The Central Inflammatory Network: A Hypothalamic fMRI Study of Experimental Endotoxemia in Humans
Conclusion: Measuring how the hypothalamus detects or modulates systemic inflammation is a first step to understand central nervous immunomodulation.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - October 5, 2021 Category: Allergy & Immunology Source Type: research
Mild Traumatic Brain Injury Contributes to the Development of Delayed Neuroinflammation
Conclusion: Overall, the results of this study indicate that mTBI induces a sustained neuroinflammatory response.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - September 28, 2021 Category: Allergy & Immunology Source Type: research
MicroRNA-22 Level in Patients with Multiple Sclerosis and Its Relationship with Vitamin D and Vitamin D Receptor Levels
Conclusion: The miRNA-22 level was significantly downregulated in MS patients, but it had a positive correlation with disability status. Patients with SPMS have a significantly higher miRNA-22 level than patients with RRMS. VD and VDR levels were significantly lower in MS patients than controls. The miRNA-22 level was positively correlated with the VDR level.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - September 17, 2021 Category: Allergy & Immunology Source Type: research
The Exosomal MicroRNA Profile Is Responsible for the Mesenchymal Stromal Cell Transplantation-Induced Improvement of Functional Recovery after Stroke in Rats
Conclusion: We confirmed that MSC transplantation repaired stroke-induced functional impairments in rats by regulating various pathways associated with nervous system protection and MSC differentiation through the deregulation of exosomal miRNAs.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - September 17, 2021 Category: Allergy & Immunology Source Type: research
Circular Ribonucleic Acid Expression Alteration in the Spinal Cord Tissue after Spinal Cord Injury in Rats
This study focused on rat SCI models and explore the relationship between circRNAs and SCI at a genomic level.Methods: We first established a rat SCI model and extracted the target spinal cord tissue according to 4 time points. Then investigated the alterations in the circRNA expression by high-throughput whole transcriptome sequencing, analyzed data by gene ontology and the Kyoto Encyclopedia of Genes and Genomes, and constructed the circRNA-miRNA network.Results: A total of 178 circRNAs were dysregulated (89 upregulated/89 downregulated). Differential circRNAs were found to be mainly involved in the composition of specif...
Source: Neuroimmunomodulation - September 14, 2021 Category: Allergy & Immunology Source Type: research
miR-433-3p Targets AJUBA to Inhibit Malignant Progression of Glioma
Conclusion: These results proved that miR-433-3p could target to inhibit the expression of AJUBA, thus inhibiting the biological function and malignant progression of glioma.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - September 10, 2021 Category: Allergy & Immunology Source Type: research
LncRNA PCAT19 Regulates Neuropathic Pain via Regulation of miR-182-5p/JMJD1A in a Rat Model of Chronic Constriction Injury
Conclusion: This study shows that PCAT19 plays a role in NP by targeting the miR-182-5p/JMJD1A axis, and PCAT19 can be used as a new therapeutic target for NP.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - September 9, 2021 Category: Allergy & Immunology Source Type: research
The Functional Roles of Curcumin on Astrocytes in Neurodegenerative Diseases
Progressive abnormality and loss of axons and neurons in the central nervous system (CNS) cause neurodegenerative diseases (NDs). Protein misfolding and its collection are the most important pathological features of NDs. Astrocytes are the most plentiful cells in the mammalian CNS (about 20 –40% of the human brain) and have several central functions in the maintenance of the health and correct function of the CNS. Astrocytes have an essential role in the preservation of brain homeostasis, and it is not surprising that these multifunctional cells have been implicated in the onset and progression of several NDs. Thus, they...
Source: Neuroimmunomodulation - September 8, 2021 Category: Allergy & Immunology Source Type: research
Long Noncoding RNA SNHG1 Promotes Lipopolysaccharide-Induced Activation and Inflammation in Microglia via Targeting miR-181b
Conclusion: SNHG1 was involved in LPS-induced microglial activation and inflammation response via targeting miR-181b, providing another evidence of the roles of SNHG1 implicated in neuroinflammation of microglia.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - September 8, 2021 Category: Allergy & Immunology Source Type: research
LncRNA RMST Regulates Neuronal Apoptosis and Inflammatory Response via Sponging miR-150-5p in Parkinson ’s Disease
Conclusion: Serum RMST serves as a promising biomarker for the diagnosis of PD. RMST downregulation may regulate the occurrence and development of PD through inhibiting neuron cell apoptosis and the release of inflammatory cytokines via targeting miR-150-5p.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - September 7, 2021 Category: Allergy & Immunology Source Type: research
VLA-4 as a Central Target for Modulating Neuroinflammatory Disorders
The complex steps leading to the central nervous system (CNS) inflammation and the progress to neuroinflammatory and neurodegenerative disorders have opened up new research and intervention avenues. This review focuses on the therapeutic targeting of the VLA-4 integrin to discuss the clear-cut effect on immune cell trafficking into brain tissues. Besides, we explore the possibility that blocking VLA-4 may have a relevant impact on nonmigratory activities of immune cells, such as antigen presentation and T-cell differentiation, during the neuroinflammatory process. Lastly, the recent refinement of computational techniques i...
Source: Neuroimmunomodulation - September 2, 2021 Category: Allergy & Immunology Source Type: research
The Protective Effect of Notoginsenoside R1 on Isoflurane-Induced Neurological Impairment in the Rats via Regulating miR-29a Expression and Neuroinflammation
Conclusion: NGR1 protects against isoflurane-induced neurological impairment. The protective effect of NGR1 might be achieved by promoting the expression of miR-29a and preventing inflammatory response.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - August 24, 2021 Category: Allergy & Immunology Source Type: research
Presence of TSHR in NK Cells and Action of TSH on NK Cells
Conclusions: Our findings confirm that TSHR is present and functional in NK cells and provide key clues for the potential regulatory effects of TSH on TSHR in NK cells in the immune system.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - August 13, 2021 Category: Allergy & Immunology Source Type: research
miR-124-3p Ameliorates Isoflurane-Induced Learning and Memory Impairment via Targeting STAT3 and Inhibiting Neuroinflammation
Conclusion: Combining the results of the current study demonstrates that miR-124-3p may have pivotal roles in improving isoflurane-induced learning and memory impairment via targeting STAT3 and inhibiting neuroinflammation.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - August 13, 2021 Category: Allergy & Immunology Source Type: research
Interleukin-1 and Interleukin-6 Polymorphisms Might Influence Predisposition to Hemorrhagic Cerebral Vascular Diseases: A Meta-Analysis
Conclusions: This meta-analysis suggested thatIL-1A rs1800587,IL-1B rs16944, andIL-6 rs1800796 polymorphisms might influence susceptibility to hemorrhagic cerebral vascular diseases, especially for aSAH. Moreover,IL-6 rs1800795 might influence susceptibility to hemorrhagic cerebral vascular diseases in Asians.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - August 13, 2021 Category: Allergy & Immunology Source Type: research
