Correlation of epidermal growth factor receptor mutation status and PD-L1 expression with [18F]FDG PET using volume-based parameters in non-small cell lung cancer
Conclusion Based on the preliminary results of this study, FDG PET may help in the prediction of PD-L1 expression level, but not EGFR mutation status, in patients with newly diagnosed NSCLC. The SUVmax rather than MTV or TLG, may be of value in predicting the six groups according to the combination of EGFR mutation status and PD-L1 expression level. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Prediction of pathological response using 18F FDG PET/CT derived metabolic parameters in locally advanced breast cancer patients
This study aims to assess the value of flurodeoxyglucose (FDG)-PET derived metabolic parameters for prediction of pathologic response in LABC postneoadjuvant therapy. Methods Totally 47 patients with LABC underwent initial and postneoadjuvant therapy PET scans. ΔSUVmax%, ΔTLG% and ΔMTV% were calculated. Post-therapy histopathologic therapeutic response was assessed. Results In total 91.5% of patients had invasive duct carcinoma and the remaining (8.5%) had invasive lobular carcinoma. Postneoadjuvant PET/CT was able to detect 91.7% of patients with pathologically proven complete response in primary tumor, 6...
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Effect of Bayesian penalty likelihood algorithm on 18F-FDG PET/CT image of lymphoma
Conclusion BPL reconstruction algorithm could effectively improve clinical image quality and diagnostic certainty. In quantitative analysis, there were no significant differences among different pathological groups, but there were significant diversities in lesion sizes. Especially for small lesions, lesion SUVmax increased and SBR was significantly improved, which may better assist in the diagnosis of small lesions of lymphoma. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The relationship between brain glucose metabolism and insulin resistance in subjects with normal cognition – a study based on 18F-FDG PET
Conclusions 18F-FDG brain PET imaging could be helpful for the early diagnosis and treatment of changes in brain glucose metabolism caused by insulin resistance. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Distinguishing between primary central nervous system lymphoma and glioblastoma using [18F]fluoromisonidazole and [18F]FDG PET
Objective The purpose of this study was to assess the diagnostic value of [18F]fluoromisonidazole (FMISO) and 2-deoxy-2-[18F]fluoro-D-glucose (FDG) PET to discriminate primary central nervous system lymphoma (PCNSL) from glioblastoma. Methods FMISO and FDG PET/CT scans before therapy obtained in 13 patients with PCNSL and in 62 patients with glioblastoma were retrospectively reviewed. PET results were evaluated by visual and semiquantitative analysis. For semiquantitative analysis, the maximum standardized uptake value (SUV) for tumor (T) and the mean SUV for normal contralateral hemisphere (N) were calculated, ...
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Evaluating the correlation of serum leptin levels with evidence of coronary artery disease on myocardial perfusion single-photon emission computed tomography in suspected coronary artery disease patients
Conclusion Based on our findings, there was no significant correlation between myocardial perfusion scan parameters and leptin levels. Serum leptin and different groups of age, sex and coronary artery risk factors were not correlated as well. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Safety and tolerability of regadenoson compared with dipyridamole in myocardial perfusion imaging in patients scheduled to undergo medium to high-risk noncardiac surgery: a randomized controlled study
Conclusion In our group of patients scheduled for myocardial perfusion imaging for preoperative assessment, the two agents, regadenoson and dipyridamole, have no significant differences in the frequency of mild adverse reactions and in aminophylline use, with regadenoson also having the advantage of faster symptom resolution. Nevertheless, dipyridamole can be considered as a well-tolerated and low-cost alternative. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

VNTR polymorphism in the SLC6A3 gene does not influence dopamine transporter availability measured by [18F]FE-PE2I PET or [123I]FP-Cit SPECT
Objective To investigate the potential impact of polymorphism in the 3′-untranslated region (3′UTR) of the SLC6A3 gene (DAT1) on normal variation in dopamine transporter (DAT) imaging with [18F]FE-PE2I PET and [123I]FP-Cit SPECT. Methods Thirty-six individuals (mean age 70.4±5.4 years) with normal [18F]FE-PE2I PET and [123I]FP-Cit SPECT were genotyped for variable number of tandem repeats (VNTR) in the 3′UTR of the DAT1 gene. The DAT-availability in the caudate and putamen as measured with [18F]FE-PE2I PET and [123I]FP-Cit SPECT, as well as in the substantia nigra with [18F]FE-PE2I PET were compared betwe...
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Renal protection during 177lutetium DOTATATE molecular radiotherapy in children: a proposal for safe amino acid infusional volume during peptide receptor radionuclide therapy
Peptide receptor radionuclide therapy (PRRT) using radiolabelled somatostatin analogues such as 177-lutetium DOTATATE is an effective treatment modality for neuroendocrine tumours, paragangliomas, and neuroblastomas. However, renal and haematopoietic toxicities are the major limitations of this therapeutic approach. The renal toxicity of PRRT is mediated by renal proximal tubular reabsorption and interstitial retention of the radiolabelled peptides resulting in excessive renal irradiation that can be dose-limiting. To protect the kidneys from PRRT-induced radiation nephropathy, basic amino acids are infused during PRRT as ...
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Technical Note Source Type: research

Using 18F-flurodeoxyglucose and 68Ga-fibroblast activation protein inhibitor PET/CT to evaluate a new periprosthetic joint infection model of rabbit due to Staphylococcus aureus
Purpose The existing periprosthetic joint infection (PJI) models have obvious limitations, and studies of PJI on animal models using PET/computed tomography (CT) for diagnosis are still lacking. Thus, the aim of this study was to establish a new PJI model and 18F-fluorodeoxyglucose (FDG) and 68Ga-fibroblast activation protein inhibitor (FAPI) were employed to study their performance. Methods A novel PJI model of rabbit was developed by placing two screws in the tibia and femur. Based on bacteria concentration, the animals were divided into five groups, control, 104, 105, 106 and 107. 18F-FDG and 68Ga-FAPI PET/CT...
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Can 18F-FDG PET/CT alone or combined with radiology be used to reliably grade cartilage bone neoplasms for surgical decision making?
Objective Treatment of chondrosarcomas is grade based; intralesional curettage for grade 1 and resection for grade 2 or more. Currently used methods to determine grades before surgery are not highly accurate and create a dilemma for the surgeon. We have used a PET-CT combined with imaging to answer the following study questions: (1) Does SUVmax value from an 18F-FDG PET/CT correlate with the grade of chondrosarcoma? (2) Can a cutoff SUVmax value be used to differentiate between various grades of chondroid neoplasms with sufficient sensitivity and specificity? (3) Does SUVmax guide the clinician and add value to radiolo...
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Impact on the long-term prognosis of FDG PET/CT in luminal-A and luminal-B breast cancer
Purpose The aim of the present study was to explore the prognostic role of 2- deoxy-2-[18F]fluoro-D-glucose PET (FDG PET)/CT in recurrent luminal A and luminal B breast cancer. Materials and methods From two institutional databases, we retrospectively retrieved data about breast cancer patients undergoing FDG PET/CT between 2011 and 2018 for the assessment of recurrency. Molecular subtypes of breast cancer were defined based on the expression of estrogen, progesterone, human epidermal growth factor receptor 2 (HER2)-b receptors and proliferation index. Overall survival (OS, intended as the time from PET/CT and t...
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Impact of 18F-fluciclovine PET/CT on salvage radiotherapy plans for men with recurrence of prostate cancer postradical prostatectomy
Conclusions Incorporating 18F-fluciclovine PET/CT into treatment planning may help identify patients suitable for salvage radiotherapy, help augment planned radiotherapy to better target lesions and support the clinician to optimise patient management. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

99mTc-HMPAO-WBC SPECT/CT versus 18F-FDG-WBC PET/CT in chronic prosthetic joint infection: a pilot study
Conclusion This pilot study showed no difference in the sensitivity or specificity of 99mTc-HMPAO-WBC SPECT/CT and 18F-FDG-WBC PET/CT when combined with 99mTc-nanocollloid SPECT/CT in the diagnosis or treatment evaluation of suspected late chronic PJI. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Prognostic significance of pretreatment 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) in patients with primary T cell lymphomas
Conclusion Pretherapy SUVmax may serve as an independent predictor of outcome in patients with newly diagnosed T cell lymphomas. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research