Diagnostic accuracy of 18F-fluciclovine PET/CT in primary lymph node staging of prostate cancer
Conclusion
18F-Fluciclovine PET/CT has a high specificity and positive predicted value for the presence of LNM in men with prostate cancer. However, the sensitivity and NPV seem to be limited to exclude the absence of LNM at a clinically acceptable level. Prospective evaluation is necessary to define patients who may benefit from 18F-fluciclovine PET/CT as a triage test for the indication for e-PLND. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 15, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Prognostic value of dynamic renal scan with 99mTc-EC in patients with kidney transplantation: a prospective descriptive study
Discussion
99mTc-EC renal scintigrahpy was able to predict kidney transplantation rejection in our patients. 99mTc-EC renal scintigrahpy is beneficial to evaluate transplant kidney function to prevent complications and helps close follow-up. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 15, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Lacrimal scintigraphy BNMS Guidelines
Purpose
The purpose of this guideline is to assist specialists in Nuclear Medicine and Radionuclide Radiology in recommending, performing, interpreting and reporting the results of lacrimal scintigraphy (also known as Dacroscintigraphy). This guideline will assist individual departments to formulate their own local protocols. This does not aim to be prescriptive regarding technical aspects of individual camera acquisitions, which need to be developed in conjunction with the local experts in medical physics. There are numerous radiological techniques to assess the physiology of the lacrimal system. This guideline will d...
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Guidelines Source Type: research
Salvage peptide receptor radionuclide therapy in patients with progressive neuroendocrine tumors: a systematic review and meta-analysis
Objective
Peptide receptor radionuclide therapy (PRRT) is an effective treatment option in patients with metastatic neuroendocrine tumors (NETs). Recently, salvage PRRT has been introduced for progressing NET patients. This systematic review and meta-analysis evaluated the therapeutic efficacy, survival, and toxicity of salvage PRRT in patients with progressive NETs.
Methods
A systematic (PubMed, Embase, Cochrane, and Scopus) were performed. To determine therapeutic efficacy, objective response rate (ORR), and disease control rate (DCR) were identified using radiologic response criteria. To determine survival, p...
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Global brain glucose uptake on 18F-FDG-PET/CT is influenced by chronic cardiovascular risk
Purpose
The goal of this study was to assess global cerebral glucose uptake in subjects with known cardiovascular risk factors by employing a quantitative 18F-fluorodeoxyglucose-PET/computed tomography (FDG-PET/CT) technique. We hypothesized that at-risk subjects would demonstrate decreased global brain glucose uptake compared to healthy controls.
Methods
We compared 35 healthy male controls and 14 male subjects at increased risk for cardiovascular disease (CVD) as assessed by the systematic coronary risk evaluation (SCORE) tool. All subjects were grouped into two age-matched cohorts: younger ( (Source: Nuclear ...
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Prognostic value of 18F-fluorodeoxyglucose PET/computed tomography metabolic parameters measured in the primary tumor and suspicious lymph nodes before neoadjuvant therapy in patients with esophageal carcinoma
Conclusion
In esophageal cancer patients, some of the 18F-FDG PET/CT metabolic parameters measured in the primary tumor and in the suspicious lymph nodes before the neoadjuvant therapy are independent indicators of overall survival and appear to be more important than the clinical stage in the prognostic definition of this group of patients. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Is F-18 FDG PET/computed tomography a useful tool to restage the patients with tongue carcinoma?
Objective
The aim of this study was to evaluate the diagnostic performance of contrast-enhanced F-18 fluoro-2-deoxyglucose (F-18 FDG) PET/computed tomography (CT) in restaging of tongue carcinoma.
Material and methods
Retrospectively analysis of carcinoma tongue patients (n = 110) who were treated and referred for FDG PET/CT. Histopathological examination and clinical or imaging follow-up were taken as gold standard.
Results
Of 110 patients, FDG PET/CT detected FDG avid lesions in 69 (62.7%) patients. Sensitivity, specificity and diagnostic accuracy of FDG PET/CT were 92.9%, 90.0% and 91.8%, respectively,...
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Digital versus analog PET/CT in patients with known or suspected liver metastases
Aim
To assess if digital PET/CT improves liver lesion detectability compared to analog PET/CT in patients with known or suspected liver metastases.
Materials and methods
We prospectively included 83 cancer patients, with one or more of these conditions: history of liver metastases, clinical risk of having liver metastases or presence of suspected liver metastases on the first of the two PET/CTs. All patients were consecutively scanned on each PET/CT on the same day after a single [18F]fluorodeoxyglucose dose injection. The order of acquisition was randomly assigned. Three nuclear medicine physicians assessed bot...
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Magnetic resonance imaging-based partial volume-corrected 18F-sodium fluoride positron emission tomography in the femoral neck
Conclusion
Our results support the use of global NaF uptake with magnetic resonance-derived partial volume correction in the femoral neck. Because osteoblastic metabolism is known to decrease with normal aging, the observed decrease in NaF uptake constitutes evidence for convergent validity, indicating that the proposed methodology likely reflects systemic osteoblastic activity. Future studies of this methodology are warranted in other instances of varying osteoblastic activity such as in metabolic bone diseases and for the evaluation of therapy targeting osteoblastic metabolism. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Sex difference in cerebral blood flow and cerebral glucose metabolism: an activation-likelihood estimation meta-analysis
Objectives
Sex differences exist in a variety of aspects including neurochemicals as well as behavioral traits of cognition, language, and aggression. We performed a meta-analysis of studies using a coordinate-based technique of activation-likelihood estimation (ALE) to identify the pooled estimated effect of sex difference.
Methods
We performed a systematic search of MEDLINE and EMBASE for English-language publications using the keywords of ‘positron emission tomography (PET)’, ‘single-photon emission computed tomography (SPECT)’, and ‘sex’. A threshold of uncorrected P (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Yttrium-90 dosimetry and implications on tumour response and survival after radioembolisation of chemo-refractory hepatic metastases from breast cancer
Conclusion
For patients with chemo-refractory breast cancer with liver metastases, achieving a mean tumour dose>70 Gy is a significant predictor of tumour response and prolonged OS. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Clinical association of CXCR4 in primary tumor of papillary thyroid cancer and response to iodine-131 treatment
Conclusion
Our data support the notion that CXCR4 are significantly expressed in PTC tumor over normal thyroid tissues. However, there is no clinical association with radioiodine treatment response. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
99mTc-antitumor necrosis factor-alpha scintigraphy for the detection of inflammatory activity in rheumatoid arthritis
Conclusions
Scintigraphy with 99mTc-anti-TNF-α was well-tolerated and had a good ability to distinguish between inflammatory and noninflammatory lesions in patients with rheumatoid arthritis. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Is 67gallium dead? A retrospective review of 67gallium imaging in a single tertiary referral centre
Conclusion
[67Ga]Ga-citrate has diagnostic value in the evaluation of complex patients with high-risk infection. High diagnostic yield is demonstrated in patients with bacteraemia with or without a confirmed site of infection, particularly when combined with SPECT/CT. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Chronic thromboembolic pulmonary hypertension: evaluation of V/Q SPECT/CT and V/Q Quotient SPECT findings with postoperative results of pulmonary endarterectomy
Conclusion
In the light of histopathological findings and post-PEA surgical specimen examinations, the results of the present study indicated that both V/Q SPECT/CT and V/Q Quotient SPECT showed relatively high efficacy for the detection of CTEPH on per-patient and per-segment bases with an excellent agreement. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
