Quantitative analysis in parathyroid adenoma scintigraphy
Conclusion
PTAs with rapid and slow washout patterns have different characteristics on quantitative analysis in later phases. No significant differences in directly measurable quantitative values (SUVmax, PTA/thyroid gland ratio) at the early stages of multi-phase examination were observed. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 16, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Optimization of cross-calibration factor for quantitative bone SPECT without attenuation and scatter correction in the lumbar spine: head-to-head comparison with attenuation and scatter correction
This study aimed to improve the accuracy of quantitative bone SPECT of the lumbar spine with the SPECT-alone system.
Methods
The cross-calibration factor (CCF) was measured using three kinds of phantoms and the optimal values were determined. The recovery coefficient with and without attenuation and scatter correction (ACSC) were compared. Bone SPECT/CT was performed on 93 consecutive patients with prostate cancer, and the standardized uptake values (SUVs) were compared using the respective CCFs. The first 60 patients were classified according to body weight, and the correlation coefficient between SUVs with and wit...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Technical Note Source Type: research
Efficacy of voxel-based dosimetry map for predicting response to trans-arterial radioembolization therapy for hepatocellular carcinoma: a pilot study
Objective
Typical clinical dosimetry models for trans-arterial radioembolization (TARE) assume uniform dose distribution in each tissue compartment. We performed simple voxel-based dosimetry using post-treatment 90Y PET following TARE with 90Y-resin microspheres and investigated its prognostic value in a pilot cohort.
Method
Ten patients with 14 hepatocellular carcinoma lesions who underwent TARE with 90Y-resin microspheres were retrospectively included. The partition model-based expected target tumor dose (TDp) was calculated using a pretreatment 99mTc-macroaggregated albumin scan. From post-treatment 90Y-micro...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Analysis of absorbed dose in radioimmunotherapy with 177Lu-trastuzumab using two different imaging scenarios: a pilot study
Objectives
Internal organ dosimetry is an important procedure to demonstrate the reliable application of 177Lu-trastuzumab radioimmunotherapy for human epidermal growth factor receptor-positive metastatic breast cancers. We are reporting the first human dosimetry study for 177Lu-trastuzumab. Another objective of our study was to calculate and compare the absorbed doses for normal organs and tumor lesions in patients before radioimmunotherapy with 177Lu-trastuzumab using two different imaging scenarios.
Methods
Eleven patients (48.27 ± 8.95 years) with a history of metastatic breast cancer were included in...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Intensity of bone involvement: a quantitative 18F-FDG PET/CT evaluation for monitoring outcome of multiple myeloma
Conclusion
Delta IBI provides quantitative data for variations of 18F-FDG uptake in the bone marrow during the follow-up of the patients. In addition, higher IBI values at diagnosis are associated with a higher risk of patient’s death. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
The new perspective of PET/CT for axillary nodal staging in early breast cancer patients according to ACOSOG Z0011 trial PET/CT axillary staging according to Z0011
Conclusion
Preoperative PET/CT predicts HNB with high accuracy and is useful for evaluating clinical T1-2N0 invasive breast cancer. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Compared to conventional PET/CT scanners, silicon-photomultiplier-based PET/CT scanners show higher arterial 18F-FDG uptake in whole-body 18F-FDG-PET/CT
Objectives
To clarify differences in arterial 18F-FDG (fluorodeoxyglucose) uptake between silicon photomultiplier (SiPM)-based and conventional PET/CT scanners, and to compare clinical and phantom results.
Patients and methods
Twenty-six patients with lung tumours underwent serial SiPM-based and conventional PET/CT scans on the same day. We compared the target-to-background ratios [TBRsi (SiPM), TBRc (conventional)] and the percentage difference between TBRsi and TBRc (ΔTBR) in the carotid artery, aorta and peripheral arteries. The correlation between ΔTBR and vessel size was also investigated. In the carotid ...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Head-to-head comparison between 68Ga-PSMA and 18F-FDG-PET/CT in lymphomas: a preliminary analysis
This study compared both tracers in patients with diverse lymphoma subtypes.
Methods
Ten patients with biopsy-proven-lymphoma underwent 18F-FDG and 68Ga-PSMA-PET/CT (maximum time interval: 6 days). Lymphoma subtypes included Hodgkin’s lymphoma (HL, three patients) and aggressive and indolent non-Hodgkin’s lymphoma (NHL, seven patients). The intensity of PSMA uptake was classified visually as low, intermediate, or high, using blood pool, liver and parotid gland uptake as references. Maximum standardized-uptake value (SUVmax) of each affected site was measured in both sets of images.
Results
FDG detected 59...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Haralick texture features extracted from Ga-68 PSMA PET/CT to differentiate normal prostate from prostate cancer: a feasibility study
Objective
Role of texture parameters on the basis of Ga-68 PSMA PET/CT in prostate cancer (Pca) is largely unexplored. Present work done is a preliminary study that aims to evaluate the role of Haralick texture features on the basis of Ga-68 PSMA PET/CT in Pca in which texture features were used to differentiate between normal prostate and Pca tissue.
Methods
The study retrospectively enrolled patients in two groups: group 1 included 30 patients with biopsy-proven adenocarcinoma prostate and median age 64 years (range: 50–82 years) who underwent baseline Ga-68 PSMA PET/CT prior to therapy; group 2 included 24 ...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Efficacy of 68Ga-PSMA PET/CT-derived whole-body volumetric parameters in predicting response to second-generation androgen receptor axis-targeted therapy, and the prognosis in metastatic hormone-refractory prostate cancer patients
Introduction
The present study investigates the role of 68Ga-PSMA PET/CT-derived whole-body metabolic and volumetric parameters in the prediction of treatment response and prognosis among metastatic hormone-refractory prostate cancer patients undergoing second-generation androgen receptor axis-targeted therapy (abiraterone or enzalutamide).
Materials and methods
This retrospective study included 44 metastatic hormone-refractory prostate cancer patients undergoing 68Ga-PSMA PET/CT, including 29 enzalutamide-treated and 15 abiraterone-treated patients.
Results
Of the 44 patients included in the study, 29 re...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Preoperative 18F-FDG SUVmax >6.3 or Size >2.3 cm of primary lesions predict lymph nodes metastasis with higher negative predictive value in peripheral cT1 non-small-cell lung cancer
Conclusions
The excellent sensitivity and NPV of preoperative of the SUVmax>6.3 or size>2.3 cm of the primary lesions based on 18F-FDG PET-CT might identify the patients at low-risk LNM in peripheral cT1 NSCLC. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Correlation of 4′-[methyl-11C]-thiothymidine PET with Ki-67 immunohistochemistry separately in patients with newly diagnosed and recurrent gliomas
Objective
4′-[methyl-11C]-thiothymidine (4DST) uptake on PET was correlated with proliferative activity separately in patients with newly diagnosed and recurrent gliomas.
Methods
A total of 29 patients, 18 with newly diagnosed gliomas and 11 with recurrent gliomas who underwent 4DST PET/computed tomography (CT) were available for a retrospective analysis of prospectively collected data. The maximum standardized uptake value (SUVmax) of tumor (T) and the mean SUV of normal contralateral hemisphere (N) were calculated, and the tumor-to-normal (T/N) ratio was determined. Proliferative tumor volume (PTV) and total...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Exploring the potential utilities of 99mTc-labeled RBC-equilibrium radionuclide angiocardiography in transfusion-dependent β-thalassemia major patients
Aims
99mTc-labeled RBC-equilibrium radionuclide angiocardiography (ERNA) is done in transfusion-dependent beta-thalassemia major (β-TM) patients routinely for cardiac dysfunction. This prospective study aimed at evaluating the potential of ERNA in demonstrating the bone marrow hyperplasia as an adjunct biomarker for monitoring the adequacy of blood transfusions in transfusion-dependent β-TM patients.
Materials and methods
One hundred and twenty-six patients of β-TM (study group) and 30 nonthalassemic patients (control) underwent ERNA study with an additional whole-body imaging. We quantitated the normalized b...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
An overview of nuclear medicine research in the UK and the landscape for clinical adoption
Conclusions
We hope that by collating this information we will provide stimulus for future discussion and consensus statements around this topic. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
18F-FDG PET and PET/CT for the evaluation of gastric signet ring cell carcinoma: a systematic review
Conclusion
Despite some limitations affect our review, GSRCC seems to have low 18F-FDG uptake, and therefore 18F-FDG PET or PET/CT reveals impaired sensitivity for its evaluation. However, a correlation between 18F-FDG uptake and some clinico-pathologic features (such as stage, depth of invasion, size and presence of nodal metastasis) has been demonstrated. Besides, a possible prognostic role of PET/CT features is starting to emerge. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Review Article Source Type: research
