Are Inflammatory Cytokines Associated with Pain during Acute Myocardial Infarction
Conclusion: Pain during MI was associated with anti- but not proinflammatory cytokines. As IL-33 has been shown to be cardioprotective, lower IL-33 levels with more intense pain may suggest a pathway through which increased pain during MI may have an impact on the medical prognosis.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - November 6, 2017 Category: Allergy & Immunology Source Type: research
Are Inflammatory Cytokines Associated with Pain during Acute Myocardial Infarction?
Conclusion: Pain during MI was associated with anti- but not proinflammatory cytokines. As IL-33 has been shown to be cardioprotective, lower IL-33 levels with more intense pain may suggest a pathway through which increased pain during MI may have an impact on the medical prognosis.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - November 3, 2017 Category: Allergy & Immunology Source Type: research
Women Serum Concentrations of the IL-10 Family of Cytokines and IFN- & #x03B3; Decrease from the Third Trimester of Pregnancy to Active Labor
Labor is regarded as increased myometrial activity with a regular contractility pattern. At this final stage of pregnancy, myometrial quiescence is lost, accompanied by altered immune homeostasis. It is well known that the interleukin (IL)-10 family of cytokines modulates immunological responses mainly in epithelial cells, including the endometrium. To investigate their inflammatory profile during labor, we performed a longitudinal study in a group of healthy pregnant women (n = 20) with uncomplicated pregnancies in the third trimester of pregnancy and during active labor. Blood was sampled from pregnant women in the third...
Source: Neuroimmunomodulation - November 3, 2017 Category: Allergy & Immunology Source Type: research
Focal Transplantation of Aberrant Glial Cells Carrying the SOD1G93A Mutation into Rat Spinal Cord Induces Extensive Gliosis
Conclusions: AbAs bearing mutant SOD1G93A have the potential to induce neuroinflammation along the spinal cord and incipient damage to the motor neurons. The emergence of AbAs during amyotrophic lateral sclerosis pathogenesis may therefore be a mechanism to boost neuroinflammation and spread motor neuron damage along the neuroaxis.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - November 1, 2017 Category: Allergy & Immunology Source Type: research
Fluoxetine Treatment in Rats Increases the Rate of Taurine Transport in Mononuclear Cells
Conclusion: Taurine transport increases with fluoxetine treatment, and so this could be related to an immunomodulatory role of fluoxetine through TauT. Inhibition of serotonin reuptake might be involved in the regulation of taurine transport in mononuclear cells.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - October 31, 2017 Category: Allergy & Immunology Source Type: research
Focal Transplantation of Aberrant Glial Cells Carrying the SOD1 < sup > G93A < /sup > Mutation into Rat Spinal Cord Induces Extensive Gliosis
Conclusions: AbAs bearing mutant SOD1G93A have the potential to induce neuroinflammation along the spinal cord and incipient damage to the motor neurons. The emergence of AbAs during amyotrophic lateral sclerosis pathogenesis may therefore be a mechanism to boost neuroinflammation and spread motor neuron damage along the neuroaxis.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - October 31, 2017 Category: Allergy & Immunology Source Type: research
Depletion of CD11c+ Cells Does Not Influence Outcomes in Mice Subjected to Transient Middle Cerebral Artery Occlusion
Conclusions: We show, for the first time, that CD11c+ cell depletion does not influence stroke volume in a mouse model of focal cerebral ischemia. Nevertheless, given the unspecificity of the CD11c surface antigen for DC, mouse models that allow a more selective depletion of DC are needed to investigate the role of DC in stroke pathophysiology.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - October 31, 2017 Category: Allergy & Immunology Source Type: research
Depletion of CD11c < sup > + < /sup > Cells Does Not Influence Outcomes in Mice Subjected to Transient Middle Cerebral Artery Occlusion
Conclusions: We show, for the first time, that CD11c+ cell depletion does not influence stroke volume in a mouse model of focal cerebral ischemia. Nevertheless, given the unspecificity of the CD11c surface antigen for DC, mouse models that allow a more selective depletion of DC are needed to investigate the role of DC in stroke pathophysiology.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - October 30, 2017 Category: Allergy & Immunology Source Type: research
The Effects of Adenosinergic Modulation on Cytokine Levels in a Pentylenetetrazole-Induced Generalized Tonic-Clonic Seizure Model
Conclusion: Our results show that there is a clear relation between adenosinergic system and brain tissue cytokine levels. Our findings indicated that TNF- α, IL-1β, and IL-6 participate in the pathogenesis of generalized seizures, and the inhibition of TNF-α, IL-1β, and IL-6 with adenosinergic modulation may decrease seizure severity.Neuroimmunomodulation 2017;24:54-59 (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - October 25, 2017 Category: Allergy & Immunology Source Type: research
GPER Agonist G1 Attenuates Neuroinflammation and Dopaminergic Neurodegeneration in Parkinson Disease
Conclusion: Our data suggest that GPER mediates the anti-neuroinflammatory effect of estrogen in experimental PD progression.Neuroimmunomodulation 2017;24:60-66 (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - October 25, 2017 Category: Allergy & Immunology Source Type: research
Interferon- & #x03B3; Is Associated with Cerebral Atrophy in Systemic Lupus Erythematosus
Objective: We evaluated the cerebrospinal fluid (CSF) cytokine profile and magnetic resonance imaging (MRI) findings in systemic lupus erythematosus (SLE) patients with central nervous system (CNS) involvement.Methods: Consecutive SLE patients followed at the rheumatology unit were enrolled into this study. Neurologically asymptomatic controls were matched for age and sex and recruited during myelography. SLE patients were assessed for disease activity (Systemic Lupus Erythematosus Disease Activity Index; SLEDAI) and cumulative damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Dama...
Source: Neuroimmunomodulation - October 25, 2017 Category: Allergy & Immunology Source Type: research
Behavioral Conditioning of Immune Responses with Cyclosporine A in a Murine Model of Experimental Autoimmune Uveitis
Conclusions: We conclude that CsA conditioning in the EAU model mitigates Th1 but enhances Th17 immune responses, and does not ameliorate disease. The results imply that in EAU the mechanism of immune conditioning interacts with CFA components during active immunization, most likely via the TLR2/NOD2 pathway, and induces differentiation of Th17 cells that drive autoimmune diseases.Neuroimmunomodulation 2017;24:87-99 (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - October 25, 2017 Category: Allergy & Immunology Source Type: research
Reply concerning Statistical Comments on “Cytokine and Chemokine Profiles in Patients with Neuromyelitis Optica Spectrum Disorder”
Neuroimmunomodulation 2017;24:121 (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - October 25, 2017 Category: Allergy & Immunology Source Type: research
Statistical Comments on “Cytokine and Chemokine Profiles in Patients with Neuromyelitis Optica Spectrum Disorder”
Neuroimmunomodulation 2017;24:120 (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - October 25, 2017 Category: Allergy & Immunology Source Type: research
Macrophage-Derived Chemokine: A Putative Marker of Pharmacological Therapy Response in Major Depression?
In this study, we investigated the changes of plasma chemokine levels (eotaxin-1, eotaxin-3, IP-10, MCP-1, MCP-4, MDC, MIP-1 α, MIP-1β, and TARC) in 47 MDD patients before (PRE) and after 1 and 6 weeks of pharmacological treatment (POST1 and POST6) in relation to the response to antidepressive therapy. We hypothesized that the direction of alterations in levels of chemokines would significantly differ between the 2 grou ps, responders and nonresponders.Results: Among the investigated chemokines, only the level of macrophage-derived chemokine (MDC) changed significantly in relation to therapy response. MDC levels were sig...
Source: Neuroimmunomodulation - October 25, 2017 Category: Allergy & Immunology Source Type: research
