Emerging role of artificial intelligence in nuclear medicine
The role of artificial intelligence is increasing in all branches of medicine. The emerging role of artificial intelligence applications in nuclear medicine is going to improve the nuclear medicine clinical workflow in the coming years. Initial research outcomes are suggestive of increasing role of artificial intelligence in nuclear medicine workflow, particularly where selective automation tasks are of concern. Artificial intelligence-assisted planning, dosimetry and procedure execution appear to be areas for rapid and significant development. The role of artificial intelligence in more directly imaging-related tasks, suc...
Source: Nuclear Medicine Communications - May 20, 2021 Category: Nuclear Medicine Tags: Review Articles Source Type: research
Extrahepatic metastases from hepatocellular carcinoma: multimodality image evaluation
The most prevalent primary malignancy of the liver is hepatocellular carcinoma (HCC); its poor prognosis is mainly related to intrahepatic recurrence and extrahepatic metastases. However, survival from HCC has improved due to better control of the primary tumor, the development of newer treatment modalities, including liver transplant, together with advances in imaging techniques. Therefore, the significance of patient management as corresponds with distant metastases has increased; since the proper evaluation and detection of extrahepatic metastases is crucial to optimize potential therapy for patients. Conventional imagi...
Source: Nuclear Medicine Communications - May 20, 2021 Category: Nuclear Medicine Tags: Review Articles Source Type: research
Abstracts: British Nuclear Medicine Society Online Spring Meeting 18th-19th May 2021
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 15, 2021 Category: Nuclear Medicine Tags: Abstracts Source Type: research
Concept proposal for a six-tier integrated dual tracer PET-CT (68Ga-PSMA and FDG) image scoring system (‘Pro-PET’ score) and examining its potential implications in metastatic castration-resistant prostate carcinoma theranostics and prognosis
Conclusion
The ‘Pro-PET’ scoring system integrating dual tracer PET-CT imaging findings in a single parameter appeared as a potentially promising prognostic marker that has the potential to enhance the objectivity and scientific basis of prostate carcinoma theranostics and prognostication. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 15, 2021 Category: Nuclear Medicine Tags: Technical Note Source Type: research
Improvement of image quality using amplitude-based respiratory gating in PET-computed tomography scanning
Conclusions
These results demonstrate that respiratory-gated PET-CT imaging can be used to accurately correct for SUV changes and image distortion caused by respiratory motion, thereby providing excellent imaging information and quality. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 15, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Relationship between tumor heterogeneity and volume in cervical cancer: Evidence from integrated fluorodeoxyglucose 18 PET/MR texture analysis
Objective
The aim of this study was to evaluate the effect of cervical cancer volume on PET/magnetic resonance (MR) texture heterogeneity.
Materials and methods
We retrospectively analyzed the PET/MR images of 138 patients with pathologically diagnosed cervical squamous cell carcinoma, including 50 patients undergoing surgery and 88 patients receiving concurrent chemoradiotherapy. Fluorodeoxyglucose 18 (18FDG)-PET/MR examination were performed for each patient before treatment, and the PET and MR texture analysis were undertaken. The texture features of the tumor based on gray-level co-occurrence matrices were e...
Source: Nuclear Medicine Communications - April 15, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Improving accuracy of 18F-fluorodeoxyglucose PET computed tomography to diagnose nodal involvement in non-small cell lung cancer: utility of using various predictive models
Conclusion
PM combining parameters like nodal SUVmax, N/A ratio, N/T ratio and HU values have shown to improve the PPV, specificity and overall accuracy of 18FDG PET CT in the preoperative diagnosis of nodal metastases. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 15, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Expression of TIGAR and its correlation with clinicopathology, prognosis, and 18F-FDG PET/CT parameters in patients with resectable pancreatic ductal adenocarcinoma
Conclusion
TIGAR is highly expressed in PDAC. Its expression is independent of clinicopathological data and can be used as an independent prognostic factor. TIGAR expression was significantly positively correlated with the 18F-FDG PET/CT parameter MTV. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 15, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Diagnostic performance of 18F-FDG PET/CT for the detection of occult primary tumors in squamous cell carcinoma of unknown primary in the head and neck: a single-center retrospective study
Conclusion
18F-FDG PET/CT was shown to be useful in detecting a primary tumor for SCCUP, but had limitations in terms of both false-positive cases and false-negative cases. Therefore, histopathological investigations such as targeted and random biopsy should be viewed as necessary practice irrespective of PET/CT results. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 15, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Clinical utility of Ga68 DOTANOC PET/CT imaging in juvenile nasal angiofibroma and the PARIS protocol: a preliminary report
Conclusion
68Ga-DOTANOC-PET/CT uptake is universal in JNA and appears to be more specific in the identification of residual/recurrent JNA. In residual tumors, DOTANOC-PET/CT may have an advantage over CEMRI in the diagnosis, decision making and planning stereotactic radiation. However, these findings are to be validated in studies with larger patients. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 15, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Radiologic and clinicopathologic characteristics of thyroid nodules with focal 68Ga-DOTATATE PET activity
Objective
Our aim was to determine the radiologic and clinicopathologic characteristics of thyroid nodules with focal 68Ga-DOTATATE activity.
Methods
In this retrospective study of 1927 consecutive 68Ga-DOTATATE PET scans, 85 patients with incidental and nonincidental focal 68Ga-DOTATATE avid thyroid nodules were identified, of which 31 patients with 33 thyroid nodules underwent fine-needle aspiration (FNA) or surgery. These 33 nodules were reviewed for Krenning score and SUVmax of the thyroid nodule, contralateral thyroid lobe and left atrium.
Results
Cytology/histopathology included 58% (19/33) with ben...
Source: Nuclear Medicine Communications - April 15, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Evaluation of 68Ga-PSMA PET/CT with volumetric parameters for staging of prostate cancer patients
Background
The aim of this study was to investigate the relationship between volumetric data obtained from staging 68Ga-prostate-specific membrane antigen (PSMA) PET computerized tomography (CT) images with prostate-specific antigen (PSA), risk groups, Gleason Grade (GG) groups and presence of metastasis.
Methods
We performed a retrospective analysis of 68Ga-PSMA PET-CT images from 88 patients undergoing initial staging of prostate adenocarcinoma between January 2015 and September 2018. Images were evaluated in LIFEx software; PSMA involvement above the background activity in prostate gland, lymph node and other...
Source: Nuclear Medicine Communications - April 15, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
The influence of colour scale in lesion detection and patient-based sensitivity in [68Ga]Ga-PSMA-PET/CT
Conclusion
Use of PET-rainbow was associated with improved lesion detection and sensitivity compared to hot-metal new, although at cost of reduced inter-rater agreement. Consequently, the use of PET-rainbow for clinical routine and future studies involving [68Ga]Ga-PSMA-11 is recommended. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 15, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Physiologic prostate-specific membrane antigen-targeted 18F-DCFPyL uptake in the epididymis head newly appreciated on digital PET/CT
Purpose
The published physiological distribution of prostate specific membrane antigen (PSMA) PET ligands includes normal uptake in the lacrimal glands, salivary glands, bowel, liver, spleen, kidneys and parasympathetic ganglia but does not include the epididymis.
Methods
Retrospective review of 134 PSMA-targeted 2-(3-(1-carboxy-5-[(6-[18F]fluoropyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid (18F-DCFPyL) PET/CT scans performed on a latest generation digital scanner for radiotracer uptake in the epididymal head region was correlated with multiple clinical and laboratory factors.
Results
Phys...
Source: Nuclear Medicine Communications - April 15, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Comparison of the diagnostic utility of 99mTc-PSMA scintigraphy versus 68Ga-PSMA-11 PET/CT in the detection of metastatic prostate cancer and dosimetry analysis: a gamma-camera-based alternate prostate-specific membrane antigen imaging modality
Conclusion
Whole-body 99mTc-PSMA combined with regional SPECT/CT could be a potential alternative to 68Ga-PSMA PET for the detection of the advanced stage metastatic prostate cancer and for response evaluation to PSMA-based targeted therapies. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 15, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
