The impact of permanent pacemaker implantation on thallium myocardial perfusion examination detecting ischemic heart disease
Objectives Patients with permanent pacemaker (PPM) implantation may have altered coronary perfusion patterns that may influence the accuracy of myocardial perfusion examination modalities, which was observed in previous studies but with limited statistic power. Our aim was to examine the performance of thallium-201 (TL-201) myocardial perfusion examination in patients with implanted PPM. Methods Data of consecutive patients from our institution who had coronary angiography examination followed by TL-201 myocardial perfusion examination in pairs within 1 year were collected between January 2010 and December 201...
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Prognostic value of left ventricular mechanical dyssynchrony in hypertrophic cardiomyopathy patients with low risk of sudden cardiac death
This study aims to explore the prognostic value of left ventricular mechanical dyssynchrony (LVMD) in hypertrophic cardiomyopathy (HCM) patients with low risk of sudden cardiac death (SCD). Methods This retrospective study was performed in 50 patients with HCM who underwent Tc-99m sestamibi GSPECT-MPI. All patients were at low risk of SCD, defined as HCM risk-SCD scores (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Direct correlation between ischemic burden induced by dipyridamole and stress peak filling rate: a gated perfusion single-photon emission computed tomography study
Aim and patients The aim of the present study was to assess the effects of dipyridamole on stress and rest peak filling rate in consecutive patients who showed perfusion and, or function abnormalities at Gated-SPECT. Were enrolled 96 patients (73 males (76%); mean age 71.7 ± 9.57). Forty patients (41.7%) had an history of myocardial infarction and fifty-seven (59.4%) of previous cardiac revascularization. All patients underwent a 2-day 99mTc-SestaMIBI gated perfusion SPECT protocol. Results Twenty-nine (30.2%) patients showed fixed perfusion defects, 54 (56.2%) showed partially or completely reversible ones, wh...
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Accuracy of next-day single-sample measurement for low glomerular filtration rate and comparison with same-day slope-intercept glomerular filtration rate
Conclusions SS-GFR with a 24-h sample is more accurate than same-day SI-GFR in patients with GFR less than 25 mL/min/1.73 m2. Using SS-GFR with a 24-h sample in routine clinical practice will result in clinically insignificant differences in GFR result compared with the reference technique, whereas a same-day SI-GFR measurement could cause large inaccuracies. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Comparison of 81mKrypton and 99mTc-Technegas for ventilation single-photon emission computed tomography in severe chronic obstructive pulmonary disease
Conclusion Caution should be taken when replacing 81mKrypton with 99mTc-Technegas as a ventilation tracer in patients with severe COPD as there are significant differences in the distribution of the tracers over the lungs. Furthermore, this patient group is prone to 99mTc-Technegas hot spots and might need additional scanning if hot spots severely hamper image interpretation. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Dosimetry-guided radioiodine therapy of hyperthyroidism: long-term experience and implications for guidelines
Conclusions We advise earlier (2–3 weeks) first follow-up checks after RIT in all Graves’ disease patients and thyroid autonomy under antithyroid drugs (ATD) and re-checks every 2–4 weeks until conversion to hypothyroidism during the first year. The first check in thyroid autonomy without ATD should be after 3–4 weeks with re-checks every 4–6 weeks. After 1 year, both groups can be re-checked every 4–6 months over the next 5 years. The success rate of RIT in thyroid autonomyincreases with age but the history of RIT is rapidly lost during follow-up. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Impact of COVID-19 on nuclear medicine in the UK
Conclusion The first wave caused a major disruption of NM service delivery and impacted on the workforce. The departmental strategies should tailor services to evolving local and regional differences in prevalence of COVID-19. A blanket shutdown of services with a ‘one size fits all’ strategy would likely have a severe impact on future delivery of NM and health services in general. Timely testing of staff and patients remains of paramount importance. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The COVID-19 pandemic: impact on NHS England PET-CT services and lessons learnt
Conclusions There is no correlation between FDG PET-CT activity (fall and recovery) in England and the ability to provide the service by NHS England. It most likely reflects a combination of changes in health-seeking behaviour, NHS health policy and a decrease in the use of investigations that carry a high risk of COVID-19 transmission. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Osteoblastic and hyperostotic craniofacial lesion detected by 99mTc-labeled methylene diphosphonate bone scintigraphy and single-photon emission computed tomography/computed tomography: a pictorial essay
99mTc-bisphophonates bone scan, planar and single-photon emission computed tomography/computed tomography (SPECT/CT) modalities, is a commonly used technique that provides high sensitivity and specificity for detection of osseous metastases. However, besides bone metastases, SPECT/CT provides an accurate evaluation of the localization of the lesions and supplies anatomic information that can be valuable for diagnosis of nonmalignant bone diseases, occasionally disclosed in the skull. Reporting of craniofacial lesions detected by 99mTc-MDP (99mTc-labeled methylene diphosphonate) bone scintigraphy and SPECT/CT in the literat...
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Review article Source Type: research

What role does 18F-fluorodeoxyglucose PET-computed tomography have in the current pandemic and beyond?
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 23, 2021 Category: Nuclear Medicine Tags: Editorial Source Type: research

Estimation of CARE Dose 4D quality reference mAs conversion factors for child to adult reference patient in child protocols on Siemens Symbia SPECT-CT systems
Conclusion Conversion factors for child to adult dose modulation references are proposed, allowing comparable delivered mAs to a child. Video abstract: http://links.lww.com/NMC/A178 (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Technical Note Source Type: research

18F-fluorodeoxyglucose uptake on PET/computed tomography in association with androgen receptor expression and other clinicopathologic factors in surgically resected triple-negative breast cancer
Objective To evaluate whether androgen receptor expression in triple-negative breast cancer (TNBC) is associated with 18F-fluorodeoxyglucose (FDG) uptake and to identify predictive factors of 18F-FDG uptake in TNBC. Methods We retrospectively assessed data of 156 surgically resected primary TNBC in 156 consecutive patients who underwent 18F-FDG PET/computed tomography between July 2013 and May 2017. Clinicopathologic features, including androgen receptor expression, were categorized and the distribution of maximum standardized uptake value (SUVmax) was compared between the groups. We also evaluated the correlati...
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The frequency and malignancy rate of incidental focal breast lesions identified by 18F-fluorodeoxyglucose positron emission tomography
Conclusion Incidental uptake of FDG in the breast was rare. However, the malignancy rate was high among these patients, particularly among patients who had a follow-up biopsy. We recommend biopsy or thorough follow-up in patients with incidental focal uptake of FDG in the breast. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Feasibility of prognosis assessment for cancer of unknown primary origin using texture analysis of 18F-fluorodeoxyglucose PET/computed tomography images of largest metastatic lymph node
Objective Cancers of unknown primary origin cannot be staged using images, making the prognosis difficult. We attempted to predict prognosis of patients with unknown primary origin using tumour heterogeneity recently introduced in 18F-fluorodeoxyglucose (18F-FDG) PET/computed tomography (CT). Methods Overall, 30 patients with unknown primary origin who underwent whole-body 18F-FDG PET/CT scans were retrospectively enrolled for texture analysis. The volume of interest was placed in the largest metastatic lymph nodes and conventional parameters and grey-level co-occurrence matrix (GLCM) were calculated. Statistica...
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Examination of metallic impurities of 68Ge/68Ga generators used for radioactive labeling of peptides in clinical PET applications
Conclusion As a result, each generator contains metallic impurities different from its certificate. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research