Utility of 18F-FDG-PET/CT in management and prognostication of treatment naïve late-stage soft tissue sarcomas
Conclusion
18F-FDG-PET/CT allows for more accurate M-staging in late-stage STSs, which in turn influences the option of curative surgical resection and thus impacts patient prognosis. Lower baseline MTV/TTV and progression in interim PET/CT are also associated with lower survival. Textural analysis may have a role in noninvasive grading. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
The influence of 68Ga-prostate-specific membrane antigen PET/computed tomography on prostate cancer staging and planning of definitive radiation therapy
Conclusions
68Ga-PSMA PET/CT changed the prostate cancer stage in around one-third of men. PSMA PET/CT significantly impacted radiation planning. Further prospective studies are still required. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Potential application value of PET/computed tomography in retroperitoneal leiomyosarcoma and a literature review
Objective
To analyze the fluorine-18 fludeoxyglucose PET/computed tomography (18F-FDG PET/CT) findings of retroperitoneal leiomyosarcoma (RLMS) and the role of this method in differentiating between benign and malignant masses and classifying the malignant degree to improve the understanding of this rare disease.
Methods
Eight leiomyomas (A group), 13 RLMSs (B group), and 20 postoperative recurrence/metastasis RLMSs (C group) were enrolled. PET/CT features of B group were analyzed. The differences of metabolic parameters between three groups were compared, receiver operating characteristic (ROC) curve analysis w...
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Correlation of 18-fluorodeoxyglucose PET/computed tomography parameters and clinical features to predict outcome for diffuse large B-cell lymphoma
Purpose
To determine if the correlation between different metabolic parameters along with clinical features can create an improved model of prognostication for diffuse large B-cell lymphoma (DLBCL) patients.
Methods
We retrospectively evaluated 89 patients with DLBCL. All patients had a baseline and an interim 18F-FDG PET/CT. Seventy-nine also had an end-of-treatment PET/CT (EOT-PET). For each scan, we collected standardized uptake value (SUVmax, SUVmean, SUVpeak), metabolic tumor volume (MTV), total lesion glycolysis (TLG), SUVmaxsum, SUVmeansum, MTVsum, and TLGsum. These metabolic parameters were combined with...
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Preclinical evaluation of [68Ga]Ga-MALAT-1-antisense oligonucleotides for specific PET imaging of MALAT-1 expressing tumours
Conclusions
We conclude that [68Ga]Ga labelling of MALAT-1 ASO is a convenient approach. The high accumulation of [68Ga]Ga-MALAT-1-ASO for tumours expressing MALAT-1 suggests that this radio compound may be used as a potential positron molecular probe. Molecular structure optimization studies need to be more in-depth to further reduce its background uptake and enhance tumour targeting. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Alterations in cerebral glucose metabolism as measured by 18F-fluorodeoxyglucose-PET in patients with persistent postconcussion syndrome
Conclusions
Overall, these findings suggest a complex pattern of cerebral metabolism in PCS patients, with a mixture of hypometabolic and hypermetabolic regions that correlate with various symptoms, highlighting both potential pathological and compensatory mechanisms in PCS. The findings also suggest that FDG PET is useful for providing neurophysiological information in the evaluation of patients with PCS and may help guide future targeted therapies. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
18F-FAZA PET/CT in pretreatment assessment of hypoxic status in high-grade glioma: correlation with hypoxia immunohistochemical biomarkers
Conclusions
The correlation of 18F-FAZA PET parameters with CD31 and CA-IX represents a reliable method for assessing tumour hypoxia in HGG. The inverse correlation between tumour vascularisation, SUVmax and SUVmean suggest that highly vascularized tumours might present more oxygen supply than hypoxia. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Rate of incidental central nervous system meningioma detected in patients undergoing 18F-fluciclovine PET/CT imaging for evaluation of prostate cancer
Conclusion
Focal 18F-fluciclovine avid intracranial lesions incidentally detected in patients undergoing PET/CT imaging for prostate cancer are most often CNS meningiomas. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Prediction of tumor response and patient outcome after radioembolization of hepatocellular carcinoma using 90Y-PET-computed tomography dosimetry
Aim
90Y-radioembolization using glass or resin microspheres is increasingly used for the treatment of hepatocellular carcinoma (HCC). The aim of this retrospective study is to determine the prognostic relevance of dosimetric parameters defined with 90Y-PET-CT obtained immediately after radioembolization.
Methods
Forty-five HCC patients, mostly with multiple lesions, were treated by radioembolization between 2011 and 2017. After treatment, all underwent a 90Y PET-CT with time of flight reconstruction (90Y-TOF-PET-CT). Tumor absorbed dose and cumulative tumor dose-volume histogram were calculated using a dose poin...
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Re-188-tricarbonyl tamoxifen as a theranostic radiopharmaceutical for estrogen receptor expressing breast cancers: radiolabeling, characterization and in-vitro cytotoxic assessment
Conclusion
Re-188-tricarbonyl tamoxifen can be synthesized in-house in radiopharmacy lab. Radionuclide therapy with Re-188-tricarbonyl tamoxifen can be given using 10 times less amount of tamoxifen as compared to cold tamoxifen. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Performance of SwiftScan planar and SPECT technology using low-energy high-resolution and sensitivity collimator compared with Siemens SPECT system
Conclusion
The SwiftScan planar and SPECT have a high sensitivity while maintaining the spatial resolution compared with the conventional system. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Does significantly elevated lung shunt fraction (LSF >20%) promote extrahepatic progression in patients with hepatocellular carcinoma treated with radioembolization?
Conclusion
HCC patients with LSF>20% treated with Y-90 radioembolization have acceptable toxicities and appear to have a rate of extrahepatic tumor development (22%) higher than expected for patients with HCC. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Dual-tracer approach vs. dual time-point approach in leukocyte scintigraphy in treatment evaluation of persistent chronic prosthetic joint infection
Conclusion
No significant difference in accuracy, sensitivity, or specificity between the approaches for treatment evaluation of suspected persistent PJI in the hip or knee was observed. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
99mTc-white blood cell SPECT/CT to assess diabetic foot osteomyelitis remission: contribution of semi-quantitative scoring system
Conclusion
The study found that conventional visual assessment of 99mTc-WBC-SPECT/CT to assess DFO remission requires experience, and supported that CSI could be useful for junior nuclear physician to discriminate residual infections and inflammatory post-treatment uptake. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - June 17, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Medical radioisotopes availability: time to look beyond the pandemic
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - May 20, 2021 Category: Nuclear Medicine Tags: Letter to the Editor Source Type: research
