The value of intravenous contrast medium in PSMA PET/CT imaging in patients with biochemical recurrence of prostate cancer
Conclusion Diagnostic abdominal ceCT increases the diagnostic certainty and interobserver agreement in Ga-68 PSMA PET/CT in BCR of prostate cancer. The diagnostic performance of cePET/CT is significantly better than ceCT alone but not nePET/CT. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Prognostic significance of 18F-FDG PET/CT parameters in IDH-1 wild-type GBM and correlation with molecular markers
Aim To assess the prognostic role of metabolic parameters on 18F-FDG PET/CT & correlation with molecular markers in IDH-1 wild-type GBM. Methods A total of 129 patients with brain lesions showing equivocal findings on baseline MRI who were referred for fluoro-deoxy-glucose PET/CT were analyzed. Of these, 50 underwent surgery/biopsy and postoperative histopathological diagnosis of IDH-1 wild-type GBM. SUVmax, metabolic tumor volume (MTV), total lesion glycolysis (TLG) & T/w ratio was calculated. Median metabolic parameters were used for stratification. Overall survival was calculated using Kaplan–Meier method a...
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Baseline 18F-FDG PET textural features as predictors of response to chemotherapy in diffuse large B-cell lymphoma
Conclusion Increased textural heterogeneity in baseline PET images was found to be associated with incomplete response in DLBCL. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Evaluation of [68Ga]Ga-PSMA PET/CT for therapy response assessment of [177Lu]Lu-PSMA radioligand therapy in metastasized castration refractory prostate cancer and correlation with survival
Conclusion In [177Lu]Lu-PSMA-617-treated mCRPC patients OS of the group of CR/PR/SD was significantly higher compared to the progressive disease group (mPERCIST/EORTC) in ERA. Therefore, [68Ga]Ga-PSMA PET might serve as a complementary diagnostic tool for TRA offering prognostic value regarding OS. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Single scan SeHCAT studies: a model for the prediction of the 3-h counts
Conclusion This work presents a model that was able to predict the counts in the 3 h SeHCAT study for patients on seven gamma cameras. This can enable a single scan study, giving significant savings to patient and staff time and imaging resources. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Clinical impact of targeted single-photon emission computed tomography/computed tomography (SPECT/CT) bone scintigraphy on the assessment of bone metastasis in cancer patients
Conclusions SPECT/CT bone scintigraphy afforded a significant reduction of the number of patients with equivocal findings who needed further evaluation with other imaging modalities, preventing unnecessary delays in diagnosis and potential changes in disease staging and treatment planning. Moreover, SPECT/CT bone scintigraphy slightly increased diagnostic sensitivity. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Ameliorating effects of N-acetyl cysteine against early liver damage of radioiodine in rats
Objective The present study was aimed to explore the potential ameliorating effects of N-acetyl cysteine (NAC) against radioiodine (RAI)-induced early liver damage. Methods Thirty Wistar Albino male rats were arbitrarily allocated into three groups each containing 10 rats: the control group (group 1); the RAI group (group 2), oral 111 MBq/kg radioiodine was administered to rats; the RAI + NAC group (group 3), 150 mg/kg/day intraperitoneal NAC treatment was initiated 3 days prior to the RAI administration and continued for 10 days. Liver samples were obtained 24 h after the last dose of NAC therapy for ...
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Factors predicting the risk of biochemical incomplete response in well-differentiated thyroid cancer after total thyroidectomy
Background Differentiated thyroid cancer (DTC) is the most common endocrine carcinoma with an overall good prognosis. However, persistent or recurrent disease (P/R disease) and incomplete biochemical response (BIR) are causes of morbidity. Histopathology and TNM stage may not predict P/R disease and BIR in all patients. Various clinical parameters, histopathological features and preablative-stimulated thyroglobulin (presTg) have been proposed to predicts P/R disease. However, there is uncertainty for presTg cutoff and diagnostic accuracy. The study’s objective was to predict the BIR before radioiodine ablation from a...
Source: Nuclear Medicine Communications - October 14, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Evaluation of 68Ga-PSMA PET/CT with Volumetric Parameters for Staging of Prostate Cancer Patients: Erratum
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Erratum Source Type: research

British Nuclear Medicine Society Autumn Meeting 2021
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Abstracts Source Type: research

In-house development, implementation and evaluation of machine learning software for automated clinical scan processing
Conclusion This work demonstrates that established machine learning technology and modest hardware can be used to create automated segmentation tools that perform well in the clinic. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

18F-FDG PET/computed tomography scan in patients with suspicion of recurrent neuroendocrine carcinoma of the cervix
Conclusions 18F-FDG PET/CT is an efficient technique for detecting recurrent cervical neuroendocrine carcinoma, and may thus contribute to improving patient management. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Peptide-based 68Ga-PET radiotracer for imaging CD133 expression in colorectal cancer
Conclusion: Rapid tumor CD133 detection and selectivity were demonstrated in vitro and in vivo with PET using the specific CD133 binding peptide 68Ga-DOTA-LS7. A robust correlation was detected in vivo between tumor signals from mouse xenograft models with different cell lines and CD133 expression. The favorable characteristics of 68Ga-DOTA-LS7, such as convenient synthesis and specific uptake, warrant its further investigation for CD133 expression imaging. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Improved 18-FDG PET/CT diagnosis of multiple myeloma diffuse disease by radiomics analysis
Conclusions Radiomics analysis of 18-FDG PET/CT images with machine-learning overcame the limitations of visual analysis, providing a highly accurate and more reliable diagnosis of diffuse bone marrow infiltration in multiple myeloma patients. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Identification of specific SUVmax ratios enhances diagnostic accuracy for staging of intrathoracic nodes in lung cancer
Conclusion In this relatively small sample, SUVmax LN/MBP 2.3 had a PPV of 100% for diagnosing malignant nodes. Using SUVmax ratios could obviate the need for staging EBUS in selected patients with resultant time and cost savings. Selecting different SUVmax ratios, chosen to provide high accuracies for the parameter of interest to change management, is a potentially powerful diagnostic tool that is overlooked when FDG uptake is only classified as ‘positive’ or ‘negative’. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - September 23, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research