MMP1, IL-1 β, sTNFR-1, and IL-6 are prognostic factors for patients with unresectable or metastatic renal cell carcinoma treated with immune checkpoint inhibitors

ConclusionMMP1 may be associated with severe irAE, and MMP1, IL-1 β, sTNFR-1, and IL-6 could serve as prognostic factors in unresectable or metastatic RCC treated with ICIs. MMP1 and IL-6 were independent predictors of PFS and OS, respectively. Thus, inhibiting these soluble factors may be promising for enhancing antitumor responses in patients with RCC treated w ith ICIs.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research