Prognostic value of fluorodeoxyglucose positron emission tomography derived metabolic parameters and textural features in pediatric sarcoma
Conclusion
In addition to the presence of distant metastasis at initial diagnosis, textural features of primary tumors may be used as prognostic biomarkers to identify patients with worse prognosis in pediatric sarcoma. Higher tumor heterogeneity is significantly associated with shorter progression-free survival and OS. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 21, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Can early phase cardiac [123I]mIBG images be used to diagnose Lewy body disease?
Conclusion
We suggest that a delayed image could be acquired only if the early result is borderline. This removes the need for delayed imaging in about 70% of patients. Adopting this protocol in clinical practice would reduce the time most patients have to wait and could free up scanner time. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 21, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Favorable tumor uptake and nuclear transport of Auger electrons by nuclear targeting with 111In-trastuzumab in an intraperitoneal tumor mouse model
Conclusion
Nuclear targeting using 111In-trastuzumab-NLS promotes a more efficient tumor cell uptake and subsequent nuclear translocation of the 111In AE-emitting radionuclide in vivo. This radio-immunoconjugate will likely be an effective agent for HER2-targeting by AE-RIT. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 21, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
The effect of coronavirus disease 2019 pneumonia on myocardial ischemia detected by single-photon emission computed tomography myocardial perfusion imaging
Conclusion
COVID-19 pneumonia was identified as an independent predictor of ischemia on SPECT-MPI. Symptoms including chest pain and shortness of breath in patients who have had COVID-19 pneumonia may be attributed to coronary ischemia. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 21, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Research progress on the role of fibroblast activation protein in diagnosis and treatment of cancer
Fibroblast activation protein (FAP) is a type II transmembrane protein, which is over-expressed in cancer-associated fibroblasts (CAFs). CAFs are tumor stromal cells that constitute a major component of cancer volume and are reportedly related to tumorigenesis, angiogenesis, metastasis, promotion of drug resistance and induction of tumor immunity. FAP is widely acknowledged as the signature protein of CAFs. At present, FAP inhibitors (FAPI) have achieved ideal results in tumor PET/computed tomography (CT) imaging. Theoretically, FAP-targeted drugs can inhibit tumor progression. Nonetheless, no satisfactory therapeutic effe...
Source: Nuclear Medicine Communications - June 21, 2022 Category: Nuclear Medicine Tags: Review article Source Type: research
Challenges in the evaluation and management of radioactive iodine-refractory differentiated thyroid cancer
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 21, 2022 Category: Nuclear Medicine Tags: Editorial Source Type: research
Report of the 2020 British Nuclear Medicine Society survey of nuclear medicine equipment, workforce and workload
This article is a report of the most recent BNMS survey which was collected during 2019 and 2020. The survey used two methods to collect data: for equipment and workforce, participants created or updated existing online records; for workload information, respondees were asked to submit 12 months of data from local radiology information systems. Following the survey, the BNMS database contained a total of 191 sites (63% of known sites) having either equipment or workforce data or both. In total 39 centres provided workload data which included over 175 000 examinations. A combination of automated tools and visual inspect...
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: BNMS Communication Source Type: research
Prospective intraindividual comparison of 18F-PSMA-7Q and 18F-DCFPyL PET/CT in patients with newly diagnosed prostate cancer
Conclusion
18F-PSMA-7Q can be used in clinical research as reliably as 18F-DCFPyL. The limited urinary excretion of 18F-PSMA-7Q may represent a potential advantage over 18F-DCFPyL for detection of lesions in the pelvis, which need to be verified by further studies. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Evaluation of response to stereotactic body radiation therapy for nonsmall cell lung cancer: PET response criteria in solid tumors versus response evaluation criteria in solid tumors
Conclusion
RECIST based on the anatomic size reduction rate did not demonstrate the correlation between radiotherapeutic response and prognosis in patients with early-stage NSCLC receiving SBRT. However, PERCIST was shown as the strongest independent predictor of outcomes. PERCIST might be considered more suitable for the evaluation of NSCLC tumor response to SBRT than RECIST. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Qualitative and quantitative methods in post-chemoradiation PET for head and neck cancer
Conclusions
Quantitative data such as SUVmax does not show additional value over qualitative evaluation of response to chemoradiation in head and neck tumors. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Role of 18F-FDG PET/CT in the assessment of therapy response and clinical outcome in metastatic renal cell carcinoma treated with tyrosine kinase inhibitors or immunotherapy
This study aimed to determine the role and prognostic significance of 18F-FDG PET/CT on treatment response and survival outcomes in metastatic renal cell carcinoma patients treated with immunotherapy or tyrosine kinase inhibitors (TKIs).
Patients and methods
Forty patients scheduled for a standard treatment protocol with TKIs (n = 17; group-1) or PD-1 inhibitors (nivolumab, n = 23; group-2) were evaluated by 18F-FDG PET/CT. Peak standardized uptake value corrected for lean body mass (SULpeak) and maximum standardized uptake value (SUVmax) were calculated, and their relationship to treatment response was evaluated.
...
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
The ‘ramp filter’ artifact in filtered back projection is due to attenuation not ramp filtering
Conclusion
The ramp filter artifact in single photon emission computed tomography reconstruction is due to attenuation, not ramp filtering per se. Adjacent splanchnic activity can result in either an increase or decrease in counts. These effects are less pronounced and more consistent with iterative reconstruction. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Pulmonary perfusion imaging and delayed imaging to measure pulmonary capillary permeability in pulmonary contusion
Purpose
Explore the application value of pulmonary perfusion imaging and delayed imaging for evaluating pulmonary capillary permeability.
Materials and methods
After establishing a rat model of pulmonary contusion, changes in the metabolic index of technetium-99m macroaggregated albumin (99mTC-MAA) in the lungs of model rats were evaluated for two consecutive days. 99mTC-MAA metabolic indices of rat lungs with pulmonary contusion of varying severity (mild, moderate, and severe) were correlated with lung wet/dry weight ratio (W/D) and Evans blue extravasation. Finally, the method was validated in patients with pu...
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Observer experience and accuracy of 18F-sodium-fluoride PET/CT for the diagnosis of bone metastases in prostate cancer
Conclusion
Novice observers used the equivocal option more frequently than observers with NaF PET/CT experience. However, on the dichotomous scale, all observers exhibited high and satisfactory accuracy for the detection of bone metastases, making NaF PET/CT an effective imaging modality even in unexperienced hands. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Bone scan with technetium 99m-methyl diphosphonate, the missing link in the initial staging of muscle-invasive bladder carcinoma
Conclusion
Bone scan has higher diagnostic performance than conventional imaging methods for detecting bone metastases. It changed the management plan in 8.8% of our patients, so we conclude that performing a whole-body bone scan in the initial staging of MIBC would be helpful. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
