Can nuclear imaging accurately detect scar in ischemic cardiac resynchronization therapy candidates?
Background
Accurate scar assessment is crucial in cardiac resynchronization therapy (CRT) candidates, since its presence is a negative predictor for CRT response. Therefore, we assessed the performance of different PET parameters to detect scar in CRT candidates.
Methods:
Twenty-nine CRT candidates underwent 18F-fluorodeoxyglucose (18F-FDG)-PET/computed tomography (CT), resting 13N-NH3-PET/CT and cardiac magnetic resonance (CMR) prior to CRT implantation. Segmental 18F-FDG uptake, late 13N-NH3 uptake and absolute myocardial blood flow (MBF) were evaluated for scar detection using late gadolinium enhancement (LGE...
Source: Nuclear Medicine Communications - April 18, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Effect of proton pump inhibitors and other commonly prescribed drugs on rescanning of patients undergoing myocardial perfusion imaging: a case-control study
Objectives
Proton pump inhibitor use is associated with increased gastric wall activity on myocardial perfusion imaging; however, the clinical impact is unknown. We sought to determine the association of the use of proton pump inhibitors and nine other commonly prescribed classes of medications on the risk of rescanning patients undergoing myocardial perfusion imaging.
Methods
A matched case-control study was performed including 337 rescanned cases and 337 same-day controls from a total of 5432 patients undergoing myocardial perfusion imaging (MPI) over a 4-year period.
Results
The odds of rescanning was ...
Source: Nuclear Medicine Communications - April 18, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Radiomics: a quantitative imaging biomarker in precision oncology
Cancer treatment is heading towards precision medicine driven by genetic and biochemical markers. Various genetic and biochemical markers are utilized to render personalized treatment in cancer. In the last decade, noninvasive imaging biomarkers have also been developed to assist personalized decision support systems in oncology. The imaging biomarkers i.e., radiomics is being researched to develop specific digital phenotype of tumor in cancer. Radiomics is a process to extract high throughput data from medical images by using advanced mathematical and statistical algorithms. The radiomics process involves various steps i....
Source: Nuclear Medicine Communications - April 18, 2022 Category: Nuclear Medicine Tags: Review Article Source Type: research
Correlation of preoperative PET/computer tomography 18F-fluorodeoxyglucose uptake (maximum standardized uptake value) with prognosis in patients with operated lung cancer
Conclusion
It is seen that preoperative SUVmax is a parameter with prognostic significance at least as much as histopathology, age, complete/incomplete status of resection and lymph node involvement. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Prediction of early biochemical response after 177Lu-PSMA radioligand therapy with 68Ga-PSMA PET, a different perspective with quantitative parameters
Conclusion
Dmax is the most prognostic parameter in predicting the early biochemical response in patients with mCRPC; high total tumor volume and burden are also parameters that give us an idea about the response to treatment. The success rate will be higher if 177Lu-PSMA RLT treatment is planned for patients with higher tumor volume and spread. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Development 68Ga trastuzumab Fab and bioevaluation by PET imaging in HER2/neu expressing breast cancer patients
Introduction
Receptors on breast cancer cells play a crucial role in the management of patients. Trastuzumab is a widely used drug for the treatment of HER2/neu expressing tumors. ImmunoPET with trastuzumab is not feasible due to slow pharmacokinetics. Fragment of antigen-binding (Fab) radiolabeled with positron emitters can be used for immunoPET.
Methods
Fab has been generated by papain digestion and conjugated with the bifunctional chelating agent NOTA. The SDS-PAGE and MALDI-TOF were used to see the integrity of Fab and conjugated Fab. In-vitro stability and target specificity for HER2/neu receptors were perf...
Source: Nuclear Medicine Communications - March 19, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
F-18 DOPA PET/CT in pediatric patients with hyperinsulinemic hypoglycemia: A correlation with genetic analysis
Conclusion
18F-DOPA PET/CT is a useful modality for localizing focal pancreatic lesions in children with persistent hyperinsulinemic hypoglycemia. The detection rate is significantly higher in patients with ABCC8 paternal monoallelic recessive gene mutation. 18F-DOPA PET/CT scan consequent to findings on genetic analysis appears to be useful in planning the management of children with hyperinsulinism. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Evaluation of fluorine-18-fluorodeoxyglucose PET/computed tomography and human epithelial growth factor receptor 2 expression in treatment-naive patients with lung adenocarcinoma
Conclusion
SUVmax had no significant association with the HER2 expression status in lung adenocarcinoma. 18F-FDG PET/CT and HER2 expression could provide valuable prognostic information for treatment-naive patients with lung adenocarcinoma. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Optimization of pediatric FDG-PET/CT examinations based on physical indicators using the SiPM-PET/CT system
Conclusion:
This study demonstrated that good PET images could be obtained with short acquisition times when the examination is performed under appropriate reconstruction conditions. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Comparison of 99mTc-methyl diphosphonate bone scintigraphy and 68Ga-DOTANOC PET/computed tomography in articular manifestation of rheumatoid arthritis
Conclusion
Ga-68 DOTANOC is equally good as an MDP scan for detection of RA with the added advantage of being used as a theranostic modality. However, further evaluation with a larger sample size and joint-to-joint comparison is warranted. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Crossed cerebellar diaschisis in Alzheimer’s disease
Conclusion
Here, we found robust evidence of CCD in a large sample of people with AD, a chronic neurodegenerative condition. The presence of this phenomenon in AD opens up a new avenue of research in AD pathogenesis and has the potential to change future diagnostic and therapeutic strategies. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Development of neutron-activated samarium-153-loaded polystyrene microspheres as a potential theranostic agent for hepatic radioembolization
Conclusions
A neutron-activated [153Sm]Sm2O3-PS microsphere formulation was successfully developed for potential application as a theranostic agent for liver radioembolization. The microspheres achieved suitable physical properties for radioembolization and demonstrated high radionuclide retention efficiency in saline solution and human blood plasma. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Optimization of image reconstruction method of cerebral blood flow perfusion imaging with digital CZT SPECT
Purpose
The purpose of this study is to evaluate the effects of filtered back projection (FBP), ordered subset expectation maximisation (OSEM), and different filters on cadmium zinc telluride single-photon emission computed tomography [CZT single-photon emission computed tomography (SPECT)] cerebral blood perfusion image quality to optimise the image reconstruction method.
Methods
Under routine clinical conditions, tomographic imaging was performed on the phantom and patients. Image processing included image reconstruction using FBP and OSEM, and the filtering method used Butterworth (Bw) and Gaussian (Gs) filte...
Source: Nuclear Medicine Communications - March 19, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Diagnostic value of single-photon emission computed tomography-CT foot and ankle studies
Conclusion
SPECT-CT is a helpful imaging test in the diagnosis of foot and ankle disorders with 89% of studies being diagnostically useful. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
A review of different methods used for quantification and assessment of FDG-PET/CT in multiple myeloma
The quantification of positron emission tomography/computed tomography (PET/CT) in multiple myeloma (MM) is challenging. Different methods of PET/CT quantification for assessment of fluorodeoxyglucose (FDG) uptake in myeloma patients have been suggested. This is the first review article that focuses on the advantages and disadvantages of each approach. Use of the maximum standardized uptake value (SUVmax) showed some promise in prognostic stratification of MM patients. However, it is affected by noise and time of flight and is subject to high variability. Volumetric PET metrics such as total lesion glycolysis and metabolic...
Source: Nuclear Medicine Communications - March 19, 2022 Category: Nuclear Medicine Tags: Review Articles Source Type: research
