A retrospective multicenter study of quantitative bone SPECT/CT to predict the surgical removal of the accessory navicular bone
Objective The maximum standardized uptake value (SUVmax) in single-photon emission computed tomography/computed tomography (SPECT/CT) can help quantify disease activity of the accessory navicular bone (ANB). In this multicenter quantitative bone SPECT/CT study, we investigated whether SUVmax was correlated with ANB severity, thereby allowing prediction of surgical resection for ANB treatment. Methods Two-hundred forty-six patients (men:women = 135:111, mean age = 39.3 years), who had undergone quantitative Tc-99m diphosphonate SPECT/CT of the feet, were recruited from four hospitals. SUVmax was measured using ve...
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Gated single-photon emission computed tomography myocardial perfusion imaging phase analysis as an imaging biomarker for mortality prediction in heart failure patients undergoing cardiac resynchronization therapy
Conclusions PSD and PHB, measured by GMPS, may serve as biomarkers for the prediction of survival in patients undergoing CRT. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Repeat injection following sentinel node nonvisualization on lymphoscintigraphy images can decrease axillary dissection rate in breast cancer patients
Conclusion Reinjection of the tracer in cases of no sentinel node visualization in lymphoscintigraphy for breast cancer increases the detection rate of sentinel nodes, and therefore a high number of unnecessary axillary lymph node dissections can be avoided. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Assessment of LV diastolic dysfunction in myocardial perfusion imaging: a correlative study with transthoracic echocardiography
Conclusion Gated SPECT MPI can be used as a highly specific means for detection of LV diastolic dysfunction when compared to echocardiography. However, grading of severity of diastolic heart failure appears to be impracticable. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Comparison of empagliflozin and sitagliptin therapy on myocardial perfusion reserve in diabetic patients with coronary artery disease
Background Sodium-glucose co-transporter 2 inhibitors reduce the risk of cardiovascular events in type 2 diabetic patients with coronary artery disease (CAD); however, the underlying mechanisms remain unclear. Objectives We compared the effects of empagliflozin vs. sitagliptin therapy on myocardial perfusion reserve (MPR) using dynamic single-photon emission computed tomography (SPECT) imaging. Methods In total, 100 patients with type 2 diabetes, CAD and an MPR (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Efficacy and safety of 177Lu-DOTMP in palliative treatment of symptomatic skeletal metastases: a prospective study
Aims Bone-seeking radiopharmaceutical 177Lu-DOTMP with favorable pharmacokinetics in the preclinical studies has been evaluated for its role in reducing bone pain and improving quality of life (QOL) in patients with symptomatic skeletal metastases. Method Patients with painful widespread skeletal metastases documented on 99mTc-MDP bone scintigraphy were intravenously administered 37 MBq/kg of 177Lu-DOTMP. Visual analogue score (VAS), analgesic score, European Cooperative Group of Oncology (ECOG) and the European Organization of Research and Treatment of Cancer QLQ-C30 of all the patients were assessed at baselin...
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The radio-europium impurities in [153Sm]-EDTMP production: a review of isolation methods
Many human cancers predominantly metastasize to the bone which causes bone pain and other symptoms. However, the management of bone metastases is challenging. Radionuclide therapy using low-energy beta-emitting radionuclides has yielded encouraging results. The aim of this therapy is to deliver the maximum dose to the metastatic sites but a minimal dose to the normal tissue. Samarium-153 [153Sm]Sm-Ethylenediamine tetramethylene phosphonate (EDTMP) is an FDA and European Medicine Agency approved (Quadramet) radionuclide and is widely used for bone pain palliation. 153Sm is reactor produced, and the presence of europium impu...
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Review Articles Source Type: research

Hybrid imaging of complicating osteomyelitis in the peripheral skeleton
Diagnosing complicating osteomyelitis (COM) is clinically challenging. Laboratory tests are of limited utility, and other than isolation of the offending organism, diagnostic imaging tests are of paramount importance. Nuclear Medicine techniques play an important role in noninvasive evaluation of osteomyelitis, using both single-photon emission tomography (SPECT) and positron emission tomography (PET) radiopharmaceuticals. It is well-known that those conventional imaging modalities are not performing well in the distinction between soft-tissue and deep bone infection due to the lack of anatomical information. These difficu...
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Review Articles Source Type: research

Characterisation of 99mTc EDDA/HYNIC-TOC (Tektrotyd) physiological and neuroendocrine tumour uptake using SPECT/CT standardised uptake values: initial experience
The objective of this study was to characterise quantitative standardised uptake value (SUV) SPECT/CT of normal physiological uptake and NET disease. Forty-four patients (22 female and 22 male) referred for 99mTc EDDA/HYNIC-TOC SPECT/CT imaging for diagnosis/primary staging (n = 28) or the assessment of residual/recurrent disease (n = 16) were included. SPECT/CT SUVmax values were determined for normal physiological uptake (spleen, kidney, liver and bone) and NET disease (liver metastases, metastatic lymph nodes, bone metastases and intrapulmonary lesions). Statistical testing was performed to compare normal uptake...
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Technical Note Source Type: research

Comparison of treatment response assessed by 18F-FDG PET/CT with the histopathological response using tumor regression grading on surgically resected specimen following neoadjuvant chemotherapy in squamous cell carcinoma of esophagus
Conclusion After neoadjuvant chemotherapy, 18F-fluorodeoxyglucose PET/CT can help to assess the response and guide the treatment. However, a larger study is warranted to evaluate their correlation with pathological response. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The prediction of spread through air spaces with preoperative 18F-FDG PET/CT in cases with primary lung adenocarcinoma, its effect on the decision for an adjuvant treatment and its prognostic role
Purpose In lung adenocarcinoma cases, ‘spread through air spaces’ (STAS) is a new indicator of invasion and directly related to disease survival. The aim of our study is to establish whether a preoperatively performed 18F-Fluorodeoxyglucose (FDG) PET/computed tomography (CT) imaging data can predict the presence of STAS in cases with lung adenocarcinoma and thus predict the decision for the type of surgery and adjuvant chemotherapy. Materials and methods Between 2000 and 2019, we retrospectively analyzed 63 patients with lung adenocarcinoma cases that had undergone lobectomy or pneumonectomy. Semiquantitativ...
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

F-18 ML-104 tau PET imaging in mild cognitive impairment
Conclusion We could demonstrate a significant increase in cortical tau deposition in aMCI patients in comparison to normal controls, thus providing in vivo evidence of the underlying pathological process in this subgroup of patients with high probability of conversion to AD. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

18F-fluciclovine PET/CT detection of biochemical recurrent prostate cancer in patients with PSA levels
Conclusion 18F-fluciclovine PET/CT demonstrated a detection rate of 56.4% among patients with a PSA below 2.0 ng/mL. The results of this study support the use of 18F-fluciclovine PET/CT for the detection of recurrent prostate cancer at lower PSA levels, even at PSA levels less than 0.5 ng/mL. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Comparison of 18F-labelled fluoro-2-deoxyglucose-PET with conventional computed tomography for staging and response assessment in paediatric and adult patients with nodular lymphocyte-predominant Hodgkin’s lymphoma
Conclusion For NLPHL, pre-therapeutic FDG-PET scan is better than CeCT staging. FDG-PET has much better specificity for response assessment than CeCT. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Determination of tumour dose response threshold and implication on survival in patients with HCC treated with Y90 radiation segmentectomy: a simple semi-quantitative analysis
Conclusion In patients with HCC undergoing Y90-RS, mean tumour dose ≥250 Gy and minimum tumour dose of ≥180 Gy to 100% of tumour volume are both significantly correlated with higher objective tumour response and prolonged survival. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research