Head-to-head comparison between 68Ga-PSMA and 18F-FDG-PET/CT in lymphomas: a preliminary analysis
This study compared both tracers in patients with diverse lymphoma subtypes. Methods Ten patients with biopsy-proven-lymphoma underwent 18F-FDG and 68Ga-PSMA-PET/CT (maximum time interval: 6 days). Lymphoma subtypes included Hodgkin’s lymphoma (HL, three patients) and aggressive and indolent non-Hodgkin’s lymphoma (NHL, seven patients). The intensity of PSMA uptake was classified visually as low, intermediate, or high, using blood pool, liver and parotid gland uptake as references. Maximum standardized-uptake value (SUVmax) of each affected site was measured in both sets of images. Results FDG detected 59...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Haralick texture features extracted from Ga-68 PSMA PET/CT to differentiate normal prostate from prostate cancer: a feasibility study
Objective Role of texture parameters on the basis of Ga-68 PSMA PET/CT in prostate cancer (Pca) is largely unexplored. Present work done is a preliminary study that aims to evaluate the role of Haralick texture features on the basis of Ga-68 PSMA PET/CT in Pca in which texture features were used to differentiate between normal prostate and Pca tissue. Methods The study retrospectively enrolled patients in two groups: group 1 included 30 patients with biopsy-proven adenocarcinoma prostate and median age 64 years (range: 50–82 years) who underwent baseline Ga-68 PSMA PET/CT prior to therapy; group 2 included 24 ...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Efficacy of 68Ga-PSMA PET/CT-derived whole-body volumetric parameters in predicting response to second-generation androgen receptor axis-targeted therapy, and the prognosis in metastatic hormone-refractory prostate cancer patients
Introduction The present study investigates the role of 68Ga-PSMA PET/CT-derived whole-body metabolic and volumetric parameters in the prediction of treatment response and prognosis among metastatic hormone-refractory prostate cancer patients undergoing second-generation androgen receptor axis-targeted therapy (abiraterone or enzalutamide). Materials and methods This retrospective study included 44 metastatic hormone-refractory prostate cancer patients undergoing 68Ga-PSMA PET/CT, including 29 enzalutamide-treated and 15 abiraterone-treated patients. Results Of the 44 patients included in the study, 29 re...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Preoperative 18F-FDG SUVmax >6.3 or Size >2.3 cm of primary lesions predict lymph nodes metastasis with higher negative predictive value in peripheral cT1 non-small-cell lung cancer
Conclusions The excellent sensitivity and NPV of preoperative of the SUVmax>6.3 or size>2.3 cm of the primary lesions based on 18F-FDG PET-CT might identify the patients at low-risk LNM in peripheral cT1 NSCLC. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Correlation of 4′-[methyl-11C]-thiothymidine PET with Ki-67 immunohistochemistry separately in patients with newly diagnosed and recurrent gliomas
Objective 4′-[methyl-11C]-thiothymidine (4DST) uptake on PET was correlated with proliferative activity separately in patients with newly diagnosed and recurrent gliomas. Methods A total of 29 patients, 18 with newly diagnosed gliomas and 11 with recurrent gliomas who underwent 4DST PET/computed tomography (CT) were available for a retrospective analysis of prospectively collected data. The maximum standardized uptake value (SUVmax) of tumor (T) and the mean SUV of normal contralateral hemisphere (N) were calculated, and the tumor-to-normal (T/N) ratio was determined. Proliferative tumor volume (PTV) and total...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Exploring the potential utilities of 99mTc-labeled RBC-equilibrium radionuclide angiocardiography in transfusion-dependent β-thalassemia major patients
Aims 99mTc-labeled RBC-equilibrium radionuclide angiocardiography (ERNA) is done in transfusion-dependent beta-thalassemia major (β-TM) patients routinely for cardiac dysfunction. This prospective study aimed at evaluating the potential of ERNA in demonstrating the bone marrow hyperplasia as an adjunct biomarker for monitoring the adequacy of blood transfusions in transfusion-dependent β-TM patients. Materials and methods One hundred and twenty-six patients of β-TM (study group) and 30 nonthalassemic patients (control) underwent ERNA study with an additional whole-body imaging. We quantitated the normalized b...
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

An overview of nuclear medicine research in the UK and the landscape for clinical adoption
Conclusions We hope that by collating this information we will provide stimulus for future discussion and consensus statements around this topic. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

18F-FDG PET and PET/CT for the evaluation of gastric signet ring cell carcinoma: a systematic review
Conclusion Despite some limitations affect our review, GSRCC seems to have low 18F-FDG uptake, and therefore 18F-FDG PET or PET/CT reveals impaired sensitivity for its evaluation. However, a correlation between 18F-FDG uptake and some clinico-pathologic features (such as stage, depth of invasion, size and presence of nodal metastasis) has been demonstrated. Besides, a possible prognostic role of PET/CT features is starting to emerge. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - November 18, 2021 Category: Nuclear Medicine Tags: Review Article Source Type: research

False positive pharmacologic myocardial perfusion SPECT study in the setting of a left bundle branch block
We herein report a case of a false positive vasodilatory pharmacologic SPECT stress test in the setting of a left bundle branch block (LBBB). While this is more commonly seen with exercise stress testing, it can also occur with pharmacologic stress testing. In our SPECT exam, we illustrate the commonly mistaken septal/anteroseptal perfusion defects in those patients with a LBBB. PET stress testing may be more reliable for patients with LBBB. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Technical Notes Source Type: research

75SeHCAT whole body retention for unexplained chronic diarrhoea based on early first whole body counting
Background There are many protocol variations in the whole-body 75SeHCAT retention test [whole-body retention (WBR)] for investigation of bile acid diarrhoea. The time between capsule consumption and first count, however, is widely taken, without debate, to be 3 h. In the Covid-19 era, it is desirable to limit the time patients spend in the department. We, therefore, questioned the need for a 3 h interval between capsule administration and the initial count. Methods Using an uncollimated gamma camera, whole-body counting was performed at 5, 30 and 180 min after capsule ingestion in 24 patients with chronic...
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Technical Notes Source Type: research

Clinical PET/CT utilization during the COVID-19 pandemic: initial experience at Yale University
Objective To determine temporal changes in PET/CT utilization during the COVID-19 pandemic and examine the impact of epidemiologic, demographic and oncologic factors on PET/CT utilization. Methods Clinical PET-CT utilization between 1 January 2020 and 15 June 2020 at a tertiary academic center was assessed using change-point-detection (CPD) analysis. COVID-19 epidemiologic trend was obtained from Connecticut Department of Public Health records. Demographic and oncologic data were gathered from electronic medical records and PET-CT scans by four reviewers in consensus. Results A total of 1685 cases were re...
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Incidence and relevance of clinically indeterminate nonregional lymph nodes in the treatment of oesophageal cancer
Conclusions EBUS and US-FNA are effective means of sampling clinically indeterminate nonregional lymph nodes, and can significantly impact prognosis, and management. Further investigations in this context are of value in this cohort and should be pursued. Nonregional clinically indeterminate lymph nodes represent a diagnostic dilemma in oesophageal cancer staging. Additional investigations in the form of endobronchial ultrasound are effective at providing additional staging information, and can substantially influence patient care. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Astrocyte activation imaging with 11C-acetate and amyloid PET in mild cognitive impairment due to Alzheimer pathology
Conclusions While further validation is required, this exploratory pilot study suggests a potential role for 11C-acetate PET as a neuroinflammatory biomarker in MCI and early AD to provide clinical and translational insights into astrocyte activation as a pathological response to amyloid. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Assessment of volumetric parameters derived from 68Ga-PSMA PET/CT in prostate cancer patients with biochemical recurrence: an institutional experience
Objective The aim of this study was to evaluate the relationship between volumetric parameters calculated using semiautomatic quantification of lesions detected in 68Ga-labeled prostate-specific membrane antigen PET-computed tomography (68Ga-PSMA PET/CT) and clinical characteristics in prostate cancer (PCa) patients with biochemical recurrence. Methods A total of 85 consecutive PCa patients with biochemical recurrence who underwent 68Ga-PSMA PET/CT at our institution from January 2019 to March 2020 were retrospectively assessed. 68Ga-PSMA PET/CT-derived volumetric parameters, including whole-body PSMA tumor volu...
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The diagnostic value of metabolic, morphological and heterogeneous parameters of 18F-FDG PET/CT in mediastinal lymph node metastasis of non–small cell lung cancer
Objectives To investigate the value of PET/CT metabolic, morphological and heterogeneous parameters in the diagnosis of 18F-FDG positive mediastinal lymph node metastasis in non–small cell lung cancer (NSCLC). Patients and methods A total of 156 patients with pathologically diagnosed NSCLC and underwent 18F-FDG PET/CT scans were enrolled in this study. Mediastinal lymph nodes with 18F-FDG uptake greater than the mediastinum were analyzed. The metabolic parameters of maximum and mean standardized uptake value (SUVmax, SUVmean), SUVratio (node SUVmax/mediastinum SUVmax), metabolic tumor volume (MTV), total lesio...
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research