68Ga-PSMA-I&T-PET/CT interobserver and intraobserver agreement for prostate cancer: a lesion based and subregional comparison study among observers with different levels of experience
Conclusion Interpretation of prostate-specific membrane antigen (PSMA) for prostate cancer is acceptably consistent among observers, but some details are noteworthy. The evaluation should be done more algorithmically for local tumors, since all observers showed relatively lower agreement. The agreement increased as prostate-specific antigen and Gleason score increased. The observer with PSMA experience (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Usefulness of PET-guided surgery with 64Cu-labeled cetuximab for resection of intrapancreatic residual tumors in a xenograft mouse model of resectable pancreatic cancer
Conclusions OpenPET-guided surgery with 64Cu-labeled-cetuximab enabled intraoperative identification and resection of intrapancreatic small residual tumors. This technology could be useful to prevent tumor residuals during surgery and improve pancreatic cancer survival. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

18F-FDG-PET/CT analysis in hospitalized patients affected by pulmonary disease: The experience of the Nuclear Medicine Unit of “Policlinico Tor Vegata”
Conclusion Data here reported showed the high accuracy of the F-FDG-PET/CT performed in our department, mainly for pulmonary diseases, also highlighting the importance of continuously updating the selection criteria for patients who need PET examinations. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Quantitative evaluation of single-photon emission computed tomography findings in lower extremity possible without computed tomography-based attenuation correction
Conclusions In bone SPECT quantitative examinations of the lower extremity, quantitative evaluation without CTAC is possible without the use of scatter correction or resolution recovery. Thus, quantitative evaluation can be performed with use of a standalone SPECT device without CT. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Comparison of bone SPECT/CT and MRI in detection of pain generator in ankle and foot pain: a retrospective diagnostic study
Objective To study the sensitivity and specificity of MRI and bone SPECT-CT in detecting the pain generator in ankle and foot pain with diagnostic dilemma. Methods Retrospectively data of patients with ankle or foot pain who underwent both MRI and Bone SPECT-CT were analyzed. The lesions and probable pain generator sites were reported as per MRI and bone SPECT-CT findings. These lesions were correlated clinically, managed accordingly and followed up. The patients who had significant improvement in response to the treatment provided were considered to have been diagnosed accurately. The foot and ankle disability ...
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Prospective evaluation of organ-specific dose and lesional doses following therapeutic [177Lu]Lu-EDTMP administration in patients with multiple skeletal metastases and its correlation with clinical hematological toxicity
Aim In patients with multiple skeletal metastases, accurate estimation of absorbed doses to radiosensitive bone marrow in bone-directed systemic radionuclide therapies (RNT) is critically important from clinical dose determination standpoint. The primary aim of the present study was to estimate the radiation absorbed doses of therapeutic [177Lu]Lu-EDTMP to bone marrow by two methods viz. Medical Internal Radiation Dose (MIRD) schema and using OLINDA software and correlate with hematological toxicity. Methods A total of 15 patients diagnosed to have multiple painful skeletal metastases being treated with [177Lu]L...
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Reassessment of the lung dose limits for radioembolization
Radioembolization, also known as selective internal radiation therapy (SIRT), is an established treatment for the management of patients with unresectable liver tumors. Advances in liver dosimetry and new knowledge about tumor dose-response relationships have helped promote the well-tolerated use of higher prescribed doses, consequently transitioning radioembolization from palliative to curative therapy. Lung dosimetry, unfortunately, has not seen the same advances in dose calculation methodology and renewed consensus in dose limits as normal liver and tumor dosimetry. Therefore, the efficacy of curative radioembolization ...
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Review Article Source Type: research

BNMS position statement on molecular radiotherapy
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Editorial Source Type: research

Simulation of the distribution of astatine-211 solution dispersion in a lab room
Conclusion We found that the solution of 211At vaporized naturally and was distributed heterogeneously in the cage, and the chemical properties of 211At influenced their behaviors. These results must be considered to minimize the risks of radiation safety. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Technical Note Source Type: research

PET/computed tomography in inpatients: part 1, international survey
Purpose The purposes of this study are to (1) identify patterns of inpatient PET/computed tomography (CT) use in and outside of the USA and (2) characterize inpatient PET/CT use by location and indication. Materials and methods The study was deemed exempt by the Institutional Review Board. A survey link through REDCap was emailed to the Society of Nuclear Medicine and Molecular Imaging (SNMMI) members and PET Centers of Excellence members and posted on the SNMMI website. Data were collected from May 2018 to August 2018. Analyses were conducted using SAS Software 9.4 with the NPAR1WAY procedure. Differences were ...
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Comparison of an in-house acquired brain F-18 FDG PET normal database with commercially available normal data
Conclusions The three software packages yielded varying Z-score output, partially explained by an age mismatch between our subjects and subjects in their normal databases. A definitive explanation for the remaining differences is lacking. This emphasizes the importance of age-matched normal data and knowledge of the included databases to allow adequate preprocessing. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Production of copper-64 using a hospital cyclotron: targetry, purification and quality analysis
Objectives To construct and evaluate a 64Cu production system that minimises the amount of costly 64Ni, radionuclidic impurities and nonradioactive metal contamination and maximises radiochemical and radionuclidic purity and molar activity; and to report analytical and quality control methods that can be used within typical PET radiochemistry production facilities to measure metal ion concentrations and radiometal molar activities. Methods Low volume was ensured by dissolving the irradiated nickel in a low volume of hydrochloric acid ( (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Feasibility of semiquantitative 18F-fluorodeoxyglucose PET/computed tomography in patients with advanced lung cancer for interim treatment evaluation of combining immunotherapy and chemotherapy
This study aimed to investigate the prognosis value of 18F-fluorodeoxyglucose PET/computed tomography (18F-FDG PET/CT) in advanced lung cancer patients with immunotherapy combined with chemotherapy. Methods Fifty-one advanced lung cancer patients were included in this retrospective study, who underwent 18F-FDG PET/CT imaging before four cycles of immunotherapy combined with chemotherapy at our institution between January 2018 and January 2020. The following PET/CT parameters were calculated: standardized uptake value SUVmax, SUVmean, SUVpeak, SUVsd, metabolic tumor volume (MTV), total lesion glycolysis (TLG), MTV25%...
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Can 68Ga-PSMA PET/CT-derived prostate-specific membrane antigen expression parameters predict prostate-specific antigen response to enzalutamide treatment?
Conclusion PSMA-TV values on 68Ga-PSMA PET/CT imaging before starting enzalutamide treatment following docetaxel failure can predict PSA response in patients with mCRPCa. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The setting of heartbeat acceptance windows on gated myocardial perfusion single-photon emission computed tomography using CZT camera: effect of left ventricular functional parameters in patients with arrhythmia
Conclusion Our study suggests that setting the heartbeat acceptance window of one peak was suitable for accurate measurement of LV function in consistently variable patients. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research