Soluble Immune Checkpoint Molecules as Predictors of Efficacy in Immuno-Oncology Combination Therapy in Advanced Renal Cell Carcinoma
In conclusion, sPD-L2 and sLAG-3 expression may serve as a potential biomarker for predicting IO combination therapy efficacy.PMID:38668032 | PMC:PMC11049572 | DOI:10.3390/curroncol31040129 (Source: Current Oncology)
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Kosuke Ueda Keiichiro Uemura Naoki Ito Yuya Sakai Satoshi Ohnishi Hiroki Suekane Hirofumi Kurose Tasuku Hiroshige Katsuaki Chikui Kiyoaki Nishihara Makoto Nakiri Shigetaka Suekane Sachiko Ogasawara Hirohisa Yano Tsukasa Igawa Source Type: research
Dose-effect Relationship of Kidney Function After Stereotactic Ablative Body Radiotherapy for Primary Renal Cell Carcinoma: Trog 15.03 Fastrack Ii
This study investigates the dose-effect relationship of kidney SABR with posttreatment renal function. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 26, 2024 Category: Radiology Authors: Mathieu Gaudreault, Nicholas Hardcastle, Price Jackson, Lachlan McIntosh, Braden Higgs, David Pryor, Mark Sidhom, Rachael Dykyj, Alisha Moore, Tomas Kron, Shankar Siva Tags: Clinical Investigation Source Type: research
Crosstalk of disulfidptosis-related subtypes identifying a prognostic signature to improve prognosis and immunotherapy responses of clear cell renal cell carcinoma patients
Disulfidptosis is a novel form of programmed cell death induced by high SLC7A11 expression under glucose starvation conditions, unlike other known forms of cell death. However, the roles of disulfidptosis in c... (Source: BMC Genomics)
Source: BMC Genomics - April 26, 2024 Category: Genetics & Stem Cells Authors: Lei Ren, Jinwen Liu, Qingyuan Lin, Tianyi He, Guankai Huang, Weifeng Wang, Xunhao Zhan, Yu He, Bin Huang and Xiaopeng Mao Tags: Research Source Type: research
Exploring the role of coagulation-related genes in renal cell carcinoma: Implications for tumor microenvironment and prognostic biomarkers
CONCLUSION: There is an obvious correlation between the coagulation and the tumor microenvironment in ccRCC. As a key coagulation-related gene, MMP9 may promote the progression of renal cell carcinoma by influencing immune infiltration of CD8+T cells and Treg cells. Additionally, the risk score could be used as a durable prognostic biomarker, which could assist in clinical decision making for ccRCC patients.PMID:38663187 | DOI:10.1016/j.compbiolchem.2024.108082 (Source: Computational Biology and Chemistry)
Source: Computational Biology and Chemistry - April 25, 2024 Category: Bioinformatics Authors: Yang Qiu Yuanpeng Liao Jianqiang Zhang Yuedian Ye Zhongshu Zhang Zheng Jiang Jiaai Zhang Jinghan Xin Shidong Lv Hongmei Peng Source Type: research
MOICS, a novel classier deciphering immune heterogeneity and aid precise management of clear cell renal cell carcinoma at multiomics level
Cancer Biol Ther. 2024 Dec 31;25(1):2345977. doi: 10.1080/15384047.2024.2345977. Epub 2024 Apr 24.ABSTRACTRecent studies have indicated that the tumor immune microenvironment plays a pivotal role in the initiation and progression of clear cell renal cell carcinoma (ccRCC). However, the characteristics and heterogeneity of tumor immunity in ccRCC, particularly at the multiomics level, remain poorly understood. We analyzed immune multiomics datasets to perform a consensus cluster analysis and validate the clustering results across multiple internal and external ccRCC datasets; and identified two distinctive immune phenotypes...
Source: Cancer Biology and Therapy - April 25, 2024 Category: Cancer & Oncology Authors: Ying Liu Lin Qi Bicheng Ye Anbang Wang Juan Lu Le Qu Peng Luo Linhui Wang Aimin Jiang Source Type: research
A new missense mutation c.1240A & gt;G in fumarate hydratase gene leads to uterine leiomyoma associated hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome in Chinese
CONCLUSION: This research adds a novel missense mutation to the repertoire of FH gene variants, emphasizing its likely pathogenic nature based on a multidimensional analysis of phenotype, family history, and literature evidence. The findings enhance our understanding of the genetic landscape associated with FH and underscore the importance of thorough characterization for accurate variant classification.PMID:38663218 | DOI:10.1016/j.tranon.2024.101963 (Source: Translational Oncology)
Source: Translational Oncology - April 25, 2024 Category: Cancer & Oncology Authors: Li Wang Ran Du Lin Han Rui Yang Yingxue Li Source Type: research
Exploring the role of coagulation-related genes in renal cell carcinoma: Implications for tumor microenvironment and prognostic biomarkers
CONCLUSION: There is an obvious correlation between the coagulation and the tumor microenvironment in ccRCC. As a key coagulation-related gene, MMP9 may promote the progression of renal cell carcinoma by influencing immune infiltration of CD8+T cells and Treg cells. Additionally, the risk score could be used as a durable prognostic biomarker, which could assist in clinical decision making for ccRCC patients.PMID:38663187 | DOI:10.1016/j.compbiolchem.2024.108082 (Source: Computational Biology and Chemistry)
Source: Computational Biology and Chemistry - April 25, 2024 Category: Bioinformatics Authors: Yang Qiu Yuanpeng Liao Jianqiang Zhang Yuedian Ye Zhongshu Zhang Zheng Jiang Jiaai Zhang Jinghan Xin Shidong Lv Hongmei Peng Source Type: research
MOICS, a novel classier deciphering immune heterogeneity and aid precise management of clear cell renal cell carcinoma at multiomics level
Cancer Biol Ther. 2024 Dec 31;25(1):2345977. doi: 10.1080/15384047.2024.2345977. Epub 2024 Apr 24.ABSTRACTRecent studies have indicated that the tumor immune microenvironment plays a pivotal role in the initiation and progression of clear cell renal cell carcinoma (ccRCC). However, the characteristics and heterogeneity of tumor immunity in ccRCC, particularly at the multiomics level, remain poorly understood. We analyzed immune multiomics datasets to perform a consensus cluster analysis and validate the clustering results across multiple internal and external ccRCC datasets; and identified two distinctive immune phenotypes...
Source: Cancer Biology and Therapy - April 25, 2024 Category: Cancer & Oncology Authors: Ying Liu Lin Qi Bicheng Ye Anbang Wang Juan Lu Le Qu Peng Luo Linhui Wang Aimin Jiang Source Type: research
A new missense mutation c.1240A & gt;G in fumarate hydratase gene leads to uterine leiomyoma associated hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome in Chinese
CONCLUSION: This research adds a novel missense mutation to the repertoire of FH gene variants, emphasizing its likely pathogenic nature based on a multidimensional analysis of phenotype, family history, and literature evidence. The findings enhance our understanding of the genetic landscape associated with FH and underscore the importance of thorough characterization for accurate variant classification.PMID:38663218 | DOI:10.1016/j.tranon.2024.101963 (Source: Translational Oncology)
Source: Translational Oncology - April 25, 2024 Category: Cancer & Oncology Authors: Li Wang Ran Du Lin Han Rui Yang Yingxue Li Source Type: research
MOICS, a novel classier deciphering immune heterogeneity and aid precise management of clear cell renal cell carcinoma at multiomics level
Cancer Biol Ther. 2024 Dec 31;25(1):2345977. doi: 10.1080/15384047.2024.2345977. Epub 2024 Apr 24.ABSTRACTRecent studies have indicated that the tumor immune microenvironment plays a pivotal role in the initiation and progression of clear cell renal cell carcinoma (ccRCC). However, the characteristics and heterogeneity of tumor immunity in ccRCC, particularly at the multiomics level, remain poorly understood. We analyzed immune multiomics datasets to perform a consensus cluster analysis and validate the clustering results across multiple internal and external ccRCC datasets; and identified two distinctive immune phenotypes...
Source: Cancer Biology and Therapy - April 25, 2024 Category: Cancer & Oncology Authors: Ying Liu Lin Qi Bicheng Ye Anbang Wang Juan Lu Le Qu Peng Luo Linhui Wang Aimin Jiang Source Type: research
A new missense mutation c.1240A & gt;G in fumarate hydratase gene leads to uterine leiomyoma associated hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome in Chinese
CONCLUSION: This research adds a novel missense mutation to the repertoire of FH gene variants, emphasizing its likely pathogenic nature based on a multidimensional analysis of phenotype, family history, and literature evidence. The findings enhance our understanding of the genetic landscape associated with FH and underscore the importance of thorough characterization for accurate variant classification.PMID:38663218 | DOI:10.1016/j.tranon.2024.101963 (Source: Translational Oncology)
Source: Translational Oncology - April 25, 2024 Category: Cancer & Oncology Authors: Li Wang Ran Du Lin Han Rui Yang Yingxue Li Source Type: research
The survival benefit of metastasectomy for metastatic non-clear cell renal cell carcinoma: a retrospective cohort study
ConclusionMetastasectomy in patients with metastatic non-ccRCC may provide clinical benefits in terms of improved PFS and OS, especially in patients without liver metastasis and those with metachronous metastasis. (Source: World Journal of Urology)
Source: World Journal of Urology - April 25, 2024 Category: Urology & Nephrology Source Type: research
To characterize small renal cell carcinoma using diffusion relaxation correlation spectroscopic imaging and apparent diffusion coefficient based histogram analysis: a preliminary study
ConclusionDR-CSI may offer improved accuracy in subtype identification for small RCC, while do not show better performance for small RCC grading compared to ADC histogram. (Source: La Radiologia Medica)
Source: La Radiologia Medica - April 25, 2024 Category: Radiology Source Type: research
Recent updates in the therapeutic uses of Pembrolizumab: a brief narrative review
CONCLUSION: Evolving research on pembrolizumab allows a deeper clinical understanding, despite challenges as variable patient responses. Pembrolizumab has emerged as a pivotal breakthrough in cancer treatment, improving patient outcomes and safety.PMID:38658461 | DOI:10.1007/s12094-024-03491-8 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 24, 2024 Category: Cancer & Oncology Authors: V ítor Silva Cristiano Matos Source Type: research
