Characterisation of 99mTc EDDA/HYNIC-TOC (Tektrotyd) physiological and neuroendocrine tumour uptake using SPECT/CT standardised uptake values: initial experience
The objective of this study was to characterise quantitative standardised uptake value (SUV) SPECT/CT of normal physiological uptake and NET disease. Forty-four patients (22 female and 22 male) referred for 99mTc EDDA/HYNIC-TOC SPECT/CT imaging for diagnosis/primary staging (n = 28) or the assessment of residual/recurrent disease (n = 16) were included. SPECT/CT SUVmax values were determined for normal physiological uptake (spleen, kidney, liver and bone) and NET disease (liver metastases, metastatic lymph nodes, bone metastases and intrapulmonary lesions). Statistical testing was performed to compare normal uptake...
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Technical Note Source Type: research
Comparison of treatment response assessed by 18F-FDG PET/CT with the histopathological response using tumor regression grading on surgically resected specimen following neoadjuvant chemotherapy in squamous cell carcinoma of esophagus
Conclusion
After neoadjuvant chemotherapy, 18F-fluorodeoxyglucose PET/CT can help to assess the response and guide the treatment. However, a larger study is warranted to evaluate their correlation with pathological response. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
The prediction of spread through air spaces with preoperative 18F-FDG PET/CT in cases with primary lung adenocarcinoma, its effect on the decision for an adjuvant treatment and its prognostic role
Purpose
In lung adenocarcinoma cases, ‘spread through air spaces’ (STAS) is a new indicator of invasion and directly related to disease survival. The aim of our study is to establish whether a preoperatively performed 18F-Fluorodeoxyglucose (FDG) PET/computed tomography (CT) imaging data can predict the presence of STAS in cases with lung adenocarcinoma and thus predict the decision for the type of surgery and adjuvant chemotherapy.
Materials and methods
Between 2000 and 2019, we retrospectively analyzed 63 patients with lung adenocarcinoma cases that had undergone lobectomy or pneumonectomy. Semiquantitativ...
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
F-18 ML-104 tau PET imaging in mild cognitive impairment
Conclusion
We could demonstrate a significant increase in cortical tau deposition in aMCI patients in comparison to normal controls, thus providing in vivo evidence of the underlying pathological process in this subgroup of patients with high probability of conversion to AD. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
18F-fluciclovine PET/CT detection of biochemical recurrent prostate cancer in patients with PSA levels
Conclusion
18F-fluciclovine PET/CT demonstrated a detection rate of 56.4% among patients with a PSA below 2.0 ng/mL. The results of this study support the use of 18F-fluciclovine PET/CT for the detection of recurrent prostate cancer at lower PSA levels, even at PSA levels less than 0.5 ng/mL. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Comparison of 18F-labelled fluoro-2-deoxyglucose-PET with conventional computed tomography for staging and response assessment in paediatric and adult patients with nodular lymphocyte-predominant Hodgkin’s lymphoma
Conclusion
For NLPHL, pre-therapeutic FDG-PET scan is better than CeCT staging. FDG-PET has much better specificity for response assessment than CeCT. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Determination of tumour dose response threshold and implication on survival in patients with HCC treated with Y90 radiation segmentectomy: a simple semi-quantitative analysis
Conclusion
In patients with HCC undergoing Y90-RS, mean tumour dose ≥250 Gy and minimum tumour dose of ≥180 Gy to 100% of tumour volume are both significantly correlated with higher objective tumour response and prolonged survival. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Attenuation correction in CZT myocardial perfusion imaging comparison of supine-prone and low-dose CT-corrected supine acquisitions
Aims
The study aimed to investigate whether additional prone imaging delivers comparable results to supine imaging with low-dose computed tomography (CT) attenuation correction (CTAC) in cadmium, zinc and telluride (CZT) myocardial perfusion imaging.
Methods and results
Thirty-four patients with an indication for myocardial perfusion imaging were studied with a CZT camera in the supine and then prone position. Furthermore, a low-dose CT was acquired. Three data sets were reconstructed and considered for analysis: (1) supine CZT, (2) supine CZT with CTAC and (3) supine CZT with additional prone CZT. Based on 17-s...
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Automated classification of increased uptake regions in bone single-photon emission computed tomography/computed tomography images using three-dimensional deep convolutional neural network
Conclusions
This study suggests that DCNN could be used for the direct classification of benign and malignant regions without extracting the features of SPECT/CT accumulation patterns. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Renogram image characteristics and the reproducibility of differential renal function measurement
This study aims to investigate factors associated with the reproducibility of DRF measurements.
Methods
The association between age, GFR and imaged derived image characteristics and reproducibility of repeated DRF estimates calculated using the area under the curve method and the Rutland Patlak method was analysed for cohort 1 (n = 127). The association between these variables and reproducibility of DRF was tested with univariate linear regression. The univariate linear regression results were used to plan the multiple linear regression combinations.
The associations between variables identified and reproduci...
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Fuzzy logic-based moving average filters for reducing noise from Tc-99m-sestamibi parathyroid images
Conclusion
On the basis of subjective assessment, the performance of ATMAV_3 fuzzy filter was found to be better compared to the classical moving average filter in reducing noise from Tc-99m-sestambi parathyroid images. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Impact of fluorine-18-fluorodeoxyglucose PET/computed tomography in staging of patients with gallbladder cancer: a systematic review and meta-analysis
Conclusion
With the limited data available currently, we found that 18F-FDG PET/CT is a quite accurate noninvasive tool in staging the workup of GBCa. However, further large multicentre trials are necessary for the generation of stronger evidence in this regard. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Reviews Source Type: research
The role of 18F-Fluorodeoxyglucose PET/CT in restaging patients with small cell lung cancer: a systematic review
Conclusions
This review encourages the use of 18F-FDG PET imaging, especially in conjunction with ceCT in recurrent SCLC patients. Further level I evidence is needed to further assess the diagnostic and prognostic capability of 18F-FDG PET/ceCT findings in SCLC. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Reviews Source Type: research
18F-FDG PET/CT imaging features of patients with multicentric Castleman disease
Conclusion
18F-FDG PET/CT is a useful tool in the diagnosis, evaluation, and follow-up of MCD by providing systemic manifestations of lymphadenopathy, pulmonary involvement, and hypermetabolic spleen or bone marrow. Furthermore, the lymphadenopathy in MCD presented a predominantly peripheral distribution, relatively symmetric, moderately hypermetabolic, and not confluent pattern on 18F-FDG PET/CT. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
FDG-PET/CT: novel method for viability assessment of livers perfused ex vivo
Conclusion
This study demonstrates the feasibility of FDG-PET/CT for viability assessment of ex vivo perfused liver grafts after 1 week. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
