GSE248774 Immune modulation with RANKL-blockade through denosumab treatment in cancer patients
We examined whether administering denosumab could modify modulate circulating immune cells in c ancer patients. Blood was collected from 23 prostate cancer patients and 3 renal cell carcinoma patients, who provided written informed consent, with advanced disease who were receiving denosumab, prior to and during denosumab treatment. Using high-dimensional mass cytometry, we found that denosumab treatment by itself induced modest effects on circulating immune cell frequency and activation. We also found minimal changes in the circulating T cell repertoire and the frequency of new thymic emigrants with denosumab treatment. H...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Cancers, Vol. 16, Pages 1454: Radiomics Machine Learning Analysis of Clear Cell Renal Cell Carcinoma for Tumour Grade Prediction Based on Intra-Tumoural Sub-Region Heterogeneity
Conclusions: Radiomics signatures combined with ML have the potential to predict the WHO/ISUP grade of ccRCC with superior performance, when compared to pre-operative biopsy. Moreover, tumour sub-regions contain useful information that should be analysed independently when determining the tumour grade. Therefore, it is possible to distinguish the grade of ccRCC pre-operatively to improve patient care and management. (Source: Cancers)
Source: Cancers - April 10, 2024 Category: Cancer & Oncology Authors: Abeer J. Alhussaini J. Douglas Steele Adel Jawli Ghulam Nabi Tags: Article Source Type: research
Development and validation of a clinical and ultrasound features-based nomogram for preoperative differentiation of renal urothelial carcinoma and central renal cell carcinoma
ConclusionA noninvasive clinical and US-based nomogram combining conventional US and CEUS features possesses good predictive value for differentiating rUC from c-RCC. (Source: World Journal of Urology)
Source: World Journal of Urology - April 10, 2024 Category: Urology & Nephrology Source Type: research
Associations Between Inflammatory Indexes, Coagulation Indexes, and Fuhrman Grade of Clear Cell Renal Cell Carcinoma
Ann Surg Oncol. 2024 Apr 9. doi: 10.1245/s10434-024-15251-7. Online ahead of print.NO ABSTRACTPMID:38592621 | DOI:10.1245/s10434-024-15251-7 (Source: Ann Oncol)
Source: Ann Oncol - April 9, 2024 Category: Cancer & Oncology Authors: Yumei Zhang Zehua Sun Zhongyi Wang Hao Guo Jing Liu Heng Ma Source Type: research
STING agonist, SMA-2, inhibits clear cell renal cell carcinoma through improving tumor microenvironment
Mol Cell Biochem. 2024 Apr 9. doi: 10.1007/s11010-024-04970-w. Online ahead of print.ABSTRACTClear cell renal cell carcinoma (ccRCC) is the most prevalent and lethal subtype of kidney cancer, patients with ccRCC usually have very poor prognosis and short survival. Therefore, it is urgent to develop more effective therapeutics or medications to suppress ccRCC progression. Here, we demonstrated that STING agonist, MSA-2 significantly inhibits tumor progress and prolongs the survival of ccRCC mice by promoting cytokines secretion. Moreover, MSA-2 triggered the trafficking and infiltration of CD8+ T cells, supported by the gen...
Source: Molecular and Cellular Biochemistry - April 9, 2024 Category: Biochemistry Authors: Wei Wang Fengqing Zhang Yan Hu Guangming Liu Source Type: research
Advanced renal cell carcinoma management: the Latin American Cooperative Oncology Group (LACOG) and the Latin American Renal Cancer Group (LARCG) consensus update
CONCLUSION: Immunotherapy and targeted therapy are the standards of care for advanced disease. The utilization and sequencing of these therapeutic agents hinge upon individual risk scores and responses to previous treatments. This consensus reflects a commitment to informed decision-making, drawn from professional expertise and evidence in the medical literature.PMID:38594593 | DOI:10.1007/s00432-024-05663-z (Source: Cell Research)
Source: Cell Research - April 9, 2024 Category: Cytology Authors: Andrey Soares Fernando Sabino Marques Monteiro Karine Martins da Trindade Adriano Gon çalves E Silva Ana Paula Garcia Cardoso Andr é Deeke Sasse Andr é P Fay Andr é Paternò Castello Dias Carneiro Antonio Machado Alencar Junior Augusto C ésar de Andr Source Type: research
Associations Between Inflammatory Indexes, Coagulation Indexes, and Fuhrman Grade of Clear Cell Renal Cell Carcinoma
Ann Surg Oncol. 2024 Apr 9. doi: 10.1245/s10434-024-15251-7. Online ahead of print.NO ABSTRACTPMID:38592621 | DOI:10.1245/s10434-024-15251-7 (Source: Ann Oncol)
Source: Ann Oncol - April 9, 2024 Category: Cancer & Oncology Authors: Yumei Zhang Zehua Sun Zhongyi Wang Hao Guo Jing Liu Heng Ma Source Type: research
STING agonist, SMA-2, inhibits clear cell renal cell carcinoma through improving tumor microenvironment
Mol Cell Biochem. 2024 Apr 9. doi: 10.1007/s11010-024-04970-w. Online ahead of print.ABSTRACTClear cell renal cell carcinoma (ccRCC) is the most prevalent and lethal subtype of kidney cancer, patients with ccRCC usually have very poor prognosis and short survival. Therefore, it is urgent to develop more effective therapeutics or medications to suppress ccRCC progression. Here, we demonstrated that STING agonist, MSA-2 significantly inhibits tumor progress and prolongs the survival of ccRCC mice by promoting cytokines secretion. Moreover, MSA-2 triggered the trafficking and infiltration of CD8+ T cells, supported by the gen...
Source: Molecular and Cellular Biochemistry - April 9, 2024 Category: Biochemistry Authors: Wei Wang Fengqing Zhang Yan Hu Guangming Liu Source Type: research
STING agonist, SMA-2, inhibits clear cell renal cell carcinoma through improving tumor microenvironment
Mol Cell Biochem. 2024 Apr 9. doi: 10.1007/s11010-024-04970-w. Online ahead of print.ABSTRACTClear cell renal cell carcinoma (ccRCC) is the most prevalent and lethal subtype of kidney cancer, patients with ccRCC usually have very poor prognosis and short survival. Therefore, it is urgent to develop more effective therapeutics or medications to suppress ccRCC progression. Here, we demonstrated that STING agonist, MSA-2 significantly inhibits tumor progress and prolongs the survival of ccRCC mice by promoting cytokines secretion. Moreover, MSA-2 triggered the trafficking and infiltration of CD8+ T cells, supported by the gen...
Source: Molecular and Cellular Biochemistry - April 9, 2024 Category: Biochemistry Authors: Wei Wang Fengqing Zhang Yan Hu Guangming Liu Source Type: research
STING agonist, SMA-2, inhibits clear cell renal cell carcinoma through improving tumor microenvironment
Mol Cell Biochem. 2024 Apr 9. doi: 10.1007/s11010-024-04970-w. Online ahead of print.ABSTRACTClear cell renal cell carcinoma (ccRCC) is the most prevalent and lethal subtype of kidney cancer, patients with ccRCC usually have very poor prognosis and short survival. Therefore, it is urgent to develop more effective therapeutics or medications to suppress ccRCC progression. Here, we demonstrated that STING agonist, MSA-2 significantly inhibits tumor progress and prolongs the survival of ccRCC mice by promoting cytokines secretion. Moreover, MSA-2 triggered the trafficking and infiltration of CD8+ T cells, supported by the gen...
Source: Molecular and Cellular Biochemistry - April 9, 2024 Category: Biochemistry Authors: Wei Wang Fengqing Zhang Yan Hu Guangming Liu Source Type: research
Visual extended reality tools in image-guided surgery in urology: a systematic review
ConclusionsAR, VR and MR techniques have emerged as highly effective new tools for image-guided surgery, especially for urologic oncology. Nevertheless, the complete clinical advantages of these innovations are still in the process of evaluation. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 9, 2024 Category: Nuclear Medicine Source Type: research
Cancers, Vol. 16, Pages 1449: The Prognostic Impact of the Surgical Margin in Renal Cell Carcinoma Treated with Partial Nephrectomy: A Multi-Center Study
Conclusions: Our study presents further evidence on the negative impact of PSM on recurrence after PN for RCC, highlighting the importance of achieving NSM, thus potentially improving clinical outcomes. A surgical approach was found to be the only predictive factor influencing the risk of PSMs, with a reduced risk observed with robot-assisted laparoscopy. (Source: Cancers)
Source: Cancers - April 9, 2024 Category: Cancer & Oncology Authors: Karina Sif S øndergaard Mosholt Mark Aagaard Andreas R øder Nessn Azawi Tags: Article Source Type: research
Interaction of immune cells with renal cancer development: Mendelian randomization (MR) study
Renal cell carcinoma (RCC) is a prevalent and extensively immune-infiltrated malignancy of the urinary system. Immune cells play a crucial role in both the progression and therapeutic interventions targeting R... (Source: BMC Cancer)
Source: BMC Cancer - April 9, 2024 Category: Cancer & Oncology Authors: Zhongwen Lu, Yu Yin, Tian Rao, Xinchi Xu, Kai Zhao, Zhanpeng Liu, Chao Qin and Min Tang Tags: Research Source Type: research
Early response assessment to targeted therapy in metastatic clear cell renal cancer using 68Ga-PSMA-11 PET/CT and comparison with CECT: a feasibility study
ConclusionEarly response assessment with68Ga-PSMA-11 PET/CT is feasible and provides more accurate prognostic information than CECT in metastatic clear cell RCC patients undergoing targeted therapy.Trial registration numberCTRI/2021/05/033805 (date of registration: 25/05/21) (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - April 9, 2024 Category: Radiology Source Type: research
Visual extended reality tools in image-guided surgery in urology: a systematic review
ConclusionsAR, VR and MR techniques have emerged as highly effective new tools for image-guided surgery, especially for urologic oncology. Nevertheless, the complete clinical advantages of these innovations are still in the process of evaluation. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 9, 2024 Category: Nuclear Medicine Source Type: research
