British Nuclear Medicine Society Spring Meeting 2022
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 18, 2022 Category: Nuclear Medicine Tags: Abstracts Source Type: research

Performance and long-term consistency of five Galliform 68Ge/68Ga generators used for clinical Ga-68 preparations over a 4 year period
Conclusion The ability to prepare in the hospital radiopharmacy high-purity and pharmaceutically acceptable 68Ga-radiolabeled probes on a routine basis facilitates patient access to precision imaging for clinical and research aims. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 18, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Predicting pathological response and overall survival in locally advanced gastric cancer patients undergoing neoadjuvant chemotherapy: the role of PET/computed tomography
Conclusions Metabolic parameters obtained with F-18 FDG PET/CT scanning before and after NACT in LAGC patients can accurately predict PR and OS. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 18, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Test–retest repeatability and interobserver variation of healthy tissue metabolism using 18F-FDG PET/CT of the thorax among lung cancer patients
Conclusion HT metabolism is stable in a test–retest scenario and has high interobserver agreement. SUVmean was the most stable metric in organs with low FDG uptake and SUVpeak in HTs with moderate uptake. Test–retest measurements in LV were highly variable irrespective of the SUV parameters used for measurements. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 18, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Pretherapy 18F-fluorodeoxyglucose positron emission tomography/computed tomography robust radiomic features predict overall survival in non-small cell lung cancer
Conclusion Ten radiomic features were robust to segmentation methods and two of them (total lesion glycolysis and gray level zone length matrix_gray level non-uniformity) were independently associated with 2-year overall survival. Together with the clinical staging, these features could be utilized towards improved risk stratification of lung cancer patients. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 18, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Combined clinical and specific positron emission tomography/computed tomography-based radiomic features and machine-learning model in prediction of thymoma risk groups
Conclusions This small dataset study has proposed a machine-learning model by MLP Classifier (ANN) analysis on 18F-FDG PET/CT images, which can predict low risk and high-risk thymoma. This study also demonstrated that the combination of clinical data and specific PET/CT-based radiomic features with image variables can predict thymoma risk groups. However, these results should be supported by studies with larger dataset. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 18, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Restoration of Tc-99m methyl diphosphonate bone scan image using Richardson–Lucy algorithm
Conclusion Tc-99 m MDP bone scan images were restored to improve image quality using the Richardson–Lucy algorithm. The optimum value of the PSF parameter was found to be of size = 11 pixels and sigma = 1.75 pixels. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 18, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Comparison of reprojected bone SPECT/CT and planar bone scintigraphy for the detection of bone metastases in breast and prostate cancer
Conclusion Whole-body bone SPECT/CT can be reprojected into more familiar anterior and posterior planar images with excellent sensitivity for bone metastases, making additional acquisition of planar BS unnecessary. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - April 18, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Can nuclear imaging accurately detect scar in ischemic cardiac resynchronization therapy candidates?
Background Accurate scar assessment is crucial in cardiac resynchronization therapy (CRT) candidates, since its presence is a negative predictor for CRT response. Therefore, we assessed the performance of different PET parameters to detect scar in CRT candidates. Methods: Twenty-nine CRT candidates underwent 18F-fluorodeoxyglucose (18F-FDG)-PET/computed tomography (CT), resting 13N-NH3-PET/CT and cardiac magnetic resonance (CMR) prior to CRT implantation. Segmental 18F-FDG uptake, late 13N-NH3 uptake and absolute myocardial blood flow (MBF) were evaluated for scar detection using late gadolinium enhancement (LGE...
Source: Nuclear Medicine Communications - April 18, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Effect of proton pump inhibitors and other commonly prescribed drugs on rescanning of patients undergoing myocardial perfusion imaging: a case-control study
Objectives Proton pump inhibitor use is associated with increased gastric wall activity on myocardial perfusion imaging; however, the clinical impact is unknown. We sought to determine the association of the use of proton pump inhibitors and nine other commonly prescribed classes of medications on the risk of rescanning patients undergoing myocardial perfusion imaging. Methods A matched case-control study was performed including 337 rescanned cases and 337 same-day controls from a total of 5432 patients undergoing myocardial perfusion imaging (MPI) over a 4-year period. Results The odds of rescanning was ...
Source: Nuclear Medicine Communications - April 18, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Radiomics: a quantitative imaging biomarker in precision oncology
Cancer treatment is heading towards precision medicine driven by genetic and biochemical markers. Various genetic and biochemical markers are utilized to render personalized treatment in cancer. In the last decade, noninvasive imaging biomarkers have also been developed to assist personalized decision support systems in oncology. The imaging biomarkers i.e., radiomics is being researched to develop specific digital phenotype of tumor in cancer. Radiomics is a process to extract high throughput data from medical images by using advanced mathematical and statistical algorithms. The radiomics process involves various steps i....
Source: Nuclear Medicine Communications - April 18, 2022 Category: Nuclear Medicine Tags: Review Article Source Type: research

Correlation of preoperative PET/computer tomography 18F-fluorodeoxyglucose uptake (maximum standardized uptake value) with prognosis in patients with operated lung cancer
Conclusion It is seen that preoperative SUVmax is a parameter with prognostic significance at least as much as histopathology, age, complete/incomplete status of resection and lymph node involvement. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Prediction of early biochemical response after 177Lu-PSMA radioligand therapy with 68Ga-PSMA PET, a different perspective with quantitative parameters
Conclusion Dmax is the most prognostic parameter in predicting the early biochemical response in patients with mCRPC; high total tumor volume and burden are also parameters that give us an idea about the response to treatment. The success rate will be higher if 177Lu-PSMA RLT treatment is planned for patients with higher tumor volume and spread. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Development 68Ga trastuzumab Fab and bioevaluation by PET imaging in HER2/neu expressing breast cancer patients
Introduction Receptors on breast cancer cells play a crucial role in the management of patients. Trastuzumab is a widely used drug for the treatment of HER2/neu expressing tumors. ImmunoPET with trastuzumab is not feasible due to slow pharmacokinetics. Fragment of antigen-binding (Fab) radiolabeled with positron emitters can be used for immunoPET. Methods Fab has been generated by papain digestion and conjugated with the bifunctional chelating agent NOTA. The SDS-PAGE and MALDI-TOF were used to see the integrity of Fab and conjugated Fab. In-vitro stability and target specificity for HER2/neu receptors were perf...
Source: Nuclear Medicine Communications - March 19, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research

F-18 DOPA PET/CT in pediatric patients with hyperinsulinemic hypoglycemia: A correlation with genetic analysis
Conclusion 18F-DOPA PET/CT is a useful modality for localizing focal pancreatic lesions in children with persistent hyperinsulinemic hypoglycemia. The detection rate is significantly higher in patients with ABCC8 paternal monoallelic recessive gene mutation. 18F-DOPA PET/CT scan consequent to findings on genetic analysis appears to be useful in planning the management of children with hyperinsulinism. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research