Impact of body composition on outcomes of immune checkpoint inhibitor combination therapy in patients with previously untreated advanced renal cell carcinoma
CONCLUSION: The SFI can be potentially utilized as an effective predictive and prognostic biomarker for first-line ICI combination therapy for advanced RCC.PMID:38653590 | DOI:10.1016/j.urolonc.2024.04.008 (Source: Urologic Oncology)
Source: Urologic Oncology - April 23, 2024 Category: Urology & Nephrology Authors: Hiroki Ishihara Koichi Nishimura Takashi Ikeda Hironori Fukuda Kazuhiko Yoshida Junpei Iizuka Tsunenori Kondo Toshio Takagi Source Type: research
The β3-AR agonist BRL37344 ameliorates the main symptoms of X-linked nephrogenic diabetes insipidus in the mouse model of the disease
J Cell Mol Med. 2024 Apr;28(8):e18301. doi: 10.1111/jcmm.18301.ABSTRACTX-linked nephrogenic diabetes insipidus (X-NDI) is a rare congenital disease caused by inactivating mutations of the vasopressin type-2 receptor (AVPR2), characterized by impaired renal concentrating ability, dramatic polyuria, polydipsia and risk of dehydration. The disease, which still lacks a cure, could benefit from the pharmacologic stimulation of other GPCRs, activating the cAMP-intracellular pathway in the kidney cells expressing the AVPR2. On the basis of our previous studies, we here hypothesized that the β3-adrenergic receptor could be such a...
Source: J Cell Mol Med - April 23, 2024 Category: Molecular Biology Authors: Serena Milano Ilenia Saponara Andrea Gerbino Monica Carmosino Maria Svelto Giuseppe Procino Source Type: research
Comprehensive bioinformatics analysis of KIF20A as a prognosis biomarker for clear cell renal cell carcinoma
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):116-124. doi: 10.14715/cmb/2024.70.3.17.ABSTRACTIt has been shown that kinesin family member 20A (KIF20A) is involved in the development of several cancers. However, research on clear cell renal cell carcinoma (ccRCC) and KIF20A is still exploratory. The current research was carried out to determine whether KIF20A expression has any prognosis value in ccRCC. Data were downloaded from The Cancer Genome Atlas (TCGA) database to validate the KIF20A mRNA expression and to perform clinicopathological analysis. Receiver operating characteristic (ROC) curves were used in evaluatin...
Source: Mol Biol Cell - April 23, 2024 Category: Molecular Biology Authors: Cankun Xie Wingkeung Yiu Yijiang Mo Source Type: research
The β3-AR agonist BRL37344 ameliorates the main symptoms of X-linked nephrogenic diabetes insipidus in the mouse model of the disease
J Cell Mol Med. 2024 Apr;28(8):e18301. doi: 10.1111/jcmm.18301.ABSTRACTX-linked nephrogenic diabetes insipidus (X-NDI) is a rare congenital disease caused by inactivating mutations of the vasopressin type-2 receptor (AVPR2), characterized by impaired renal concentrating ability, dramatic polyuria, polydipsia and risk of dehydration. The disease, which still lacks a cure, could benefit from the pharmacologic stimulation of other GPCRs, activating the cAMP-intracellular pathway in the kidney cells expressing the AVPR2. On the basis of our previous studies, we here hypothesized that the β3-adrenergic receptor could be such a...
Source: Molecular Medicine - April 23, 2024 Category: Molecular Biology Authors: Serena Milano Ilenia Saponara Andrea Gerbino Monica Carmosino Maria Svelto Giuseppe Procino Source Type: research
A First-in-Human Phase 1 Study of a Tumor-Directed RNA-Interference Drug against HIF2 α in Patients with Advanced Clear Cell Renal Cell Carcinoma
CONCLUSIONS: ARO-HIF2 downregulated HIF2α in advanced ccRCC-inhibiting tumor growth in a subset of subjects. Further development was hampered by off-target neurotoxicity and low response rate. This study provides proof of concept that siRNA can target tumors in a specific manner.PMID:38652038 | DOI:10.1158/1078-0432.CCR-23-3029 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 23, 2024 Category: Cancer & Oncology Authors: James Brugarolas Gregory Obara Kathryn E Beckermann Brian Rini Elaine T Lam James Hamilton Thomas Schluep Min Yi So Wong Zhongping Lily Mao Erick Gamelin Nizar M Tannir Source Type: research
Comprehensive bioinformatics analysis of KIF20A as a prognosis biomarker for clear cell renal cell carcinoma
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):116-124. doi: 10.14715/cmb/2024.70.3.17.ABSTRACTIt has been shown that kinesin family member 20A (KIF20A) is involved in the development of several cancers. However, research on clear cell renal cell carcinoma (ccRCC) and KIF20A is still exploratory. The current research was carried out to determine whether KIF20A expression has any prognosis value in ccRCC. Data were downloaded from The Cancer Genome Atlas (TCGA) database to validate the KIF20A mRNA expression and to perform clinicopathological analysis. Receiver operating characteristic (ROC) curves were used in evaluatin...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Cankun Xie Wingkeung Yiu Yijiang Mo Source Type: research
Network analysis of histopathological image features and genomics data improving prognosis performance in clear cell renal cell carcinoma
CONCLUSION: This study developed a histopathological-genetic-related nomogram by combining histopathological features and clinical predictors, providing a more comprehensive prognostic assessment for clear cell renal cell carcinoma patients.PMID:38653593 | DOI:10.1016/j.urolonc.2024.03.016 (Source: Urologic Oncology)
Source: Urologic Oncology - April 23, 2024 Category: Urology & Nephrology Authors: Jianrui Ji Yunsong Liu Yongxing Bao Yu Men Zhouguang Hui Source Type: research
Impact of body composition on outcomes of immune checkpoint inhibitor combination therapy in patients with previously untreated advanced renal cell carcinoma
CONCLUSION: The SFI can be potentially utilized as an effective predictive and prognostic biomarker for first-line ICI combination therapy for advanced RCC.PMID:38653590 | DOI:10.1016/j.urolonc.2024.04.008 (Source: Urologic Oncology)
Source: Urologic Oncology - April 23, 2024 Category: Urology & Nephrology Authors: Hiroki Ishihara Koichi Nishimura Takashi Ikeda Hironori Fukuda Kazuhiko Yoshida Junpei Iizuka Tsunenori Kondo Toshio Takagi Source Type: research
Comprehensive bioinformatics analysis of KIF20A as a prognosis biomarker for clear cell renal cell carcinoma
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):116-124. doi: 10.14715/cmb/2024.70.3.17.ABSTRACTIt has been shown that kinesin family member 20A (KIF20A) is involved in the development of several cancers. However, research on clear cell renal cell carcinoma (ccRCC) and KIF20A is still exploratory. The current research was carried out to determine whether KIF20A expression has any prognosis value in ccRCC. Data were downloaded from The Cancer Genome Atlas (TCGA) database to validate the KIF20A mRNA expression and to perform clinicopathological analysis. Receiver operating characteristic (ROC) curves were used in evaluatin...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Cankun Xie Wingkeung Yiu Yijiang Mo Source Type: research
Network analysis of histopathological image features and genomics data improving prognosis performance in clear cell renal cell carcinoma
CONCLUSION: This study developed a histopathological-genetic-related nomogram by combining histopathological features and clinical predictors, providing a more comprehensive prognostic assessment for clear cell renal cell carcinoma patients.PMID:38653593 | DOI:10.1016/j.urolonc.2024.03.016 (Source: Urologic Oncology)
Source: Urologic Oncology - April 23, 2024 Category: Urology & Nephrology Authors: Jianrui Ji Yunsong Liu Yongxing Bao Yu Men Zhouguang Hui Source Type: research
Impact of body composition on outcomes of immune checkpoint inhibitor combination therapy in patients with previously untreated advanced renal cell carcinoma
CONCLUSION: The SFI can be potentially utilized as an effective predictive and prognostic biomarker for first-line ICI combination therapy for advanced RCC.PMID:38653590 | DOI:10.1016/j.urolonc.2024.04.008 (Source: Urologic Oncology)
Source: Urologic Oncology - April 23, 2024 Category: Urology & Nephrology Authors: Hiroki Ishihara Koichi Nishimura Takashi Ikeda Hironori Fukuda Kazuhiko Yoshida Junpei Iizuka Tsunenori Kondo Toshio Takagi Source Type: research
Comprehensive bioinformatics analysis of KIF20A as a prognosis biomarker for clear cell renal cell carcinoma
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):116-124. doi: 10.14715/cmb/2024.70.3.17.ABSTRACTIt has been shown that kinesin family member 20A (KIF20A) is involved in the development of several cancers. However, research on clear cell renal cell carcinoma (ccRCC) and KIF20A is still exploratory. The current research was carried out to determine whether KIF20A expression has any prognosis value in ccRCC. Data were downloaded from The Cancer Genome Atlas (TCGA) database to validate the KIF20A mRNA expression and to perform clinicopathological analysis. Receiver operating characteristic (ROC) curves were used in evaluatin...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Cankun Xie Wingkeung Yiu Yijiang Mo Source Type: research
Can We Predict the Grade of Clear Cell Renal Cell Carcinoma from Houns-Field Unit of Renal Lesion on Computerized Tomography Scan, a Retrospective Cross-Sectional Study
(Source: International Journal of General Medicine)
Source: International Journal of General Medicine - April 23, 2024 Category: General Medicine Tags: International Journal of General Medicine Source Type: research
GSE246846 PML restrains p53 activity and cellular senescence in clear cell renal cell carcinoma
Contributors : Matilde Simoni ; Chiara Menegazzi ; Cristina Fracassi ; Claudia C Biffi ; Francesca Genova ; Nazario P Tenace ; Roberta Lucian ò ; Andrea Raimondi ; Carlo Tacchetti ; James Brugarolas ; Davide Mazza ; Rosa BernardiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensClear cell renal cell carcinoma (ccRCC), the major subtype of RCC, is frequently diagnosed at late/metastatic stage with 13% 5-year disease-free survival. Functional inactivation of the wild type p53 protein is implicated in ccRCC therapy resistance, but the detailed mechanisms of p53 malfunction are s...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Surgical management of renal cell carcinoma with subhepatic inferior vena cava tumor thrombus: a case report and review of the literature
ConclusionOpen surgery is a safe and efficient way to treat renal cell carcinoma involving the renal vein and inferior vena cava. It is superior to other therapeutic modalities. When properly done it provides acceptable long time survival and good quality of life to patients. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - April 23, 2024 Category: General Medicine Source Type: research
