Early Prognosis Effect of Cellular Immune Paralysis on Brain Complications of Extracorporeal Membrane Oxygenation Children with Severe Sepsis
Conclusion: ECMO support with brain complication was related to the upregulation of HMGB1 and YTHDF1 protein; the decreased number of CD63+ macrophages and neutrophils; the increased denatured neutrophil subgroup, especially the upregulated ratio of CCR2highCX3CR1low/CCR2lowCX3CR1high of macrophages and neutrophils; the imbalance of Th17/Th1, LPS-specific CD8+ CTL adaptive immune response paralysis; and the reduced endothelial sTIE2 protein expression level which caused clinical deterioration and prolonged average hospitalization days.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - August 10, 2021 Category: Allergy & Immunology Source Type: research
Determination of Cytokines and Oxidative Stress Biomarkers in Cognitive Impairment Induced by Methylmalonic Acidemia
Conclusions: The high-concentration methylmalonic acid in the blood induced immune cells to release pro-inflammatory cytokines such as TNF- α and IL-6. These cytokines and high-concentration methylmalonic acid stimulated the immune cells to produce reactive oxygen species (ROS) and reactive nitrogen species (RNS). The serum methylmalonic acid, cytokines, ROS, and RNS were across the blood-brain barrier and induced cognitive impairment. The small molecule substances such as serum NO, MDA, and GSH participated in the process of neuroinflammation and oxidative stress injury induced by MMA and could be useful for distinguishi...
Source: Neuroimmunomodulation - August 2, 2021 Category: Allergy & Immunology Source Type: research
Sophocarpine Attenuates Cognitive Impairment and Promotes Neurogenesis in a Mouse Model of Alzheimer ’s Disease
Conclusions: Sophocarpine could potentially alleviate cognitive impairment and brain damage in APP/PS1 mice with its neuroprotective effects via modulation of the inflammatory pathway.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - July 28, 2021 Category: Allergy & Immunology Source Type: research
Zuoguiwan Ameliorates Cognitive Deficits and Neuro-Inflammation in Streptozotocin-Induced Alzheimer ’s Disease Rats
Conclusion: The results indicated that ZGW might be a novel therapeutic strategy to slow the process of AD by modulating ER β.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - July 28, 2021 Category: Allergy & Immunology Source Type: research
Cyclosporin A as an Alternative Neuroimmune Strategy to Control Neurites and Recover Neuronal Tissues in Leprosy
Leprosy, also known as Hansen ’s disease, continues to have a substantial impact on infectious diseases throughout the world. Leprosy is a chronic granulomatous infection caused byMycobacterium leprae and shows a wide clinical and immunopathological spectrum related to the immune response of the host. This disease affects the skin and other internal organs with a predilection to infect Schwann cells, which play an active role during axonal degeneration, affecting peripheral nerves and promoting neurological damage. This chronic inflammation influences immune function, leading to neuroimmune disorders. Leprosy is also ass...
Source: Neuroimmunomodulation - July 27, 2021 Category: Allergy & Immunology Source Type: research
Rhamnazin Ameliorates Traumatic Brain Injury in Mice via Reduction in Apoptosis, Oxidative Stress, and Inflammation
Conclusion: Collectively, our study is first to demonstrate the protective effect of RMZ against experimentally induced TBI in rats.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - July 15, 2021 Category: Allergy & Immunology Source Type: research
Exercise-Mediated Alteration of miR-192-5p Is Associated with Cognitive Improvement in Alzheimer ’s Disease
Conclusion: MiR-192-5p can be modulated by the exercise intervention and involved in the protective effect of exercise on AD.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - July 13, 2021 Category: Allergy & Immunology Source Type: research
Erratum
Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - July 9, 2021 Category: Allergy & Immunology Source Type: research
Clinical Value and Potential Target of miR-27a-3p in Pulpitis
Conclusion: MiR-27a-3p might be a promising biomarker for the diagnosis of pulpitis and predict the development of irreversible pulpitis. MiR-27a-3p might be involved in the pathogenesis of pulpitis via targeting TLR4.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - July 8, 2021 Category: Allergy & Immunology Source Type: research
Protein A Immunoadsorption Relieves Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy after Unsuccessful Methylprednisolone Treatment
Conclusion: Psychological impairment can be the first sign of autoimmune GFAP-A. PAIA might be an effective treatment for patients with GFAP-A who respond poorly to conventional IVMP and IVIG therapy.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - July 8, 2021 Category: Allergy & Immunology Source Type: research
The Effect of Different Administration Time and Dosage of Vitamin D Supplementation in Patients with Multiple Sclerosis: A Meta-Analysis of Randomized Controlled Trials
Conclusion: According to our meta-analysis, the administration of vitamin D in different dosages (ranging from 2,857 to 14,007 IU/day) and treatment period (ranging from 6 to 24 months) did not affect the clinical outcomes (EDSS and relapses during research) in patients with MS. Additional RCTs should be conducted to explore whether a longer duration and a larger dosage of vitamin D without serious adverse effects might produce therapeutic effects in patients with MS.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - July 2, 2021 Category: Allergy & Immunology Source Type: research
The Effect of IFN- β Treatment on Plasma Levels of BDNF and IL-6 in Relapsing-Remitting Multiple Sclerosis Patients
Conclusion: The IFN- β treatment seems not to be effective for upregulating BDNF and IL-6 in RRMS patients.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - June 28, 2021 Category: Allergy & Immunology Source Type: research
Glial Metabolic Reprogramming in Amyotrophic Lateral Sclerosis
ALS is a human neurodegenerative disorder that induces a progressive paralysis of voluntary muscles due to motor neuron loss. The causes are unknown, and there is no curative treatment available. Mitochondrial dysfunction is a hallmark of ALS pathology; however, it is currently unknown whether it is a cause or a consequence of disease progression. Recent evidence indicates that glial mitochondrial function changes to cope with energy demands and critically influences neuronal death and disease progression. Aberrant glial cells detected in the spinal cord of diseased animals are characterized by increased proliferation rate...
Source: Neuroimmunomodulation - June 25, 2021 Category: Allergy & Immunology Source Type: research
Association of Exposure to Particulate Matters and Multiple Sclerosis: A Systematic Review and Meta-Analysis
The association between air pollution and multiple sclerosis (MS) is not entirely clear. This meta-analysis was aimed at determining the correlation between particulate matter (PM)2.5, PM10, and MS incidence/relapse. The literature search was performed in EMBASE, Web of Science, PubMed, and the gray literature. Sixteen articles were retrieved, and ten articles were included and evaluated. Three measures of association were used for the meta-analysis: odds ratio (cross-sectional and case-control studies), incidence rate ratio, or hazard ratio (cohort studies). Meta-analysis of those 3 studies on PM2.5 indicated that exposur...
Source: Neuroimmunomodulation - June 16, 2021 Category: Allergy & Immunology Source Type: research
Contribution of Growth Arrest-Specific 5/miR-674 to the Hypothalamus Pituitary Adrenal Axis Regulation Effect by Electroacupuncture following Trauma
Conclusions: Our study demonstrated the involvement of the hypothalamic Gas5/miRNA-674/SGK1 signaling pathway in EA regulation of HPA axis function after trauma.Neuroimmunomodulation (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - June 7, 2021 Category: Allergy & Immunology Source Type: research
