Exosome-mediated secretion of miR-127-3p regulated by RAB27A accelerates metastasis in renal cell carcinoma
The exosome-mediated extracellular secretion of miRNAs occurs in many cancers, and RAB27A is a potent regulator of exosome secretion. For metastatic renal cell carcinoma (RCC), this study examines the mechanis... (Source: Cancer Cell International)
Source: Cancer Cell International - April 29, 2024 Category: Cancer & Oncology Authors: Dae Hyun Song, Jong Sil Lee, Jeong-Hee Lee, Dong Chul Kim, Jung Wook Yang, Min Hye Kim, Ji Min Na, Hyun-kyung Cho, Jiyun Yoo and Hyo Jung An Tags: Research Source Type: research
Analyses of tumor microenvironment in patients with advanced renal cell carcinoma receiving immunotherapy (Meet-URO 18 study)
Future Oncology, Ahead of Print. (Source: Future Oncology)
Source: Future Oncology - April 29, 2024 Category: Cancer & Oncology Authors: Fabio Catalano Matteo Brunelli Alessio Signori Pasquale Rescigno Sebastiano Buti Luca Galli Massimiliano Spada Cristina Masini Francesca Galuppini Valerio Gaetano Vellone Gabriele Gaggero Marco Maruzzo Sara Merler Francesca Vignani Alessia Cavo Davide Bim Source Type: research
Engineering Cyanine- and Hemicyanine-Based Probes for Optical Imaging of Kidney Diseases
ChemMedChem. 2024 Apr 28:e202400227. doi: 10.1002/cmdc.202400227. Online ahead of print.ABSTRACTMolecular optical probes paly pivotal roles in in vivo imaging of biomarkers associated to kidney diseases. Relying on structural tunability and high fluorescence quantum yields, versatile optical probes have been constructed on cyanine or hemicyanine-based scaffold in recent years. This review summaries the recent progress on the development of optical probes for imaging of kidney diseases, particularly through near-infrared fluorescence, chemiluminescence and photoacoustic imaging modalities. The chemical design and sensing me...
Source: ChemMedChem - April 28, 2024 Category: Chemistry Authors: Shujuan Yi Baoshuai Liang Jiaguo Huang Source Type: research
Engineering Cyanine- and Hemicyanine-Based Probes for Optical Imaging of Kidney Diseases
ChemMedChem. 2024 Apr 28:e202400227. doi: 10.1002/cmdc.202400227. Online ahead of print.ABSTRACTMolecular optical probes paly pivotal roles in in vivo imaging of biomarkers associated to kidney diseases. Relying on structural tunability and high fluorescence quantum yields, versatile optical probes have been constructed on cyanine or hemicyanine-based scaffold in recent years. This review summaries the recent progress on the development of optical probes for imaging of kidney diseases, particularly through near-infrared fluorescence, chemiluminescence and photoacoustic imaging modalities. The chemical design and sensing me...
Source: ChemMedChem - April 28, 2024 Category: Chemistry Authors: Shujuan Yi Baoshuai Liang Jiaguo Huang Source Type: research
Commentary on “Predictive Model of CK7 Expression in Patients With Clear Cell Renal Cell Carcinoma by Combined Multimodal Ultrasound Diagnostic Techniques”
Sir, we read Zhu's paper [1] with great interest. A training group (103 cases) and a testing group (54 cases) were included in this study, this study aimed to develop and validate a predictive model for cytokeratin 7 (CK7) expression in clear cell renal cell carcinoma (ccRCC) patients by combining multimodal ultrasound diagnostic techniques. Their univariate logistic regression analysis revealed that B-mode ultrasound (US), and color Doppler flow imaging (CDFI) observations were not correlated with CK7 expression and could not predict it. (Source: Ultrasound in Medicine and Biology)
Source: Ultrasound in Medicine and Biology - April 28, 2024 Category: Radiology Authors: Lucou Chen, Jianhua Zhang Tags: Letter to the Editor Source Type: research
High serum sodium predicts immunotherapy response in metastatic renal cell and urothelial carcinoma
The development of reliable biomarkers for the prediction of immune checkpoint inhibition (ICI) response in patients with metastatic renal cell carcinoma (mRCC) and urothelial carcinoma (mUC) remains an unresolved challenge. Conventional ICI biomarkers typically focus on tumor-related factors such as PD-L1 expression. However, a comprehensive evaluation of the predictive value of serum electrolyte levels, a so far widely unexplored area, is still pending. (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 28, 2024 Category: Cancer & Oncology Authors: KlumperNiklas Kl ümper, Alexander Cox, Markus Eckstein, Christoph Kuppe, Manuel Ritter, Peter Brossart, Julian Luetkens, HolzelMichael Hölzel, Johannes Stein, Jonas Saal Tags: Original Research Source Type: research
Machine Learning Gene Signature to Metastatic ccRCC Based on ceRNA Network
This study aims to build a ceRNA network and a gene signature for ccRCC associated with metastatic development and analyze their biological functions. Using data from The Cancer Genome Atlas (TCGA), we constructed the ceRNA network with differentially expressed genes, assembled nine preliminary gene signatures from eight feature selection techniques, and evaluated the classification metrics to choose a final signature. After that, we performed a genomic analysis, a risk analysis, and a functional annotation analysis. We present an 11-gene signature: SNHG15, AF117829.1, hsa-miR-130a-3p, hsa-mir-381-3p, BTBD11, INSR, HECW2, ...
Source: Cancer Control - April 27, 2024 Category: Cancer & Oncology Authors: Epit ácio Farias Patrick Terrematte Beatriz Stransky Source Type: research
Noninvasive Ambulatory Electrocardiographic Markers from Patients with COVID-19 Pneumonia: A Report of Three Cases
Medicina (Kaunas). 2024 Apr 19;60(4):655. doi: 10.3390/medicina60040655.ABSTRACTCoronavirus disease 2019 (COVID-19) has affected medical practice. More than 7,000,000 patients died worldwide after being infected with COVID-19; however, no specific laboratory markers have yet been established to predict death related to this disease. In contrast, electrocardiographic changes due to COVID-19 include QT prolongation and ST-T changes; however, there have not been studies on the ambulatory electrocardiographic markers of COVID-19. We encountered three patients diagnosed as having COVID-19 who did not have a prior history of sig...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Motohiro Kimata Kenichi Hashimoto Naomi Harada Yusuke Kawamura Yoshifumi Kimizuka Yuji Fujikura Mayuko Kaneko Nobuaki Kiriu Yasumasa Sekine Natsumi Iwabuchi Tetsuro Kiyozumi Akihiko Kawana Susumu Matsukuma Yuji Tanaka Source Type: research
Noninvasive Ambulatory Electrocardiographic Markers from Patients with COVID-19 Pneumonia: A Report of Three Cases
Medicina (Kaunas). 2024 Apr 19;60(4):655. doi: 10.3390/medicina60040655.ABSTRACTCoronavirus disease 2019 (COVID-19) has affected medical practice. More than 7,000,000 patients died worldwide after being infected with COVID-19; however, no specific laboratory markers have yet been established to predict death related to this disease. In contrast, electrocardiographic changes due to COVID-19 include QT prolongation and ST-T changes; however, there have not been studies on the ambulatory electrocardiographic markers of COVID-19. We encountered three patients diagnosed as having COVID-19 who did not have a prior history of sig...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Motohiro Kimata Kenichi Hashimoto Naomi Harada Yusuke Kawamura Yoshifumi Kimizuka Yuji Fujikura Mayuko Kaneko Nobuaki Kiriu Yasumasa Sekine Natsumi Iwabuchi Tetsuro Kiyozumi Akihiko Kawana Susumu Matsukuma Yuji Tanaka Source Type: research
Noninvasive Ambulatory Electrocardiographic Markers from Patients with COVID-19 Pneumonia: A Report of Three Cases
Medicina (Kaunas). 2024 Apr 19;60(4):655. doi: 10.3390/medicina60040655.ABSTRACTCoronavirus disease 2019 (COVID-19) has affected medical practice. More than 7,000,000 patients died worldwide after being infected with COVID-19; however, no specific laboratory markers have yet been established to predict death related to this disease. In contrast, electrocardiographic changes due to COVID-19 include QT prolongation and ST-T changes; however, there have not been studies on the ambulatory electrocardiographic markers of COVID-19. We encountered three patients diagnosed as having COVID-19 who did not have a prior history of sig...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Motohiro Kimata Kenichi Hashimoto Naomi Harada Yusuke Kawamura Yoshifumi Kimizuka Yuji Fujikura Mayuko Kaneko Nobuaki Kiriu Yasumasa Sekine Natsumi Iwabuchi Tetsuro Kiyozumi Akihiko Kawana Susumu Matsukuma Yuji Tanaka Source Type: research
Cancers, Vol. 16, Pages 1697: A Review of the Paradigmatic Role of Adipose Tissue in Renal Cancer: Fat Measurement and Tumor Behavior Features
Conclusions: Methodological variations and limitations, such as retrospective designs and sample size constraints, pose challenges to standardization and generalizability. Further research is needed to understand these associations better and establish standardized approaches for adiposity assessment in RCC patients, which could inform clinical practice and therapeutic decision-making. (Source: Cancers)
Source: Cancers - April 27, 2024 Category: Cancer & Oncology Authors: Eliodoro Faiella Elva Vergantino Federica Vaccarino Amalia Bruno Gloria Perillo Rosario Francesco Grasso Bruno Beomonte Zobel Domiziana Santucci Tags: Review Source Type: research
Treatment options in first-line metastatic renal carcinoma: A meta-analysis of 2556 patients treated with immune checkpoint inhibitors-based combinations in randomised controlled trials
The average five-year survival of metastatic renal cell carcinoma (mRCC) is 71%. However, there is significant variability in patient prognosis. Immune checkpoint inhibitors (ICIs) have been introduced into the treatment landscape of mRCC. This meta-analysis aimed to estimate progression-free and overall survival probabilities and identify possible outcome predictors of mRCC patients treated with ICI combination as first-line treatment. (Source: Cancer Treatment Reviews)
Source: Cancer Treatment Reviews - April 27, 2024 Category: Cancer & Oncology Authors: Marcello Tucci, Marta Mandar à, Jacopo Giuliani, Emilia Durante, Consuelo Buttigliero, Fabio Turco, Erica Palesandro, Ilaria Campisi, Navdeep Singh, Marco Muraro, Fernando Munoz, Francesco Fiorica Tags: Systematic or Meta-analysis Studies Source Type: research
Long-term functional outcomes in patients undergoing radical nephrectomy for renal cell carcinoma and tumor thrombus
ConclusionsThe presence of TT in RCC patients represents a key risk factor for worse perioperative, as well as long-term renal function. Specifically, patients with TT harbor a significant and early estimated glomerular filtration rate (eGFR) decrease. However, despite TT patients show a greater eGFR decline after surgery, they retain acceptable renal function, which remains stable over time. (Source: World Journal of Urology)
Source: World Journal of Urology - April 27, 2024 Category: Urology & Nephrology Source Type: research
Patient's self-reported quality of life as a prognostic factor in metastatic renal cell carcinoma initially treated with TKI: nomogram proposal
ConclusionAlthough it would need external validation, the proposed nomogram could be an alternative to other previously described models. The NCCN FKSI 19 baseline score could replace the clinician ’s subjective determination of PS.Clinical trial registrationNot applicable. (Source: World Journal of Urology)
Source: World Journal of Urology - April 27, 2024 Category: Urology & Nephrology Source Type: research
Antibody-Drug Conjugates in the Treatment of Genitourinary Cancers: An Updated Review of Data
In this study, we have thoroughly completed a narrative review of the current literature and summarized preclinical studies and clinical trials that evaluated the utility, activity, and toxicity of ADCs in GU cancers, the prospects of ADC development, and the ongoing clinical trials. Prospective clinical trials, retrospective studies, case reports, and scoping reviews were included.PMID:38668075 | DOI:10.3390/curroncol31040172 (Source: Current Oncology)
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Prathana Nathan Adnan Rajeh Meh Noor Gabriel Boldt Ricardo Fernandes Source Type: research
