Attenuation correction in CZT myocardial perfusion imaging comparison of supine-prone and low-dose CT-corrected supine acquisitions
Aims The study aimed to investigate whether additional prone imaging delivers comparable results to supine imaging with low-dose computed tomography (CT) attenuation correction (CTAC) in cadmium, zinc and telluride (CZT) myocardial perfusion imaging. Methods and results Thirty-four patients with an indication for myocardial perfusion imaging were studied with a CZT camera in the supine and then prone position. Furthermore, a low-dose CT was acquired. Three data sets were reconstructed and considered for analysis: (1) supine CZT, (2) supine CZT with CTAC and (3) supine CZT with additional prone CZT. Based on 17-s...
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Automated classification of increased uptake regions in bone single-photon emission computed tomography/computed tomography images using three-dimensional deep convolutional neural network
Conclusions This study suggests that DCNN could be used for the direct classification of benign and malignant regions without extracting the features of SPECT/CT accumulation patterns. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Renogram image characteristics and the reproducibility of differential renal function measurement
This study aims to investigate factors associated with the reproducibility of DRF measurements. Methods The association between age, GFR and imaged derived image characteristics and reproducibility of repeated DRF estimates calculated using the area under the curve method and the Rutland Patlak method was analysed for cohort 1 (n = 127). The association between these variables and reproducibility of DRF was tested with univariate linear regression. The univariate linear regression results were used to plan the multiple linear regression combinations. The associations between variables identified and reproduci...
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Fuzzy logic-based moving average filters for reducing noise from Tc-99m-sestamibi parathyroid images
Conclusion On the basis of subjective assessment, the performance of ATMAV_3 fuzzy filter was found to be better compared to the classical moving average filter in reducing noise from Tc-99m-sestambi parathyroid images. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Impact of fluorine-18-fluorodeoxyglucose PET/computed tomography in staging of patients with gallbladder cancer: a systematic review and meta-analysis
Conclusion With the limited data available currently, we found that 18F-FDG PET/CT is a quite accurate noninvasive tool in staging the workup of GBCa. However, further large multicentre trials are necessary for the generation of stronger evidence in this regard. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Reviews Source Type: research

The role of 18F-Fluorodeoxyglucose PET/CT in restaging patients with small cell lung cancer: a systematic review
Conclusions This review encourages the use of 18F-FDG PET imaging, especially in conjunction with ceCT in recurrent SCLC patients. Further level I evidence is needed to further assess the diagnostic and prognostic capability of 18F-FDG PET/ceCT findings in SCLC. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - July 22, 2021 Category: Nuclear Medicine Tags: Reviews Source Type: research

18F-FDG PET/CT imaging features of patients with multicentric Castleman disease
Conclusion 18F-FDG PET/CT is a useful tool in the diagnosis, evaluation, and follow-up of MCD by providing systemic manifestations of lymphadenopathy, pulmonary involvement, and hypermetabolic spleen or bone marrow. Furthermore, the lymphadenopathy in MCD presented a predominantly peripheral distribution, relatively symmetric, moderately hypermetabolic, and not confluent pattern on 18F-FDG PET/CT. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

FDG-PET/CT: novel method for viability assessment of livers perfused ex vivo
Conclusion This study demonstrates the feasibility of FDG-PET/CT for viability assessment of ex vivo perfused liver grafts after 1 week. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Utility of 18F-FDG-PET/CT in management and prognostication of treatment naïve late-stage soft tissue sarcomas
Conclusion 18F-FDG-PET/CT allows for more accurate M-staging in late-stage STSs, which in turn influences the option of curative surgical resection and thus impacts patient prognosis. Lower baseline MTV/TTV and progression in interim PET/CT are also associated with lower survival. Textural analysis may have a role in noninvasive grading. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The influence of 68Ga-prostate-specific membrane antigen PET/computed tomography on prostate cancer staging and planning of definitive radiation therapy
Conclusions 68Ga-PSMA PET/CT changed the prostate cancer stage in around one-third of men. PSMA PET/CT significantly impacted radiation planning. Further prospective studies are still required. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Potential application value of PET/computed tomography in retroperitoneal leiomyosarcoma and a literature review
Objective To analyze the fluorine-18 fludeoxyglucose PET/computed tomography (18F-FDG PET/CT) findings of retroperitoneal leiomyosarcoma (RLMS) and the role of this method in differentiating between benign and malignant masses and classifying the malignant degree to improve the understanding of this rare disease. Methods Eight leiomyomas (A group), 13 RLMSs (B group), and 20 postoperative recurrence/metastasis RLMSs (C group) were enrolled. PET/CT features of B group were analyzed. The differences of metabolic parameters between three groups were compared, receiver operating characteristic (ROC) curve analysis w...
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Correlation of 18-fluorodeoxyglucose PET/computed tomography parameters and clinical features to predict outcome for diffuse large B-cell lymphoma
Purpose To determine if the correlation between different metabolic parameters along with clinical features can create an improved model of prognostication for diffuse large B-cell lymphoma (DLBCL) patients. Methods We retrospectively evaluated 89 patients with DLBCL. All patients had a baseline and an interim 18F-FDG PET/CT. Seventy-nine also had an end-of-treatment PET/CT (EOT-PET). For each scan, we collected standardized uptake value (SUVmax, SUVmean, SUVpeak), metabolic tumor volume (MTV), total lesion glycolysis (TLG), SUVmaxsum, SUVmeansum, MTVsum, and TLGsum. These metabolic parameters were combined with...
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Preclinical evaluation of [68Ga]Ga-MALAT-1-antisense oligonucleotides for specific PET imaging of MALAT-1 expressing tumours
Conclusions We conclude that [68Ga]Ga labelling of MALAT-1 ASO is a convenient approach. The high accumulation of [68Ga]Ga-MALAT-1-ASO for tumours expressing MALAT-1 suggests that this radio compound may be used as a potential positron molecular probe. Molecular structure optimization studies need to be more in-depth to further reduce its background uptake and enhance tumour targeting. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Alterations in cerebral glucose metabolism as measured by 18F-fluorodeoxyglucose-PET in patients with persistent postconcussion syndrome
Conclusions Overall, these findings suggest a complex pattern of cerebral metabolism in PCS patients, with a mixture of hypometabolic and hypermetabolic regions that correlate with various symptoms, highlighting both potential pathological and compensatory mechanisms in PCS. The findings also suggest that FDG PET is useful for providing neurophysiological information in the evaluation of patients with PCS and may help guide future targeted therapies. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

18F-FAZA PET/CT in pretreatment assessment of hypoxic status in high-grade glioma: correlation with hypoxia immunohistochemical biomarkers
Conclusions The correlation of 18F-FAZA PET parameters with CD31 and CA-IX represents a reliable method for assessing tumour hypoxia in HGG. The inverse correlation between tumour vascularisation, SUVmax and SUVmean suggest that highly vascularized tumours might present more oxygen supply than hypoxia. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research