A First-in-Human Phase 1 Study of a Tumor-Directed RNA-Interference Drug against HIF2 α in Patients with Advanced Clear Cell Renal Cell Carcinoma
CONCLUSIONS: ARO-HIF2 downregulated HIF2α in advanced ccRCC-inhibiting tumor growth in a subset of subjects. Further development was hampered by off-target neurotoxicity and low response rate. This study provides proof of concept that siRNA can target tumors in a specific manner.PMID:38652038 | DOI:10.1158/1078-0432.CCR-23-3029
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: James Brugarolas Gregory Obara Kathryn E Beckermann Brian Rini Elaine T Lam James Hamilton Thomas Schluep Min Yi So Wong Zhongping Lily Mao Erick Gamelin Nizar M Tannir Source Type: research
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