CASE REPORT Source Type: research
Interventional probability of causation (IPoC) with epidemiological and partial mechanistic evidence: benzene vs. formaldehyde and acute myeloid leukemia (AML)
. (Source: Critical Reviews in Toxicology)
Source: Critical Reviews in Toxicology - May 16, 2024 Category: Toxicology Authors: Louis A. CoxWilliam J. ThompsonKenneth A. Mundta Cox Associates and University of Colorado, Denver, CO, USAb Independent Consultants in Epidemiology, Hume, MO, USAc Independent Consultants in Epidemiology, Amherst, MA, USAd Adjunct Professor of Epidemiolo Source Type: research
Multiple Reactions During Desensitization May Predict Decreased Efficacy of Pegaspargase Chemotherapy
Asparaginase is considered a cornerstone of acute lymphoblastic leukemia (ALL) management, and its use has significantly improved survival rates for ALL1,2. Unfortunately, some patients do not receive its benefits due to either silent inactivation (less than 5%) or, more commonly, truncation of treatment because of toxicity or hypersensitivity1,3. Hypersensitivity to Pegaspargase, the preferred agent, occurs in 3-24% of patients 1,4. Since 2018, there have been shortages of the alternative agent, Erwinia asparaginase, which has led some centers to pursue desensitizations as means to administer Pegaspargase. (Source: Annals...
Source: Annals of Allergy, Asthma and Immunology - May 16, 2024 Category: Allergy & Immunology Authors: Elizabeth A. Gilje, Christine Cho Tags: Letters Source Type: research
Total body irradiation versus thiotepa/busulfan-based conditioning regimens for myeloablative allogeneic stem cell transplantation in adults with acute lymphoblastic leukemia
Bone Marrow Transplantation, Published online: 16 May 2024; doi:10.1038/s41409-024-02298-zTotal body irradiation versus thiotepa/busulfan-based conditioning regimens for myeloablative allogeneic stem cell transplantation in adults with acute lymphoblastic leukemia (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - May 16, 2024 Category: Hematology Authors: Elvira Mora Juan Montoro Aitana Balaguer Montserrat Rovira Monica Cabrero Inmaculada Heras Josep-Maria Ribera Gabriela Antelo Ana Africa Martin Oriana Lopez Godino Anna Torrent Marta Villalba Pedro Chorao Miguel A. Sanz Jaime Sanz Source Type: research
Blinatumomab Bridge Therapy for Mitigating Chemotoxicity in Children with Acute Lymphoblastic Leukemia
We report two pediatric patients with pre-B ALL, treated with blinatumomab because of chemotherapy-associated toxicity, with recovery and successful bridging to further chemotherapy. Blinatumomab can be considered in pediatric ALL patients who develop chemotherapy toxicity and whose treatment is delayed. (Source: Indian Journal of Hematology and Blood Transfusion)
Source: Indian Journal of Hematology and Blood Transfusion - May 16, 2024 Category: Hematology Source Type: research
ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia—2024 update
Leukemia, Published online: 16 May 2024; doi:10.1038/s41375-024-02267-xERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia—2024 update (Source: Leukemia)
Source: Leukemia - May 16, 2024 Category: Hematology Authors: Jitka Malcikova Sarka Pavlova Panagiotis Baliakas Thomas Chatzikonstantinou Eugen Tausch Mark Catherwood Davide Rossi Thierry Soussi Boris Tichy Arnon P. Kater Carsten U. Niemann Frederic Davi Gianluca Gaidano Stephan Stilgenbauer Richard Rosenquist Kosta Source Type: research
Asciminib monotherapy in patients with chronic-phase chronic myeloid leukemia with the T315I mutation after ≥1 prior tyrosine kinase inhibitor: 2-year follow-up results
Leukemia, Published online: 16 May 2024; doi:10.1038/s41375-024-02278-8Asciminib monotherapy in patients with chronic-phase chronic myeloid leukemia with the T315I mutation after ≥1 prior tyrosine kinase inhibitor: 2-year follow-up results (Source: Leukemia)
Source: Leukemia - May 16, 2024 Category: Hematology Authors: Jorge E. Cortes Koji Sasaki Dong-Wook Kim Timothy P. Hughes Gabriel Etienne Michael J. Mauro Andreas Hochhaus Fabian Lang Michael C. Heinrich Massimo Breccia Michael Deininger Yeow Tee Goh Jeroen J.W.M. Janssen Moshe Talpaz Valle Gomez Garcia de Soria Phi Source Type: research
Cancers, Vol. 16, Pages 1889: & ldquo;Oh, Dear We Are in Tribble & rdquo;: An Overview of the Oncogenic Functions of Tribbles 1
Cancers, Vol. 16, Pages 1889: “Oh, Dear We Are in Tribble”: An Overview of the Oncogenic Functions of Tribbles 1
Cancers doi: 10.3390/cancers16101889
Authors:
Karnika Singh
Christian A. Showalter
Heather R. Manring
Saikh Jaharul Haque
Arnab Chakravarti
Pseudokinases are catalytically inactive proteins in the human genome that lack the ability to transfer phosphate from ATP to their substrates. The Tribbles family of pseudokinases contains three members: Tribbles 1, 2, and 3. Tribbles 1 has recently gained importance because of its involvement in various diseases, including cancer. It act...
Source: Cancers - May 16, 2024 Category: Cancer & Oncology Authors: Karnika Singh Christian A. Showalter Heather R. Manring Saikh Jaharul Haque Arnab Chakravarti Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1891: Comparing the Outcomes of Matched and Mismatched Unrelated Allogeneic Hematopoietic Stem Cell Transplantation with Different Anti-Thymocyte Globulin Formulations: A Retrospective, Double-Centre Experience on Behalf of the Polish Adult Leukemia Group
ław Dybko
Despite notable advancements in immunotherapy in the past decades, allogeneic hematopoietic stem cell transplantation (allo-HCT) remains a promising, potentially curative treatment modality. Only a limited number of studies have performed a direct comparison of two prevalent rabbit anti-thymocyte globulin (r-ATG) formulations—specifically, Thymoglobuline (ATG-T, formerly Genzyme) and Grafalon (ATG-G, formerly Fresenius). The primary objective of our retrospective analysis was to compare the outcomes of adult patients undergoing matched or mismatched unrelated donor (MUD/MMUD) allo-HCT, with a g...
Source: Cancers - May 16, 2024 Category: Cancer & Oncology Authors: Ugo Giordano Monika Mordak-Domaga ła Ma łgorzata Sobczyk-Kruszelnicka Sebastian Giebel Lidia Gil Krzysztof D. Dudek Jaros ław Dybko Tags: Article Source Type: research
Analytical validation of the DropXpert S6 system for diagnosis of chronic myelocytic leukemia
Lab Chip, 2024, Advance Article DOI: 10.1039/D4LC00175C, PaperWenjia Wei, Shujun Li, Ying Zhang, Simin Deng, Qun He, Xielan Zhao, Yajing Xu, Linfen Yu, Junwei Ye, Weiwei Zhao, Zhiping Jiang With high system integration, the process of droplet generation, PCR amplification, and detection of the DropXpert S6 system is completed on one chip, showing high precision and sensitivity in CML patients. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - May 15, 2024 Category: Chemistry Authors: Wenjia Wei Source Type: research
Structural studies of intrinsically disordered MLL ‐fusion protein AF9 in complex with peptidomimetic inhibitors
In this study, we present a successful protein engineering strategy to facilitate structural investigation of the intrinsically disordered AF9 AHD domain in complex with peptidomimetic inhibitors by using maltose binding protein (MBP) as a crystallization chaperone connected with linkers of varying flexibility and length. The strategic incorporation of disulfide bonds provided diffraction-quality crystals of the two disulfide-bridged MBP –AF9 AHD fusion proteins in complex with the peptidomimetics. These successfully determined first series of 2.1–2.6 Å crystal complex structures provide high-resolution insights int...
Source: Protein Science - May 15, 2024 Category: Biochemistry Authors: Yuting Yang,
Ejaz Ahmad,
Vidhya Premkumar,
Alicen Liu,
S. M. Ashikur Rahman,
Zaneta Nikolovska ‐Coleska Tags: RESEARCH ARTICLE Source Type: research
