Prospective intraindividual comparison of 18F-PSMA-7Q and 18F-DCFPyL PET/CT in patients with newly diagnosed prostate cancer
Conclusion 18F-PSMA-7Q can be used in clinical research as reliably as 18F-DCFPyL. The limited urinary excretion of 18F-PSMA-7Q may represent a potential advantage over 18F-DCFPyL for detection of lesions in the pelvis, which need to be verified by further studies. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Evaluation of response to stereotactic body radiation therapy for nonsmall cell lung cancer: PET response criteria in solid tumors versus response evaluation criteria in solid tumors
Conclusion RECIST based on the anatomic size reduction rate did not demonstrate the correlation between radiotherapeutic response and prognosis in patients with early-stage NSCLC receiving SBRT. However, PERCIST was shown as the strongest independent predictor of outcomes. PERCIST might be considered more suitable for the evaluation of NSCLC tumor response to SBRT than RECIST. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Qualitative and quantitative methods in post-chemoradiation PET for head and neck cancer
Conclusions Quantitative data such as SUVmax does not show additional value over qualitative evaluation of response to chemoradiation in head and neck tumors. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Role of 18F-FDG PET/CT in the assessment of therapy response and clinical outcome in metastatic renal cell carcinoma treated with tyrosine kinase inhibitors or immunotherapy
This study aimed to determine the role and prognostic significance of 18F-FDG PET/CT on treatment response and survival outcomes in metastatic renal cell carcinoma patients treated with immunotherapy or tyrosine kinase inhibitors (TKIs). Patients and methods Forty patients scheduled for a standard treatment protocol with TKIs (n = 17; group-1) or PD-1 inhibitors (nivolumab, n = 23; group-2) were evaluated by 18F-FDG PET/CT. Peak standardized uptake value corrected for lean body mass (SULpeak) and maximum standardized uptake value (SUVmax) were calculated, and their relationship to treatment response was evaluated. ...
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

The ‘ramp filter’ artifact in filtered back projection is due to attenuation not ramp filtering
Conclusion The ramp filter artifact in single photon emission computed tomography reconstruction is due to attenuation, not ramp filtering per se. Adjacent splanchnic activity can result in either an increase or decrease in counts. These effects are less pronounced and more consistent with iterative reconstruction. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Pulmonary perfusion imaging and delayed imaging to measure pulmonary capillary permeability in pulmonary contusion
Purpose Explore the application value of pulmonary perfusion imaging and delayed imaging for evaluating pulmonary capillary permeability. Materials and methods After establishing a rat model of pulmonary contusion, changes in the metabolic index of technetium-99m macroaggregated albumin (99mTC-MAA) in the lungs of model rats were evaluated for two consecutive days. 99mTC-MAA metabolic indices of rat lungs with pulmonary contusion of varying severity (mild, moderate, and severe) were correlated with lung wet/dry weight ratio (W/D) and Evans blue extravasation. Finally, the method was validated in patients with pu...
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Observer experience and accuracy of 18F-sodium-fluoride PET/CT for the diagnosis of bone metastases in prostate cancer
Conclusion Novice observers used the equivocal option more frequently than observers with NaF PET/CT experience. However, on the dichotomous scale, all observers exhibited high and satisfactory accuracy for the detection of bone metastases, making NaF PET/CT an effective imaging modality even in unexperienced hands. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Bone scan with technetium 99m-methyl diphosphonate, the missing link in the initial staging of muscle-invasive bladder carcinoma
Conclusion Bone scan has higher diagnostic performance than conventional imaging methods for detecting bone metastases. It changed the management plan in 8.8% of our patients, so we conclude that performing a whole-body bone scan in the initial staging of MIBC would be helpful. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Analysis of correlation factors influencing the outcome of initial 131I remnant ablative therapy in intermediate- to high-risk patients with papillary thyroid microcarcinoma
Objective To investigate the factors influencing the outcome of initial 131I remnant ablative therapy in intermediate- to high-risk patients with papillary thyroid microcarcinoma (PTMC). Methods We divided 99 patients with PTMC who underwent total thyroidectomy into two groups according to their response to initial 131I remnant ablative therapy: excellent response (ER) and non-ER groups. Clinical and laboratory characteristics were collected and retrospectively analyzed using univariate and multivariate binary logistic regression. Receiver operator characteristic (ROC) curves and diagnostic cutoff values were an...
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Is there an added value for whole body scan combined with stimulated thyroglobulin testing for follow-up of differentiated thyroid cancer patients?
Background Aim The aim of this study was to evaluate the incidence of positive WBS in patients with negative stimulated thyroglobulin (sTg), to define the clinical characteristics of this group, and the association with disease outcome. Methods DTC patients who underwent surveillance with simultaneous sTg and WBS were included. Results Two hundred seventy-two patients were included. Age at diagnosis was 46.5 ± 15.2 years, 79% were female. Mean duration of follow-up was 11.6 ± 6.8 years. Patients were categorised according to stimulation test results: sTg(−)/WBS(−) in 192/272 (70.6%); sTg...
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Youtube videos for the most commonly applied radionuclide treatments: sufficient for patients as an information source?
Conclusion Although high-quality videos about radionuclide treatments on YouTube may enlighten and motivate patients positively; it should be kept in mind that improper information may also be uploaded to this platform. Under the guidance of the European Association of Nuclear Medicine, it is necessary to generate an official video in English with multilingual subtitles. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Optimized cocktail of 90Y/177Lu for radionuclide therapy of neuroendocrine tumors of various sizes: a simulation study
Conclusion Our work showed that to achieve a more uniform dose distribution within the tumor, 177Lu alone is more effective for small tumors. For medium and large tumors, a ratio of 90Y to 177Lu with more or less 177Lu, respectively, is recommended. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

18F-fluorodeoxyglucose PET and PET/computed tomography for the evaluation of immunoglobulin G4-related disease: a systematic review
Conclusion Despite some limitations that affect our review, 18F-FDG PET or PET/CT demonstrated the ability to assess IgG4RD both at initial evaluation and after therapy. In general, no correlation between PET/CT parameters and IgG4 serum levels has been reported. A possible role for 18F-FDG PET/CT to drive differential diagnosis with other disease is starting to emerge. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Review Articles Source Type: research

Role of 68Ga and 18F PSMA PET/CT and PET/MRI in biochemical recurrence of prostate cancer: a systematic review of prospective studies
Conclusion There is prospective evidence for efficacy of PSMA PET/CT and PET/MRI in localizing disease recurrence in BCR, which increases with increasing PSA level at the time of scanning. There are no reported significant adverse effects related to the PSMA PET ligands. There is evidence of major change in management but no evidence for whether this achieves any improvement in outcome. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Review Articles Source Type: research

Nuclear medicine in the management of superficial skin abnormalities and institutional experience
Keloid, hypertrophic scars and basal cell carcinoma (BCC) falls under the category of non-melanoma skin cancer. Intralesional steroids, external beam radiation therapy, 5-Fluorouracil, cryotherapy, laser, etc are the available treatment options. However, recurrence has been reported with each type of treatment mode. In the present article, various treatment modes have been discussed and institutional experience of Rhenium-188 skin patches for the treatment of keloids and BCC has been discussed. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 24, 2022 Category: Nuclear Medicine Tags: Review Articles Source Type: research