Early kinetics of C-reactive protein as prognosticator for survival in a real-world cohort of patients with metastatic renal cell cancer under first-line therapy with immune checkpoint inhibitors
ConclusionsThe present study emphasizes the prognostic potential of early CRP kinetics in CPI-treated mRCC. As a standard laboratory parameter, CRP can be easily implemented into clinical routine to facilitate therapy monitoring. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
Radiomics and machine learning for renal tumor subtype assessment using multiphase computed tomography in a multicenter setting
ConclusionRadiomic feature analyses can distinguish renal tumor subtypes on routinely acquired CTs, with oncocytomas being the hardest subtype to identify.Clinical relevance statementRadiomic feature analyses yield robust results for renal tumor assessment on routine CTs. Although radiologists routinely rely on arterial phase CT for renal tumor assessment and operative planning, radiomic features derived from arterial phase did not improve the accuracy of renal tumor subtype identification in our cohort. (Source: European Radiology)
Source: European Radiology - April 18, 2024 Category: Radiology Source Type: research
Impact of smoking status on clinical outcomes in patients with metastatic renal cell carcinoma treated with first-line immune checkpoint inhibitor-based regimens
CONCLUSION: Smoking status does not appear to independently influence the clinical outcomes to first-line ICI-based regimens in patients with mRCC. Nonetheless, patient counseling on tobacco cessation remains a crucial aspect of managing patients with mRCC, as it significantly reduces all-cause mortality.PMID:38630540 | DOI:10.1093/oncolo/oyae072 (Source: The Oncologist)
Source: The Oncologist - April 17, 2024 Category: Cancer & Oncology Authors: Eddy Saad Georges Gebrael Karl Semaan Marc Eid Ren ée Maria Saliby Chris Labaki Nicolas Sayegh J Connor Wells Kosuke Takemura Matthew Scott Ernst Audreylie Lemelin Naveen S Basappa Lori A Wood Thomas Powles D Scott Ernst Aly-Khan A Lalani Neeraj Agarwal Source Type: research
Real World Analysis of Peritoneal Metastasis From Renal Cell Carcinoma. Meet-Uro27
CONCLUSION: We report one of the largest case series regarding PM from RCC. Characteristics of patients suggest a more aggressive behavior of PM from mRCC. Outcome data suggest that TKI-IO as first line treatment, and TKI as second line, confirm their activity for these patients with dismal prognosis.PMID:38631104 | DOI:10.1016/j.clgc.2024.102078 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Marco Stellato Sebastiano Buti Marco Maruzzo Maria Bassanelli Melissa Bersanelli Marilena Di Napoli Michele Dionese Martina Fanelli Roberto Filippi Giuseppe Fotia Luca Galli Francesco Grillone Michele Maffezzoli Brigida Anna Maiorano Cecilia Nasso Sara El Source Type: research
GSE263369 Gene expression in kidney cells after unilateral ischemia-reperfusion
Contributors : Jamie R Privratsky ; Yanting ChenSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTo determine changes in gene expression due to ischemia-reperfusion AKI in different intra-renal cell populations (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE239889 VHL loss reprograms the immune landscape to promote an inflammatory myeloid microenvironment in renal tumorigenesis
Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusClear cell renal cell carcinoma (ccRCC) is an aggressive disease characterized by dysregulated hypoxia signaling, metabolic defects, and a complex tumor microenvironment (TME) highly enriched in lymphoid and myeloid immune cells. Loss of the oxygen sensing gene, von Hippel Lindau (VHL), is a critical early event in ccRCC pathogenesis and promotes stabilization of hypoxia inducible factors (HIF) that upregulate pro-growth signaling pathways, including angiogenesis and aerobic glycolysis. However, whether VHL loss in cancer ...
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research
GSE216494 Impact of sunitinib resistance on clear cell renal cell carcinoma therapeutic sensitivity in vitro
Contributors : Ghosh Susmita ; Carole Sourbier ; Alexis L NorrisSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSunitinib resistance creates a major clinical challenge for the treatment of advanced clear cell renal cell carcinoma (ccRCC) and functional and metabolic changes linked to sunitinib resistance are not fully understood. We sought to characterize the molecular and metabolic changes induced by the development of sunitinib resistance in ccRCC by developing and characterizing the transcriptome of two human ccRCC cell lines resistant to sunitinib. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Cancers, Vol. 16, Pages 1528: Perioperative and Oncological Outcomes of Percutaneous Radiofrequency Ablation versus Partial Nephrectomy for cT1a Renal Cancers: A Retrospective Study on Groups with Similar Clinical Characteristics
In this study, we investigated the results of US-guided percutaneous radiofrequency ablation (RFA) and partial nephrectomy (PN) in the treatment of cT1a renal cancers. Between August 2016 and February 2022, 271 patients with renal tumours underwent percutaneous RFA as initial treatment in our institution. In the same period, 396 patients with renal tumours underwent surgical tumour excision. For the purpose of this study, only patients with confirmed renal cancer with matched age and tumour characteristics (size, location) were selected for both groups. Thus, a group of 44 PN patients and 41 RFA patients were formed with t...
Source: Cancers - April 17, 2024 Category: Cancer & Oncology Authors: Milosz Jasinski Przemyslaw Wisniewski Marta Bielinska Jerzy Siekiera Krzysztof Kamecki Maciej Salagierski Tags: Article Source Type: research
Adverse events of nivolumab plus ipilimumab versus nivolumab plus cabozantinib: a real-world pharmacovigilance study
ConclusionOur findings contribute to the selection and clinical management of NIVO-IPI and NIVO-CABO, which minimizes the risk of AEs for individual patients with mRCC by considering distinctive differences in the AE profiles. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - April 17, 2024 Category: Drugs & Pharmacology Source Type: research
Moringa isothiocyanate-1 mitigates the damage of oxidative stress and apoptosis in diabetic nephropathy mice
CONCLUSIONS: MIC-1 ameliorated the kidney injury in DN mice, and its mechanism may be associated with the suppression of renal cell apoptosis, oxidative stress, and inflammatory responses.PMID:38623789 | DOI:10.14670/HH-18-741 (Source: Histology and Histopathology)
Source: Histology and Histopathology - April 16, 2024 Category: Cytology Authors: Zhou Hua Jiuhong Deng Guiying Wang Source Type: research
Von Hippel Lindau tumor suppressor controls m6A-dependent gene expression in renal tumorigenesis
In this study, we demonstrate that VHL binds and promotes METTL3/METTL14 complex formation while VHL depletion suppresses m6A modification, which is distinctive from its canonical E3 ligase role. m6A RNA immunoprecipitation sequencing (RIP-Seq) coupled with RNA-Seq allows us to identify a selection of genes whose expression may be regulated by VHL-m6A signaling. Specifically, PIK3R3 is identified to be a critical gene whose mRNA stability is regulated by VHL in a m6A-dependent but HIF-independent manner. Functionally, PIK3R3 depletion promotes renal cancer cell growth and orthotopic tumor growth while its overexpression le...
Source: Journal of Clinical Investigation - April 15, 2024 Category: Biomedical Science Authors: Cheng Zhang, Miaomiao Yu, Austin J. Hepperla, Zhao Zhang, Rishi Raj, Hua Zhong, Jin Zhou, Lianxin Hu, Jun Fang, Hongyi Liu, Qian Liang, Liwei Jia, Chengheng Liao, Sichuan Xi, Jeremy M. Simon, Kexin Xu, Zhijie Liu, Yunsun Nam, Payal Kapur, Qing Zhang Source Type: research
VHL governs m6A modification and PIK3R3 mRNA stability in clear cell renal cell carcinomas
N6-Methyladenosine (m6A), a prevalent posttranscriptional modification, plays an important role in cancer progression. Clear cell renal cell carcinoma (ccRCC) is chiefly associated with the loss of the von Hippel-Lindau (VHL) gene, encoding a component of the E3 ubiquitin ligase complex. In this issue of the JCI, Zhang and colleagues unveiled a function of VHL beyond its canonical role as an E3 ubiquitin ligase in regulating hypoxia-inducible factors (HIFs). It also governed m6A modification by orchestrating the assembly of m6A writer proteins METTL3 and METTL14, thereby stabilizing PIK3R3 mRNA. Mechanistically, PIK3R3 con...
Source: Journal of Clinical Investigation - April 15, 2024 Category: Biomedical Science Authors: Hyemin Lee, Li Zhuang, Boyi Gan Source Type: research
VHL loss reprograms the immune landscape to promote an inflammatory myeloid microenvironment in renal tumorigenesis
Clear cell renal cell carcinoma (ccRCC) is characterized by dysregulated hypoxia signaling and a tumor microenvironment (TME) highly enriched in myeloid and lymphoid cells. Loss of the von Hippel Lindau (VHL) gene is a critical early event in ccRCC pathogenesis and promotes stabilization of HIF. Whether VHL loss in cancer cells affects immune cells in the TME remains unclear. Using Vhl WT and Vhl-KO in vivo murine kidney cancer Renca models, we found that Vhl-KO tumors were more infiltrated by immune cells. Tumor-associated macrophages (TAMs) from Vhl-deficient tumors demonstrated enhanced in vivo glucose consumption, phag...
Source: Journal of Clinical Investigation - April 15, 2024 Category: Biomedical Science Authors: Melissa M. Wolf, Matthew Z. Madden, Emily N. Arner, Jackie E. Bader, Xiang Ye, Logan Vlach, Megan L. Tigue, Madelyn D. Landis, Patrick B. Jonker, Zaid Hatem, KayLee K. Steiner, Dakim K. Gaines, Bradley I. Reinfeld, Emma S. Hathaway, Fuxue Xin, M. Noor Tan Source Type: research
Multi-omics and immunogenomics analysis revealed PFKFB3 as a targetable hallmark and mediates sunitinib resistance in papillary renal cell carcinoma: in silico study with laboratory verification
Eur J Med Res. 2024 Apr 15;29(1):236. doi: 10.1186/s40001-024-01808-5.ABSTRACTGlycolysis-related metabolic reprogramming is a central hallmark of human cancers, especially in renal cell carcinoma. However, the regulatory function of glycolytic signature in papillary RCC has not been well elucidated. In the present study, the glycolysis-immune predictive signature was constructed and validated using WGCNA, glycolysis-immune clustering analysis. PPI network of DEGs was constructed and visualized. Functional enrichments and patients' overall survival were analyzed. QRT-PCR experiments were performed to detect hub genes' expre...
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Zhongwen Lu Yongsheng Pan Songbo Wang Jiajin Wu Chenkui Miao Zengjun Wang Source Type: research
zDHHC3-mediated S-palmitoylation of SLC9A2 regulates apoptosis in kidney clear cell carcinoma
CONCLUSION: Our findings suggest that zDHHC3 plays an important role in KIRC, due partly to its regulation of SLC9A2 S-palmitoylation. The targeting of the zDHHC3-SLC9A2 axis may provide a new option for the clinical treatment of KIRC.PMID:38619631 | DOI:10.1007/s00432-024-05737-y (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Xiuyun Zhang Junpeng Hou Guangyuan Zhou Haixia Wang Zeang Wu Source Type: research
