Simulation of the distribution of astatine-211 solution dispersion in a lab room
Conclusion We found that the solution of 211At vaporized naturally and was distributed heterogeneously in the cage, and the chemical properties of 211At influenced their behaviors. These results must be considered to minimize the risks of radiation safety. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Technical Note Source Type: research

PET/computed tomography in inpatients: part 1, international survey
Purpose The purposes of this study are to (1) identify patterns of inpatient PET/computed tomography (CT) use in and outside of the USA and (2) characterize inpatient PET/CT use by location and indication. Materials and methods The study was deemed exempt by the Institutional Review Board. A survey link through REDCap was emailed to the Society of Nuclear Medicine and Molecular Imaging (SNMMI) members and PET Centers of Excellence members and posted on the SNMMI website. Data were collected from May 2018 to August 2018. Analyses were conducted using SAS Software 9.4 with the NPAR1WAY procedure. Differences were ...
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Comparison of an in-house acquired brain F-18 FDG PET normal database with commercially available normal data
Conclusions The three software packages yielded varying Z-score output, partially explained by an age mismatch between our subjects and subjects in their normal databases. A definitive explanation for the remaining differences is lacking. This emphasizes the importance of age-matched normal data and knowledge of the included databases to allow adequate preprocessing. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Production of copper-64 using a hospital cyclotron: targetry, purification and quality analysis
Objectives To construct and evaluate a 64Cu production system that minimises the amount of costly 64Ni, radionuclidic impurities and nonradioactive metal contamination and maximises radiochemical and radionuclidic purity and molar activity; and to report analytical and quality control methods that can be used within typical PET radiochemistry production facilities to measure metal ion concentrations and radiometal molar activities. Methods Low volume was ensured by dissolving the irradiated nickel in a low volume of hydrochloric acid ( (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Feasibility of semiquantitative 18F-fluorodeoxyglucose PET/computed tomography in patients with advanced lung cancer for interim treatment evaluation of combining immunotherapy and chemotherapy
This study aimed to investigate the prognosis value of 18F-fluorodeoxyglucose PET/computed tomography (18F-FDG PET/CT) in advanced lung cancer patients with immunotherapy combined with chemotherapy. Methods Fifty-one advanced lung cancer patients were included in this retrospective study, who underwent 18F-FDG PET/CT imaging before four cycles of immunotherapy combined with chemotherapy at our institution between January 2018 and January 2020. The following PET/CT parameters were calculated: standardized uptake value SUVmax, SUVmean, SUVpeak, SUVsd, metabolic tumor volume (MTV), total lesion glycolysis (TLG), MTV25%...
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Can 68Ga-PSMA PET/CT-derived prostate-specific membrane antigen expression parameters predict prostate-specific antigen response to enzalutamide treatment?
Conclusion PSMA-TV values on 68Ga-PSMA PET/CT imaging before starting enzalutamide treatment following docetaxel failure can predict PSA response in patients with mCRPCa. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The setting of heartbeat acceptance windows on gated myocardial perfusion single-photon emission computed tomography using CZT camera: effect of left ventricular functional parameters in patients with arrhythmia
Conclusion Our study suggests that setting the heartbeat acceptance window of one peak was suitable for accurate measurement of LV function in consistently variable patients. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

A retrospective multicenter study of quantitative bone SPECT/CT to predict the surgical removal of the accessory navicular bone
Objective The maximum standardized uptake value (SUVmax) in single-photon emission computed tomography/computed tomography (SPECT/CT) can help quantify disease activity of the accessory navicular bone (ANB). In this multicenter quantitative bone SPECT/CT study, we investigated whether SUVmax was correlated with ANB severity, thereby allowing prediction of surgical resection for ANB treatment. Methods Two-hundred forty-six patients (men:women = 135:111, mean age = 39.3 years), who had undergone quantitative Tc-99m diphosphonate SPECT/CT of the feet, were recruited from four hospitals. SUVmax was measured using ve...
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Gated single-photon emission computed tomography myocardial perfusion imaging phase analysis as an imaging biomarker for mortality prediction in heart failure patients undergoing cardiac resynchronization therapy
Conclusions PSD and PHB, measured by GMPS, may serve as biomarkers for the prediction of survival in patients undergoing CRT. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Repeat injection following sentinel node nonvisualization on lymphoscintigraphy images can decrease axillary dissection rate in breast cancer patients
Conclusion Reinjection of the tracer in cases of no sentinel node visualization in lymphoscintigraphy for breast cancer increases the detection rate of sentinel nodes, and therefore a high number of unnecessary axillary lymph node dissections can be avoided. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Assessment of LV diastolic dysfunction in myocardial perfusion imaging: a correlative study with transthoracic echocardiography
Conclusion Gated SPECT MPI can be used as a highly specific means for detection of LV diastolic dysfunction when compared to echocardiography. However, grading of severity of diastolic heart failure appears to be impracticable. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Comparison of empagliflozin and sitagliptin therapy on myocardial perfusion reserve in diabetic patients with coronary artery disease
Background Sodium-glucose co-transporter 2 inhibitors reduce the risk of cardiovascular events in type 2 diabetic patients with coronary artery disease (CAD); however, the underlying mechanisms remain unclear. Objectives We compared the effects of empagliflozin vs. sitagliptin therapy on myocardial perfusion reserve (MPR) using dynamic single-photon emission computed tomography (SPECT) imaging. Methods In total, 100 patients with type 2 diabetes, CAD and an MPR (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Efficacy and safety of 177Lu-DOTMP in palliative treatment of symptomatic skeletal metastases: a prospective study
Aims Bone-seeking radiopharmaceutical 177Lu-DOTMP with favorable pharmacokinetics in the preclinical studies has been evaluated for its role in reducing bone pain and improving quality of life (QOL) in patients with symptomatic skeletal metastases. Method Patients with painful widespread skeletal metastases documented on 99mTc-MDP bone scintigraphy were intravenously administered 37 MBq/kg of 177Lu-DOTMP. Visual analogue score (VAS), analgesic score, European Cooperative Group of Oncology (ECOG) and the European Organization of Research and Treatment of Cancer QLQ-C30 of all the patients were assessed at baselin...
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The radio-europium impurities in [153Sm]-EDTMP production: a review of isolation methods
Many human cancers predominantly metastasize to the bone which causes bone pain and other symptoms. However, the management of bone metastases is challenging. Radionuclide therapy using low-energy beta-emitting radionuclides has yielded encouraging results. The aim of this therapy is to deliver the maximum dose to the metastatic sites but a minimal dose to the normal tissue. Samarium-153 [153Sm]Sm-Ethylenediamine tetramethylene phosphonate (EDTMP) is an FDA and European Medicine Agency approved (Quadramet) radionuclide and is widely used for bone pain palliation. 153Sm is reactor produced, and the presence of europium impu...
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Review Articles Source Type: research

Hybrid imaging of complicating osteomyelitis in the peripheral skeleton
Diagnosing complicating osteomyelitis (COM) is clinically challenging. Laboratory tests are of limited utility, and other than isolation of the offending organism, diagnostic imaging tests are of paramount importance. Nuclear Medicine techniques play an important role in noninvasive evaluation of osteomyelitis, using both single-photon emission tomography (SPECT) and positron emission tomography (PET) radiopharmaceuticals. It is well-known that those conventional imaging modalities are not performing well in the distinction between soft-tissue and deep bone infection due to the lack of anatomical information. These difficu...
Source: Nuclear Medicine Communications - August 19, 2021 Category: Nuclear Medicine Tags: Review Articles Source Type: research