Characteristics of different histological subtypes of thyroid nodules classified with 99mTc-methoxy-isobutyl-isonitrile imaging and Thyroid Imaging Reporting And Data System
Conclusion TIRADS is useful to detect PTC, but FVPTC and FTC may be missed. MIBI imaging seems to be more suitable to detect FVPTC and FTC. However, neither TIRADS nor MIBI imaging are able to differentiate between follicular adenoma and FTC or FVPTC. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Correction of slope-intercept glomerular filtration rate measurement without scaling for body size
Aim The aim of this study was to evaluate a slope-intercept glomerular filtration rate (GFR) one-compartment correction method based exclusively on the rate constant (α2) of the exponential between 2 and 4 h post-injection that requires no scaling for BSA. Methods The correction factor is 1/([C.α2]+1). C depends on the difference between one-compartment-corrected and uncorrected GFR, so varies with different correction procedures. Patients were in four groups: group 1 (51Cr-EDTA; n = 141) and group 2 (99mTc-DTPA; n = 47) had sampling at 2, 3 and 4 h. Groups 3A (99mTc-DTPA; n = 168) and 3B (99mTc-DTPA; n = 361)...
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The value of skeletal standardized uptake values obtained by quantitative single-photon emission computed tomography-computed tomography in differential diagnosis of bone metastases
Purpose The aim of this study was to explore the value of skeletal standardized uptake value (SUV) obtained by quantitative single-photon emission computed tomography-computed tomography (SPECT/CT) in differential diagnosis of bone metastases from benign lesions. Materials and methods Retrospective analysis has been conducted to 51 patients with extraskeletal malignant tumors who underwent whole-body bone scan with quantitative SPECT/CT imaging, and there are no more than three hotspots that were visually detected in the SPECT/CT imaging range. Fifty-one patients were enrolled, including 28 men and 23 women with...
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

New gender-specific formulae for estimating extracellular fluid volume from height and weight in adults
Conclusions New formulae are described for estimating eECV. Scaling GFR to eECV is more physiological than scaling to eBSA and accounts for gender. eECV used for measuring GFR from a single blood sample should be gender-specific. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Monitoring jaw osteomyelitis therapy with single-photon emission computed tomography/computed tomography
Conclusion SPECT/CT is a valuable tool to accurately assess therapy response, disease exacerbation and complications of jaw osteomyelitis. Low-grade (grade 1) residual tracer uptake is common in patients with clinically complete remission and is suggestive of ongoing bone remodeling and healing. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Empirical 188Re-HDD/lipiodol intra-arterial therapy based on tumor volume, in patients with solitary inoperable hepatocellular carcinoma
Conclusion After the administration of 1.2–3.7 GBq 188Re-HDD/lipiodol based on empirical activity calculation of 0.8–1.2 mCi/mL of tumor volume, more than half of the patients in the present study had an objective response on imaging and biochemically. No significant adverse side effects were noted and most of the laboratory markers as well as symptoms returned to normal after 48–72 h post-administration. Selective administration of the radiopharmaceutical into the tumor feeding arteries gives a good anti-tumoral effect with minimal side effects and damage to surrounding normal liver tissue. (Source: Nuclea...
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Dual-tracer radionuclide imaging in hyperparathyroidism: thallium-201 parathyroid scintigraphy revisited
Conclusion The results of this pilot study strongly advocate a role for thallium parathyroid SPECT/CT imaging in patients with primary and secondary hyperparathyroidism where the initial 99mTc-sestamibi scan is deemed to be false-negative in the presence of biochemical hyperparathyroidism. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

A review of pediatric neuroendocrine tumors, their detection, and treatment by radioisotopes
Neuroendocrine tumors (NETs) are rare in childhood. Neuroblastoma is the most common pediatric extracranial solid tumor, occurring>90% in children younger than 5 years of age. Pheochromocytoma and paraganglioma are rare NETs, causing hypertension in 0.5–2% of hypertensive children. Gastroenteropancreatic NETs can occur in children and are classified into carcinoids and pancreatic tumors. Nuclear medicine procedures have an essential role both in the diagnosis and treatment of NETs. Metaiodobenzylguanidine (MIBG) labeled with radioiodine has a well-established role in diagnosis as well as therapeutic management of the neu...
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Review Articles Source Type: research

Bone single-photon emission computed tomography/computed tomography in cancer care in the past decade: a systematic review and meta-analysis as well as recommendations for further work
In conclusion, targeted SPECT/CT improves the specificity of diagnosing bone metastases, but efforts need to be made to standardise the thresholds for SPECT/CT, methodology, as well as harmonising the reporting and interpretation criteria. We also make some recommendations for future works. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Review Articles Source Type: research

PET in the diagnostic management of infectious/inflammatory pulmonary pathologies: a revisit in the era of COVID-19
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Editorials Source Type: research

Radionuclide therapy services in an era of COVID-19: the radiation protection challenges, opportunities and considerations
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - December 15, 2020 Category: Nuclear Medicine Tags: Editorials Source Type: research

Chromosome aberrations during in-vitro labeling of red blood cells with 99mTc: a study with cytokinesis block micronucleus assay in human peripheral blood lymphocytes
Radiopharmaceuticals are special medicines composed by a radionuclide and a non-radioactive compound characterized by non-pharmacodynamic effects, low prevalence of side effects, and a possible risk of oncogenesis, since its administration to patients supposes a radiation dose to organism. Over these years, radiation damage induced by diagnosis radiopharmaceuticals has been evaluated, including the radiolabeled autologous cells, a group of radiopharmaceuticals where blood cells extracted from patients are labeled in-vitro and readministered for diagnosis. There is not a consensus about the possibility of increasement of ri...
Source: Nuclear Medicine Communications - November 17, 2020 Category: Nuclear Medicine Tags: Technical Notes Source Type: research

Safe practice ventilation technique in lung scanning for pulmonary embolism
Ventilation/Perfusion scanning for suspected pulmonary embolism is undergoing a renaissance due to the advent of single-photon emission computed tomography (SPECT). The scan protocol demands the inhalation of a radioactive gas or vapour for the ventilation scan. The purpose of this article is to report the radioactive environmental contamination that can occur when Tc99m Technegas vapours are administered to patients for the ventilation SPECT scan. This contamination can concentrate within gamma camera heads to degrade images and is also a radiation hazard to staff. A method for sequestrating this airborne contamination wa...
Source: Nuclear Medicine Communications - November 17, 2020 Category: Nuclear Medicine Tags: Technical Notes Source Type: research

Evaluation of dual time-point fluorodeoxyglucose PET/computed tomography imaging in gastric cancer
Background We aimed to evaluate the efficiency of dual time-point fluorodeoxyglucose (FDG) PET/computed tomography (CT) imaging in detecting primary and metastatic lesions in gastric cancer. Methods Between May 2019 and January 2020, 52 patients with gastric carcinoma were prospectively involved in our study. And dual time-point FDG PET/CT imaging performed to the patients. Of detected primary and metastatic lesions, the ones that are better visualized or only appear in delayed imaging were visually identified. Also, maximum standardized uptake value (SUVmax) of the primary and metastatic lesions and the intact ...
Source: Nuclear Medicine Communications - November 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Diagnostic performance of F-18 fluorodeoxyglucose PET/computed tomography for diagnosis of polymyalgia rheumatica: a meta-analysis
Objective The purpose of the current study was to investigate the diagnostic performance of F-18 fluorodeoxyglucose (FDG) PET/computed tomography (CT) for diagnosis of polymyalgia rheumatic (PMR) through a meta-analysis. Methods The PubMed, Cochrane and EMBASE database, from the earliest available date of indexing up to 29 February 2020, were searched for studies evaluating the diagnostic performance of F-18 FDG PET/CT for diagnosis of PMR. Results Across the 11 results of seven studies selected for analysis (684 patients), the pooled sensitivity for F-18 FDG PET/CT was 0.76 [95% confidence interval (CI),...
Source: Nuclear Medicine Communications - November 17, 2020 Category: Nuclear Medicine Tags: Original Articles Source Type: research