Renal protection during 177lutetium DOTATATE molecular radiotherapy in children: a proposal for safe amino acid infusional volume during peptide receptor radionuclide therapy
Peptide receptor radionuclide therapy (PRRT) using radiolabelled somatostatin analogues such as 177-lutetium DOTATATE is an effective treatment modality for neuroendocrine tumours, paragangliomas, and neuroblastomas. However, renal and haematopoietic toxicities are the major limitations of this therapeutic approach. The renal toxicity of PRRT is mediated by renal proximal tubular reabsorption and interstitial retention of the radiolabelled peptides resulting in excessive renal irradiation that can be dose-limiting. To protect the kidneys from PRRT-induced radiation nephropathy, basic amino acids are infused during PRRT as ...
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Technical Note Source Type: research
Using 18F-flurodeoxyglucose and 68Ga-fibroblast activation protein inhibitor PET/CT to evaluate a new periprosthetic joint infection model of rabbit due to Staphylococcus aureus
Purpose
The existing periprosthetic joint infection (PJI) models have obvious limitations, and studies of PJI on animal models using PET/computed tomography (CT) for diagnosis are still lacking. Thus, the aim of this study was to establish a new PJI model and 18F-fluorodeoxyglucose (FDG) and 68Ga-fibroblast activation protein inhibitor (FAPI) were employed to study their performance.
Methods
A novel PJI model of rabbit was developed by placing two screws in the tibia and femur. Based on bacteria concentration, the animals were divided into five groups, control, 104, 105, 106 and 107. 18F-FDG and 68Ga-FAPI PET/CT...
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Can 18F-FDG PET/CT alone or combined with radiology be used to reliably grade cartilage bone neoplasms for surgical decision making?
Objective
Treatment of chondrosarcomas is grade based; intralesional curettage for grade 1 and resection for grade 2 or more. Currently used methods to determine grades before surgery are not highly accurate and create a dilemma for the surgeon. We have used a PET-CT combined with imaging to answer the following study questions: (1) Does SUVmax value from an 18F-FDG PET/CT correlate with the grade of chondrosarcoma? (2) Can a cutoff SUVmax value be used to differentiate between various grades of chondroid neoplasms with sufficient sensitivity and specificity? (3) Does SUVmax guide the clinician and add value to radiolo...
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Impact on the long-term prognosis of FDG PET/CT in luminal-A and luminal-B breast cancer
Purpose
The aim of the present study was to explore the prognostic role of 2- deoxy-2-[18F]fluoro-D-glucose PET (FDG PET)/CT in recurrent luminal A and luminal B breast cancer.
Materials and methods
From two institutional databases, we retrospectively retrieved data about breast cancer patients undergoing FDG PET/CT between 2011 and 2018 for the assessment of recurrency. Molecular subtypes of breast cancer were defined based on the expression of estrogen, progesterone, human epidermal growth factor receptor 2 (HER2)-b receptors and proliferation index. Overall survival (OS, intended as the time from PET/CT and t...
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Impact of 18F-fluciclovine PET/CT on salvage radiotherapy plans for men with recurrence of prostate cancer postradical prostatectomy
Conclusions
Incorporating 18F-fluciclovine PET/CT into treatment planning may help identify patients suitable for salvage radiotherapy, help augment planned radiotherapy to better target lesions and support the clinician to optimise patient management. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
99mTc-HMPAO-WBC SPECT/CT versus 18F-FDG-WBC PET/CT in chronic prosthetic joint infection: a pilot study
Conclusion
This pilot study showed no difference in the sensitivity or specificity of 99mTc-HMPAO-WBC SPECT/CT and 18F-FDG-WBC PET/CT when combined with 99mTc-nanocollloid SPECT/CT in the diagnosis or treatment evaluation of suspected late chronic PJI. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Prognostic significance of pretreatment 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) in patients with primary T cell lymphomas
Conclusion
Pretherapy SUVmax may serve as an independent predictor of outcome in patients with newly diagnosed T cell lymphomas. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Derivation and validation of a 18F-FDG PET/CT scoring model to predict malignant pleural effusion
Conclusions
The PET/CT scoring model is a valuable strategy to help physicians to distinguish malignant–benign pleural effusion and stratify patients who will benefit from invasive procedures. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
The impact of 18F-fluorodeoxyglucose PET/computed tomography on clinical staging in bladder cancer
Conclusion
18F-FDG PET/CT can potentially change the clinical stage determined by CT and MRI when used for staging in bladder cancer, and can lead to nodal up-staging particularly in cases with muscle-invasive bladder cancer. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Reduction of radiation accumulation in salivary glands through oral vitamin C during 68Ga-PSMA-11 total-body dynamic PET/CT imaging
Conclusion
Oral vitamin C could reduce the accumulation of radiation in the salivary glands during 68Ga-PSMA-11 total-body dynamic PET/CT imaging. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Accurate measurement of coronary artery calcium in cancer patients using the CT component of PET/CT scans
Conclusion
Estimation of CAC from the CT component of PET/CT scans is a reliable method for the detection of significant CAC in cancer patients and correlates well with the standard method. This technique should permit the calculation of cardiovascular risk in cancer patients undergoing PET/CT without any additional radiation exposure. A significant number of asymptomatic low-to-intermediate-risk cancer patients were found to have a high risk of cardiovascular disease. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Reference values of mandibular condylar growth activity: a study of SUVmax with quantitative bone SPECT/CT
Conclusions
The condylar SUVmax varied with age. Different cutoff values of condylar SUVmax should be employed for diagnosing active UCH for patients in different ages. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Postoperative radioiodine therapy impact on survival in poorly differentiated thyroid carcinoma: a population-based study
Purpose
The true impact of postoperative radioiodine therapy on survival has been controversial for patients with poorly differentiated thyroid carcinoma (PDTC). We aimed to determine the impact of postoperative radioiodine on survival in PDTC through a population-based study.
Methods
Data on patients with PDTC were collected from the US SEER database (2004 to 2015). Patients were divided into the radioiodine group and nonradioiodine group. Survival comparison between groups was evaluated by Kaplan–Meier curves, log-rank test and multivariate Cox regression analysis. Akaike information criterion was used to se...
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Tandem high-dose 131I-MIBG therapy supported by dosimetry in pediatric patients with relapsed-refractory high-risk neuroblastoma: the Bambino Gesu’ Children’s Hospital experience
Conclusion
High-dose 131I-MIBG therapy combined with chemotherapy represent a well-tolerated and effective modality of treatment in heavily pretreated patients affected by relapsed/refractory NBL. However, further studies, including a wider cohort of patients, are needed. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
18F-FDG PET/CT for the evaluation of male breast cancer: a systematic review
Conclusion
Despite some limitations affecting our review, 18F-FDG PET/CT seems to be a valuable tool to assess MBC. Further research studies are required to better underline the role of hybrid imaging with 18F-FDG for the evaluation of MBC, especially in comparison with female breast cancer. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Review Article Source Type: research
