ASO Visual Abstract: Gross Hematuria Does Not Affect the Selection of Nephrectomy Types for Clinical Stage 1 Clear Cell Renal Cell Carcinoma—A Multicenter Retrospective Cohort Study
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 6, 2024 Category: Cancer & Oncology Source Type: research
Tumor-associated macrophages impair NK cell IFN- γ production and contribute to tumor progression in clear cell renal cell carcinoma
Eur J Immunol. 2024 Apr 6:e2350878. doi: 10.1002/eji.202350878. Online ahead of print.ABSTRACTTumor-associated macrophages (TAM) are abundant in several tumor types and usually correlate with poor prognosis. Previously, we demonstrated that anti-inflammatory macrophages (M2) inhibit NK cell effector functions. Here, we explored the impact of TAM on NK cells in the context of clear-cell renal cell carcinoma (ccRCC). Bioinformatics analysis revealed that an exhausted NK cell signature strongly correlated with an M2 signature. Analysis of TAM from human ccRCC samples confirmed that they exhibited an M2-skewed phenotype and in...
Source: European Journal of Immunology - April 6, 2024 Category: Allergy & Immunology Authors: Sol Yanel N úñez Aldana Trotta Mar ía Victoria Regge Mar ía Sofía Amarilla Florencia Secchiari Jessica Mariel Sierra Mar ía Cecilia Santilli Mariana Gantov Agust ín Rovegno Nicol ás Richards Carlos Ameri Hernando R íos Pita Luis Rico Mauro Mieggi Source Type: research
Tumor-associated macrophages impair NK cell IFN- γ production and contribute to tumor progression in clear cell renal cell carcinoma
Eur J Immunol. 2024 Apr 6:e2350878. doi: 10.1002/eji.202350878. Online ahead of print.ABSTRACTTumor-associated macrophages (TAM) are abundant in several tumor types and usually correlate with poor prognosis. Previously, we demonstrated that anti-inflammatory macrophages (M2) inhibit NK cell effector functions. Here, we explored the impact of TAM on NK cells in the context of clear-cell renal cell carcinoma (ccRCC). Bioinformatics analysis revealed that an exhausted NK cell signature strongly correlated with an M2 signature. Analysis of TAM from human ccRCC samples confirmed that they exhibited an M2-skewed phenotype and in...
Source: European Journal of Immunology - April 6, 2024 Category: Allergy & Immunology Authors: Sol Yanel N úñez Aldana Trotta Mar ía Victoria Regge Mar ía Sofía Amarilla Florencia Secchiari Jessica Mariel Sierra Mar ía Cecilia Santilli Mariana Gantov Agust ín Rovegno Nicol ás Richards Carlos Ameri Hernando R íos Pita Luis Rico Mauro Mieggi Source Type: research
TFE3/PI3K/Akt/mTOR axis in renal cell carcinoma affects tumor microenvironment
The role of the PI3K/Akt pathway in renal cell carcinoma (RCC) progression, metastasis, and resistance to therapies has not been thoroughly investigated. Transcription factor E3 (TFE3) expression is related to poorer prognosis and tumor microenvironment in patients with RCC. We aimed to determine the relationship between TFE3 and the PI3K/Akt pathway. TFE3 downregulation was achieved by transient transfection of small interfering RNA (siRNA) and short hairpin RNA (shRNA) in UOK146 cells. TFE3 overexpression was induced by transient transfection with pcDNA3.1 encoding the constitutively active form of TFE3. (Source: America...
Source: American Journal of Pathology - April 6, 2024 Category: Pathology Authors: Chung Su Hwang, Yun Kyung Kang, Ji Yun Kim, So Hyun Shin, Joon Young Park, Ji Sun Song, So Young Kim, Se Jin Jung, Jung Hee Lee, Ju-Young Na, Dong Hoon Shin, Jee Yeon Kim, Sung Woo Park, Hyun Jung Lee Tags: Regular Article Source Type: research
MMP1, IL-1 β, sTNFR-1, and IL-6 are prognostic factors for patients with unresectable or metastatic renal cell carcinoma treated with immune checkpoint inhibitors
ConclusionMMP1 may be associated with severe irAE, and MMP1, IL-1 β, sTNFR-1, and IL-6 could serve as prognostic factors in unresectable or metastatic RCC treated with ICIs. MMP1 and IL-6 were independent predictors of PFS and OS, respectively. Thus, inhibiting these soluble factors may be promising for enhancing antitumor responses in patients with RCC treated w ith ICIs. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 6, 2024 Category: Cancer & Oncology Source Type: research
Transcription Factor E3/Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin Axis in Renal Cell Carcinoma Affects Tumor Microenvironment
This study aimed to determine the relationship between TFE3 and the PI3K/Akt pathway. TFE3 down-regulation was achieved by transient transfection of siRNA and shRNA in UOK146 cells. TFE3 overexpression was induced by transient transfection with pcDNA3.1 encoding the constitutively active form of TFE3. (Source: American Journal of Pathology)
Source: American Journal of Pathology - April 6, 2024 Category: Pathology Authors: Chung Su Hwang, Yun Kyung Kang, Ji Yun Kim, So Hyun Shin, Joon Young Park, Ji Sun Song, So Young Kim, Se Jin Jung, Jung Hee Lee, Ju-Young Na, Dong Hoon Shin, Jee Yeon Kim, Sung Woo Park, Hyun Jung Lee Tags: Regular article Source Type: research
Clinically Undiagnosed Diseases in Autopsies: Frequency and Risk Factors
CONCLUSIONS.—: Autopsy is a useful investigation for the detection of clinically undiagnosed entities. In our cohort, cardiac amyloidosis showed the highest number of underlying risk factors, but was clinically underdiagnosed. Our findings underline the necessity of improved clinical detection of cardiac amyloidosis, especially in light of emerging therapeutic options. Moreover, we characterize the most common entities prone to clinical underdiagnosis.PMID:38576236 | DOI:10.5858/arpa.2023-0429-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 5, 2024 Category: Laboratory Medicine Authors: Umberto Maccio Christoph Andreas Meier Michael Reinehr Frank Ruschitzka Reto Sch üpbach Holger Moch Zsuzsanna Varga Source Type: research
CLO24-068: The Role of Obesity in Influencing Patient Survival in Metastatic Renal Cell Carcinoma Patients Receiving Immunotherapy: A Systematic Review and Meta-Analysis
J Natl Compr Canc Netw. 2024 Apr 5;22(2.5):CLO24-068. doi: 10.6004/jnccn.2023.7287.NO ABSTRACTPMID:38580276 | DOI:10.6004/jnccn.2023.7287 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - April 5, 2024 Category: Cancer & Oncology Authors: Chalothorn Wannaphut Sakditad Saowapa Natchaya Polpichai Pharit Siladech Manasawee Tanariyakul Phuuwadith Wattanachayakul Pakin Lalitnithi Source Type: research
