Hyperinflammation and Immune Response Generation in COVID-19
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) pandemic has affected millions of people worldwide. The pathophysiology of this virus is not very clearly known, thus, enormous efforts are being made by the scientific community to delineate its evading mechanism. In this review, we have summarized the hyperinflammation and humoral and cell-mediated immune response generated in human body after infection with the SARS-CoV-2 virus. The inflammatory response generated after infection by increased proinflammatory cytokines and chemokines, and complement proteins activ...
Source: Neuroimmunomodulation - December 18, 2020 Category: Allergy & Immunology Source Type: research
Correlation of Vitamin D3 with the Expression of ROR γt and Foxp3 mRNAs in the Peripheral Blood of Myasthenia Gravis Patients
Conclusions: The levels of 1,25(OH)2D3 were shown to be lower in patients with MG compared to normal controls. The observed low levels of 1,25(OH)2D3 may lead to changes in the expression of ROR γt and Foxp3 mRNAs involved in MG.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - December 3, 2020 Category: Allergy & Immunology Source Type: research
Evaluation of Brain Cytokines and the Level of Brain-Derived Neurotrophic Factor in an Inflammatory Model of Depression
Conclusion: In summary, dexamethasone decreased proinflammatory and increased anti-inflammatory levels of cytokines and prevented a reduction in BDNF levels induced by the inflammatory stimulus. Thus, the attenuation of depressive-like behavior induced by dexamethasone may be related to the effects on these parameters.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - November 11, 2020 Category: Allergy & Immunology Source Type: research
The Expression of ZnT3 and GFAP Is Potentiated in the Hippocampus of Drug-Resistant Epileptic Rats Induced by Amygdala Kindling
Conclusions: Taken together, obvious synapses, neuronal degeneration, necrosis, mossy fiber sprouting, and astrogliosis were found in the drug-resistant epileptic rat model induced by amygdala kindling.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - November 6, 2020 Category: Allergy & Immunology Source Type: research
CD49d Is Upregulated in Circulating T Lymphocytes from HTLV-1-Infected Patients
Conclusion: Our findings suggest that the increased expression of adhesion molecules, such as CD49d on T lymphocytes from HTLV-1-infected patients may contribute to the pathogenesis of the disease, in both oligo/asymptomatic and HAM/TSP-infected subjects. Accordingly, it is conceivable that there is a potential use of CD49d as target for a therapeutic approach aiming at blocking migration of activated T cells from HTLV-1-infected patients into the CNS, thus avoiding the progression to HAM/TSP.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - August 5, 2020 Category: Allergy & Immunology Source Type: research
Proinflammatory α-Adrenergic Neuronal Regulation of Splenic IFN-γ, IL-6, and TGF-β of Mice from Day 15 onwards in Arthritis
Conclusion: Sympathetic nerve fibers are rapidly lost in the spleen, and only proinflammatory α-adrenergic neuronal regulation of cytokine secretion takes place throughout the course of arthritis. These results support a predominance of a proinflammatory α-adrenergic sympathetic influence in arthritis.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - July 1, 2020 Category: Allergy & Immunology Source Type: research
Neuronal Surface Antibody Syndrome: A Review of the Characteristics of the Disease and Its Association with Autoantibodies
Several studies have certified that autoantibodies play an important role in the manifestation of neuromuscular diseases. Scientists have discovered specific neuronal tumor antibodies in patients with typical paraneoplastic neurological disorders. But in some clinical cases, it is not useful to cure this disease with common treatments unless the autoantibodies are addressed. In addition, recent studies have shown a close relationship between certain antibodies and neuronal surface proteins in some special cases. These antibodies, which act on the surface of neurons, mainly include voltage-gated calcium channel (VGKC) antib...
Source: Neuroimmunomodulation - June 18, 2020 Category: Allergy & Immunology Source Type: research
Attenuation of mTOR Signaling Is the Major Response Element in the Rescue Pathway of Chronic Kidney Disease in Rats
Conclusion: Activation of mTOR is the major responsive element with activation of miRNAs as an elementary role in the progression of kidney disease. Hence, targeting mTOR would be a possible strategy of treatment for CKD.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - June 11, 2020 Category: Allergy & Immunology Source Type: research
Regulating the Enteric Nervous System against Obesity in Mice by Electroacupuncture
Conclusions: These results suggested ENS may be a new treatment approach to obesity.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - June 9, 2020 Category: Allergy & Immunology Source Type: research
Covid-19 and Exercise-Induced Immunomodulation
Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - June 5, 2020 Category: Allergy & Immunology Source Type: research
Polyinosinic-Polycytidylic Acid Induces CXCL1 Expression in Cultured hCMEC/D3 Human Cerebral Microvascular Endothelial Cells
Conclusions: Poly IC induces the expression of CXCL1 in hCMEC/D3 cells. NF- κB, p38 MAPK, and JNK are involved in this reaction. There is a cross-talk between NF-κB and p38, and NF-κB partially regulates phosphorylation of p38. CXCL1 produced by brain microvascular endothelial cells may contribute to the brain’s defense against viral infection and various neurological diseases associated with neutrophil accumulation.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - April 15, 2020 Category: Allergy & Immunology Source Type: research
Semaphorin-3A-Related Reduction of Thymocyte Migration in Chemically Induced Diabetic Mice
Conclusions: Taken together, our data clearly unravel a disruption in the normal cell migration pattern of developing thymocytes following chemically induced insulin-dependent diabetes, as ascertained by the altered migratory response to sempahorin-3A. In conceptual terms, it is plausible to think that such disturbances in the migration pattern of thymocytes from these diabetic animals may exert an impact in the cell-mediated immune response of these mice.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - March 10, 2020 Category: Allergy & Immunology Source Type: research
Overlapping Clinical Syndromes in Patients with Glial Fibrillary Acidic Protein IgG
Conclusions: Although overlapping syndromes are rare, we report positive GFAP-IgG in 2 cases with NMOSD or RP. Both patients had clinical features of GFAP astrocytopathy, but diagnosis of the condition was very challenging because of the overlapping presentation.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - February 26, 2020 Category: Allergy & Immunology Source Type: research
Contents
Neuroimmunomodulation 2019;26:I –IV (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - February 26, 2020 Category: Allergy & Immunology Source Type: research
Acknowledgment to Reviewers
Neuroimmunomodulation 2019;26:309 (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - February 26, 2020 Category: Allergy & Immunology Source Type: research
