Digital versus analog PET/CT in patients with known or suspected liver metastases
Aim To assess if digital PET/CT improves liver lesion detectability compared to analog PET/CT in patients with known or suspected liver metastases. Materials and methods We prospectively included 83 cancer patients, with one or more of these conditions: history of liver metastases, clinical risk of having liver metastases or presence of suspected liver metastases on the first of the two PET/CTs. All patients were consecutively scanned on each PET/CT on the same day after a single [18F]fluorodeoxyglucose dose injection. The order of acquisition was randomly assigned. Three nuclear medicine physicians assessed bot...
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Magnetic resonance imaging-based partial volume-corrected 18F-sodium fluoride positron emission tomography in the femoral neck
Conclusion Our results support the use of global NaF uptake with magnetic resonance-derived partial volume correction in the femoral neck. Because osteoblastic metabolism is known to decrease with normal aging, the observed decrease in NaF uptake constitutes evidence for convergent validity, indicating that the proposed methodology likely reflects systemic osteoblastic activity. Future studies of this methodology are warranted in other instances of varying osteoblastic activity such as in metabolic bone diseases and for the evaluation of therapy targeting osteoblastic metabolism. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Sex difference in cerebral blood flow and cerebral glucose metabolism: an activation-likelihood estimation meta-analysis
Objectives Sex differences exist in a variety of aspects including neurochemicals as well as behavioral traits of cognition, language, and aggression. We performed a meta-analysis of studies using a coordinate-based technique of activation-likelihood estimation (ALE) to identify the pooled estimated effect of sex difference. Methods We performed a systematic search of MEDLINE and EMBASE for English-language publications using the keywords of ‘positron emission tomography (PET)’, ‘single-photon emission computed tomography (SPECT)’, and ‘sex’. A threshold of uncorrected P  (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Yttrium-90 dosimetry and implications on tumour response and survival after radioembolisation of chemo-refractory hepatic metastases from breast cancer
Conclusion For patients with chemo-refractory breast cancer with liver metastases, achieving a mean tumour dose>70 Gy is a significant predictor of tumour response and prolonged OS. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Clinical association of CXCR4 in primary tumor of papillary thyroid cancer and response to iodine-131 treatment
Conclusion Our data support the notion that CXCR4 are significantly expressed in PTC tumor over normal thyroid tissues. However, there is no clinical association with radioiodine treatment response. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

99mTc-antitumor necrosis factor-alpha scintigraphy for the detection of inflammatory activity in rheumatoid arthritis
Conclusions Scintigraphy with 99mTc-anti-TNF-α was well-tolerated and had a good ability to distinguish between inflammatory and noninflammatory lesions in patients with rheumatoid arthritis. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Is 67gallium dead? A retrospective review of 67gallium imaging in a single tertiary referral centre
Conclusion [67Ga]Ga-citrate has diagnostic value in the evaluation of complex patients with high-risk infection. High diagnostic yield is demonstrated in patients with bacteraemia with or without a confirmed site of infection, particularly when combined with SPECT/CT. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Chronic thromboembolic pulmonary hypertension: evaluation of V/Q SPECT/CT and V/Q Quotient SPECT findings with postoperative results of pulmonary endarterectomy
Conclusion In the light of histopathological findings and post-PEA surgical specimen examinations, the results of the present study indicated that both V/Q SPECT/CT and V/Q Quotient SPECT showed relatively high efficacy for the detection of CTEPH on per-patient and per-segment bases with an excellent agreement. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Two-bed SPECT/CT versus planar bone scintigraphy: prospective comparison of reproducibility and diagnostic performance
Conclusion TBSCT demonstrated higher reproducibility and significantly decreased the proportion of inconclusive readings of PBS. TBSCT resulted in significant gain in sensitivity and accuracy in the unselected group of patients with solid tumors. However, that gain may be better appreciated in patients with nonbreast cancer. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Adverse reactions to radiopharmaceuticals: liver radiopharmaceuticals
Radiopharmaceuticals are radioactive compounds used in nuclear medicine, consisting of a radioactive moiety and a pharmaceutical part. Radiopharmaceuticals are used for diagnosis (predominantly) and therapy (to a lesser extent). Adverse drug reactions are undesirable, unexpected, often harmful drug responses that occur when the drug is administered in therapeutic doses. Adverse reactions are more minor and rare because radiopharmaceuticals contain small amounts of pharmaceuticals and are administered to the patient in small doses. The main cause of the rare adverse reactions to radiopharmaceuticals is not the radiation its...
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Review Article Source Type: research

Hyperthyroid radioiodine therapy in the time of COVID-19: easy does it
No abstract available (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - March 19, 2021 Category: Nuclear Medicine Tags: Editorial Source Type: research

Dose-response for yttrium-90 resin microsphere radioembolisation
The fundamental premise of yttrium-90 radioembolisation is to balance safety with efficacy. To achieve this, dose-response guidance must be provided. This is a tabulation of published data of key dose-response metrics for yttrium-90 resin microsphere radioembolisation of liver malignancies. Metrics are expressed in terms of mean radiation absorbed doses (Gy), dose-volume histograms, Biologically Effective Doses, Normal Tissue Complication Probability and Tumour Control Probability. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 12, 2021 Category: Nuclear Medicine Tags: Technical Note Source Type: research

Prognostic value of imaging-based parameters in patients with intermediate-stage hepatocellular carcinoma undergoing transarterial radioembolization
Conclusions LSF, MTV and TLG are significant independent prognostic indicators of outcome in patients undergoing TARE for HCC. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 12, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Radium-223 therapy for metastatic castration-resistant prostate cancer: survival benefit when used earlier in the treatment pathway
Conclusion We found a significant survival benefit when Ra-223 was used earlier in the mCRPC treatment pathway, with additional survival advantage seen in those patients completing all six Ra-223 cycles. Our results support the use of Ra-223 earlier in the treatment pathway. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 12, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Assessment of early oxidative stress following the use of radiotheranostics agents 177Lu-PSMA for prostate cancer and 177Lu-DOTATATE for neuroendocrine tumors; radioprotective effect of vitamin C
Conclusion: According to the results of this study, RNT with Lu-PSMA and Lu-DOTATATE may induce oxidative stress via the generation of free radicals and reactive oxygen species. Consumption of vitamin C prior to RNT may ameliorate this oxidative stress. These preliminary results have positive implications for clinical practice. Verification of these noteworthy results is needed and can be conducted with larger randomized controlled trials with longer time points. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 12, 2021 Category: Nuclear Medicine Tags: Original Articles Source Type: research