IL-18 Serum Levels and Variants of the Serotonin Transporter Gene Are Related to Awareness of Emotions in Healthy Subjects: A Preliminary Study
Conclusions: These results indicate a possible novel interaction between IL-18 and the serotoninergic system to mediate emotional unawareness, suggesting putative biological predictors of emotional dysregulation, which in turn can act as a risk factor for a variety of medical conditions in susceptible subjects.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - October 16, 2018 Category: Allergy & Immunology Source Type: research
Peripheral Neuroimmunoendocrine Interactions: Contribution of TNFRp55 to the Circadian Synchronization of Progesterone and Cytokine Production in Joints of Mice in Late Pregnancy
Conclusions: Our results show that TNF, via TNFRp55 signaling, modulates articular Pg and cytokine circadian rhythms in late pregnancy. These findings suggest a temporal neuroimmunoendocrine association in peripheral tissues in late pregnancy.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - October 10, 2018 Category: Allergy & Immunology Source Type: research
The Relationship between Cytokines and Verbal Memory in Individuals with Schizophrenia and Their Unaffected Siblings
Conclusion: The results are compatible with the hypothesis that deficits in verbal memory of individuals with SZ could be secondary to inadequate functioning of cognitive processing areas, such as proactive cognitive control.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - October 4, 2018 Category: Allergy & Immunology Source Type: research
Dysregulated Network of Immune, Endocrine and Metabolic Markers is Associated to More Severe Human Chronic Chagas Cardiomyopathy
Individuals who are infected withTrypanosoma cruzi develop chronic Chagas cardiomyopathy (CCC), which is a complication involving a series of immune pathogenetic mechanisms, although an association between immune and metabolic alterations was more recently proposed. Accordingly, we investigated the immuno-metabolic response in chagasic patients and their possible influence on CCC pathogenesis. To this end,T. cruzi-seropositive (asymptomatic or with CCC) and sero-negative individuals were studied. Serum tumour necrosis factor (TNF)- α, interleukin (IL)-6, adipocytokines and the expression of their receptors in peripheral b...
Source: Neuroimmunomodulation - October 4, 2018 Category: Allergy & Immunology Source Type: research
Assessment of Pyrexia and Associated Sickness Behavior in Patients with Chronic Periodontitis
Conclusion: The study demonstrated that there is a significant increase in the sublingual temperature amongst patients with severe chronic periodontitis. The subgingival temperature has a positive correlation with the sublingual temperature. There was a linear trend of an association of sickness behavior with the severity of chronic periodontitis. A significant increase in the circulating inflammatory mediators, CRP and ESR, were noticed in subjects with elevated body temperature.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - September 10, 2018 Category: Allergy & Immunology Source Type: research
Immunological Dysfunction in Autism Spectrum Disorder: A Potential Target for Therapy
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with an unknown etiology and currently few effective therapies. Immune system alterations have being demonstrated in ASD, both in humans and via animal models; immune imbalance thus arises as a possible pathway for drug intervention. In this review, the studies were classified into 2 major groups: (1) clinical research whose authors classify therapies with primary anti-inflammatory and immunomodulatory actions, making use of: sulforaphane, celecoxib, lenalidomide, pentoxifylline, spironolactone, flavonoid luteolin, corticosteroids, oral immunoglobulin,...
Source: Neuroimmunomodulation - September 7, 2018 Category: Allergy & Immunology Source Type: research
Neuroimmune Alterations in Autism: A Translational Analysis Focusing on the Animal Model of Autism Induced by Prenatal Exposure to Valproic Acid
Autism spectrum disorder (ASD) is a highly prevalent developmental disorder characterized by deficits in communication and social interaction and in stereotyped or repetitive behaviors. Besides the classical behavioral dyad, several comorbidities are frequently present in patients with ASD, such as anxiety, epilepsy, sleep disturbances, and gastrointestinal tract dysfunction. Although the etiology of ASD remains unclear, there is supporting evidence for the involvement of both genetic and environmental factors. Valproic acid (VPA) is an anticonvulsant and mood stabilizer that, when used during the gestational period, incre...
Source: Neuroimmunomodulation - September 2, 2018 Category: Allergy & Immunology Source Type: research
Thyroid Function and Autoimmune Indications in Patients with Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Conclusions: Low T3 syndrome often copresents in anti-NMDAR encephalitis and indicates a longer hospitalization, abnormal MRI findings, consciousness declination, and a higher clinical severity. However, fT3 levels do not seem to influence the prognosis of anti-NMDAR encephalitis.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - September 2, 2018 Category: Allergy & Immunology Source Type: research
Zinc Alleviates Lipopolysaccharide Interference with Both Body Temperature and Sickness Behavior in Virgin Female Rats
Conclusion: Zinc treatment is beneficial as it reduces the increased tympanic temperature induced by LPS, but it does not influence other sickness behavior caused by exposure to LPS.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - August 24, 2018 Category: Allergy & Immunology Source Type: research
Intracellular Pathogen Infections and Immune Response in Autism
Conclusion: The immune responses generated by organisms that cause perinatal maternal infection, i.e., bacteria, viruses, or parasites, have been associated with the development of autism in offspring. Physiological changes transmitted from the mother during chronic or acute inflammation should be further investigated so that modulatory preventive measures can be developed.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - August 21, 2018 Category: Allergy & Immunology Source Type: research
Reduced CD4 T Lymphocytes in Lymph Nodes of the Mouse Model of Autism Induced by Valproic Acid
Objective: Considering the potential role of lymphocytes in the pathophysiology of autism spectrum disorder (ASD), we aimed to evaluate possible alterations of T cell pools in the lymphoid organs of an animal model of autism induced by valproic acid (VPA). Pregnant Swiss mice received a single intraperitoneal injection of 600 mg/kg of VPA (VPA group) or saline (control group) on day 11 of gestation. Male offspring were euthanized on postnatal day 60 for removal of thy muses, spleens, and a pool of inguinal, axillary and brachial lymph nodes. Cellularity was evaluated, and flow cytometry analysis was performed on cell sus...
Source: Neuroimmunomodulation - August 17, 2018 Category: Allergy & Immunology Source Type: research
Interleukin 4 Leads to Sustained Phosphorylation of the STAT6 and ERK Pathways in the Retina and Disrupts Subcortical Visual Circuitry in Rodents
Conclusions: These data suggest that a single in vivo treatment with IL-4 during the early stages of development modulates signaling pathways in the retina, resulting in altered binocular subcortical visual connectivity.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - August 15, 2018 Category: Allergy & Immunology Source Type: research
High Frequency of Tc22 and Th22 Cells in Myasthenia Gravis Patients and Their Significant Reduction after Thymectomy
Conclusion: Our findings suggest a possible role of Th22 and Tc22 in MG pathogenesis.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - August 2, 2018 Category: Allergy & Immunology Source Type: research
Glutamic Acid Decarboxylase Antibody in a Patient with Myelitis: A Retrospective Study
Conclusions: Although serum GAD65 antibodies were present in a patient, it is not recommended to routinely screen for GAD65 antibodies in patients with myelitis because of their rare occurrence. However, screening for GAD65 antibodies should be considered in patients who have been diagnosed with cancer or a thymic abnormality.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - July 26, 2018 Category: Allergy & Immunology Source Type: research
Modulation of Neuroinflammation by Taklisodok-um in a Spinal Cord Injury Model
Conclusion: These findings suggest that TLSDU attenuates neuroinflammation after SCI in part by regulating TLR4 signaling at the injury site.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - July 25, 2018 Category: Allergy & Immunology Source Type: research
