Foetal haemoglobin elevation, unfavourable prognosis, and protective role of genetic variants < em > HBG2 < /em > rs7482144, < em > HBS1L-MYB < /em > rs9399137 and < em > BCL11A < /em > rs4671393 in children with ALL
In conclusion, variants HBG2 rs7482144, HBS1L-MYB rs9399137 and BCL11A rs4671393 may play a significant role in ALL.PMID:38736250 (Source: Journal of Genetics)
Source: Journal of Genetics - May 13, 2024 Category: Genetics & Stem Cells Authors: Francisco Javier Borrayo-L óPez Bertha Ibarra-Cort és FranciscoJavier Perea-D íaz Abril Ixchel Mu ñOz-Zúñiga H éctor Montoya-Fuentes Janeth Margarita Soto-Padilla Lourdes Del Carmen Rizo-De La Torre Source Type: research
A Targeted Deep Sequencing Method to Quantify Endogenous Retrovirus Gag Sequence Variants and Open Reading Frames Expressed in Nonobese Diabetic Mice
J Immunol. 2024 May 13:ji2300660. doi: 10.4049/jimmunol.2300660. Online ahead of print.ABSTRACTEndogenous retroviruses (ERVs) are involved in autoimmune diseases such as type 1 diabetes (T1D). ERV gene products homologous to murine leukemia retroviruses are expressed in the pancreatic islets of NOD mice, a model of T1D. One ERV gene, Gag, with partial or complete open reading frames (ORFs), is detected in the islets, and it contains many sequence variants. An amplicon deep sequencing analysis was established by targeting a conserved region within the Gag gene to compare NOD with T1D-resistant mice or different ages of pred...
Source: Journal of Immunology - May 13, 2024 Category: Allergy & Immunology Authors: Yang D Dai Wenge Du Yaqin Wang Wen-Yuan Hu Source Type: research
Triple Trouble
We present a case of a 24-year-old female recently diagnosed with acute leukemia who came with complaints of fever for 14 days, progressive lower limb weakness, and multiple episodes of vomiting in the last 1 day. In nerve conduction studies, a diagnosis of Guillain-Barré syndrome (GBS) was established. Fever with thrombocytopenia workup revealed a positive dengue nonstructural protein 1 (NS1) and immunoglobulin M (IgM) report. Immunophenotyping confirmed pre-B acute lymphoblastic leukemia (ALL). As leukemia is an immunocompromised state, the peripheral nervous system vulnerability is increased, or infection could precipi...
Source: Journal of the Association of Physicians of India - May 13, 2024 Category: General Medicine Authors: Arundhati Diwan Supriya Barsode Source Type: research
Comprehensive analysis of the efficacy and safety of CAR T-cell therapy in patients with relapsed or refractory B-cell acute lymphoblastic leukaemia: a systematic review and meta-analysis
CONCLUSION: Choosing a more efficacious and safer CAR T-cell treatment is crucial for improving overall survival in acute leukaemia. Beyond the promising anti-CD22 CAR T-cell, exploring costimulatory domains and new CD targets could enhance treatment effectiveness for r/r B-ALL.PMID:38738799 | PMC:PMC11095278 | DOI:10.1080/07853890.2024.2349796 (Source: Annals of Medicine)
Source: Annals of Medicine - May 13, 2024 Category: Internal Medicine Authors: Sebastian Emmanuel Willyanto Yohanes Audric Alimsjah Krisanto Tanjaya Aekkachai Tuekprakhon Aulia Rahmi Pawestri Source Type: research
Foetal haemoglobin elevation, unfavourable prognosis, and protective role of genetic variants < em > HBG2 < /em > rs7482144, < em > HBS1L-MYB < /em > rs9399137 and < em > BCL11A < /em > rs4671393 in children with ALL
In conclusion, variants HBG2 rs7482144, HBS1L-MYB rs9399137 and BCL11A rs4671393 may play a significant role in ALL.PMID:38736250 (Source: Journal of Genetics)
Source: Journal of Genetics - May 13, 2024 Category: Genetics & Stem Cells Authors: Francisco Javier Borrayo-L óPez Bertha Ibarra-Cort és FranciscoJavier Perea-D íaz Abril Ixchel Mu ñOz-Zúñiga H éctor Montoya-Fuentes Janeth Margarita Soto-Padilla Lourdes Del Carmen Rizo-De La Torre Source Type: research
Aberrant expression of CD markers in AML in patients attending RIMS, Ranchi - An observational study
CONCLUSION: Immunophenotyping has a significant role in diagnosis and predicting prognosis of hematopoietic malignancies in the absence of more advanced diagnostic tools like cytogenetics.PMID:38736799 | PMC:PMC11086789 | DOI:10.4103/jfmpc.jfmpc_754_23 (Source: Primary Care)
Source: Primary Care - May 13, 2024 Category: Primary Care Authors: Amit Ranjan Sunil K Mahto Nicky Anand Nidhi P A Barla Source Type: research
Comprehensive analysis of the efficacy and safety of CAR T-cell therapy in patients with relapsed or refractory B-cell acute lymphoblastic leukaemia: a systematic review and meta-analysis
CONCLUSION: Choosing a more efficacious and safer CAR T-cell treatment is crucial for improving overall survival in acute leukaemia. Beyond the promising anti-CD22 CAR T-cell, exploring costimulatory domains and new CD targets could enhance treatment effectiveness for r/r B-ALL.PMID:38738799 | DOI:10.1080/07853890.2024.2349796 (Source: Annals of Medicine)
Source: Annals of Medicine - May 13, 2024 Category: Internal Medicine Authors: Sebastian Emmanuel Willyanto Yohanes Audric Alimsjah Krisanto Tanjaya Aekkachai Tuekprakhon Aulia Rahmi Pawestri Source Type: research
Triple Trouble
We present a case of a 24-year-old female recently diagnosed with acute leukemia who came with complaints of fever for 14 days, progressive lower limb weakness, and multiple episodes of vomiting in the last 1 day. In nerve conduction studies, a diagnosis of Guillain-Barré syndrome (GBS) was established. Fever with thrombocytopenia workup revealed a positive dengue nonstructural protein 1 (NS1) and immunoglobulin M (IgM) report. Immunophenotyping confirmed pre-B acute lymphoblastic leukemia (ALL). As leukemia is an immunocompromised state, the peripheral nervous system vulnerability is increased, or infection could precipi...
Source: Journal of the Association of Physicians of India - May 13, 2024 Category: General Medicine Authors: Arundhati Diwan Supriya Barsode Source Type: research
A Targeted Deep Sequencing Method to Quantify Endogenous Retrovirus Gag Sequence Variants and Open Reading Frames Expressed in Nonobese Diabetic Mice
J Immunol. 2024 May 13:ji2300660. doi: 10.4049/jimmunol.2300660. Online ahead of print.ABSTRACTEndogenous retroviruses (ERVs) are involved in autoimmune diseases such as type 1 diabetes (T1D). ERV gene products homologous to murine leukemia retroviruses are expressed in the pancreatic islets of NOD mice, a model of T1D. One ERV gene, Gag, with partial or complete open reading frames (ORFs), is detected in the islets, and it contains many sequence variants. An amplicon deep sequencing analysis was established by targeting a conserved region within the Gag gene to compare NOD with T1D-resistant mice or different ages of pred...
Source: Journal of Immunology - May 13, 2024 Category: Allergy & Immunology Authors: Yang D Dai Wenge Du Yaqin Wang Wen-Yuan Hu Source Type: research
Phytochemical study of < em > Magonia pubescens < /em > A. St.-Hil. and cytotoxicity of branches aqueous extract on breast cancer and leukemia cells
Nat Prod Res. 2024 Jun;38(11):1956-1960. doi: 10.1080/14786419.2023.2227988. Epub 2023 Jun 26.ABSTRACTMagonia pubescens is a natural species from the Brazilian cerrado biome. Its fruits and seeds are used in the treatment of seborrheic dermatitis, a common inflammatory skin disease. In this work, the known compounds lapachol, stigmasterol, maniladiol and scopoletin were isolated from hexane and dichloromethane extracts of M. pubescens branches. The aqueous extract of this material was fractioned through a liquid-liquid partition and the obtained fractions were analyzed by UHPLC-MS/MS. The results obtained were compared wit...
Source: Cell Research - May 13, 2024 Category: Cytology Authors: Ac ácio R A Moraes Ezequias P Siqueira Markus Kohlhoff Fernanda C G Evangelista Adriano P Sabino Sidney A Vieira Filho Ant ônio F C Alcântara Lucienir P Duarte Grasiely F Sousa Source Type: research
Phytochemical study of < em > Magonia pubescens < /em > A. St.-Hil. and cytotoxicity of branches aqueous extract on breast cancer and leukemia cells
Nat Prod Res. 2024 Jun;38(11):1956-1960. doi: 10.1080/14786419.2023.2227988. Epub 2023 Jun 26.ABSTRACTMagonia pubescens is a natural species from the Brazilian cerrado biome. Its fruits and seeds are used in the treatment of seborrheic dermatitis, a common inflammatory skin disease. In this work, the known compounds lapachol, stigmasterol, maniladiol and scopoletin were isolated from hexane and dichloromethane extracts of M. pubescens branches. The aqueous extract of this material was fractioned through a liquid-liquid partition and the obtained fractions were analyzed by UHPLC-MS/MS. The results obtained were compared wit...
Source: Natural Product Research - May 13, 2024 Category: Biochemistry Authors: Ac ácio R A Moraes Ezequias P Siqueira Markus Kohlhoff Fernanda C G Evangelista Adriano P Sabino Sidney A Vieira Filho Ant ônio F C Alcântara Lucienir P Duarte Grasiely F Sousa Source Type: research
Deep PIM kinase substrate profiling reveals new rational co-therapeutic strategies for acute myeloid leukemia
Blood Adv. 2024 May 13:bloodadvances.2022008144. doi: 10.1182/bloodadvances.2022008144. Online ahead of print.ABSTRACTProvirus integration site for Moloney murine leukemia virus (PIM) family serine/threonine kinases perform pro-tumorigenic functions in hematologic malignancies and solid tumors by phosphorylating substrates involved in tumor metabolism, cell survival, metastasis, inflammation, and immune cell invasion. However, a comprehensive understanding of PIM kinase functions is currently lacking. Multiple small molecule PIM kinase inhibitors are currently being evaluated as co-therapeutics in cancer patients. To furth...
Source: Adv Data - May 13, 2024 Category: Epidemiology Authors: Tejashree Joglekar Alexander Chin Alin Voskanian-Kordi Baek Seungchul Azim Raja Apurv Rege Weiliang Huang Maureen A Kane Marikki Laiho Thomas Webb Xiaoxuan Fan Michael Rubenstein Charles J Bieberich Xiang Li Source Type: research
The CNS Relapse in T-Cell Lymphoma Index Predicts CNS Relapse in Patients with T- and NK-Cell Lymphomas
Blood Adv. 2024 May 13:bloodadvances.2024012800. doi: 10.1182/bloodadvances.2024012800. Online ahead of print.ABSTRACTLittle is known about risk factors for central nervous system (CNS) relapse in mature T- and NK-cell neoplasms (MTNKN). We aimed to describe the clinical epidemiology of CNS relapse in patients with MTNKN and developed the CNS relapse In T-cell lymphoma Index (CITI) to predict patients at highest risk of CNS relapse. We reviewed data from 135 patients with MTNKN and CNS relapse from 19 North American institutions. After exclusion of leukemic and most cutaneous forms of MTNKN, patients were pooled with non-C...
Source: Adv Data - May 13, 2024 Category: Epidemiology Authors: Rahul S Bhansali Fredrik Ellin Thomas Relander Miao Cao Wenrui Li Qi Long Nivetha Ganesan Robert N Stuver Steven M Horwitz Kitsada Wudhikarn Steven R Hwang N Nora Bennani Julio C Chavez Lubomir Sokol Hayder Saeed Frank Duan Pierluigi Porcu Priyanka Pullar Source Type: research
Foetal haemoglobin elevation, unfavourable prognosis, and protective role of genetic variants < em > HBG2 < /em > rs7482144, < em > HBS1L-MYB < /em > rs9399137 and < em > BCL11A < /em > rs4671393 in children with ALL
In conclusion, variants HBG2 rs7482144, HBS1L-MYB rs9399137 and BCL11A rs4671393 may play a significant role in ALL.PMID:38736250 (Source: Journal of Genetics)
Source: Journal of Genetics - May 13, 2024 Category: Genetics & Stem Cells Authors: Francisco Javier Borrayo-L óPez Bertha Ibarra-Cort és FranciscoJavier Perea-D íaz Abril Ixchel Mu ñOz-Zúñiga H éctor Montoya-Fuentes Janeth Margarita Soto-Padilla Lourdes Del Carmen Rizo-De La Torre Source Type: research
Aberrant expression of CD markers in AML in patients attending RIMS, Ranchi - An observational study
CONCLUSION: Immunophenotyping has a significant role in diagnosis and predicting prognosis of hematopoietic malignancies in the absence of more advanced diagnostic tools like cytogenetics.PMID:38736799 | PMC:PMC11086789 | DOI:10.4103/jfmpc.jfmpc_754_23 (Source: Primary Care)
Source: Primary Care - May 13, 2024 Category: Primary Care Authors: Amit Ranjan Sunil K Mahto Nicky Anand Nidhi P A Barla Source Type: research
