Molecular mechanism of formation and destruction of a pseudo ‑capsule in clear cell renal cell carcinoma
In conclusion, the present study provides insights into the formation and destruction of a PC, and the results may aid the treatment and management of patients with ccRCC.PMID:38586200 | PMC:PMC10996032 | DOI:10.3892/ol.2024.14358 (Source: Oncology Letters)
Source: Oncology Letters - April 8, 2024 Category: Cancer & Oncology Authors: Takuto Shimizu Makito Miyake Kota Iida Sayuri Onishi Tomomi Fujii Yusuke Iemura Kazuki Ichikawa Chihiro Omori Fumisato Maesaka Mitsuru Tomizawa Tatsuki Miyamoto Nobumichi Tanaka Kiyohide Fujimoto Source Type: research
GHITM regulates malignant phenotype and sensitivity to PD-1 blockade of renal cancer cells via Notch signalling
J Cell Mol Med. 2024 Apr;28(8):e18290. doi: 10.1111/jcmm.18290.ABSTRACTGrowth hormone inducible transmembrane protein (GHITM), one member of Bax inhibitory protein-like family, has been rarely studied, and the clinical importance and biological functions of GHITM in kidney renal clear cell carcinoma (KIRC) still remain unknown. In the present study, we found that GHITM was downregulated in KIRC. Aberrant GHITM downregulation related to clinicopathological feature and unfavourable prognosis of KIRC patients. GHITM overexpression inhibited KIRC cell proliferation, migration and invasion in vitro and in vivo. Mechanistically,...
Source: J Cell Mol Med - April 8, 2024 Category: Molecular Biology Authors: Shiyu Huang Jiachen Liu Juncheng Hu Yanguang Hou Min Hu Banghua Zhang Hongbo Luo Shujie Fu Yujie Chen Xiuheng Liu Zhiyuan Chen Lei Wang Source Type: research
Visual extended reality tools in image-guided surgery in urology: a systematic review
CONCLUSIONS: AR, VR and MR techniques have emerged as highly effective new tools for image-guided surgery, especially for urologic oncology. Nevertheless, the complete clinical advantages of these innovations are still in the process of evaluation.PMID:38589511 | DOI:10.1007/s00259-024-06699-6 (Source: Molecular Medicine)
Source: Molecular Medicine - April 8, 2024 Category: Molecular Biology Authors: Enrico Checcucci Alberto Piana Gabriele Volpi Alberto Quar à Sabrina De Cillis Federico Piramide Mariano Burgio Juliette Meziere Edoardo Cisero Marco Colombo Gabriele Bignante Michele Sica Stefano Granato Paolo Verri Cecilia Gatti Paolo Alessio Michele D Source Type: research
GHITM regulates malignant phenotype and sensitivity to PD-1 blockade of renal cancer cells via Notch signalling
J Cell Mol Med. 2024 Apr;28(8):e18290. doi: 10.1111/jcmm.18290.ABSTRACTGrowth hormone inducible transmembrane protein (GHITM), one member of Bax inhibitory protein-like family, has been rarely studied, and the clinical importance and biological functions of GHITM in kidney renal clear cell carcinoma (KIRC) still remain unknown. In the present study, we found that GHITM was downregulated in KIRC. Aberrant GHITM downregulation related to clinicopathological feature and unfavourable prognosis of KIRC patients. GHITM overexpression inhibited KIRC cell proliferation, migration and invasion in vitro and in vivo. Mechanistically,...
Source: Molecular Medicine - April 8, 2024 Category: Molecular Biology Authors: Shiyu Huang Jiachen Liu Juncheng Hu Yanguang Hou Min Hu Banghua Zhang Hongbo Luo Shujie Fu Yujie Chen Xiuheng Liu Zhiyuan Chen Lei Wang Source Type: research
Celastrol Elicits Antitumor Effects through Inducing Immunogenic Cell Death and Downregulating PD-L1 in ccRCC
CONCLUSION: These findings indicate that CeT not only induces ICD but also suppresses PD-L1 by down-regulating MAPK1 expression, which will provide an attractive strategy for ccRCC immunotherapy.PMID:38584553 | DOI:10.2174/0113816128288970240321073436 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Hong-Fang Li Neng Zhu Jia-Jun Wu Ya-Ning Shi Jia Gu Li Qin Source Type: research
Molecular mechanism of formation and destruction of a pseudo ‑capsule in clear cell renal cell carcinoma
In conclusion, the present study provides insights into the formation and destruction of a PC, and the results may aid the treatment and management of patients with ccRCC.PMID:38586200 | PMC:PMC10996032 | DOI:10.3892/ol.2024.14358 (Source: Oncology Letters)
Source: Oncology Letters - April 8, 2024 Category: Cancer & Oncology Authors: Takuto Shimizu Makito Miyake Kota Iida Sayuri Onishi Tomomi Fujii Yusuke Iemura Kazuki Ichikawa Chihiro Omori Fumisato Maesaka Mitsuru Tomizawa Tatsuki Miyamoto Nobumichi Tanaka Kiyohide Fujimoto Source Type: research
TFE3/PI3K/Akt/mTOR axis in renal cell carcinoma affects tumor microenvironment
Am J Pathol. 2024 Apr 6:S0002-9440(24)00122-6. doi: 10.1016/j.ajpath.2024.02.022. Online ahead of print.ABSTRACTThe role of the PI3K/Akt pathway in renal cell carcinoma (RCC) progression, metastasis, and resistance to therapies has not been thoroughly investigated. Transcription factor E3 (TFE3) expression is related to poorer prognosis and tumor microenvironment in patients with RCC. We aimed to determine the relationship between TFE3 and the PI3K/Akt pathway. TFE3 downregulation was achieved by transient transfection of small interfering RNA (siRNA) and short hairpin RNA (shRNA) in UOK146 cells. TFE3 overexpression was i...
Source: The American Journal of Pathology - April 8, 2024 Category: Pathology Authors: Chung Su Hwang Yun Kyung Kang Ji Yun Kim So Hyun Shin Joon Young Park Ji Sun Song So Young Kim Se Jin Jung Jung Hee Lee Ju-Young Na Dong Hoon Shin Jee Yeon Kim Sung Woo Park Hyun Jung Lee Source Type: research
TFE3/PI3K/Akt/mTOR axis in renal cell carcinoma affects tumor microenvironment
Am J Pathol. 2024 Apr 6:S0002-9440(24)00122-6. doi: 10.1016/j.ajpath.2024.02.022. Online ahead of print.ABSTRACTThe role of the PI3K/Akt pathway in renal cell carcinoma (RCC) progression, metastasis, and resistance to therapies has not been thoroughly investigated. Transcription factor E3 (TFE3) expression is related to poorer prognosis and tumor microenvironment in patients with RCC. We aimed to determine the relationship between TFE3 and the PI3K/Akt pathway. TFE3 downregulation was achieved by transient transfection of small interfering RNA (siRNA) and short hairpin RNA (shRNA) in UOK146 cells. TFE3 overexpression was i...
Source: Am J Pathol - April 8, 2024 Category: Pathology Authors: Chung Su Hwang Yun Kyung Kang Ji Yun Kim So Hyun Shin Joon Young Park Ji Sun Song So Young Kim Se Jin Jung Jung Hee Lee Ju-Young Na Dong Hoon Shin Jee Yeon Kim Sung Woo Park Hyun Jung Lee Source Type: research
GHITM regulates malignant phenotype and sensitivity to PD-1 blockade of renal cancer cells via Notch signalling
J Cell Mol Med. 2024 Apr;28(8):e18290. doi: 10.1111/jcmm.18290.ABSTRACTGrowth hormone inducible transmembrane protein (GHITM), one member of Bax inhibitory protein-like family, has been rarely studied, and the clinical importance and biological functions of GHITM in kidney renal clear cell carcinoma (KIRC) still remain unknown. In the present study, we found that GHITM was downregulated in KIRC. Aberrant GHITM downregulation related to clinicopathological feature and unfavourable prognosis of KIRC patients. GHITM overexpression inhibited KIRC cell proliferation, migration and invasion in vitro and in vivo. Mechanistically,...
Source: J Cell Mol Med - April 8, 2024 Category: Molecular Biology Authors: Shiyu Huang Jiachen Liu Juncheng Hu Yanguang Hou Min Hu Banghua Zhang Hongbo Luo Shujie Fu Yujie Chen Xiuheng Liu Zhiyuan Chen Lei Wang Source Type: research
Visual extended reality tools in image-guided surgery in urology: a systematic review
CONCLUSIONS: AR, VR and MR techniques have emerged as highly effective new tools for image-guided surgery, especially for urologic oncology. Nevertheless, the complete clinical advantages of these innovations are still in the process of evaluation.PMID:38589511 | DOI:10.1007/s00259-024-06699-6 (Source: Molecular Medicine)
Source: Molecular Medicine - April 8, 2024 Category: Molecular Biology Authors: Enrico Checcucci Alberto Piana Gabriele Volpi Alberto Quar à Sabrina De Cillis Federico Piramide Mariano Burgio Juliette Meziere Edoardo Cisero Marco Colombo Gabriele Bignante Michele Sica Stefano Granato Paolo Verri Cecilia Gatti Paolo Alessio Michele D Source Type: research
GHITM regulates malignant phenotype and sensitivity to PD-1 blockade of renal cancer cells via Notch signalling
J Cell Mol Med. 2024 Apr;28(8):e18290. doi: 10.1111/jcmm.18290.ABSTRACTGrowth hormone inducible transmembrane protein (GHITM), one member of Bax inhibitory protein-like family, has been rarely studied, and the clinical importance and biological functions of GHITM in kidney renal clear cell carcinoma (KIRC) still remain unknown. In the present study, we found that GHITM was downregulated in KIRC. Aberrant GHITM downregulation related to clinicopathological feature and unfavourable prognosis of KIRC patients. GHITM overexpression inhibited KIRC cell proliferation, migration and invasion in vitro and in vivo. Mechanistically,...
Source: Molecular Medicine - April 8, 2024 Category: Molecular Biology Authors: Shiyu Huang Jiachen Liu Juncheng Hu Yanguang Hou Min Hu Banghua Zhang Hongbo Luo Shujie Fu Yujie Chen Xiuheng Liu Zhiyuan Chen Lei Wang Source Type: research
Celastrol Elicits Antitumor Effects through Inducing Immunogenic Cell Death and Downregulating PD-L1 in ccRCC
CONCLUSION: These findings indicate that CeT not only induces ICD but also suppresses PD-L1 by down-regulating MAPK1 expression, which will provide an attractive strategy for ccRCC immunotherapy.PMID:38584553 | DOI:10.2174/0113816128288970240321073436 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Hong-Fang Li Neng Zhu Jia-Jun Wu Ya-Ning Shi Jia Gu Li Qin Source Type: research
TFE3/PI3K/Akt/mTOR axis in renal cell carcinoma affects tumor microenvironment
Am J Pathol. 2024 Apr 6:S0002-9440(24)00122-6. doi: 10.1016/j.ajpath.2024.02.022. Online ahead of print.ABSTRACTThe role of the PI3K/Akt pathway in renal cell carcinoma (RCC) progression, metastasis, and resistance to therapies has not been thoroughly investigated. Transcription factor E3 (TFE3) expression is related to poorer prognosis and tumor microenvironment in patients with RCC. We aimed to determine the relationship between TFE3 and the PI3K/Akt pathway. TFE3 downregulation was achieved by transient transfection of small interfering RNA (siRNA) and short hairpin RNA (shRNA) in UOK146 cells. TFE3 overexpression was i...
Source: The American Journal of Pathology - April 8, 2024 Category: Pathology Authors: Chung Su Hwang Yun Kyung Kang Ji Yun Kim So Hyun Shin Joon Young Park Ji Sun Song So Young Kim Se Jin Jung Jung Hee Lee Ju-Young Na Dong Hoon Shin Jee Yeon Kim Sung Woo Park Hyun Jung Lee Source Type: research
TFE3/PI3K/Akt/mTOR axis in renal cell carcinoma affects tumor microenvironment
Am J Pathol. 2024 Apr 6:S0002-9440(24)00122-6. doi: 10.1016/j.ajpath.2024.02.022. Online ahead of print.ABSTRACTThe role of the PI3K/Akt pathway in renal cell carcinoma (RCC) progression, metastasis, and resistance to therapies has not been thoroughly investigated. Transcription factor E3 (TFE3) expression is related to poorer prognosis and tumor microenvironment in patients with RCC. We aimed to determine the relationship between TFE3 and the PI3K/Akt pathway. TFE3 downregulation was achieved by transient transfection of small interfering RNA (siRNA) and short hairpin RNA (shRNA) in UOK146 cells. TFE3 overexpression was i...
Source: Am J Pathol - April 8, 2024 Category: Pathology Authors: Chung Su Hwang Yun Kyung Kang Ji Yun Kim So Hyun Shin Joon Young Park Ji Sun Song So Young Kim Se Jin Jung Jung Hee Lee Ju-Young Na Dong Hoon Shin Jee Yeon Kim Sung Woo Park Hyun Jung Lee Source Type: research
Celastrol Elicits Antitumor Effects through Inducing Immunogenic Cell Death and Downregulating PD-L1 in ccRCC
CONCLUSION: These findings indicate that CeT not only induces ICD but also suppresses PD-L1 by down-regulating MAPK1 expression, which will provide an attractive strategy for ccRCC immunotherapy.PMID:38584553 | DOI:10.2174/0113816128288970240321073436 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Hong-Fang Li Neng Zhu Jia-Jun Wu Ya-Ning Shi Jia Gu Li Qin Source Type: research
