Increase of Mast Cell-Nerve Association and Neuropeptide Receptor Expression on Mast Cells in Perennial Allergic Rhinitis
Conclusions: This study revealed for the first time an increase of MC-nerve association and neuropeptide receptor expression on MCs during AR as well as nerve fibres containing receptors for MCs. These results suggest that targeting or controlling airway sensory nerve function as a modulator of MCs may prevent allergic airway inflammation such as AR.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - December 28, 2016 Category: Allergy & Immunology Source Type: research
Effects of Total Sleep Deprivation on Mouse Cytokine Levels
Conclusion: The biochemical mechanisms responsible for sleep regulation are very complex. These results suggest the involvement of 3 cytokines (FGF-basic, LIF, and MIG) in sleep/wake regulation.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - December 8, 2016 Category: Allergy & Immunology Source Type: research
Sustained Effects of Neonatal Systemic Lipopolysaccharide on IL-1 β and Nrf2 in Adult Rat Substantia Nigra Are Partly Normalized by a < b > < i > Spirulina < /i > < /b > -Enriched Diet
Conclusion: Early-life infection can negatively affect Nrf2, pAKT, and pGSK-3 β for a long time in SN. A diet enriched with antioxidant and anti-inflammatory phytochemicals can partly restore some, but not all, of the effects on the antioxidant defense, possibly via normalizing effects on pAKT.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - December 8, 2016 Category: Allergy & Immunology Source Type: research
Plasma Levels of Leptin and Adiponectin in Fragile X Syndrome
Fragile X syndrome (FXS) is the most common form of familial mental retardation and one of the leading known causes of autism. The mutation responsible for FXS is a large expansion of the CGG repeats in the promoter region of theFMR1 gene, resulting in the transcriptional silencing of the gene. Leptin may be considered a cytokine-like hormone with pleiotropic actions since it may be involved in the regulation of neuroendocrine functions and the immune system response, in addition to playing a role in development. Leptin and adiponectin may act in parallel as opposing metabolic counterparts. The involvement of leptin and ad...
Source: Neuroimmunomodulation - November 30, 2016 Category: Allergy & Immunology Source Type: research
Significant Role(s) of CXCL12 and the SDF-1 3 ′A Genetic Variant in the Pathogenesis of Multiple Sclerosis
Both cellular and molecular components of the immune system are among the substantial factors involved in the pathogenesis of multiple sclerosis (MS). Accumulating evidence confirms that chemokines, as the main members of the immune system, play key roles in the regulation of immune responses. Immune system genetic parameters are believed to influence the onset of immune system-related diseases. Regarding the significant role of the CXCR4/CXCL12 axis in cell differentiation and survival and homing of hematopoietic progenitors to the bone marrow and regulation of neuronal progenitor cell migration in the central nervous sys...
Source: Neuroimmunomodulation - November 28, 2016 Category: Allergy & Immunology Source Type: research
Minocycline Suppresses NLRP3 Inflammasome Activation in Experimental Ischemic Stroke
Conclusion: We demonstrated that minocycline can ameliorate ischemia-induced brain damage via inhibiting NLRP3 inflammasome activation.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - November 15, 2016 Category: Allergy & Immunology Source Type: research
Dr. James Matthew Lipton, 1938-2016
Neuroimmunomodulation 2016;23:194-195 (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - November 14, 2016 Category: Allergy & Immunology Source Type: research
Activated Phosphorylated STAT1 Levels as a Biologically Relevant Immune Signal in Schizophrenia
Discussion: pSTAT1 levels may provide a measure of the biological relevance of widely reported elevations in levels of cytokines in SZ over the past several decades. Activation of kinase cascades can be used to partition or disassemble the composite immune signal in patients living with SZ.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - November 7, 2016 Category: Allergy & Immunology Source Type: research
Curcumin (Diferulolylmethane) Reduces Transglutaminase 2 Overexpression Induced by Retinoic Acid in Human Nervous Cell Lines
Conclusions: These results suggest a possible use of curcumin in reducing TG2 overexpression in human nervous cells.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - October 25, 2016 Category: Allergy & Immunology Source Type: research
Toll-Like Receptor 3 Contributes to Wallerian Degeneration after Peripheral Nerve Injury
Conclusion: These data show that TLR3 signaling contributes to Wallerian degeneration after peripheral nerve injury by affecting Schwann cell activation and macrophage recruitment to injured nerves.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - October 21, 2016 Category: Allergy & Immunology Source Type: research
Effects of the Sympathetic Nervous System on Regulatory T Cell and T Helper 1 Chemokine Expression in Patients with Acute Coronary Syndrome
Objective: To observe the effects of sympathetic overactivity on the immune system involved in the imbalance of T helper (Th) lymphocytes, we investigated the correlation between autonomic dysregulation and the generation of regulatory T (Treg) and Th1 chemokines in patients with acute coronary syndrome (ACS).Methods: Blood samples obtained from patients with coronary artery disease and controls were analyzed for levels of Th1 and Treg cells and their associated cytokines by flow cytometry. In addition, the activity of the cyclic adenosine monophosphate (cAMP), the levels of norepinephrine (NE), epinephrine (EPI) and serum...
Source: Neuroimmunomodulation - October 20, 2016 Category: Allergy & Immunology Source Type: research
The Role of Biogenic Amines in the Regulation of Interaction between the Immune and Nervous Systems in Multiple Sclerosis
Conclusions: These data suggest an anti-inflammatory role for biogenic amines in MS.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - October 6, 2016 Category: Allergy & Immunology Source Type: research
Rutin Acid Ameliorates Neural Apoptosis Induced by Traumatic Brain Injury via Mitochondrial Pathways in Mice
This study investigates the effect of rutin on potential mechanisms for neuroprotective effects, using the weight-drop model of traumatic brain injury (TBI) in male mice treated either with rutin or a vehicle via intraperitoneal injection 30 min after TBI. After euthanasia and 24 h after TBI, all mice were examined by tests, including neurologic scores, blood-brain barrier permeability, brain water content and neuronal cell death in the cerebral cortex. Results indicate that the levels of cytochrome c, malondialdehyde (MDA) and superoxide dismutase (SOD) were restored by rutin treatment. Rutin treatment resulted in the dow...
Source: Neuroimmunomodulation - September 19, 2016 Category: Allergy & Immunology Source Type: research
Immunological Profile in Individuals with Schistosomal Myeloradiculopathy
Conclusions: These results indicate thatS. mansoni-specific IgE in the CSF is a promising marker for the diagnosis of SMR and that the cytokines and chemokines associated with the Th2 profile may be important factors in the immunopathogenesis of SMR.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - September 9, 2016 Category: Allergy & Immunology Source Type: research
Multiple Autoantibodies and Neuromyelitis Optica Spectrum Disorders
Conclusions: NMOSD is closely associated with elevated autoantibodies, particularly antinuclear and anti-SSA/Ro antibodies. NMOSD rarely coexists with organ-specific autoimmune diseases.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - September 7, 2016 Category: Allergy & Immunology Source Type: research
