Dosimetry in Lu-177-PSMA-617 prostate-specific membrane antigen targeted radioligand therapy: a systematic review
Conclusion
177Lu-PSMA systemic radiation therapy (SRT) is a well-tolerated and reliable treatment option against the management of the mCRPC stage of prostate carcinoma. Lacrimal glands and salivary glands are the major critical organs in 177Lu-PSMA SRT. Besides, tumors receive 3–6 times higher absorbed doses compared to organs at risk. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2022 Category: Nuclear Medicine Tags: Review Articles Source Type: research
[18F]FDG PET/MRI in the follow-up of hepatocellular carcinoma after liver transplantation
Conclusions
PET/MRI is useful for oncological surveillance of patients who have undergone liver transplantation for HCC, particularly in cases of allergy to contrast media, renal failure or persistently elevated alpha-fetoprotein levels, and with no identification of metastatic/relapsing foci at standard-of-care imaging. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
The diagnostic accuracy of O-(2-18F-fluoroethyl)-L-tyrosine parameters for the differentiation of brain tumour progression from treatment-related changes
Conclusions
18F-FET static parameters alone showed a comparably high sensitivity in the differentiation between brain tumour true progression and TRC. Combining static and kinetic parameters provided improved diagnostic performance. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Radiomics model based on preoperative 18F-fluorodeoxyglucose PET predicts N2-3b lymph node metastasis in gastric cancer patients
Objective
The aim of the study was to construct and validate 18F-fluorodeoxyglucose (18F-FDG) PET-based radiomics nomogram and use it to predict N2-3b lymph node metastasis in Chinese patients with gastric cancer (GC).
Methods
A total of 127 patients with pathologically confirmed GC who underwent preoperative 18F-FDG PET/CT imaging between January 2014 and September 2020 were enrolled as subjects in this study. We use the LIFEx software to extract PET radiomic features. A radiomics signature (Rad-score) was developed with the least absolute shrinkage and selection operator algorithm. Then a prediction model, whi...
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Semiautomatic assessment of whole-body tumor burden with 18F-PSMA-1007 in biochemical recurrent prostate cancer
Objective
The aim of the study was to evaluate the 18F-PSMA-1007 PET/computed tomography (CT) semiautomatic volumetric parameters to assess the whole-body tumor burden and its correlation with prostate-specific antigen (PSA) and Gleason score in patients with biochemically recurrent prostate cancer (PCa).
Materials and methods
A total of 110 patients referred for 18F-PSMA-1007 PET/CT due to biochemical recurrence were retrospectively analyzed. Whole-body total lesion prostate-specific membrane antigen (wbTl-PSMA) and whole-body PSMA-derived tumor volume (wbPSMA-TV) metrics on 18F-PSMA-1007 were obtained semiauto...
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Radiosynthesis and biological evaluation of 18F-labeled bispecific heterodimer targeted dual gastrin-releasing peptide receptor and prostate-specific membrane antigen for prostate cancer imaging
Conclusion
[18F]AlF-GRPR-PSMA has the potential to simultaneously target PSMA and GRPR for PCa imaging. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Lung adenocarcinoma: development of nomograms based on PET/CT images for prediction of epidermal growth factor receptor mutation status and subtypes
Conclusion
EGFR 21 L858R mutation was more likely to be nonsolid texture with air bronchograms and pleural retraction on CT images. And they were more likely to be associated with lower FDG metabolic activity compared with those wild-types. The sex difference was mainly caused by the 19 deletion mutation, and calcification was more frequent in them. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Correlation of epidermal growth factor receptor mutation status and PD-L1 expression with [18F]FDG PET using volume-based parameters in non-small cell lung cancer
Conclusion
Based on the preliminary results of this study, FDG PET may help in the prediction of PD-L1 expression level, but not EGFR mutation status, in patients with newly diagnosed NSCLC. The SUVmax rather than MTV or TLG, may be of value in predicting the six groups according to the combination of EGFR mutation status and PD-L1 expression level. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Prediction of pathological response using 18F FDG PET/CT derived metabolic parameters in locally advanced breast cancer patients
This study aims to assess the value of flurodeoxyglucose (FDG)-PET derived metabolic parameters for prediction of pathologic response in LABC postneoadjuvant therapy.
Methods
Totally 47 patients with LABC underwent initial and postneoadjuvant therapy PET scans. ΔSUVmax%, ΔTLG% and ΔMTV% were calculated. Post-therapy histopathologic therapeutic response was assessed.
Results
In total 91.5% of patients had invasive duct carcinoma and the remaining (8.5%) had invasive lobular carcinoma. Postneoadjuvant PET/CT was able to detect 91.7% of patients with pathologically proven complete response in primary tumor, 6...
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Effect of Bayesian penalty likelihood algorithm on 18F-FDG PET/CT image of lymphoma
Conclusion
BPL reconstruction algorithm could effectively improve clinical image quality and diagnostic certainty. In quantitative analysis, there were no significant differences among different pathological groups, but there were significant diversities in lesion sizes. Especially for small lesions, lesion SUVmax increased and SBR was significantly improved, which may better assist in the diagnosis of small lesions of lymphoma. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
The relationship between brain glucose metabolism and insulin resistance in subjects with normal cognition – a study based on 18F-FDG PET
Conclusions
18F-FDG brain PET imaging could be helpful for the early diagnosis and treatment of changes in brain glucose metabolism caused by insulin resistance. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Distinguishing between primary central nervous system lymphoma and glioblastoma using [18F]fluoromisonidazole and [18F]FDG PET
Objective
The purpose of this study was to assess the diagnostic value of [18F]fluoromisonidazole (FMISO) and 2-deoxy-2-[18F]fluoro-D-glucose (FDG) PET to discriminate primary central nervous system lymphoma (PCNSL) from glioblastoma.
Methods
FMISO and FDG PET/CT scans before therapy obtained in 13 patients with PCNSL and in 62 patients with glioblastoma were retrospectively reviewed. PET results were evaluated by visual and semiquantitative analysis. For semiquantitative analysis, the maximum standardized uptake value (SUV) for tumor (T) and the mean SUV for normal contralateral hemisphere (N) were calculated, ...
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Evaluating the correlation of serum leptin levels with evidence of coronary artery disease on myocardial perfusion single-photon emission computed tomography in suspected coronary artery disease patients
Conclusion
Based on our findings, there was no significant correlation between myocardial perfusion scan parameters and leptin levels. Serum leptin and different groups of age, sex and coronary artery risk factors were not correlated as well. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Safety and tolerability of regadenoson compared with dipyridamole in myocardial perfusion imaging in patients scheduled to undergo medium to high-risk noncardiac surgery: a randomized controlled study
Conclusion
In our group of patients scheduled for myocardial perfusion imaging for preoperative assessment, the two agents, regadenoson and dipyridamole, have no significant differences in the frequency of mild adverse reactions and in aminophylline use, with regadenoson also having the advantage of faster symptom resolution. Nevertheless, dipyridamole can be considered as a well-tolerated and low-cost alternative. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
VNTR polymorphism in the SLC6A3 gene does not influence dopamine transporter availability measured by [18F]FE-PE2I PET or [123I]FP-Cit SPECT
Objective
To investigate the potential impact of polymorphism in the 3′-untranslated region (3′UTR) of the SLC6A3 gene (DAT1) on normal variation in dopamine transporter (DAT) imaging with [18F]FE-PE2I PET and [123I]FP-Cit SPECT.
Methods
Thirty-six individuals (mean age 70.4±5.4 years) with normal [18F]FE-PE2I PET and [123I]FP-Cit SPECT were genotyped for variable number of tandem repeats (VNTR) in the 3′UTR of the DAT1 gene. The DAT-availability in the caudate and putamen as measured with [18F]FE-PE2I PET and [123I]FP-Cit SPECT, as well as in the substantia nigra with [18F]FE-PE2I PET were compared betwe...
Source: Nuclear Medicine Communications - February 10, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
