Comparison of 18F-FDG PET/CT and 68Ga-FAPI-04 PET/CT in the staging and restaging of gastric adenocarcinoma
Conclusion 68Ga-FAPI-04 PET/CT is an imaging modality with the potential of yielding more sensitive and specific findings 18F-FDG PET/CT. This modality may help avoid invasive diagnostic procedures that may be frequently required in GAc. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 16, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

FDG PETCT for assessing marrow involvement at staging pediatric nonhematological round cell malignancies
Conclusion FDG PETCT with sensitivity and NPV of 100% can be considered as a first stop imaging and biopsy can be avoided in patients with a negative scan. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 16, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Associations of whole-body 18F-FDG PET/CT parameters and SCC-Ag level with overall survival in patients with cervical cancer
Objective To explore the whole-body metabolic tumour volume (WBMTV), whole-body total lesion glycolysis (WBTLG) and tumour whole-body maximum standardised uptake value (WBSUVmax) of post-treatment 18F-fluorodeoxyglucose PET/computed tomography (18F-FDG PET/CT) in predicting the overall survival (OS) in patients with cervical squamous cell carcinoma (SCC). Methods The clinical data of 74 patients with cervical SCC who received 18F-FDG PET/CT were retrospectively analysed. WBMTV, WBTLG and WBSUVmax, as well as the serum SCC-Ag level, were measured. The Kaplan–Meier method and Cox regression were used to analyse ...
Source: Nuclear Medicine Communications - December 16, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Clinical and metabolic parameters for predicting disease progression of gallbladder adenocarcinoma
Conclusion In GB adenocarcinoma, clinical stage and MTV are the most powerful parameters for predicting recurrence and disease progression. Based on clinical stage, MTV will represent a strong prognostic predictor. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 16, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Site-based performance of 131I-MIBG imaging and 99mTc-HYNIC-TOC scintigraphy in the detection of nonmetastatic extra-adrenal paraganglioma
Conclusions 131I-MIBG imaging could become the first-line investigation modality in patients with extra-adrenal abdominal paragangliomas. However, 99mTc-HYNIC-TOC scintigraphy has high sensitivity and is superior to 131I-MIBG imaging for detecting head & neck and thoracic paraganglioma. Both 131I-MIBG imaging and 99mTc-HYNIC-TOC scintigraphy have poor performance for detecting urinary bladder paragangliomas. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 16, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Prognostic value of lung shunt fraction in hepatocellular carcinoma and unresectable liver dominant metastatic colorectal cancer undergoing transarterial radioembolisation
Aim To assess the overall survival and determine whether pre-TARE shunt fraction, tumor volume and tumor marker impact the outcome. Methods This is a retrospective study of 75 patients who were referred for 90Y-glass microsphere radioembolisation by a joint clinic decision between 1 January 2010 and 31 December 2014. All patients underwent pre-TARE CECT and 99mTc-MAA lung shunt fraction (LSF) imaging. Results Overall survival was 19 months for hepatocellular carcinoma (HCC) and 24 months for metastatic colorectal carcinoma. For hepatocellular carcinoma-LSF higher than 6.51 % was predictive of significantl...
Source: Nuclear Medicine Communications - December 16, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Three-dimensional semiquantitative analysis of gastric emptying SPECT
Conclusion D-SPECT imaging can overcome the interference in the semiquantitative data of residual GE caused in 2D mode. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 16, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Impact of reconstruction parameters on spatial resolution and its comparison between cadmium-zinc-telluride SPECT/CT and conventional SPECT/CT
Conclusion The spatial resolution was improved with the increase of iterations. Increasing the cutoff frequency of the Butterworth filter and decreasing the Gauss filter enhanced spatial resolution. The spatial resolution was better reconstructed by OSEM associated with attenuation correction, scatter correction and resolution recovery than FBP. CZT-SPECT/CT had better spatial resolution than conventional SPECT/CT. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 16, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Quantitative analysis in parathyroid adenoma scintigraphy
Conclusion PTAs with rapid and slow washout patterns have different characteristics on quantitative analysis in later phases. No significant differences in directly measurable quantitative values (SUVmax, PTA/thyroid gland ratio) at the early stages of multi-phase examination were observed. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 16, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Optimization of cross-calibration factor for quantitative bone SPECT without attenuation and scatter correction in the lumbar spine: head-to-head comparison with attenuation and scatter correction
This study aimed to improve the accuracy of quantitative bone SPECT of the lumbar spine with the SPECT-alone system. Methods The cross-calibration factor (CCF) was measured using three kinds of phantoms and the optimal values were determined. The recovery coefficient with and without attenuation and scatter correction (ACSC) were compared. Bone SPECT/CT was performed on 93 consecutive patients with prostate cancer, and the standardized uptake values (SUVs) were compared using the respective CCFs. The first 60 patients were classified according to body weight, and the correlation coefficient between SUVs with and wit...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Technical Note Source Type: research

Efficacy of voxel-based dosimetry map for predicting response to trans-arterial radioembolization therapy for hepatocellular carcinoma: a pilot study
Objective Typical clinical dosimetry models for trans-arterial radioembolization (TARE) assume uniform dose distribution in each tissue compartment. We performed simple voxel-based dosimetry using post-treatment 90Y PET following TARE with 90Y-resin microspheres and investigated its prognostic value in a pilot cohort. Method Ten patients with 14 hepatocellular carcinoma lesions who underwent TARE with 90Y-resin microspheres were retrospectively included. The partition model-based expected target tumor dose (TDp) was calculated using a pretreatment 99mTc-macroaggregated albumin scan. From post-treatment 90Y-micro...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Analysis of absorbed dose in radioimmunotherapy with 177Lu-trastuzumab using two different imaging scenarios: a pilot study
Objectives Internal organ dosimetry is an important procedure to demonstrate the reliable application of 177Lu-trastuzumab radioimmunotherapy for human epidermal growth factor receptor-positive metastatic breast cancers. We are reporting the first human dosimetry study for 177Lu-trastuzumab. Another objective of our study was to calculate and compare the absorbed doses for normal organs and tumor lesions in patients before radioimmunotherapy with 177Lu-trastuzumab using two different imaging scenarios. Methods Eleven patients (48.27 ± 8.95 years) with a history of metastatic breast cancer were included in...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Intensity of bone involvement: a quantitative 18F-FDG PET/CT evaluation for monitoring outcome of multiple myeloma
Conclusion Delta IBI provides quantitative data for variations of 18F-FDG uptake in the bone marrow during the follow-up of the patients. In addition, higher IBI values at diagnosis are associated with a higher risk of patient’s death. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The new perspective of PET/CT for axillary nodal staging in early breast cancer patients according to ACOSOG Z0011 trial PET/CT axillary staging according to Z0011
Conclusion Preoperative PET/CT predicts HNB with high accuracy and is useful for evaluating clinical T1-2N0 invasive breast cancer. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Compared to conventional PET/CT scanners, silicon-photomultiplier-based PET/CT scanners show higher arterial 18F-FDG uptake in whole-body 18F-FDG-PET/CT
Objectives To clarify differences in arterial 18F-FDG (fluorodeoxyglucose) uptake between silicon photomultiplier (SiPM)-based and conventional PET/CT scanners, and to compare clinical and phantom results. Patients and methods Twenty-six patients with lung tumours underwent serial SiPM-based and conventional PET/CT scans on the same day. We compared the target-to-background ratios [TBRsi (SiPM), TBRc (conventional)] and the percentage difference between TBRsi and TBRc (ΔTBR) in the carotid artery, aorta and peripheral arteries. The correlation between ΔTBR and vessel size was also investigated. In the carotid ...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research